Search clinical trials for: left ventricular outflow tract obstruction

Total 110825 results

St. Antonius Hospital

Recruiting

Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction (RASTA)

HOCM, Hypertrophic Obstructive Cardiomyopathy | LVOTO - Left Ventricular Outflow Tract Obstruction | Remodeling, Ventricular

Netherlands
Bristol-Myers Squibb

Completed

A Study to Evaluate the Effects of Mavacamten in Healthy Participants

Healthy Participants

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation

Mitral Valve Failure

United States
University of Michigan
National Institutes of Health (NIH)

Active, not recruiting

Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period (T-NOX)

Tetralogy of Fallot | Cardiopulmonary Bypass | Hypoplastic Left Heart Syndrome | Transposition of the Great Arteries | Double Outlet Right Ventricle, Subpulmonary VSD | Pulmonary Atresia With Ventricular Septal Defect | Truncus Arteriosus | Total Anomalous Pulmonary Venous Return | Double Outlet Right...

United States
University Hospital, Motol

Completed

Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

Czechia
University Hospital, Bordeaux
Amicus Therapeutics; Fédération Française de Cardiologie; Fondation Bordeaux...

Completed

Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies (HCM-Vein)

Endothelial Dysfunction | Hypertrophic Cardiomyopathy

France
Mayo Clinic

Withdrawn

Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy | Cardiomyopathy, Hypertrophic | Hypertrophic Obstructive Cardiomyopathy
MyoKardia, Inc.

Completed

A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction (PIONEER-HCM)

Cardiomyopathy, Hypertrophic Obstructive | Left Ventricular Outflow Tract Obstruction

United States
Washington University School of Medicine

Terminated

Aortic Stenosis and PhosphodiEsterase Type 5 iNhibition (ASPEN): A Pilot Study (ASPEN)

Aortic Stenosis | LV Remodeling, Hypertrophy

United States
Washington University School of Medicine

Terminated

Aortic Stenosis and PhosphodiEsterase iNhibition With Aortic Valve Replacement (ASPEN-AVR): A Pilot Study (ASPEN-AVR)

Aortic Stenosis

United States
National Heart, Lung, and Blood Institute (NHLBI)

Not yet recruiting

NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study

Aortic Valve Stenosis | Hypertrophic Cardiomyopathy | Mitral Valve Disease | Left Ventricular Septal Hypertrophy

United States
Xiang Wei
Fudan University; Guangdong Provincial People's Hospital; Beijing Anzhen Hospital and other collaborators

Recruiting

Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center Study

Hypertrophic Obstructive Cardiomyopathy

China
University Medical Centre Ljubljana

Not yet recruiting

Conventional Versus Left Bundle Branch Pacing in TAVI

Heart Failure | Aortic Valve Stenosis | Pacemaker-Induced Cardiomyopathy | Transcatheter Aortic Valve Implantation

Slovenia
Lisa Gundestrup

Not yet recruiting

Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery (SALVAGE)

Aortic Valve Stenosis
Medical University of Warsaw
Institute of Cardiology, Warsaw, Poland; Medical University of Lodz; Medical... and other collaborators

Recruiting

Polish Transcatheter Transfemoral Mitral Valve-in-Valve Implantation (Mitral ViV) Registry

Heart Failure | Mitral Insufficiency | Mitral Stenosis | Mitral Stenosis With Insufficiency | Bioprosthesis Failure

Poland
Main Line Health
Medtronic; Sharpe-Strumia Research Foundation

Recruiting

Comparison of Left Bundle Branch Area Versus Right Ventricular Septal Pacing in Patients With High-degree Conduction Disease After Transcatheter Aortic Valve Replacement (Left Bundle BRAVE)

Aortic Valve Stenosis | Complete Heart Block | High Degree Second Degree Atrioventricular Block | Pacemaker-Induced Cardiomyopathy

United States
Avicenna Military Hospital

Recruiting

Is Mitral Velocity Time-integral a Marker of Preload-responsiveness in Patients With Acute Circulatory Failure?

Preload-responsiveness

Morocco
PECA Labs

Recruiting

MASA Valve Early Feasibility Study (MVEFS)

Transposition of Great Vessels | Pulmonary Atresia | Pulmonary Stenosis | Tetrology of Fallot | Truncus Arteriosus | Ross Procedure

United States
Queen Silvia Children's Hospital, Gothenburg, Sweden
Sahlgrenska University Hospital, Sweden; Swedish Heart Lung Foundation

Recruiting

Effect of Fetal Aortic Valvuloplasty on Outcomes (FASSprosp)

Aortic Valve Stenosis | Congenital Heart Disease | Hypoplastic Left Heart Syndrome | Fetal Cardiac Disorder

United States, Austria, Canada, Finland, Germany, Poland, Spain, Sweden
Erasmus Medical Center

Recruiting

Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions (POTUS)

Coronary Artery Disease | Aortic Valve Stenosis | Mitral Regurgitation | Fractional Flow Reserve

Netherlands
Xiang Wei

Recruiting

Transapical Beating-heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy

China
University of Aarhus
Aarhus University Hospital

Recruiting

Effect of Dapagliflozin on Myocardial and Renal Function Following Aortic Valve Stenosis Intervention (DAPAS)

Aortic Stenosis | Left Ventricle Hypertrophied

Denmark
Ludwig-Maximilians - University of Munich

Recruiting

Left Bundle Branch Area Pacing in Patients After TAVR (PLANET)

Aortic Valve Stenosis | AV Block | Pacing-Induced Cardiomyopathy

Germany
Institut universitaire de cardiologie et de pneumologie...
Odense University Hospital

Recruiting

Angiotensin Receptor Blockers in Aortic Stenosis (ARBAS)

Aortic Stenosis

Denmark, Canada
Scripps Health

Recruiting

Evaluating Infrasonic Hemodynography

Cardiovascular Diseases | Coronary Artery Disease | Aortic Stenosis | Mitral Regurgitation | Pulmonary Hypertension | Heart Failure, Systolic

United States
Massachusetts General Hospital

Recruiting

Imaging Histone Deacetylase in the Heart

Diabetes | Aortic Valve Stenosis | Heart Failure With Normal Ejection Fraction | Left Ventricular Hypertrophy

United States
Medical University of Warsaw

Recruiting

Polish Registry of Common Carotid Artery Access for TAVI (POL-CAROTID)

Aortic Valve Stenosis | Ventricular Outflow Obstruction, Left

Poland
Medical University of Warsaw

Recruiting

Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry

Aortic Valve Stenosis | Aortic Valve Insufficiency | Ventricular Outflow Obstruction, Left

Poland
Montreal Heart Institute

Recruiting

Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI (COME-TAVI)

Aortic Valve Stenosis | Left Bundle-Branch Block

Canada
Fatebenefratelli Hospital
Federico II University; Federal University of Rio Grande do Sul; Royal Brompton... and other collaborators

Recruiting

Stress Echo 2020 - The International Stress Echo Study (SE2020)

Coronary Artery Disease | Heart Failure | Aortic Valve Disease | Pulmonary Arterial Hypertension | Tetralogy of Fallot | Hypertrophic Cardiomyopathy | Athletes Heart

Italy
University of Turku
Helsinki University Central Hospital; Kuopio University Hospital; St. Antonius... and other collaborators

Recruiting

Left Atrial Appendage CLOSURE for the Prevention of Thromboembolisms in Patients Undergoing Aortic Bioprosthesis Surgery (LAA-CLOSURE)

Aortic Stenosis

Finland, Netherlands
Laval University
University Hospital, Brest

Recruiting

Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)

Aortic Valve Stenosis

United States, France, Austria, Belgium, Canada, Germany
Tampere University
Finnish Cultural Foundation; Sigrid Jusélius Foundation; Päivikki and Sakari... and other collaborators

Recruiting

HaemoDYNAMICs in Primary and Secondary Hypertension (DYNAMIC)

Renal Insufficiency | Aortic Stenosis | Primary Hypertension | Secondary Hypertension

Finland
University of Edinburgh
Sir Jules Thorn Charitable Trust

Active, not recruiting

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS (EVoLVeD)

Aortic Valve Stenosis | Hypertrophy, Left Ventricular

United Kingdom
University of Edinburgh

Completed

Mechanism of Decompensation Evaluation - Aortic Stenosis (MODE-AS)

Myocardial Fibrosis | Aortic Stenosis | Left Ventricular Hypertrophy

United Kingdom
University of Zurich
Abbott Medical Devices

Active, not recruiting

Comparison of Left Atrial Appendage Occlusion vs Standard Medical Therapy in Patients in AF Undergoing TAVI (TAVI/LAAO)

Atrial Fibrillation | Aortic Stenosis

Switzerland
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States
Erasmus Medical Center
Dutch Heart Foundation

Active, not recruiting

Cardiac Imaging in Adults With Congenital Aortic Stenosis (CAS)

Congenital Aortic Stenosis

Netherlands
Bristol-Myers Squibb

Active, not recruiting

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Hypertrophic Cardiomyopathy | Non-obstructive Hypertrophic Cardiomyopathy | Obstructive Hypertrophic Cardiomyopathy

Denmark, United States, Belgium, Czechia, France, Germany, Israel, Italy, Netherlands, Poland, Portugal, Spain, United Kingdom
Bristol-Myers Squibb

Completed

Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER (PIONEER-OLE)

Hypertrophic Cardiomyopathy

United States
Aarhus University Hospital Skejby

Completed

Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis (PREFLOW)

Aortic Valve Stenosis

Denmark
University Hospital Augsburg

Completed

On Dose Efficiency of Modern CT-scanners in Chest Scans

Pneumonia | Aortic Stenosis | Lung Cancer | Pulmonary Disease | Pulmonary Embolism

Germany
Haukeland University Hospital

Completed

Transcatheter Aortic Valve Implantation in Western NORway (TAVI-NOR)

Hypertension | Aortic Stenosis
Cardiovascular Research Foundation, New York
Cardialysis BV; Avania

Active, not recruiting

Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

Aortic Valve Stenosis

United States, Canada, Netherlands
Oslo University Hospital

Completed

Better Patient Selection to Transcatheter Aortic Valve Implantation

Myocardial Fibrosis | Aortic Valve Stenosis | Left Ventricular Dysfunction

Norway
University Hospital, Rouen

Active, not recruiting

Aortic Stenosis: Determinants and Prognostic Value of Preoperative Left Ventricular Remodeling After Valvular Replacement

Aortic Valve Stenosis

France
University Hospital, Rouen

Active, not recruiting

Aortic Stenosis: Determinants of Progression, Severity and Left Ventricular Remodeling (AS-PROGRESSION)

Aortic Valve Stenosis

France
Assistance Publique Hopitaux De Marseille

Completed

Right and Left Ventricle Remodeling Predictors After Pulmonary Valve Replacement in Patients With Repaired Tetralogy of Fallot

Tetralogy of Fallot With Pulmonary Stenosis

France
University Hospital, Limoges

Withdrawn

Efficacy of Angiotensin Receptor Blocker Following aortIc Valve Intervention for Aortic STenOsis: a Randomized mulTi-cEntric Double-blind Phase II Study (ARISTOTE)

Aortic Valve Stenosis | Transcatheter Aortic Valve Replacement | Hypertrophy, Left Ventricular | Angiotensin Receptor Antagonists | Heart Valve Prosthesis Implantation | Valsartan

France
Rennes University Hospital

Terminated

Randomized Study for the Optimal Treatment of Symptomatic Patients With Low Gradient Severe Aortic Valve Stenosis and Preserved Left Ventricular Ejection Fraction (ROTAS)

Aortic Valve Stenosis

France, Belgium

Search clinical trials for: left ventricular outflow tract obstruction

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