Changes in Scalp Condition After Using a Moisturizer: a Prospective Clinical Trial Using Artificial Intelligence (scalp)

March 6, 2026 updated by: Bo Ri Kim, Seoul National University Bundang Hospital

Changes in Scalp Condition After Using a Moisturizer Containing Celastrol and Cichorium Intybus Root Extract: a Prospective Clinical Trial Using Artificial Intelligence

The goal of this clinical trial is to evaluate whether a scalp moisturizer containing celastrol and Cichorium intybus root extract can improve scalp condition in adults aged 19 years or older who require scalp moisturization due to dryness, scaling, erythema, or dandruff. The main questions it aims to answer are:

Does once-daily application of the study moisturizer improve scalp condition from baseline to week 4, as assessed by SPI-AI (Scalp Photographic Index-Artificial Intelligence)?

Does the moisturizer improve scalp biophysical parameters (erythema index, stratum corneum hydration, and transepidermal water loss) and patient-reported symptom severity over the 4-week treatment period?

Participants will:

Apply the study moisturizer once daily at bedtime to dry scalp for 4 weeks and rinse it off the following morning using their usual shampoo.

Attend study visits at baseline (week 0), week 2, and week 4 for scalp imaging, biophysical measurements, symptom questionnaires, adherence assessment, and safety monitoring.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

23

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • South Korea
    • Kyeonggi
      • Seongnam-si, Kyeonggi, South Korea
        • Seoul National University Bundang Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria

  • Age ≥19 years
  • Presence of scalp erythema, dryness, scaling, or dandruff requiring scalp moisturization

Exclusion Criteria:

  • Active infectious scalp dermatoses
  • Use of topical or systemic therapies affecting scalp status within 4 weeks prior to enrollment or during the study period
  • Inability to comply with the study protocol

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Moisturizer
participants applies the moisturizer once daily to the entire scalp at bedtime
Other: Ducray Kertyol P.S.O. Concentrate Cream, Ducray Laboratory, France
participants applied the moisturizer once daily to the entire scalp at bedtime

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
SPI-AI
Time Frame: 4week
Scalp Photographic Index with artificial intelligence
4week

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
SPI-AI
Time Frame: 2week
Scalp Photographic Index with artificial intelligence
2week
Biophysical parameter
Time Frame: 2week
erythema index (arbitrary unit)
2week
Biophysical parameter
Time Frame: 4week
erythema index (arbitrary unit)
4week
Biophysical parameter
Time Frame: 2 week
corneometer (arbitrary unit)
2 week
Biophysical parameter
Time Frame: 4 week
corneometer (arbitrary unit)
4 week
Biophysical parameter
Time Frame: 2 week
transepidermal water loss (g/m2/h)
2 week
Biophysical parameter
Time Frame: 4 week
transepidermal water loss (g/m2/h)
4 week
Patient-reported outcome
Time Frame: 2 week
visual analog scale (0-10) : higher is worse
2 week
Patient-reported outcome
Time Frame: 4 week
visual analog scale (0-10) : higher is worse
4 week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Bundang Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2025

Primary Completion (Actual)

December 31, 2025

Study Completion (Actual)

December 31, 2025

Study Registration Dates

First Submitted

February 26, 2026

First Submitted That Met QC Criteria

March 6, 2026

First Posted (Actual)

March 9, 2026

Study Record Updates

Last Update Posted (Actual)

March 9, 2026

Last Update Submitted That Met QC Criteria

March 6, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • B-2504-964-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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