Search clinical trials for: Increase Risk of Severe Outcomes

Total 436041 results

Pfizer

Withdrawn

A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19 (EPIC-HOS)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19) | Immunocompromised | Hospitalization | Child, Hospitalized

United States, Bulgaria
National Heart, Lung, and Blood Institute (NHLBI)

Completed

COV2Base-A Rare Disease by COVID Study

Chronic Health Conditions | Older Age is Associated With Increased Pathogenicity

United States
Peking Union Medical College Hospital

Not yet recruiting

Multicenter Randomized Double-blind Placebo-controlled Study to Investigate Azvudine in Symptomatic Adults With COVID-19 at Increased Risk of Progressing to Severe Illness

COVID-19 Respiratory Infection
Kaiser Permanente
Patient-Centered Outcomes Research Institute

Recruiting

Treating Genital Herpes Infection to Reduce Racial Disparities in the Risk of Severe Maternal Morbidity (PCORISMM)

Maternal Morbidity | Racial Disparities | Genital Herpes Simplex

United States
Hull University Teaching Hospitals NHS Trust

Recruiting

Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC) (ELEVATE-ASUC)

Severe Ulcerative Colitis

United Kingdom
National Institute of Allergy and Infectious Diseases...
Rho Federal Systems Division, Inc.

Completed

COVID-19: Human Epidemiology and Response to SARS-CoV-2 (HEROS)

SARS-CoV-2 | Coronavirus Disease 2019 (COVID-19)

United States
Merck Sharp & Dohme LLC

Active, not recruiting

Clesrovimab (MK-1654) in Infants and Children at Increased Risk for Severe Respiratory Syncytial Virus (RSV) Disease (MK-1654-007)

RSV Infection

United States, Australia, Canada, Chile, Colombia, Czechia, Finland, France, Germany, Greece, Hong Kong, Hungary, Italy, Japan, Malaysia, Mexico, New Zealand, Norway, Peru, Puerto Rico, Singapore, South Africa, Spain, Taiwan, Thailand, Tu... and more
Ionis Pharmaceuticals, Inc.

Completed

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia

Hypertriglyceridemia | Atherosclerotic Cardiovascular Disease | Severe Hypertriglyceridemia

United States, Canada
Canadian Cancer Trials Group
Canadian Cancer Society (CCS); ATGen Canada Inc; Ontario Institute for Cancer... and other collaborators

Active, not recruiting

Immunization With IMM-101 vs Observation for Prevention of Respiratory and Severe COVID-19 Related Infections in Cancer Patients at Increased Risk of Exposure (COV-IMMUNO)

Covid-19 | Cancer

Canada
Hospital San Carlos, Madrid

Completed

Increased Risk of Severe Coronavirus Disease 2019 in Patients With Vitamin D Deficiency (COVIT-D)

Coronavirus Disease 2019 (COVID-19)

Spain
Laboratoire De Recherche Sur Le Diabete, Université...
ATRSS, DGRST, Algeria

Unknown

Covid-19 and Diabetes in West of Algeria (COVIDIAB-13)

Severe Acute Respiratory Syndrome | Coronavirus Infections | Diabetes Mellitus | Prevalence | Risk Factors | Patient Outcome Assessment

Algeria
Pfizer

Completed

Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza (ACCESS 2008)

Pain

United States, Puerto Rico
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L) (DESAR-L)

Low-to-intermediate-risk Prostate Carcinoma

Korea, Republic of
Seoul St. Mary's Hospital

Not yet recruiting

Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery

Protein Malnutrition

Korea, Republic of
AstraZeneca

Recruiting

Patient Characteristics, Treatment Patterns and Outcomes of Patients Enrolled in the Tezepelumab Patient Access Programme; a Retrospective, Observational Medical Chart Review Conducted in UK Severe Asthma Centres (TPAP)

Severe Asthma

United Kingdom
Ohio State University
Patient-Centered Outcomes Research Institute; The George Washington University...

Not yet recruiting

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes (DECIDE)

Pregnancy, High Risk | Gestational Diabetes Mellitus

United States
University of North Carolina, Chapel Hill
University of Pennsylvania; Centers for Disease Control and Prevention

Not yet recruiting

Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management (PROMOTE IBD)

Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis | Colitis

United States
University of Haifa
Bnai Zion Medical Center; Clalit Health Services, Haifa and West Galilee

Not yet recruiting

Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL) (MBL RiskConseq)

Cardiovascular Diseases | Infections | Autoimmune Diseases | Parkinson Disease | Dementia | Alzheimer Disease | Chronic Lymphocytic Leukemia | Monoclonal B-Cell Lymphocytosis | Cancers
GlaxoSmithKline

Recruiting

A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared to Older Adults 60 Years of Age and Above

Respiratory Syncytial Virus Infections

United States, Canada, Japan, Germany, Australia, South Africa
Eli Lilly and Company

Recruiting

The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)

Overweight and Obesity

United States, Australia, Italy, Hungary, Spain, Canada, Germany, Argentina, Belgium, Czechia, Greece, Israel, Austria, Brazil, Mexico, Netherlands, Romania, India, United Kingdom, Slovakia, Poland, Turkey, Puerto Rico, France, Denmark
Ivan de Kouchkovsky, MD

Not yet recruiting

Hyperpolarized (HP) 13C Pyruvate Magnetic Resonance Imaging (MRI) for Response Monitoring to Neoadjuvant Abiraterone

Prostate Cancer | High Risk Prostate Carcinoma

United States
Saint Petersburg State University, Russia

Not yet recruiting

Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients

Ischemic Heart Disease | Mitral Insufficiency | Aortic Stenosis, Severe | Mitral Stenosis | Aortic Insufficiency | Ascending Aortic Aneurysm | Mitral Stenosis With Insufficiency | Tricuspid Insufficiency

Russian Federation
Hoffmann-La Roche
Roche Molecular Systems, Inc

Not yet recruiting

A Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increased Risk of Sexually Transmitted Infections

Chlamydia Trachomatis Infection | Mycoplasma Genitalium Infection | Neisseria Gonorrhoeae Infection
Helios Klinik Gotha/Ohrdruf
Helios Klinikum Erfurt

Not yet recruiting

Outcomes of Patient Blood Management in Severely Anemic Patients

Severe Anemia

Germany
FANG HE

Recruiting

Pregnancy Outcomes in Normotensive VS stage1 Hypertension

Preeclampsia | stage1 Hypertension

China
Chinese PLA General Hospital

Not yet recruiting

The Clinical Outcomes and Prediction of Thermal Ablation for Low-risk Papillary Thyroid Carcinoma

Papillary Thyroid Cancer
AOP Orphan Pharmaceuticals AG
GCP-Service International Ltd. & Co. KG; ANOVA CRO s.r.o.; PharmaLex Belgium; Aixial...

Recruiting

Initial Triple Therapy Including Parenteral Treprostinil vs Initial Double Oral Therapy in PAH Group I Patients (TripleTRE)

Pulmonary Arterial Hypertension

Austria, Spain, France, Germany, Italy, Czechia, Hungary, Poland, Portugal, Romania
University of Calgary

Not yet recruiting

Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT

Ankle Fractures
Assiut University

Not yet recruiting

Outcomes and Risk Factors of CPR in PICU

Cardio Respiratory Arrest
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute; Vanderbilt University Medical... and other collaborators

Not yet recruiting

Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 1 (SPIRE1)

Healthy Aging | Health Care Utilization | Health-Related Behavior
University of Pennsylvania
Columbia University; National Institute on Minority Health and Health Disparities... and other collaborators

Recruiting

Improving Health Outcomes and Equity by Targeting Postpartum Mothers at Highest Risk (HOME)

Postpartum Depression | Maternal Behavior

United States
University of Bonn
Federal Ministry of Food and Agriculture (BMEL); Federal Office for Agriculture...

Recruiting

Acute Effects of Legume-enriched Meals Compared to Western Diet Meals on Postprandial Metabolism in Participants With Increased Cardiometabolic Risk (LeguPlan_1)

Cardiovascular Diseases | Metabolic Syndrome

Germany
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Severe Erythema Multiforme - CORTICO (SEMCORTICO)

Erythema Multiforme
Baskent University Ankara Hospital
Pamukkale University; Hacettepe University; Kanuni Sultan Suleyman Training and... and other collaborators

Recruiting

Evaluation of the Frequency, Risk Factors, and Outcomes of ROP in Infants With a BW >1500 Grs or GA ≥33 Wks in Turkey. (TR-BigROP)

Retinopathy of Prematurity

Turkey
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Trial of HHPG-19K Injection and Auto-HHPG-19K Injection in Prevention of Chemotherapy-related Moderate to Severe Neutropenia of Patients With Nonmyeloid Malignancies

Patients With Nonmyeloid Malignancies Receiving Antineoplastic Therapy Based on Chemotherapy Regimens at Moderate to High Febrile Neutropenia (FN) Risk

China
Zhujiang Hospital

Recruiting

Dynamic Changes in Human Microbiome Predict the Risk of Adverse Outcomes in Patients With Acute Ischemic Stroke: a Multicenter Prospective Cohort Study

Acute Ischemic Stroke

China
Guangdong Provincial People's Hospital

Recruiting

Short-term Effects of Preoperative Exercise in Moderate-to-high Perioperative Risk Lung Cancer Patients (PRE-EXELUCA)

Lung Cancer

China
Cairo University

Recruiting

IMT Outcomes in Sufferers of Severe Walking Disabilities and Intensive Care Unit Acquired Weakness

Intensive Care Unit Acquired Weakness

Egypt
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute; University of Colorado, Denver; Emory University and other collaborators

Not yet recruiting

Promoting Shared Decision Making for Severe Aortic Stenosis (IMPACT SDM)

Aortic Stenosis

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
First Affiliated Hospital, Sun Yat-Sen University; First Affiliated Hospital... and other collaborators

Recruiting

TEER for Severe DMR of Low to Intermediate Surgery Risk

Mitral Regurgitation

China
Hospices Civils de Lyon

Not yet recruiting

Impact of Non-invasive Individualized Goal-directed Fluid Therapy on Outcomes Following Thoracic Cancer Surgery (GDFT-TCS)

High-risk Thoracic Cancer Surgery

France
Chulalongkorn University

Recruiting

Comparison of Outcomes Between Low Dose Emicizumab and Factor VIII in Clinically Severe Hemophilia A

Joint Bleed | Severe Hemophilia A Without Inhibitor

Thailand
Johns Hopkins University
Patient-Centered Outcomes Research Institute; Children's Hospital of Philadelphia and other collaborators

Not yet recruiting

Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

Suicide, Attempted | Suicide | Suicide Ideation | Suicide Prevention
Ruijin Hospital

Recruiting

Risk Factors and Outcomes in Coronary Chronic Total Occlusion

Coronary Artery Disease | Chronic Total Occlusion

China
National Cancer Center, Korea
Seoul National University Hospital

Not yet recruiting

Tripegfilgrastim Trial to Reduce the Risk of Severe Neutropenia in Patients With Unresectable Pancreaticobiliary Cancers (Dulastin)

Unresectable Pancreatic Cancer | Unresectable Biliary Tract Carcinoma | Unresectable Bile Duct Carcinoma
The Hospital for Sick Children
Alliance for International Medical Action; University of N'Djaména, Chad

Recruiting

Evaluating RISQ System Implementation in Acutely Malnourished Children in Chad (CRIMSON) (CRIMSON)

Severe Acute Malnutrition

Chad
University of Minnesota

Recruiting

FAM (Follower, Action Plan, and Remote Monitoring) Intervention to Reduce Severe Hyperglycemia in Adults With Type 1 Diabetes Mellitus at Risk for Diabetic Ketoacidosis

Type 1 Diabetes

United States
FANG HE

Recruiting

Aspirin Discontinuation in High-Risk Pregnant Women of Preeclampsia

Preeclampsia | Perinatal Haemorrhage

China
H. Lee Moffitt Cancer Center and Research Institute
National Comprehensive Cancer Network; Puma Biotechnology, Inc.

Recruiting

Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal Cancer

Gastric Cancer | GastroEsophageal Cancer

United States

Search clinical trials for: Increase Risk of Severe Outcomes

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mauritius

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations