Metabolomic Characteristics of Patients With Non-small Cell Lung Cancer in Plasma, Tissue and Exhaled Breath Condensate

April 15, 2026 updated by: People's Hospital of Xinjiang Uygur Autonomous Region

Metabolomic Characteristics of Patients With Non-small Cell Lung Cancer in Plasma, Tissue and Exhaled Breath Condensate: A Case-control Study

Investigators collected tissue and plasma samples from patients with benign pulmonary nodules and non-small cell lung cancer (NSCLC). Exhaled breath condensate (EBC) samples were obtained from these patients using a breath condenser. Differential metabolites were identified in samples from 22 NSCLC patients and 20 benign controls using ultra-performance liquid chromatography-high resolution mass spectrometry-based untargeted metabolomics.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

74

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
      • Ürümqi, China, 830000
        • People's Hospital of Xinjiang Uygur Autonomous Region

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Patients with non-small cell lung cancer and benign pulmonary nodules

Description

Inclusion Criteria:

Patients with non-small cell lung cancer or benign pulmonary nodules

Exclusion Criteria:

Metastatic lung cancer

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Non-small cell lung cancer - adjacent tissue group
Non-small cell lung cancer - Cancer tissue group
Non-small cell lung cancer - Preoperative peripheral blood group
Non-small cell lung cancer - Postoperative peripheral blood group
Benign pulmonary nodules - Peripheral blood group
Non-small cell lung cancer - exhaled breath condensate group
Benign pulmonary nodules - exhaled breath condensate group

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Untargeted metabolomics
Time Frame: 2022-2026
2022-2026

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

People's Hospital of Xinjiang Uygur Autonomous Region

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 30, 2022

Primary Completion (Actual)

December 31, 2025

Study Completion (Actual)

December 31, 2025

Study Registration Dates

First Submitted

April 8, 2026

First Submitted That Met QC Criteria

April 8, 2026

First Posted (Actual)

April 15, 2026

Study Record Updates

Last Update Posted (Actual)

April 20, 2026

Last Update Submitted That Met QC Criteria

April 15, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2022E02127 (Other Grant/Funding Number: Regional Collaborative Innovation Special Project - Science and Technology Aid Xinjiang Program)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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