Prospective Evaluation of Upright Versus Supine CT Myelography of the Lumbar Spine

June 3, 2026 updated by: Samuel Hund, University of Kansas Medical Center
The purpose of this prospective study is to compare the diagnostic utility of standing (upright, weight-bearing) CT myelography with standard supine CT myelography for the evaluation of lumbar central canal and neural foraminal stenoses. This study aims to determine whether upright positioning provides additional diagnostic information in patients unable to undergo MRI, with the goal of improving assessment and management of degenerative lumbar spine disease.

Study Overview

Status

Enrolling by invitation

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Kansas
      • Kansas City, Kansas, United States, 66160
        • The University of Kansas Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Age ≥ 18 years
  • Outpatient status
  • Scheduled for routine supine CT myelography

Exclusion Criteria:

  • Inpatient status
  • Prior lumbar spine surgical intervention or presence of metallic lumbar spinal hardware (thoracic or cervical spinal procedures are permitted)
  • History of osseous metastatic disease involving the lumbar spine
  • Acute traumatic injury involving the lumbar spine
  • Pregnancy
  • Participant body habitus exceeding the scanner's safe operational limits (e.g., gantry/bore size clearance, table weight capacity) as defined by the device manufacturer.
  • Inability to tolerate CT scanning (e.g., severe pain, unable to stand independently for an extended period)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Upright and Supine CT Myelography
Radiation: Upright CT
Upright CT Myelography
Other Names:
  • Upright CT Myelography

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Does upright CT imaging change management plans for patients with lumbar spinal stenosis
Time Frame: 1 week
To determine whether upright CT imaging changes the management plan (yes or no) for patients with lumbar spinal stenosis.
1 week

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Spine measurements
Time Frame: 1 day
Objective measurements at different angles (mm) will be taken of the spine.
1 day
Severity grading of central canal stenosis
Time Frame: 1 day
Severity grading (mild, moderate, severe) of central canal stenosis in the spine.
1 day
Severity grading of neural foraminal stenosis
Time Frame: 1 day
Severity grading (mild, moderate, severe) of neural foraminal stenosis in the spine.
1 day
Presence or absence of nerve root compression
Time Frame: 1 day
Presence or absence of nerve root compression in the spine.
1 day
Presence or absence of disc bulges
Time Frame: 1 day
Presence or absence of disc bulges in the spine.
1 day
Presence or absence of herniations
Time Frame: 1 day
Presence or absence of herniations in the spine.
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Kansas Medical Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

December 1, 2026

Study Registration Dates

First Submitted

November 13, 2025

First Submitted That Met QC Criteria

March 3, 2026

First Posted (Actual)

March 6, 2026

Study Record Updates

Last Update Posted (Actual)

June 8, 2026

Last Update Submitted That Met QC Criteria

June 3, 2026

Last Verified

November 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • STUDY00162088

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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