PET-CT in Lymphoma Among the Eldery

November 21, 2025 updated by: Marwa Mamdouh Ekram, Assiut University

PET-CT Imaging Findings and Metabolic Parameters in Elderly Patients With Lymphoma

This study investigates PET-CT imaging patterns and metabolic parameters in elderly patients (≥60 years) diagnosed with lymphoma, aiming to enhance diagnostic accuracy and prognosis using 18F-FDG PET/CT scans.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

This cross-sectional study involves both retrospective and prospective data collection from elderly lymphoma patients (aged 60 years or older) at the Nuclear Medicine Unit, South Egypt Cancer Institute. It evaluates the PET-CT imaging findings alongside metabolic parameters such as Standardized Uptake Value (SUV), Metabolic Tumor Volume (MTV), and Total Lesion Glycolysis (TLG). The study addresses diagnostic challenges in elderly patients due to atypical presentations and comorbidities and fills the gap of scarce local data in Egypt. Imaging analysis includes visual and semiquantitative assessment of lymphatic and extranodal lesions post-injection of 18F-FDG, assessing tumor metabolic activity to provide prognostic insights. Data analysis uses SPSS with relevant statistical tests to validate findings.

Study Type

Observational

Enrollment (Estimated)

63

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

The participants include elderly patients (≥60 years) with confirmed lymphoma diagnosis through histopathological examination. Excluded are individuals with other active cancers or uncontrolled diabetes mellitus (blood glucose > 200 mg/dL), which could interfere with PET scan accuracy. Patients must have fasting blood glucose < 200 mg/dL before 18F-FDG injection and are prepared per standardized protocols. The sample size is calculated to be approximately 63 patients, providing adequate statistical power based on confidence limits and previous positive PET findings in elderly lymphoma cohorts.

Description

Inclusion Criteria:

- Age ≥ 60 years

Histopathological diagnosis of lymphoma

Exclusion Criteria:

- Presence of other concurrent active malignancies

Uncontrolled diabetes mellitus with blood glucose > 200 mg/dL at the time of PET/CT scan

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
FDG-PET/CT Imaging Pattern Description in Elderly Lymphoma Patients
Time Frame: At time of initial PET/CT scan performed as part of routine clinical evaluation
The main outcome is the characterization of metabolic and anatomical findings from 18F-FDG PET/CT scans among elderly patients (≥60 years) diagnosed with lymphoma. This includes describing the visual appearance, extent, and distribution of disease lesions observed on initial imaging.
At time of initial PET/CT scan performed as part of routine clinical evaluation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 1, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

February 1, 2027

Study Registration Dates

First Submitted

November 21, 2025

First Submitted That Met QC Criteria

November 21, 2025

First Posted (Actual)

December 2, 2025

Study Record Updates

Last Update Posted (Actual)

December 2, 2025

Last Update Submitted That Met QC Criteria

November 21, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PET-CT Imaging in Lymphoma

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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