Search clinical trials for: Tenofovir alafenamide (TAF)

Total 4851 results

Merck Sharp & Dohme LLC

Completed

Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024) (Impower-024)

HIV Preexposure Prophylaxis

United States, Brazil, France, Japan, South Africa, Thailand, Peru
Huashan Hospital
The First Affiliated Hospital with Nanjing Medical University; Peking University... and other collaborators

Recruiting

Real-world Study Optimizing Nucleotide-analogues

Hepatitis B, Chronic

China
First Affiliated Hospital Xi'an Jiaotong University

Unknown

Study of Antiretroviral Therapy to Prevent HBV Intrauterine Infection

Hepatitis B, Chronic

China
Humanity and Health Research Centre

Recruiting

Change of Renal Function and Bone Mineral Density in CHB Patients Switch From TDF to TAF vs. Maintaining TDF (SWITAF)

Chronic Hepatitis B

Hong Kong
University of California, Los Angeles
Gilead Sciences; University of Cape Town; Desmond Tutu HIV Foundation

Completed

PK of TAF and TDF for PrEP in Pregnant and Postpartum Women (PrEP-PP PK)

Hiv

South Africa
Yonsei University

Unknown

Switching From Tenofovir Disoproxi Fumarate to Tenofovir Alafenamide in Chronic Hepatitis B Patients With Antiviral Resistance

Hepatitis B | Antiviral Drug Adverse Reaction
Gilead Sciences

Active, not recruiting

Study to Evaluate the Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide (F/TAF) Fixed-Dose Combination Once Daily for Pre-Exposure Prophylaxis in Men and Transgender Women Who Have Sex With Men and Are At Risk of HIV-1 Infection (DISCOVER)

Pre-Exposure Prophylaxis of HIV-1 Infection

United States, Austria, Denmark, United Kingdom, Netherlands, Italy, Germany, Canada, Ireland, France, Spain
Janssen Pharmaceutica N.V., Belgium

Withdrawn

A Study in Chronic Hepatitis B e-Antigen Negative Participants After Discontinuation of Nucleos(t)Ide Analog (NA) Treatment (SALMONS)

Hepatitis B, Chronic

Germany, France, Italy, Spain, Denmark, Portugal, Greece
Janssen Research & Development, LLC

Terminated

A Single and Multiple Ascending Dose Study of JNJ-64457744

Healthy | Hepatitis B, Chronic

New Zealand
University of Maryland, Baltimore
Gilead Sciences

Completed

B/F/TAF Switch Study for HIV-HBV Coinfection (BEST-HBV)

Hepatitis B | HIV-1-infection

United States
Brigham and Women's Hospital
Boston Medical Center; Tufts Medical Center

Completed

Effects of Biktarvy on CFR in Stable HIV Patients (BETTER)

HIV

United States
Assembly Biosciences

Completed

A Study Evaluating ABI-H0731 as Adjunctive Therapy in Participants With Chronic Hepatitis B Infection

Chronic Hepatitis B

New Zealand, United States, Canada
Merck Sharp & Dohme LLC

Active, not recruiting

Study of Doravirine/Islatravir (DOR/ISL 100 mg/0.75 mg) to Evaluate the Antiretroviral Activity, Safety, and Tolerability in Treatment-Naïve Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-020)

HIV-1 Infection

United States, Argentina, Canada, Chile, Colombia, France, Germany, Israel, Italy, Japan, South Africa, Spain, Taiwan
Midland Research Group, Inc.
Gilead Sciences

Completed

Efficacy, Safety & Tolerability of Switching EFV/TDF/FTC to BIC/FTC/TAF in Virologically Suppressed Adults With HIV-1

Human Immunodeficiency Virus

United States
Assembly Biosciences
Arbutus Biopharma Corporation

Terminated

A Study Evaluating Treatment Regimens Containing Vebicorvir (ABI-H0731) in Participants With Chronic Hepatitis B Infection

Chronic Hepatitis B

Australia, Canada, Bulgaria, New Zealand
Hospital Italiano de Buenos Aires
Sociedad Argentina de Infectología (SADI) (Argentine Society of Infectious...

Unknown

TAF/FTC for Pre-exposure Prophylaxis of COVID-19 in Healthcare Workers (CoviPrep Study)

COVID-19 | Healthcare Workers | SARS-CoV 2

Argentina
Janssen Sciences Ireland UC

Completed

Relative Bioavailability and Food Effect for Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination

Healthy

Belgium
Thomas Jefferson University
Gilead Sciences

Active, not recruiting

Entecavir to TAF Switch

Hepatitis B

United States
Gilead Sciences

Active, not recruiting

Pre-Exposure Prophylaxis Study of Lenacapavir and Emtricitabine/Tenofovir Alafenamide in Adolescent Girls and Young Women at Risk of HIV Infection (PURPOSE 1)

Pre-Exposure Prophylaxis of HIV Infection

South Africa, Uganda
Prism Health North Texas
Merck Sharp & Dohme LLC

Withdrawn

Doravirine and Weight Gain in Antiretroviral Naive (DAWN)

Obesity | Metabolic Syndrome | Body Weight Changes | Human Immunodeficiency Virus | Fasting | Minority Health | ART | BMD

United States
Unity Health Toronto
Canadian Institutes of Health Research (CIHR); CIHR Canadian HIV Trials Network

Recruiting

Optimizing the Delivery of HIV nPEP

HIV Infections

Canada
National Institute of Allergy and Infectious Diseases...

Terminated

Emtricitabine/Tenofovir Alafenamide as Salvage ART

HIV

United States
The First Hospital of Jilin University

Unknown

A Perspective Study of the Antiviral Efficacy and Safety of Switching to TAF Treatment in CHB Adults With Suboptimal Response (SOR) and Intolerant to Entecavir

HBV
Gilead Sciences

Completed

Safety and Efficacy of Switching From Dolutegravir and ABC/3TC or ABC/DTG/3TC to B/F/TAF in HIV-1 Infected Adults Who Are Virologically Suppressed

HIV-1 Infection

Spain, United States, France, Italy, Germany, Canada, United Kingdom, Belgium, Puerto Rico, Australia
University of Colorado, Denver
Gilead Sciences

Terminated

Rapid Start vs. Standard Start Antiretroviral Therapy (ART) in HIV (B-HASTE)

HIV/AIDS

United States
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Active, not recruiting

Early ART to Limit Infection and Establishment of Reservoir (EARLIER)

HIV-1 Infection

United States, Brazil, Malawi, Zimbabwe, Thailand, Peru
Taichung Veterans General Hospital
Institute of Adherence to Medication

Recruiting

Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection

Safety Issues

Taiwan
Thai Red Cross AIDS Research Centre

Recruiting

Assessment of Drug-drug Interactions Between Masculinizing Hormone Therapy and Antiretroviral Agents Concomitantly for Pre-exposure Prophylaxis Among Transgender Men

Drug Interaction

Thailand
Janssen Sciences Ireland UC

Completed

A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection

Hepatitis B, Chronic

Belgium, United Kingdom, France, Italy, Germany, Spain, Poland
National Taiwan University Hospital
Chiayi Christian Hospital; E-DA Hospital; Taipei City Hospital; Taipei Tzu Chi... and other collaborators

Recruiting

Chronic Hepatitis b Patients Switch to tAf After Discontinuation of Nucleoside Analogue (CHANGE)

Chronic Hepatitis b | Hepatitis B Reactivation

Taiwan
First People's Hospital of Hangzhou

Recruiting

Study of Tenofovir Alafenamide in HBV-Infected Pregnant Women

Chronic Hepatitis b | Tenofovir Alafenamide Fumarate

China
Taichung Veterans General Hospital
Institute of Adherence to Medication

Recruiting

Tenofovir Alafenamide Switch Therapy in Chronic Hepatitis B

Patient Satisfaction | Safety Issues | Efficacy, Self | Drug Adherence

Taiwan
State University of New York at Buffalo
Gilead Sciences

Active, not recruiting

Bictegravir in the Elderly Living With HIV (BICEP)

HIV-1-infection

United States
Technical University of Munich

Completed

Changes in Insulin Sensitivity in Healthy Volunteers Taking Tenofovir Alafenamide (TAF)-Containing Antiretroviral Medication (TAF-IR)

Insulin Resistance

Germany
Taipei Veterans General Hospital, Taiwan

Recruiting

Tenofovir Alafenamide(TAF) Reduces the Risk of Hepatocellular Carcinoma(HCC) Recurrence

HCC Patients After Curative Treatment With Low HBV Viral Load

Taiwan
University of North Carolina, Chapel Hill
Gilead Sciences

Completed

Dose Proportionality of TFV-DP After a Single Dose of GS-7340 in Women

Healthy

United States
Asian Pacific Liver Center at Coalition of Inclusive...

Unknown

TAF Switch Study in Hepatitis B Monoinfection

Hepatitis B
Janssen Research & Development, LLC

Active, not recruiting

A Study of JNJ-73763989 + Nucleos(t)Ide Analog in Participants Co-Infected With Hepatitis B and Hepatitis D Virus (REEF-D)

Hepatitis D, Chronic

France, Taiwan, Italy, Germany, Japan, Spain, Russian Federation, Turkey, United Kingdom, Australia, Sweden, United States, New Zealand, China, Brazil
National Institute of Allergy and Infectious Diseases...

Completed

Evaluating the Efficacy and Safety of Dolutegravir-Containing Versus Efavirenz-Containing Antiretroviral Therapy Regimens in HIV-1-Infected Pregnant Women and Their Infants (VESTED)

HIV Infections

United States, South Africa, Thailand, Botswana, Brazil, Tanzania, Zimbabwe, India, Uganda
Erasmus Medical Center
Gilead Sciences

Unknown

Switching From Tenofovir Disoproxil Fumarate to Abacavir or Tenofovir Alafenamide (BACTAF)

Hiv | Renal Insufficiency,Chronic | Therapeutic Agent Toxicity

Netherlands
Assembly Biosciences

Terminated

A Study of ABI-H0731 + Nucleos(t)Ide as Finite Treatment for Chronic Hepatitis B Patients

Chronic Hepatitis B

United States, Canada, Hong Kong, New Zealand, United Kingdom
F-star Therapeutics, Inc.
PRA Health Sciences

Terminated

Evaluating the Safety and Efficacy of Inarigivir in Non-cirrhotic Treatment Naive Subjects Infected With Hepatitis B Virus

Hepatitis B | Hepatitis B, Chronic | HBV

Hong Kong
Mahidol University

Recruiting

TDF Dose Adjustment VS. Switching to TAF in TDF-experienced CHB Patients With Renal Impairment

Renal Insufficiency | Tenofovir

Thailand
Rhonda Brand
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs (APTAMER)

HIV | Medication Adherence

United States
Taipei Veterans General Hospital, Taiwan

Not yet recruiting

The Efficacy of Prophylactic TAF for HBsAg-positive Patients Receiving bDMARDs

Inflammatory Arthritis | HBV
ANRS, Emerging Infectious Diseases
Gilead Sciences; Ministry of Health, Thailand; Assistance Publique - Hôpitaux... and other collaborators

Not yet recruiting

Efficacy, Acceptability and Safety of Event-driven HIV PrEP Using TAF/FTC in MSM in Thailand and France. (SimpPrEP)

HIV/AIDS

France, Thailand
Vancouver Infectious Diseases Centre

Unknown

Switching to a Fixed Dose Combination of Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1 Infected Marginalized Populations Who Are Virologically Suppressed

Drug Use | Human Immunodeficiency Virus I Infection

Canada
Valley AIDS Council
Gilead Sciences

Not yet recruiting

Advanced HIV: Outcomes for Rapid ART (AHORA)

HIV-1-infection
University of Nebraska
Gilead Sciences

Completed

Bictegravir/Emtricitabine/Tenofovir Alafenamide (B/F/TAF) in HIV-1 Infected Patients With Active Illicit Substance usE (BASE)

HIV-1-infection

United States
Fenway Community Health

Completed

Biktarvy for Non-Occupational Post-Exposure Prophylaxis (nPEP)

HIV Prevention

United States

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