Search clinical trials for: Adaptive trial design

Total 43587 results

Cardresearch

Recruiting

A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial (REVIVE)

Chronic Fatigue Syndrome | Long COVID-19 Syndrome

Brazil
McGill University Health Centre/Research Institute...
Centre hospitalier de l'Université de Montréal (CHUM)

Recruiting

The MARVIN Chatbots to Provide Information for Different Health Conditions

HIV Infections | Breast Cancer | Pediatric Emergency Medicine

Canada
Mayo Clinic

Recruiting

Randomized Double-Blind Placebo-Controlled Adaptive Design Trial Of Intrathecally Administered Autologous Mesenchymal Stem Cells In Multiple System Atrophy

Multiple System Atrophy

United States
Columbia University
Emergency Medicine Foundation; Mailman School of Public Health

Completed

Dose-Finding Study of Intranasal Midazolam for Procedural Sedation in Children

Procedural Anxiety

United States
CanSino Biologics Inc.
Beijing Institute of Biotechnology

Completed

Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above

COVID-19

Mexico, Argentina, Chile, Pakistan, Russian Federation
University of California, San Francisco
National Institute of Mental Health (NIMH)

Completed

An Adaptive Intervention for Depression Among Latinos Living With HIV (Latino-SMART)

Depression

United States
University of Kansas Medical Center
Ohio State University; Nationwide Children's Hospital; University of Cincinnati

Completed

Assessment of DHA On Reducing Early Preterm Birth (ADORE)

Preterm Birth

United States
St. Mary's Research Center, Canada
McGill University

Completed

Adaptive Internet-based Stress Management Among Adults With a Cardiovascular Disease: A Pilot Sequential Multiple Assignment Randomized Trial (SMART) Design

Cardiovascular Diseases | Stress, Psychological

Canada
National Institute of Allergy and Infectious Diseases...

Completed

Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications (IRC003)

Influenza

United States, Australia, Argentina, Mexico, Thailand
US Department of Veterans Affairs

Completed

Enhancing Fitness in Older Pre-diabetic Veterans

Obesity | Diabetes | Impaired Glucose Tolerance

United States
Ironshore Pharmaceuticals and Development, Inc

Completed

A Phase II, Adaptive Trial Design Examining the Pharmacokinetic and Pharmacodynamic Effects of Modified Release Amphetamine (HLD100, Formulations B, C and E)) in Adolescents and Children With Attention-Deficit Hyperactivity Disorder (ADHD)

Attention-Deficit Hyperactivity Disorder

Canada
GlaxoSmithKline

Completed

An Adaptive Design Trial Of GW274150 In The Treatment Of Acute Migraine

Migraine | Migraine Disorders

Australia, New Zealand
University of Texas Southwestern Medical Center

Not yet recruiting

Precision Medicine in Action: Phase II Trial of Response Adaptive Ablative Pre-operative SPBI (RAPS) and Non-operative Sentinel Lymph Node Biopsy in Patients With Early-stage ER+ Breast Cancer: RAPS Trial

Breast Cancer

United States
Semmelweis University
Institut Straumann AG

Recruiting

Effect of Abutment Configuration on Peri-implant Soft and Hard Tissue in the Esthetic Zone - Randomized Clinical Trial

Dental Implant-Abutment Design | Dental Implants, Single-Tooth

Hungary
Euclid Systems Corporation

Not yet recruiting

Euclid Phoenix Lens Design Trial 2

Myopia | Cornea

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial (PALETTE)

Sepsis
The George Institute
Changhai Hospital; University of Calgary

Not yet recruiting

Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial (ENCHANTED3/MT)

Ischemic Stroke, Acute
The George Institute
University of Calgary; Berry Consultants

Not yet recruiting

ACT-GLOBAL Adaptive Platform Trial for Stroke (ACT-GLOBAL)

Stroke
Northwestern University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

A Micro-Randomized Trial to Optimize Just-in-Time Adaptive Intervention for Binge Eating & Weight-related Behaviors

Obesity | Binge Eating

United States
Mayo Clinic

Not yet recruiting

Evaluating Changes in Quality of Life After Near Margin-less Adaptive Radiation Therapy Compared to Standard Stereotactic Ablative Body Radiotherapy in Localized Prostate Cancer

Stage I Prostate Cancer AJCC v8 | Stage II Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Localized Prostate Adenocarcinoma

United States
University of Calgary
The George Institute for Global Health, Australia

Not yet recruiting

ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 (ACT-WHEN)

Acute Ischemic Stroke AIS | Stroke, Acute, Stroke Ischemic | Stroke Acute

Canada, Australia
Rady Pediatric Genomics & Systems Medicine Institute

Recruiting

An Adaptive Clinical Trial of BeginNGS Newborn Screening for Hundreds of Genetic Diseases by Genome Sequencing (BeginNGS)

Genetic Disease

United States
Beijing 302 Hospital

Recruiting

Clinical Trial of Metal-Reinforced Teeth Designed for Endoscopic Clips

Pilot Study | Clips

China
Advesya SAS

Not yet recruiting

An Adaptive Open-label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of CCTx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients With Relapsed/Refractory Acute Myeloid Leukaemia (RESOLVE AML001)

Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory

France, Sweden, Spain, Germany
University of Social Sciences and Humanities, Warsaw
National Science Centre, Poland

Recruiting

The Effect of an Online ACT Intervention on Meaning-Making Process in Cancer Patients Following Hematopoietic Cell Transplantation

Hematopoietic Cell Transplantation Recipient | Acceptance and Commitment Therapy

Poland
RTI International
New Jersey Prevention Network; RWJBarnabas Health Institute for Prevention...

Recruiting

Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program

Substance-Related Disorders | Adverse Childhood Experiences

United States
University of Michigan Rogel Cancer Center

Recruiting

Trial of Individualized Adaptive RT in HPV-related High Risk Oropharynx Cancer (ARTHOUSE)

Oropharynx Cancer | HPV-Related Carcinoma

United States
Region Skane

Not yet recruiting

Meditation, Mindfulness, and Yoga to Reduce Perceived Stress in Resident Doctors - A Randomized Controlled Trial With Crossover Design (MindYou)

Stress, Job
Wake Forest University Health Sciences
National Cancer Institute (NCI); University of Virginia

Recruiting

Developing an Internet-Delivered Sexual Health Program for Breast Cancer Survivors, SHINE Trial (SHINE)

Breast Cancer Female

United States
West China Hospital

Not yet recruiting

Study of Adaptive Radiotherapy for High-grade Glioma Based on Interfraction MRI

High-grade Glioma

China
University College, London
Place2Be; Anna Freud

Recruiting

Evaluating Knowledge Insight Tools (KIT) for Reducing Anxiety and Low Mood in UK Secondary School Students

Depression | Anxiety | Low Mood | Internalizing Problems

United Kingdom
Multiple Myeloma Research Consortium

Not yet recruiting

Horizon Adaptive Platform Trial Evaluating Therapies in RRMM

Refractory Multiple Myeloma | Relapse Multiple Myeloma
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

Pilot Trial of Adaptive Radiotherapy Boost for HNSCC

Head and Neck Cancer | Squamous Cell Carcinoma

United States
Medical University of South Carolina
National Cancer Institute (NCI)

Recruiting

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse (ADAPT)

Treatment | Cigarette Smoking | Smoking Behaviors

United States
Boehringer Ingelheim

Recruiting

A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)

Obesity

United States, Korea, Republic of, Belgium, Australia, United Kingdom, Mexico, Spain, Germany, Taiwan, Netherlands, Brazil, Hungary, Denmark, Canada, Poland, Austria, China, Finland, Greece, Italy, Hong Kong, Czechia, Portugal, Saudi... and more
Mayo Clinic
National Cancer Institute (NCI)

Not yet recruiting

Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Unresectable Intrahepatic Cholangiocarcinoma | Locally Advanced Intrahepatic Cholangiocarcinoma | Oligometastatic Intrahepatic Cholangiocarcinoma

United States
The George Institute

Not yet recruiting

The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE)

Chronic Kidney Diseases
Aga Khan University
Pakistan Science Foundation

Recruiting

Efficacy of Injectable Vitamin D Supplementation in Females With Polycystic Ovary Syndrome

Anovulatory Infertility

Pakistan
Spanish National Research Council
Andalusian Health Service; Universidad Pablo de Olavide

Recruiting

Oleanolic Acid as Therapeutic Adjuvant for Type 2 Diabetes Mellitus (OLTRAD STUDY) (OLTRAD)

Type II Diabetes Mellitus | Diabetic Patients

Spain
Mayo Clinic

Recruiting

Adaptive Virtual Consultation Tool to Enhance Education and Understanding in Patients With Prostate Cancer

Prostate Carcinoma

United States
Yanbing Li

Not yet recruiting

Efficacy and Safety of Chiglitazar Added to Glargine in Patients With Type 2 Diabetes

Efficacy and Safety of Chiglitazar Sodium in the Treatment of T2DM Patients | Metformin Combined With Insulin Glargine in the Treatment of Type 2 Diabetes Patients Who Still Have Poor Hypoglycemic Effect | 128 Patients Were Randomly Assigned 1:1 | Metformin and Insulin Glargine Combined... and other conditions

China
University of Chicago

Recruiting

Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer

HPV-Negative Squamous Cell Carcinoma

United States
Queen Mary University of London
University of Washington; University of Oxford; KEMRI-Wellcome Trust Collaborative... and other collaborators

Not yet recruiting

An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM (Co-SAM)

HIV | Severe Acute Malnutrition | Comorbidities and Coexisting Conditions | Child Malnutrition
Peking Union Medical College Hospital

Recruiting

Moderately Hypofractionated Adaptive Radiotherapy for Cervical Cancer

Cervical Neoplasm | Radiotherapy; Adverse Effect | Adaptive Radiotherapy

China
Mayo Clinic

Recruiting

Randomized Evaluation of Machine Learning Assisted Radiation Treatment Planning vs Standard Radiation Treatment Planning

Cancer Head Neck | Cancer Neck | Cancer, Head

United States
Andalusian Network for Design and Translation of...

Recruiting

Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs

Venous Ulcer

Spain
Nord University

Not yet recruiting

Educational Intervention for Better Nutrition to Preserve Functionality - Design of a Randomised Clinical Trial

Malnutrition

Norway
U.S. Army Medical Research and Development Command
PPD; Idorsia Pharmaceuticals Ltd.; Berry Consultants; Cambridge Cognition Ltd; Ci...

Recruiting

Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant

Post Traumatic Stress Disorder

United States
U.S. Army Medical Research and Development Command
PPD; Idorsia Pharmaceuticals Ltd.; Berry Consultants; Cambridge Cognition Ltd; Ci...

Not yet recruiting

Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone

Post Traumatic Stress Disorder
U.S. Army Medical Research and Development Command
PPD; Idorsia Pharmaceuticals Ltd.; Berry Consultants; Cambridge Cognition Ltd; Ci...

Recruiting

Department of Defense PTSD Adaptive Platform Trial Intervention A - Fluoxetine

Post Traumatic Stress Disorder

United States

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