Impact of Erector Spinae Plane Block on Systemic Immune-inflammation Index

Impact of Erector Spinae Plane Block on Systemic Immune-inflammation Index in Breast-conserving Surgery: A Retrospective Cohort Study

The primary objective of the study is to determine whether there is a relationship between postoperative SII and erector spinae plane block application. If data emerges indicating a more suppressed inflammatory response in patients undergoing block, widespread use of this block in the specified patient group would reflect the clinical significance of the study.

The searches did not uncover any studies investigating the effects of trunk blocks, such as erector spinae plane block, on postoperative systemic inflammatory response, indicating that this study could make a significant contribution to the literature.

Study Overview

• Status: Completed
• Conditions: Erector Spinae Plane Block; Breast Conserving Surgery; Systemic Immune-inflammatory Index
• Intervention / Treatment: Procedure: Erector Spinae Plane Block

Detailed Description

Because the study will be conducted retrospectively, it carries no potential risks.

If it can be demonstrated that blocking has a suppressive effect on the inflammatory response, the main expected benefit of the study is its widespread use to improve postoperative outcomes.

• Study Type: Observational
• Enrollment (Actual): 127

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey
    • Basaksehir Cam ve Sakura City Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

women who have undergone breast-conserving surgery for malignant causes

Description

Inclusion Criteria: ASA score ≤ 3, breast-conversing surgery, age > 18 -

Exclusion Criteria: ASA score > 3, reoperation, surgical wound infection, chemotherapy in less than 2 weeks, bening lesions

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Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
ESPB + group; the patients who received erector spinae plane block	Procedure: Erector Spinae Plane Block; A standardized perioperative care management protocol is applied for all breast-conserving surgery procedures in our department. All patients are informed about ESPB and offered its application preoperatively. Patients who accept the procedure receive ESPB (preoperatively, in the sitting position, at the level of ipsilateral T4 vertebra, USG guided, out-of-plane approach) while those who refuse are subjected to routine intravenous analgesia protocols. All blocks were performed by an anesthesiologist experienced in the application of truncal blocks and 20 cc 0.5% bupivacaine (within the safe dose range for all patients to be used according to their weight) are injected and its spread is visualized under USG.
ESPB - group; the patients who didn't receive erector spinae plane block

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
systemic immune-inflammation index	Platelet count × Neutrophil count / Lymphocyte count	7 days after surgery

Collaborators and Investigators

• Sponsor: Taner Abdullah

Study record dates

Study Major Dates

• Study Start (Actual): July 15, 2025
• Primary Completion (Actual): August 15, 2025
• Study Completion (Actual): August 15, 2025

Study Registration Dates

• First Submitted: August 16, 2025
• First Submitted That Met QC Criteria: August 16, 2025
• First Posted (Actual): August 22, 2025

Study Record Updates

• Last Update Posted (Actual): August 22, 2025
• Last Update Submitted That Met QC Criteria: August 16, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Keywords: breast conserving surgery; erector spinae plane block; systemic immune-inflammatory index
• Additional Relevant MeSH Terms: Pathologic Processes; Inflammation
• Other Study ID Numbers: 2025-225

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No