Clinical Trials on Functional Outcomes in South Africa

Total 128 results

University of KwaZulu
University of Cape Town; African Perioperative Research Group (APORG); Safe Surgery...

Completed

An African, Multi-centre Evaluation of Patient Care and Clinical Outcomes for Paediatric Patients Undergoing Surgery (ASOS-Paeds)

Surgery | Perioperative/Postoperative Complications | Perioperative Outcomes | Outcome Assessment | Prospective Studies | Paediatrics | Hospital Mortality | Paediatric Surgery | Developing Countries

South Africa, Sudan
Centre for the AIDS Programme of Research in South...

Completed

Trial to Assess the Impact of PrEP to Tenofovir Gel on the Efficacy of Tenofovir-containing ART on Viral Suppression (TOAST)

Antiretroviral Treatment Outcomes

South Africa
University of Witwatersrand, South Africa

Completed

The HIV Testing Trends and Outcomes at a Johannesburg Trauma ICU Unit

Outcome, Fatal

South Africa
Prof Mags Beksinska

Completed

Functional Performance and Acceptability Study of Synthetic Nitrile, and Latex Graphene, Compared to Standard Latex Male Condom

Functional Performance

South Africa
National Institute of Environmental Health Sciences...

Completed

Study of DDT and Loss of Clinically-Recognized Pregnancies in South Africa

HIV Infections | Malaria | Pregnancy Outcome | Stillbirth | Spontaneous Abortion

South Africa
University of Stellenbosch
Nestlè Nutrition Institute Africa; National Research Foundation (NRF) (RSA)

Completed

Effect of Lactobacillus Plantarum 299v on Symptoms of Irritable Bowel Syndrome

Irritable Bowel Syndrome

South Africa
Foundation for Professional Development (Pty) Ltd
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes

HIV/AIDS | Pregnancy | Cost-effectiveness | Antenatal Care | Chlamydia Trachomatis | Vaginal Microbiome | Birth Outcomes | Sexually Transmitted Infection | Neisseria Gonorrhoeae | Trichomonas Vaginalis

South Africa
University of Cape Town
Stanford University

Recruiting

Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia

Preeclampsia | Pulmonary Edema | Cardiac Function

South Africa
Royal North Shore Hospital

Completed

Wearable and Patient-reported Outcome-based Continuous Assessment and Support Alerts in Palliative Care (wePRO-CASA)

Cancer | Palliative Care | Patient Reported Outcome Measures | Caregiver | Digital Health | Wearable Electronic Devices

Australia
Unity Health Toronto

Completed

Transfusion Requirements in Cardiac Surgery III (TRICS-III)

Disorder; Heart, Functional, Postoperative, Cardiac Surgery

Canada, Spain, United States, Israel, Australia, New Zealand, Denmark, Colombia, Egypt, Germany, Singapore, Switzerland, China, Brazil, Greece, India, Malaysia, Romania, South Africa
Cardiac Dimensions Pty Ltd

Terminated

An Initial Evaluation of the Carillon Mitral Contour System for Treatment of Atrial Function Mitral Regurgitation (AFIRE)

Atrial Fibrillation | Functional Mitral Regurgitation | Atrial Functional Mitral Regurgitation

Australia, Greece
Medical University of South Carolina
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Individualizing tDCS Dose

tDCS | Motor Function

United States
Rutgers, The State University of New Jersey
Harokopio University

Completed

A Study of Chios Mastic Water in Irritable Bowel Syndrome (MASTIQUA)

Irritable Bowel Syndrome

Greece
GlaxoSmithKline

Completed

A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers

Irritable Bowel Syndrome

Australia
GlaxoSmithKline

Completed

A Phase I, Randomized, Placebo-controlled, Double Blind, Repeat Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Gastrointestinal Transit Time and Pharmacodynamic Biomarkers of GSK3179106 in Normal Subjects

Irritable Bowel Syndrome

Australia
GlaxoSmithKline

Completed

A Phase 1, Randomized, Placebo-Controlled, Ascending Cohort, Dose Escalation Study in Normal Healthy Volunteers

Irritable Bowel Syndrome

Australia
Sheffield Teaching Hospitals NHS Foundation Trust

Recruiting

Traditional Dietary Advice Versus Low FODMAP Diet in Postprandial Functional Dyspepsia

Dyspepsia | Functional Gastrointestinal Disorders

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Recruiting

Traditional Dietary Advice Versus Reassurance-alone in Postprandial Functional Dyspepsia

Dyspepsia | Functional Gastrointestinal Disorders

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Recruiting

Traditional Dietary Advice Vs. Mediterranean Diet in IBS

Irritable Bowel Syndrome

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

A Study Comparing the Effectiveness and Convenience of Dietary Therapy for Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome

United Kingdom
Aghia Sophia Children's Hospital of Athens
BioGaia AB

Completed

Efficacy of Dietary Supplementation With Lactobacilllus Reuteri DSM 17938 on Functional Abdominal Pain (FAP) in Children

Functional Abdominal Pain (FAP) in Children

Greece, Poland, Slovenia
Sucampo Pharma Americas, LLC
Sucampo AG

Completed

Evaluation of the Safety of Lubiprostone in Pediatric Participants Aged ≥ 6 Years to < 18 Years With Functional Constipation

Constipation - Functional

United States
University of South Carolina
Centers for Disease Control and Prevention

Recruiting

Mindful Walking Program for Older African Americans

Cognitive Function | Behavior, Health | Aging Well

United States
Australian and New Zealand Intensive Care Research...
National Health and Medical Research Council, Australia; Medical Research Institute... and other collaborators

Enrolling by invitation

The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))

Critically Ill | Mechanical Ventilation | Long Term Outcome

Australia
Case Comprehensive Cancer Center

Terminated

Older Patients With Newly Diagnosed Breast Cancer or Colon Cancer

Breast Cancer | Colorectal Cancer | Cognitive/Functional Effects | Psychosocial Effects of Cancer and Its Treatment

United States
Anji Pharma
Covance

Completed

A Proof of Concept Study of Pradigastat in Patients With Functional Constipation

Functional Constipation

China, United States
Allergan
Ironwood Pharmaceuticals, Inc.

Completed

Linaclotide Safety and Efficacy in 2 to 5-Year-Old Participants With Functional Constipation

Functional Constipation

United States
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield; University of Liverpool

Completed

Muscle in Obesity: Imaging, Function and microRNA

Muscle Function

United Kingdom
AbbVie
Ironwood Pharmaceuticals, Inc.

Recruiting

A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide

Functional Constipation

United States, Bulgaria, United Kingdom, Croatia, Germany, Hungary
Medical University of South Carolina
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Completed

Functional Viability Duck Duck Punch (DDPSBIR)

Stroke | Rehabilitation | Recovery of Function

United States
GlaxoSmithKline

Completed

A Study To Investigate GW427353 In Subjects With Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome (IBS)

Germany, Australia, France
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of PDR001 in Patients With Advanced or Metastatic, Well-differentiated, Non-functional Neuroendocrine Tumors of Pancreatic, Gastrointestinal (GI), or Thoracic Origin or Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)

Well-differentiated Non-functional NET of Thoracic Origin | Well-differentiated Non-functional NET of Gastrointestinal Origin | Well-differentiated Non-functional NET of Pancreatic Origin | Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma

United States, Italy, Spain, Japan, Belgium, Netherlands, Germany, France, Canada, Austria, United Kingdom, Australia
Prolong Pharmaceuticals

Completed

Efficacy and Safety of SANGUINATE™ for Reduction of Delayed Graft Function in Patients Receiving a Kidney Transplant

Delayed Function of Renal Transplant

United States
AbbVie
Ironwood Pharmaceuticals, Inc.

Enrolling by invitation

Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C

Irritable Bowel Syndrome With Constipation | Functional Constipation

United States, Canada, Israel, Netherlands
Sucampo Pharma Americas, LLC
Takeda

Completed

Lubiprostone for Children With Constipation

Constipation - Functional

United States, United Kingdom, Netherlands, Poland, Belgium, France, Canada
GlaxoSmithKline

Completed

Eight-Weeks Of Treatment With Talnetant In Subjects With Irritable Bowel Syndrome (IBS)

Irritable Colon

United States, Spain, South Africa, Sweden, Australia, Canada, Germany, United Kingdom, France, Netherlands
Urovant Sciences GmbH

Completed

Study to Evaluate the Efficacy and Safety of Vibegron Administered Orally for 12 Weeks to Women With Irritable Bowel Syndrome

Irritable Bowel Syndrome

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of DV890 in Patients With COVID-19 Pneumonia

COVID-19 Pneumonia, Impaired Respiratory Function

Germany, India, Spain, Russian Federation, Mexico, Netherlands, Peru, Brazil, Hungary, Argentina, Denmark, South Africa
Sucampo Pharma Americas, LLC
Sucampo AG

Completed

Lubiprostone in Children With Functional Constipation

Constipation - Functional

United States, United Kingdom, Canada, Netherlands, Poland, Belgium, France
AbbVie
Ironwood Pharmaceuticals, Inc.

Active, not recruiting

Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) (LINZESS)

Irritable Bowel Syndrome With Constipation | Functional Constipation

United States, Belgium, Bulgaria, Canada, Estonia, Israel, Italy, Netherlands, Poland, Puerto Rico, Spain, Ukraine, United Kingdom, Germany
TheraBracelet, Inc.
Medical University of South Carolina

Completed

TheraBracelet Phase I

Stroke | Hemiparesis | Cerebrovascular Accident | Stroke Rehabilitation | Upper Extremity | Hand Function

United States
Dynogen Pharmaceuticals

Completed

8 Weeks Treatment With DDP225 in Patients With Diarrhea Predominant IBS

Irritable Bowel Syndrome

Canada, United States
Arena Pharmaceuticals

Terminated

Olorinab in Irritable Bowel Syndrome With Predominant Constipation (IBS-C) and Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D) (CAPTIVATE)

Irritable Bowel Syndrome

United States
Procter and Gamble
Alimentary Health Ltd

Completed

Efficacy of an Encapsulated Probiotic Bifidobacterium Infantis 35624 in Irritable Bowel Syndrome

Irritable Bowel Syndrome

United Kingdom
Faeth Therapeutics

Active, not recruiting

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Advanced Solid Tumor | PIK3CA Mutation | PTEN Loss of Function Mutation

United States
Ardelyx

Enrolling by invitation

Safety Study of Tenapanor for the Treatment of Pediatric Patients (6 to Less Than 18 Years Old) With IBS-C

Irritable Bowel Syndrome With Constipation (IBS-C)

United States
Ardelyx

Recruiting

Study to Assess Safety and Efficacy of Tenapanor for Treatment of IBS-C in Pediatric Patients 12 to Less Than 18 Years

Irritable Bowel Syndrome With Constipation (IBS-C)

United States
AbbVie
Ironwood Pharmaceuticals, Inc.

Recruiting

A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation

Functional Constipation (FC) | Chronic Idiopathic Constipation (CIC)

United States, United Kingdom, Bulgaria, Netherlands
Forest Laboratories
Ironwood Pharmaceuticals, Inc.

Completed

A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)

Functional Constipation in Children Ages 6-17 Years

United States, Canada
Alexion Pharmaceuticals
CTI Clinical Trial and Consulting Services

Completed

Prevention of Delayed Graft Function Using Eculizumab Therapy (PROTECT Study)

Delayed Graft Function

France, Germany, Italy, Spain, United States, Canada, Brazil, Australia, Czechia

Clinical Trials on Functional Outcomes in South Africa

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CROs in Mali

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