Clinical Trials on Mutation, Point

Total 14982 results

Massachusetts Institute of Technology
Hanger Clinic: Prosthetics & Orthotics

Recruiting

Evaluation of High-Performance, Customized, Rapidly-Manufacturable Prosthetic Feet That Provide Improved Mobility

Amputation of Lower Limb Below Knee

United States
University of Washington

Completed

Auto Control of Volume Management for Limb Loss

Lower Limb Amputation Below Knee (Injury)

United States
Proteor Group

Completed

Above-knee Socket Evaluation : Sub-ischial vs Ischial Containment (P20-EMBSUBI)

Lower Limb Amputation Above Knee (Injury)

France
Vrije Universiteit Brussel

Unknown

Decoding Motion Planning Using Cortical Potentials

Lower Limb Amputation Above Knee (Injury)

Belgium
Southern California Institute for Research and...
Vanderbilt University

Unknown

Kinematic, Kinetic, and Metabolic Comparison of Bilateral Transfemoral Ambulation With Passive Versus Powered Prosthetic Devices

Amputation | Energy Expenditure | Artificial Limbs | Kinetics

United States
University Hospital, Angers

Completed

Comparing New Prothesis PROPRIO-FOOT® Versus Usual Prothesis Tasks Tibial Amputees (PROPRIO-FOOT)

Lower Limb Amputation at Ankle (Injury)

France
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Influence of Socket Volume on Prosthesis Performance (CAD)

Lower Limb Amputation Below Knee (Injury)

United States
Uppsala University
Malmö University

Completed

A Community-based Participatory Intervention to Change Attitudes Towards Female Circumcision Among Somali Immigrants in Sweden

Female Circumcision | Female Genital Mutilation/Cutting

Sweden
Azienda Ospedaliera San Gerardo di Monza

Completed

Evaluation of a Closed Suction System to Remove Secretions From the Endotracheal Tube

Intubation | Expected Duration of Ventilation > 48h

Italy
University Health Network, Toronto

Completed

Effect of Remifentanil Boluses on Hemodynamics in Skull Pin Insertion

Skull Pin Insertion | Short Duration Analgesia

Canada
Brain Electrophysiology Laboratory Company

Recruiting

Non-Invasive At-Home Sleep Therapy System

Sleep | Sleep Quality | Sleep Duration

United States
University Hospital, Brest

Recruiting

Lipofilling Versus Conservative Treatment in Fingertips Injuries Sequelae (LIPOFILLING)

Distal Amputation of the Fingers

France
Eurofertil IVF Health Center

Completed

Effect of Duration and Follicle Diameter During Oocyte Pick up on Embryological Parameters

Follicle Size | Embryologic Parameters | Duration

Turkey
University Ghent
Fund for Scientific Research, Flanders, Belgium

Completed

Glenohumeral Internal Rotation Deficit (GIRD) (GIRD)

Glenohumeral Internal Rotation Deficit (GIRD)

Belgium
Rajavithi Hospital

Completed

The Effect of Entonox on Stages of Labor in Nulliparous Women

Nulliparous | ENTONOX | Duration of Labor

Thailand
Hutchmed

Recruiting

A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH

Isocitrate Dehydrogenase Gene Mutation

Spain, United States
Centre Hospitalier Universitaire, Amiens

Completed

C677T Methylenetetrahydrofolate Reductase Mutation (C677T)

Mutation
University of Michigan
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals

Amputation | Amputation Neuroma

United States
Second Xiangya Hospital of Central South University
The First Affiliated Hospital of Nanchang University; Xiangya Hospital of Central... and other collaborators

Recruiting

Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study) (PRECISE)

Lung Cancer, Non-small Cell | Circulating Tumor DNA | EGFR Gene Mutation | EGFR-TKI Resistant Mutation | Primary Resistance

China
Sameek Roychowdhury
National Cancer Institute (NCI)

Withdrawn

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | ALK Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Advanced Malignant Neoplasm | ALK Fusion Protein Expression | Metastatic Malignant Neoplasm in the Central Nervous System | ROS1 Gene Mutation | ALK Gene... and other conditions

United States
Women's College Hospital
Canadian Institutes of Health Research (CIHR); London Health Sciences Centre; H. Lee Moffitt Cancer Center and Research Institute and other collaborators

Unknown

Cancer Prevention in Women With a BRCA Mutation

Breast Cancer | Ovarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene Mutation

Canada
University of Illinois at Chicago
American Heart Association

Recruiting

The Effect of Ischemic Conditioning on Strength and Ambulation in Subjects With PAD

Peripheral Arterial Disease | Lower Limb Amputation Below Knee (Injury) | Lower Limb Amputation Above Knee (Injury) | Amputation | Peripheral Vascular Disease | Lower Limb Amputation Knee

United States
University Health Network, Toronto
AbbVie; Celgene

Terminated

Study of Enasidenib and Venetoclax in IDH2-Mutated Blood Cancers

Acute Myeloid Leukemia | Relapsed Cancer | Refractory Cancer | IDH2 Gene Mutation

Canada
National Human Genome Research Institute (NHGRI)

Completed

Dabrafenib and Trametinib in People With BRAF V600E Mutation Positive Lesions in Erdheim Chester Disease

BRAF V600E Mutation

United States
Orum Therapeutics USA, Inc.

Recruiting

Study of ORM-5029 in Subjects With HER2-Expressing Advanced Solid Tumors

HER2-positive Breast Cancer | HER-2 Gene Amplification | HER2 Gene Mutation | HER-2 Protein Overexpression

United States
Biogen
Ionis Pharmaceuticals, Inc.

Active, not recruiting

Long-Term Evaluation of BIIB067 (Tofersen)

ALS Caused by Superoxide Dismutase 1 (SOD1) Mutation

United States, Canada, Italy, Belgium, New Zealand, Japan, France, Germany, United Kingdom
QED Therapeutics, Inc.
Helsinn Healthcare SA

Terminated

A Phase II, Single Arm Study of BGJ398 in Patients With Advanced Cholangiocarcinoma

FGFR2 Gene Mutation | Advanced Cholangiocarcinoma

United States, Belgium, Germany, Italy, Korea, Republic of, Russian Federation, Singapore, Spain, Taiwan, Thailand, United Kingdom
Centre Hospitalier Universitaire de Saint Etienne

Completed

Hyperekplexia in Patients With CTNNB1 Mutation (CTNNB1)

CTNNB1 Gene Mutation | Hyperekplexia

France
China Medical University Hospital

Not yet recruiting

Nintedanib Plus EGFR TKI In EGFR-mutated Non-small Cell Lung Cancer Patients

Non-small Cell Lung Cancer | EGFR Gene Mutation | EGFR-TKI Resistant Mutation
Leiden University Medical Center
University Medical Center Groningen; Erasmus Medical Center

Recruiting

Functional Analysis of BRCAness (FAB)

BRCA1 Mutation | BRCA2 Mutation | Homologous Recombination Deficiency | Ovarian Neoplasm Epithelial

Netherlands
Università Vita-Salute San Raffaele
IRCCS San Raffaele; Merck Sharp & Dohme LLC

Unknown

GePheRal: Clinical Validation of the Genotypic Diagnosis of Hiv-1 Resistance to Raltegravir by Parallel Analysis of the Genotype and Phenotype Profiles of Resistance

HIV-1 Infected Patients | Fold-change Resistance | Resistance Mutations

Italy
Uma Borate

Recruiting

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Acute Myeloid Leukemia With FLT3/ITD Mutation | Acute Myeloid Leukemia With KMT2A Rearrangement | Acute Myeloid Leukemia With NPM1 Mutation

United States
First Affiliated Hospital of Jinan University
Ruijin Hospital

Recruiting

Sodium Stibogluconate in the MDS/AML With One of the 65 Defined p53 Mutations

Acute Myeloid Leukemia | Myelodysplastic Syndromes | P53 Mutation | Myeloid Malignancy | Temperature-Sensitive p53 Mutation | Sodium Stibogluconate

China
Women and Infants Hospital of Rhode Island

Completed

Lysophosphatidic Acid Assay in Patients With Ovarian Cancer or Who Are at Risk for Ovarian Cancer

Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
University of Alabama at Birmingham
National Cancer Institute (NCI)

Withdrawn

Celecoxib in Preventing Cancer in Patients at High Risk for Ovarian Epithelial Cancer Who Are Undergoing Prophylactic Oophorectomy

Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
University of Arizona
National Cancer Institute (NCI)

Completed

Fenretinide in Preventing Ovarian Cancer in Participants Who Are at High Risk for Developing Ovarian Cancer and Planning to Undergo Surgery to Remove the Ovaries

Ovarian Cancer | brca1 Mutation Carrier | brca2 Mutation Carrier

United States
Simons Searchlight
Boston Children's Hospital; Geisinger Clinic; Simons Foundation

Recruiting

Online Study of People Who Have Genetic Changes and Features of Autism: Simons Searchlight

SMARCA4 Gene Mutation | DDX3X | 16P11.2 Deletion Syndrome | 16p11.2 Duplications | 1Q21.1 Deletion | 1Q21.1 Microduplication Syndrome (Disorder) | ACTL6B | ADNP | AHDC1 | ANK2 | ANKRD11 | ARID1B | ASH1L | BCL11A | CHAMP1 | CHD2 | CHD8 | CSNK2A1 | CTBP1 | CTNNB1 Gene Mutation | CUL3 | DNMT3A | DSCAM | DYRK1A | FOXP1 | GRIN2A | GRIN2B | HIVEP2-Related Intellectual... and other conditions

United States
CHU de Reims

Recruiting

Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time (PARALSTER)

Duration of Hospitalization in Intensive Care Unit

France
IRCCS Centro Neurolesi "Bonino-Pulejo"

Not yet recruiting

Virtual Reality Rehabilitation to Promote Motor Recovery in Amputees

Injuries | Lower Limb Amputation Knee | Biomechanical Lesion

Italy
Gaziler Physical Medicine and Rehabilitation Education...

Not yet recruiting

The Relationship of Stump Length With Muscle Strength in Patients With Traumatic Unilateral Transfemoral Amputation

Amputation, Traumatic
University of Wisconsin, Madison

Recruiting

Patient Reported Outcomes Following Targeted Muscle Reinnervation

Amputation

United States
VA Office of Research and Development

Completed

Understanding Prosthetic Needs and Outcomes in Women Veterans With Amputation

Amputation

United States
University of Michigan

Enrolling by invitation

Studying Electromyographic Activity in Patients With Upper Limb Amputations

Amputation, Traumatic
Gaziler Physical Medicine and Rehabilitation Education...

Completed

Isokinetic Parameters and the Amputee Mobility Predictor Scale

Amputation, Traumatic

Turkey
Össur Ehf

Completed

An Investigation Into a New Manufacture Technique of Trans-femoral Sockets

Amputation

United States
Gaziler Physical Medicine and Rehabilitation Education...

Completed

Sonographic Evaluation Of Nerve Thickness In Traumatic Lower-Limb Amputees

Amputation, Traumatic

Turkey
Marmara University

Completed

Rectus Femoris Thickness Measurement in Unilateral Transtibial Amputated Prosthesis Users

Amputation, Traumatic

Turkey
Loma Linda University

Completed

Massage on Pain Levels, Range of Motion, and Muscle Strength in Unilateral Lower Limb Amputees

Amputation

United States
Laura Kair
The Gerber Foundation; Children's Miracle Network

Completed

Rx Milk Study of Donor Milk Supplementation to Improve Breastfeeding Outcomes (Rx Milk)

Exclusive Breastfeeding | Breastfeeding Duration | Donor Milk Supplementation

United States
Istituto Ortopedico Rizzoli
I.R.C.C.S. Fondazione Santa Lucia

Completed

Pain in Trans Femoral and Trans Tibial Amputees (AMPUPHANTOM)

Lower Limb Amputation Below Knee | Lower Limb Amputation Above Knee

Italy

Clinical Trials on Mutation, Point

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mongolia

Conditions

Rare Diseases

Drug Interventions

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