Pattern of Microbial Keratitis in Assiut University Hospital

December 30, 2025 updated by: Liza Mamdouh, Assiut University
The aim of the study is to explore the epidemiology, including risk factors, causative microorganisms, complications and clinical outcomes of microbial keratitis among patients attending cornea clinic at Assiut University Hospital.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Microbial keratitis (MK) is a potentially-serious, sight-threatening infection that may cause significant visual impairment or even blindness if not diagnosed and treated promptly.It can be caused by a range of pathogens including bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae), viruses(herpes viruses), parasites (e.g., Acanthamoeba), and fungi (yeasts, and filaments).

Bacterial keratitis (BK) is the most common cause of microbial keratitis Incidence, risk factors and impact of disease, vary widely according to region, access to health care, socioeconomic and environmental factors, predisposing conditions and causative organisms.The frequency and severity of keratitis are significantly higher in low-income countries.

The history of contact lens (CL) wear, ocular trauma, ocular surface disease (e.g. blepharitis, and dry eye), and systemic diseases (diabetes, and rheumatoid arthritis) are common risk factors associated with MK.

Early treatment reduces the risk of corneal scarring, vascularization, or perforation.Treatment with different anti-microbial agents depend on the presenting clinical picture, initiated with broad spectrum empirical antibiotics in suspected bacterial keratitis, prior to targeted treatment guided by corneal scraping for gram-stain, culture and sensitivity.

The diagnosis of MK is made on the clinical basis together with microbiological evaluation. The microbiological profile of microbial keratitis has shown great differences worldwide. Due to the continuous shifting in microbiological profile and antibiotics resistance profiles reported in several studies, microbiological investigations and antibiotic susceptibility are mandatory to provide an effective treatment.

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

  1. Full history taking: age, gender, residency ( urbn or rural ), literacy, present or past medical and surgical histories
  2. Full ophthalmological examination,visual acuity at presentation and after healing.
  3. Slit-lamp biomicroscopy

3. outcome of corneal scraping including direct smear, culture and sensitivity

Description

Inclusion Criteria:

  • All cases presented with Microbial keratitis at cornea clinic , Assiut university hospital during the study period.

Exclusion Criteria:

  • Non-microbial keratitis including Moorens ulcers, chemical burns, and Shield ulcers.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
pattern of microbial keratitis in Assiut university hospital.
Time Frame: At initial presentation ( baseline)
Identification of different causative microbial agents of microbial keratitis among patients presenting to Assiut University Hospital.
At initial presentation ( baseline)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 1, 2026

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

March 1, 2027

Study Registration Dates

First Submitted

December 16, 2025

First Submitted That Met QC Criteria

December 30, 2025

First Posted (Actual)

January 5, 2026

Study Record Updates

Last Update Posted (Actual)

January 5, 2026

Last Update Submitted That Met QC Criteria

December 30, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Pattern Mk in A.U.H

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Keratitis

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Nigeria

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe