The HIV Testing Trends and Outcomes at a Johannesburg Trauma ICU Unit

A retrospective observational study on the HIV testing trend and outcomes in a trauma population admitted to a critical care unit for care.

Study Overview

• Status: Completed
• Conditions: Outcome, Fatal
• Intervention / Treatment: Diagnostic test: Elisa HIV testing

Detailed Description

Trauma ICU admission of 18 years and older were enrolled in the study. The HIV status was further divided into HIV-positive, HIV-negative, and HIV-unknown subgroups. The gender, ages, mechanism of injury, injuries sustained, ISS, physiological data, septic-related complications, and in-hospital mortality were noted and further analyzed.

Descriptive statistics were utilised using STATA version 15, and a p-value of <0.05 was considered statistically significant.

• Study Type: Observational
• Enrollment (Actual): 868

Contacts and Locations

Study Locations

• South Africa
  • Gauteng
    • Johannesburg, Gauteng, South Africa, 2193
      • Charlotte Maxeke Johanneburg Academic Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Major Trauma patients admitted to a Trauma unit at a Johannesburg Trauma Unit

Description

Inclusion Criteria: Trauma patients admitted to a Trauma ICU at CMJAH -

Exclusion Criteria: Those under the age of 18 or with incomplete data

-

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
HIV-positive; Those that were actually tested and had HIV-positive results	Diagnostic test: Elisa HIV testing; HIV testing on a voluntary basis
HIV-Negative; Those tested and had HIV-negative results	Diagnostic test: Elisa HIV testing; HIV testing on a voluntary basis
HIV-Unknown; those who had not volunteered for HIV testing

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The HIV testing trends	Number tested for HIV in the study group	study period over two years (from 01 January 2017 till 31 December 2018)
Outcomes	Septic related complications (wound infections, chest sepsis, septicaemia and sepsis related organ failure incidents	study period over two years (from 01 January 2017 till 31 December 2018)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	In-hospital mortality in the cohort	study period over two years (from 01 January 2017 till 31 December 2018)

Collaborators and Investigators

• Sponsor: University of Witwatersrand, South Africa

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 1, 2017
• Primary Completion (ACTUAL): December 31, 2018
• Study Completion (ACTUAL): August 18, 2021

Study Registration Dates

• First Submitted: July 23, 2022
• First Submitted That Met QC Criteria: July 30, 2022
• First Posted (ACTUAL): August 2, 2022

Study Record Updates

• Last Update Posted (ACTUAL): August 2, 2022
• Last Update Submitted That Met QC Criteria: July 30, 2022
• Last Verified: July 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: Witwatersrand

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: only with close collaboration of future studies

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No