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Inotuzumab Ozogamicin og frontline kemoterapi til behandling af unge voksne med nyligt diagnosticeret B Akut lymfoblastisk leukæmi

2. november 2026 opdateret af: Alliance for Clinical Trials in Oncology

Et fase III-forsøg for at evaluere effektiviteten af ​​tilsætningen af ​​Inotuzumab Ozogamicin (et konjugeret anti-CD22 monoklonalt antistof) til frontlinjeterapi hos unge voksne (alder 18-39 år) med nydiagnosticeret precursor B-celle ALL

This phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a chemotherapy drug called ozogamicin. Inotuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD22 receptors, and delivers ozogamicin to kill them. Chemotherapy drugs, such as [intervention], work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving inotuzumab ozogamicin with chemotherapy may work better in treating young adults with B acute lymphoblastic leukemia.

Studieoversigt

Status

Status

Angiver den aktuelle rekrutteringsstatus eller den udvidede adgangsstatus.
Rekruttering

Betingelser

Betingelser

Den sygdom, lidelse, syndrom, sygdom eller skade, der undersøges. På ClinicalTrials.gov kan tilstande også omfatte andre sundhedsrelaterede problemer, såsom levetid, livskvalitet og sundhedsrisici.

Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.

Detaljeret beskrivelse

PRIMARY OBJECTIVES:

I. To confirm tolerability of the combination regimen with the addition of inotuzumab ozogamicin to the pediatric-inspired regimen of cancer and leukemia group B (CALGB) 10403.

II. To determine whether the addition of inotuzumab ozogamicin significantly improves the event-free survival (EFS) in patients who achieve an induction response achieved with the pediatric-inspired regimen of CALGB 10403, without censoring for transplant. (Phase III) III. To determine the safety and tolerability of a reduced dose of inotuzumab ozogamicin and two cycles of blinatumomab added to the pediatric-inspired regimen of CALGB 10403 (Pilor cohort).

SECONDARY OBJECTIVES:

I. To determine the impact of inotuzumab ozogamicin on disease-free (DFS) and overall survival (OS) in patients who achieve an induction response.

II. To determine whether the addition of inotuzumab ozogamicin significantly improves the event-free survival (EFS) in patients who achieve an induction response achieved with the pediatric-inspired regimen of CALGB 10403, with censoring for transplant.

III. To determine the impact of inotuzumab ozogamicin on minimal residual disease (MRD) and correlate this with the EFS, DFS and OS.

IV. To determine the prognosis based on patients' low-density array (LDA) gene signature in terms of EFS, DFS, and OS after treatment with or without inotuzumab ozogamicin when added to the C10403 backbone regimen.

V. To evaluate the toxicity and tolerability of the addition of inotuzumab ozogamicin to the pediatric-inspired regimen of CALGB 10403.

CORRELATIVE SCIENCE OBJECTIVES:

I. To assess both the correlation of MRD post-induction and at sequential timepoints with LDA signature.

II. To evaluate the influence of MRD status (detectable vs. not and as a continuous measure) in relation to EFS both in the univariate setting as well as adjusting for other clinical features including initial white blood cell (WBC), ethnicity, sex and age at diagnosis.

III. To evaluate the impact of inotuzumab ozogamicin (inotuzumab) on the kinetics of MRD during treatment with inotuzumab in patients randomized to the experimental treatment arm.

IV. To perform genomic analyses to identify and evaluate the incidence and clinical significance of recurring novel fusion genes including those associated with the BCR-ABL1-like signature and to correlate with MRD status, CR rate, EFS and OS.

V. To assess whether rs4958351 is correlated with L-asp allergic reaction in the adolescent and young adult (AYA) population.

VI. To assess the incidence of inherited genetic variants in the GR1A1, CEP72, CPA2, TPMT, NUDT15, GRIN3A, GRIK1, and other genes (which can be found using a whole genome association study [GWAS]), are correlated with increased rates of target toxicities including peripheral neuropathy, hepatotoxicity, pancreatitis, myelosuppression, neurotoxicity, thrombosis, and osteonecrosis, and correlate with treatment discontinuation and other clinical response parameters including complete response (CR) rate, EFS, and OS.

VII. To evaluate asparaginase pharmacokinetics in adolescents and young adults, and investigate its correlation with toxicities and treatment outcomes.

VIII. To investigate the effect of anti-polyethylene glycol (PEG) and anti-agouti signaling protein (ASP) antibodies (PEG-ASP) on ASP enzyme activity.

IX. To measure adherence to oral 6 mercaptopurine (MP) and methotrexate in AYAs with acute lymphoblastic leukemia (ALL) and to examine sociodemographic and behavioral determinants of adherence.

X. To determine the impact of adherence on risk of relapse among AYAs with ALL. XI. To correlate specific karyotype groups (normal or various primary and secondary chromosomal abnormalities) with clinical and laboratory parameters.

XII. To correlate specific karyotype groups with response rates, response duration, survival, and cure in patients treated on this protocol.

XIII. To correlate specific karyotype groups with MRD. XIV. To determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse.

XV. To define the rate, analytical performance, and diagnostic yield of ChromoSeq vs. conventional G-banded karyotyping and fluorescence in situ hybridization (FISH) for B ALL patients in a multicenter setting.

OUTLINE:

COURSE I (REMISSION INDUCTION THERAPY): All patients receive allopurinol orally (PO) once daily until peripheral blasts and extramedullary disease are reduced and cytarabine intrathecally (IT) over 1 minute on day 1. Patients also receive daunorubicin hydrochloride intravenously, over 1 to 30 minutes (IV) and vincristine sulfate IV on days 1, 8, 15 and 22, dexamethasone PO or IV twice daily (BID) on days 1-7 and 15-21, pegaspargase for patients >21.5 years IV, over 1 to 2 hours on day 4, 5, or 6, or calaspargase pegol IV, over 1 hour, on days 4, 5 or 6 and methotrexate IT over 1 minute on days 8 and 29. Patients with central nervous system (CNS) 3 disease receive methotrexate IT over 1 minute also on days 15 and 22. All patients then undergo bone marrow aspirate and biopsy on day 29.

Patients enrolled prior to Update 8 with response to remission induction therapy are randomized to 1 of 2 arms. Patients enrolled after amendment 8 are assigned to the pilot cohort. Patients with no response are omitted from the study.

ARM I (CLOSED 7/23/2025):

COURSE II (REMISSION CONSOLIDATION CHEMOTHERAPY): Patients receive cyclophosphamide IV on days 1 and 29, cytarabine IV or SC on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14 and 29-42, and vincristine sulfate IV, over 1 to 10 minutes on days 15, 22, 43, and 50. Patients >21.5 years also receive pegaspargase IV, over 1 to 2 hours, on days 15 and 43 and patients <21.5 years old receive calaspargase pegol IV, over 1 hour, on days 2 and 22, and methotrexate IT on days 1, 8, 15, and 22. Patients with CNS3 receive methotrexate IT only on days 1 and 8. CD20 positive (+) patients receive rituximab IV on days 1, 8, 29, and 36. Patients with evidence of testicular disease at diagnosis also receive radiation therapy (RT). Patients who are MRD+ and CD19+ after completion of this course receive dexamethasone IV or PO on day 1 and blinatumomab IV via continuous infusion on days 1-28, followed by a 14 day break. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients then undergo bone marrow aspirate and biopsy on day 56.

COURSE III (INTERIM MAINTENANCE CHEMOTHERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 11, 21, 31, and 41, methotrexate IV, over 24 hours, and IT on days 1, 11, 21, 31, and 41, patients >21.5 years old receive pegaspargase IV, over 1 to 2 hours, and patients < 21.5 years old receive calaspargase pegol IV, over 1 hour on days 2 and 22. CD20+ patients receive rituximab IV on days 1 and 11.

COURSE IV (DELAYED INTENSIFICATION): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 8, 15, 43, and 50, dexamethasone PO or IV BID on days 1-7 and 15-21, doxorubicin IV, over 3 to 60 minutes, on days 1, 8, and 15, patients >21.5 years old receive pegaspargase IV, over 1 to 2 hours, on day 4, 5, or 6 and day 43, patients <21.5 years old receive calaspargase pegol IV, over 1 hour, on days 2 and 22. Patients also receive cyclophosphamide IV on day 29, cytarabine IV or SC on days 29-32 and 36-39, thioguanine PO on days 29-42 and methotrexate IT on days 1, 29, and 36. CD20+ patients receive rituximab IV on days 1 and 8. Patients then undergo bone marrow aspirate and biopsy one week after completion of course IV.

COURSE V (MAINTENANCE THERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 29, and 57, dexamethasone PO or IV BID on days 1-5, 29-33, and 57-61, and mercaptopurine PO on days 1-84. Patients also receive methotrexate IT or PO on days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, and 78. Treatment repeats every 12 weeks for up to 3 years in the absence of disease progression or unacceptable toxicity.

Patients undergo multigated acquisition scan (MUGA) or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.

ARM II (CLOSED 7/23/2025): Patients receive inotuzumab ozogamicin IV, over 1 hour, on days 1, 8, and 15 and undergo bone marrow aspirate and biopsy on day 28. Treatment repeats every 28 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity. Patients who are MRD+ and CD19+ after completion of 2 cycles of inotuzumab ozogamicin receive dexamethasone IV or PO on day 1 and blinatumomab IV via continuous infusion on days 1-28, followed by a 14 day break. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive remission consolidated chemotherapy, interim maintenance chemotherapy, delayed intensification, and maintenance therapy as in Arm I.

Patients undergo MUGA or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.

PILOT COHORT: Patients receive inotuzumab ozogamicin IV, over 1 hour, on days 1, 8, and 15 and undergo bone marrow aspirate and biopsy on day 28.

COURSE II (REMISSION CONSOLIDATION CHEMOTHERAPY): Patients receive cyclophosphamide IV on days 1 and 29, cytarabine IV or SC on days 1-4, 8-11, 29-32, and 36-39, mercaptopurine PO on days 1-14 and 29-42, and vincristine sulfate IV, over 1 to 10 minutes, on days 15, 22, 43, and 50. Patients > 21.5 years old also receive pegaspargase IV, over 1 to 2 hours, on days 15 and 43 and patients < 21.5 years old receive calaspargase pegol IV, over 1 hour, on days 15 and 43, and methotrexate IT on days 1, 8, 15, and 22. Patients with CNS3 receive methotrexate IT only on days 1 and 8. CD20+ patients receive rituximab IV on days 1, 8, 29, and 36. Patients with evidence of testicular disease at diagnosis also receive RT. Patients then undergo bone marrow aspirate and biopsy on day 56.

BLINATUMOMAB: Patients receive blinatumomab IV, continuously, on days 1-28 of one 42-day cycle in the absence of disease progression or unacceptable toxicity. Patients also receive dexamethasone PO or IV prior to starting the blinatumomab cycle, and a single dose of methotrexate IT between cycle days 29 and 42.

COURSE III (INTERIM MAINTENANCE CHEMOTHERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes, on days 1, 11, 21, 31, and 41, methotrexate IV, over 24 hours, and IT on days 1, 11, 21, 31, and 41, patients >21.5 years old receive pegaspargase IV, over 1 to 2 hours, and patients < 21.5 years old receive calaspargase pegol IV, over 1 hour on days 2 and 22. CD20+ patients receive rituximab IV on days 1 and 11.

BLINATUMOMAB: Patients receive blinatumomab IV, continuously, on days 1-28 of one 42-day cycle in the absence of disease progression or unacceptable toxicity. Patients also receive dexamethasone PO or IV prior to starting the blinatumomab cycle, and a single dose of methotrexate IT between cycle days 29 and 42. Patients who are MRD positive and CD19+ after Course II may continue to receive blinatumomab IV, continuously on days 1-28 of each cycle. Cycles repeat every 42 days for an additional 2 cycles in the absence of disease progression or unacceptable toxicity, per investigator discretion.

COURSE IV (DELAYED INTENSIFICATION): Patients receive vincristine sulfate IV, over 1 to 10 minutes on days 1, 8, 15, 43, and 50, dexamethasone PO or IV BID on days 1-7 and 15-21, doxorubicin IV, over 3 to 60 minutes, on days 1, 8, and 15, patients > 21.5 years old receive pegaspargase IV, over 1 to 2 hours, on day 4, 5, or 6 and day 43, patients < 21.5 years old receive calaspargase pegol IV, over 1 hour, on day 4, 5, or 6 and 43. Patients also receive cyclophosphamide IV on day 29, cytarabine IV or SC on days 29-32 and 36-39, thioguanine PO on days 29-42 and methotrexate IT on days 1, 29, and 36. CD20+ patients receive rituximab IV on days 1 and 8. Patients then undergo bone marrow aspirate and biopsy one week after completion of course IV.

COURSE V (MAINTENANCE THERAPY): Patients receive vincristine sulfate IV, over 1 to 10 minutes on days 1, 29, and 57, dexamethasone PO or IV BID on days 1-5, 29-33, and 57-61, and mercaptopurine PO on days 1-84. Patients also receive methotrexate IT on day 1 of cycles 1-4 and PO once weekly (QW) of each cycle. Treatment repeats every 12 weeks for up to 3 years in the absence of disease progression or unacceptable toxicity.

Patients undergo MUGA or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.

After completion of study treatment, patients are followed up every 2 months for 2 years, every 3 months 2 years, and then every 6 months for up to 10 years.

Undersøgelsestype

Undersøgelsestype

Beskriver karakteren af ​​en klinisk undersøgelse. Undersøgelsestyper omfatter interventionelle undersøgelser (også kaldet kliniske forsøg), observationsundersøgelser (herunder patientregistre) og udvidet adgang.
Interventionel

Tilmelding (Anslået)

Tilmelding

Antallet af deltagere i en klinisk undersøgelse. Den "forventede" tilmelding er det mål for antallet af deltagere, som forskerne skal bruge til undersøgelsen.
303

Fase

Fase

Stadiet af et klinisk forsøg, der studerer et lægemiddel eller et biologisk produkt, baseret på definitioner udviklet af U.S. Food and Drug Administration (FDA). Fasen tager udgangspunkt i undersøgelsens formål, antallet af deltagere og andre karakteristika. Der er fem faser: Tidlig fase 1 (tidligere opført som fase 0), fase 1, fase 2, fase 3 og fase 4. Ikke relevant bruges til at beskrive forsøg uden FDA-definerede faser, herunder forsøg med enheder eller adfærdsmæssige indgreb.
  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiekontakt

Navn og kontaktoplysninger for den person, der kan besvare spørgsmål om tilmelding til en klinisk undersøgelse. Hvert sted, hvor undersøgelsen udføres, kan også have en specifik kontaktperson, som kan være bedre i stand til at besvare disse spørgsmål.

Studiesteder

  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 5G2
        • Suspenderet
        • Arthur J E Child Comprehensive Cancer Centre
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • Suspenderet
        • CancerCare Manitoba
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • Rekruttering
        • QEII Health Sciences Centre/Nova Scotia Health Authority
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 902-473-6000
        • Ledende efterforsker:
          • Nicholas A. Forward
    • Ontario
      • Ottawa, Ontario, Canada, K1H 8L6
        • Rekruttering
        • Ottawa Hospital and Cancer Center-General Campus
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 613-761-4395
        • Ledende efterforsker:
          • Jill Fulcher
    • Quebec
      • Montreal, Quebec, Canada, H3T 1E2
        • Suspenderet
        • Jewish General Hospital
  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • Aktiv, ikke rekrutterende
        • University of Alabama at Birmingham Cancer Center
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 98508
        • Suspenderet
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Forenede Stater, 99504
        • Suspenderet
        • Anchorage Radiation Therapy Center
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Katmai Oncology Group
      • Anchorage, Alaska, Forenede Stater, 99508
        • Suspenderet
        • Providence Alaska Medical Center
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Suspenderet
        • Fairbanks Memorial Hospital
    • Arizona
      • Kingman, Arizona, Forenede Stater, 86401
        • Suspenderet
        • Kingman Regional Medical Center
      • Phoenix, Arizona, Forenede Stater, 85054
        • Suspenderet
        • Mayo Clinic Hospital in Arizona
      • Scottsdale, Arizona, Forenede Stater, 85259
        • Trukket tilbage
        • Mayo Clinic in Arizona
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Suspenderet
        • Mercy Hospital Fort Smith
    • California
      • Antioch, California, Forenede Stater, 94531
        • Rekruttering
        • Kaiser Permanente-Deer Valley Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Arroyo Grande, California, Forenede Stater, 93420
        • Suspenderet
        • PCR Oncology
      • Burbank, California, Forenede Stater, 91505
        • Suspenderet
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Clovis, California, Forenede Stater, 93611
        • Rekruttering
        • Community Cancer Institute
        • Ledende efterforsker:
          • Mohammed S. Bukari
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 559-387-1827
      • Clovis, California, Forenede Stater, 93611
        • Suspenderet
        • University Oncology Associates
      • Costa Mesa, California, Forenede Stater, 92627
        • Rekruttering
        • UC Irvine Health Cancer Center-Newport
        • Ledende efterforsker:
          • Deepa Jeyakumar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-827-8839
      • Dublin, California, Forenede Stater, 94568
        • Rekruttering
        • Kaiser Permanente Dublin
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Fremont, California, Forenede Stater, 94538
        • Rekruttering
        • Kaiser Permanente-Fremont
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Fresno, California, Forenede Stater, 93720
        • Rekruttering
        • Kaiser Permanente-Fresno
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Fresno, California, Forenede Stater, 93720
        • Suspenderet
        • Fresno Cancer Center
      • Fresno, California, Forenede Stater, 93720
        • Rekruttering
        • Kaiser Permanente Fresno Orchard Plaza
        • Ledende efterforsker:
          • Jennifer M. Suga
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 833-574-2273
      • Irvine, California, Forenede Stater, 92612
        • Rekruttering
        • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
        • Ledende efterforsker:
          • Deepa Jeyakumar
        • Kontakt:
      • Modesto, California, Forenede Stater, 95356
        • Rekruttering
        • Kaiser Permanente-Modesto
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Modesto, California, Forenede Stater, 95356
        • Rekruttering
        • Kaiser Permanente- Modesto MOB II
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Oakland, California, Forenede Stater, 94611
        • Rekruttering
        • Kaiser Permanente-Oakland
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Oakland, California, Forenede Stater, 94611
        • Suspenderet
        • Kaiser Permanente Oakland-Broadway
      • Orange, California, Forenede Stater, 92868
        • Rekruttering
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
        • Ledende efterforsker:
          • Deepa Jeyakumar
        • Kontakt:
      • Palo Alto, California, Forenede Stater, 94304
        • Rekruttering
        • Stanford Cancer Institute Palo Alto
        • Ledende efterforsker:
          • Michaela Liedtke
        • Kontakt:
      • Rancho Cordova, California, Forenede Stater, 95670
        • Suspenderet
        • Kaiser Permanente-Rancho Cordova Cancer Center
      • Redwood City, California, Forenede Stater, 94063
        • Suspenderet
        • Kaiser Permanente-Redwood City
      • Redwood City, California, Forenede Stater, 94063
        • Suspenderet
        • Kaiser Permanente- Marshall Medical Offices
      • Richmond, California, Forenede Stater, 94801
        • Rekruttering
        • Kaiser Permanente-Richmond
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Rohnert Park, California, Forenede Stater, 94928
        • Suspenderet
        • Rohnert Park Cancer Center
      • Roseville, California, Forenede Stater, 95661
        • Rekruttering
        • Kaiser Permanente-Roseville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Roseville, California, Forenede Stater, 95678
        • Suspenderet
        • The Permanente Medical Group-Roseville Radiation Oncology
      • Sacramento, California, Forenede Stater, 95817
        • Rekruttering
        • University of California Davis Comprehensive Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 916-734-3089
        • Ledende efterforsker:
          • Brian A. Jonas
      • Sacramento, California, Forenede Stater, 95814
        • Rekruttering
        • Kaiser Permanente Downtown Commons
        • Ledende efterforsker:
          • Jennifer M. Suga
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: kpoct@kp.org
      • Sacramento, California, Forenede Stater, 95823
        • Rekruttering
        • Kaiser Permanente-South Sacramento
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Sacramento, California, Forenede Stater, 95823
        • Suspenderet
        • South Sacramento Cancer Center
      • Sacramento, California, Forenede Stater, 95825
        • Suspenderet
        • Kaiser Permanente Sacramento Medical Center
      • San Francisco, California, Forenede Stater, 94115
        • Rekruttering
        • Kaiser Permanente-San Francisco
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Jose, California, Forenede Stater, 95119
        • Rekruttering
        • Kaiser Permanente-Santa Teresa-San Jose
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Leandro, California, Forenede Stater, 94577
        • Rekruttering
        • Kaiser Permanente San Leandro
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Rafael, California, Forenede Stater, 94903
        • Rekruttering
        • Kaiser San Rafael-Gallinas
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • San Rafael, California, Forenede Stater, 94903
        • Suspenderet
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Rekruttering
        • Kaiser Permanente Medical Center - Santa Clara
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Santa Rosa, California, Forenede Stater, 95403
        • Rekruttering
        • Kaiser Permanente-Santa Rosa
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • South San Francisco, California, Forenede Stater, 94080
        • Suspenderet
        • Kaiser Permanente Cancer Treatment Center
      • South San Francisco, California, Forenede Stater, 94080
        • Rekruttering
        • Kaiser Permanente-South San Francisco
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Stockton, California, Forenede Stater, 95210
        • Rekruttering
        • Kaiser Permanente-Stockton
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Vacaville, California, Forenede Stater, 95688
        • Rekruttering
        • Kaiser Permanente Medical Center-Vacaville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Vallejo, California, Forenede Stater, 94589
        • Rekruttering
        • Kaiser Permanente-Vallejo
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
      • Walnut Creek, California, Forenede Stater, 94596
        • Rekruttering
        • Kaiser Permanente-Walnut Creek
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
        • Ledende efterforsker:
          • Jennifer M. Suga
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Suspenderet
        • The Medical Center of Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Aurora
      • Boulder, Colorado, Forenede Stater, 80303
        • Aktiv, ikke rekrutterende
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Boulder
      • Centennial, Colorado, Forenede Stater, 80112
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers - Centennial
      • Denver, Colorado, Forenede Stater, 80220
        • Suspenderet
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80204
        • Suspenderet
        • Cancer Center of Colorado at Sloan's Lake
      • Denver, Colorado, Forenede Stater, 80206
        • Suspenderet
        • National Jewish Health-Main Campus
      • Denver, Colorado, Forenede Stater, 80218
        • Aktiv, ikke rekrutterende
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80209
        • Aktiv, ikke rekrutterende
        • The Women's Imaging Center
      • Denver, Colorado, Forenede Stater, 80218
        • Aktiv, ikke rekrutterende
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80218
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80220
        • Aktiv, ikke rekrutterende
        • Western Surgical Care
      • Denver, Colorado, Forenede Stater, 80218
        • Suspenderet
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Englewood, Colorado, Forenede Stater, 80113
        • Suspenderet
        • Swedish Medical Center
      • Englewood, Colorado, Forenede Stater, 80113
        • Aktiv, ikke rekrutterende
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Forenede Stater, 80113
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers - Swedish
      • Englewood, Colorado, Forenede Stater, 80113
        • Aktiv, ikke rekrutterende
        • The Melanoma and Skin Cancer Institute
      • Golden, Colorado, Forenede Stater, 80401
        • Suspenderet
        • National Jewish Health-Western Hematology Oncology
      • Grand Junction, Colorado, Forenede Stater, 81501
        • Suspenderet
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • Suspenderet
        • Banner North Colorado Medical Center
      • Lafayette, Colorado, Forenede Stater, 80026
        • Suspenderet
        • Good Samaritan Hospital - Cancer Centers of Colorado
      • Lakewood, Colorado, Forenede Stater, 80228
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Forenede Stater, 80120
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Littleton
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Suspenderet
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Loveland, Colorado, Forenede Stater, 80539
        • Suspenderet
        • Banner North Colorado Medical Center - Loveland Campus
      • Thornton, Colorado, Forenede Stater, 80260
        • Suspenderet
        • National Jewish Health-Northern Hematology Oncology
      • Thornton, Colorado, Forenede Stater, 80260
        • Aktiv, ikke rekrutterende
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Forenede Stater, 80401
        • Suspenderet
        • Intermountain Health Lutheran Hospital
    • Connecticut
      • Hartford, Connecticut, Forenede Stater, 06105
        • Suspenderet
        • Smilow Cancer Hospital Care Center at Saint Francis
      • New Haven, Connecticut, Forenede Stater, 06520
        • Rekruttering
        • Yale University
        • Kontakt:
        • Ledende efterforsker:
          • Lourdes M. Mendez
      • New Haven, Connecticut, Forenede Stater, 06510
        • Suspenderet
        • Smilow Cancer Center/Yale-New Haven Hospital
    • Florida
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Suspenderet
        • Holy Cross Hospital
      • Hollywood, Florida, Forenede Stater, 33021
        • Rekruttering
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 954-265-1847
          • E-mail: OHR@mhs.net
        • Ledende efterforsker:
          • Fernando M. Vargas Madueno
      • Miami, Florida, Forenede Stater, 33176
        • Aktiv, ikke rekrutterende
        • Miami Cancer Institute
      • Orlando, Florida, Forenede Stater, 32806
      • Pembroke Pines, Florida, Forenede Stater, 33028
        • Suspenderet
        • Memorial Hospital West
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30322
        • Rekruttering
        • Emory University Hospital/Winship Cancer Institute
        • Ledende efterforsker:
          • William G. Blum
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 404-778-1868
      • Augusta, Georgia, Forenede Stater, 30912
        • Rekruttering
        • Augusta University Medical Center
        • Ledende efterforsker:
          • Vamsi Kota
        • Kontakt:
    • Hawaii
      • Hilo, Hawaii, Forenede Stater, 96720
        • Suspenderet
        • Island Urology-Hilo
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Rekruttering
        • Kapiolani Medical Center for Women and Children
        • Ledende efterforsker:
          • Craig S. Boddy
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 808-983-6090
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Suspenderet
        • Island Urology
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Rekruttering
        • Straub Clinic and Hospital
        • Ledende efterforsker:
          • Craig S. Boddy
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 808-522-4333
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Suspenderet
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Suspenderet
        • Queen's Cancer Cenrer - POB I
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Suspenderet
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Suspenderet
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Suspenderet
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Suspenderet
        • Kuakini Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Suspenderet
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Suspenderet
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Suspenderet
        • Kaiser Permanente Moanalua Medical Center
      • Lihue, Hawaii, Forenede Stater, 96766
        • Suspenderet
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Rekruttering
        • Pali Momi Medical Center
        • Ledende efterforsker:
          • Craig S. Boddy
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 808-486-6000
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Suspenderet
        • Queen's Cancer Center - Pearlridge
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Suspenderet
        • The Cancer Center of Hawaii-Pali Momi
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Suspenderet
        • Hawaii Cancer Care - Westridge
    • Idaho
      • Boise, Idaho, Forenede Stater, 83712
        • Rekruttering
        • Saint Luke's Cancer Institute - Boise
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Boise, Idaho, Forenede Stater, 83706
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Boise
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Caldwell, Idaho, Forenede Stater, 83605
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Caldwell
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Rekruttering
        • Kootenai Health - Coeur d'Alene
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Emmett, Idaho, Forenede Stater, 83617
        • Suspenderet
        • Walter Knox Memorial Hospital
      • Fruitland, Idaho, Forenede Stater, 83619
        • Rekruttering
        • Saint Luke's Cancer Institute - Fruitland
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Meridian, Idaho, Forenede Stater, 83642
        • Suspenderet
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forenede Stater, 83642
        • Rekruttering
        • Saint Luke's Cancer Institute - Meridian
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Nampa, Idaho, Forenede Stater, 83687
        • Rekruttering
        • Saint Luke's Cancer Institute - Nampa
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Nampa, Idaho, Forenede Stater, 83687
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Nampa
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Post Falls, Idaho, Forenede Stater, 83854
        • Rekruttering
        • Kootenai Clinic Cancer Services - Post Falls
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Rekruttering
        • Kootenai Clinic Cancer Services - Sandpoint
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Twin Falls, Idaho, Forenede Stater, 83301
        • Rekruttering
        • Saint Luke's Cancer Institute - Twin Falls
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Suspenderet
        • OSF Saint Anthony's Health Center
      • Burr Ridge, Illinois, Forenede Stater, 60527
        • Suspenderet
        • Loyola Center for Health at Burr Ridge
      • Chicago, Illinois, Forenede Stater, 60637
        • Rekruttering
        • University of Chicago Comprehensive Cancer Center
        • Ledende efterforsker:
          • Wendy Stock
        • Kontakt:
      • Chicago, Illinois, Forenede Stater, 60611
        • Rekruttering
        • Northwestern University
        • Ledende efterforsker:
          • Shira N. Dinner
        • Kontakt:
      • Chicago, Illinois, Forenede Stater, 60612
        • Rekruttering
        • University of Illinois
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-355-3046
        • Ledende efterforsker:
          • John G. Quigley
      • Chicago, Illinois, Forenede Stater, 60612
        • Rekruttering
        • Rush MD Anderson Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Melissa L. Larson
      • Evanston, Illinois, Forenede Stater, 60201
        • Rekruttering
        • NorthShore University HealthSystem-Evanston Hospital
        • Ledende efterforsker:
          • Amy Y. Wang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
      • Glenview, Illinois, Forenede Stater, 60026
        • Rekruttering
        • NorthShore University HealthSystem-Glenbrook Hospital
        • Ledende efterforsker:
          • Amy Y. Wang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
      • Highland Park, Illinois, Forenede Stater, 60035
        • Rekruttering
        • NorthShore University HealthSystem-Highland Park Hospital
        • Ledende efterforsker:
          • Amy Y. Wang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
      • Homer Glen, Illinois, Forenede Stater, 60491
        • Suspenderet
        • Loyola Medicine Homer Glen
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Aktiv, ikke rekrutterende
        • Northwestern Medicine Lake Forest Hospital
      • Lisle, Illinois, Forenede Stater, 60532
        • Suspenderet
        • Rush MD Anderson Cancer Center at Rush Lisle
      • Maywood, Illinois, Forenede Stater, 60153
        • Rekruttering
        • Loyola University Medical Center
        • Ledende efterforsker:
          • Patrick A. Hagen
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 708-226-4357
      • Melrose Park, Illinois, Forenede Stater, 60160
        • Suspenderet
        • Marjorie Weinberg Cancer Center at Loyola-Gottlieb
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Suspenderet
        • SSM Health Good Samaritan
      • New Lenox, Illinois, Forenede Stater, 60451
        • Rekruttering
        • UC Comprehensive Cancer Center at Silver Cross
        • Ledende efterforsker:
          • Wendy Stock
        • Kontakt:
      • Orland Park, Illinois, Forenede Stater, 60462
        • Rekruttering
        • University of Chicago Medicine-Orland Park
        • Ledende efterforsker:
          • Wendy Stock
        • Kontakt:
    • Iowa
      • Carroll, Iowa, Forenede Stater, 51401
        • Aktiv, ikke rekrutterende
        • Saint Anthony Regional Hospital
      • Des Moines, Iowa, Forenede Stater, 50314
        • Aktiv, ikke rekrutterende
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Aktiv, ikke rekrutterende
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50316
        • Aktiv, ikke rekrutterende
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • Aktiv, ikke rekrutterende
        • Blank Children's Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • Aktiv, ikke rekrutterende
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • Aktiv, ikke rekrutterende
        • UI Healthcare Mission Cancer and Blood - Fort Dodge
      • Iowa City, Iowa, Forenede Stater, 52242
        • Rekruttering
        • University of Iowa/Holden Comprehensive Cancer Center
        • Ledende efterforsker:
          • Grerk Sutamtewagul
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-237-1225
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Aktiv, ikke rekrutterende
        • Methodist West Hospital
    • Kansas
      • Garden City, Kansas, Forenede Stater, 67846
        • Suspenderet
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forenede Stater, 67530
        • Suspenderet
        • Central Care Cancer Center - Great Bend
      • Kansas City, Kansas, Forenede Stater, 66160
        • Rekruttering
        • University of Kansas Cancer Center
        • Ledende efterforsker:
          • Kenneth Byrd
        • Kontakt:
      • Lawrence, Kansas, Forenede Stater, 66044
        • Suspenderet
        • Lawrence Memorial Hospital
      • Westwood, Kansas, Forenede Stater, 66205
        • Rekruttering
        • University of Kansas Hospital-Westwood Cancer Center
        • Ledende efterforsker:
          • Kenneth Byrd
        • Kontakt:
      • Wichita, Kansas, Forenede Stater, 67214
        • Rekruttering
        • Cancer Center of Kansas - Wichita
        • Kontakt:
        • Ledende efterforsker:
          • Dennis F. Moore
      • Wichita, Kansas, Forenede Stater, 67208
        • Suspenderet
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Suspenderet
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Forenede Stater, 67214
        • Suspenderet
        • Wesley Medical Center
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40536
        • Rekruttering
        • University of Kentucky/Markey Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 859-257-3379
        • Ledende efterforsker:
          • Ayman Qasrawi
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Aktiv, ikke rekrutterende
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, Forenede Stater, 70816
        • Aktiv, ikke rekrutterende
        • Medical Center of Baton Rouge
      • Baton Rouge, Louisiana, Forenede Stater, 70836
        • Aktiv, ikke rekrutterende
        • Ochsner High Grove
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Aktiv, ikke rekrutterende
        • Ochsner Medical Center Jefferson
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21201
        • Rekruttering
        • University of Maryland/Greenebaum Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-888-8823
        • Ledende efterforsker:
          • Shella Saint Fleur-Lominy
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02215
        • Suspenderet
        • Beth Israel Deaconess Medical Center
      • Boston, Massachusetts, Forenede Stater, 02114
        • Suspenderet
        • Massachusetts General Hospital Cancer Center
      • Boston, Massachusetts, Forenede Stater, 02215
        • Suspenderet
        • Dana-Farber Cancer Institute
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Suspenderet
        • Bronson Battle Creek
      • Brighton, Michigan, Forenede Stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Brighton, Michigan, Forenede Stater, 48114
        • Rekruttering
        • Trinity Health Medical Center - Brighton
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Canton, Michigan, Forenede Stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Canton, Michigan, Forenede Stater, 48188
        • Rekruttering
        • Trinity Health Medical Center - Canton
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Caro, Michigan, Forenede Stater, 48723
        • Suspenderet
        • Caro Cancer Center
      • Chelsea, Michigan, Forenede Stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Chelsea, Michigan, Forenede Stater, 48118
      • Clarkston, Michigan, Forenede Stater, 48346
        • Suspenderet
        • Hematology Oncology Consultants-Clarkston
      • Clarkston, Michigan, Forenede Stater, 48346
        • Suspenderet
        • Newland Medical Associates-Clarkston
      • Detroit, Michigan, Forenede Stater, 48201
        • Rekruttering
        • Wayne State University/Karmanos Cancer Institute
        • Ledende efterforsker:
          • Jay Yang
        • Kontakt:
      • Detroit, Michigan, Forenede Stater, 48236
        • Suspenderet
        • Henry Ford Health Saint John Hospital
      • East China Township, Michigan, Forenede Stater, 48054
        • Suspenderet
        • Henry Ford River District Hospital
      • Farmington Hills, Michigan, Forenede Stater, 48334
        • Rekruttering
        • Weisberg Cancer Treatment Center
        • Ledende efterforsker:
          • Jay Yang
        • Kontakt:
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Genesys Hurley Cancer Institute
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Hurley Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Flint, Michigan, Forenede Stater, 48503
        • Suspenderet
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Cancer Hematology Centers - Flint
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Rekruttering
        • Trinity Health Grand Rapids Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Rekruttering
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Suspenderet
        • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Suspenderet
        • Henry Ford Saint John Hospital - Academic
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Suspenderet
        • Henry Ford Saint John Hospital - Breast
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Suspenderet
        • Henry Ford Saint John Hospital - Van Elslander
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Rekruttering
        • Bronson Methodist Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Rekruttering
        • West Michigan Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Kalamazoo, Michigan, Forenede Stater, 49009
        • Rekruttering
        • Beacon Kalamazoo Cancer Center
        • Ledende efterforsker:
          • Kathleen Y. Butler
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 574-647-7370
      • Kalamazoo, Michigan, Forenede Stater, 49048
        • Suspenderet
        • Beacon Kalamazoo
      • Lansing, Michigan, Forenede Stater, 48912
        • Suspenderet
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Forenede Stater, 48154
        • Suspenderet
        • Hope Cancer Clinic
      • Livonia, Michigan, Forenede Stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Macomb, Michigan, Forenede Stater, 48044
        • Suspenderet
        • Henry Ford Warren Hospital - Breast Macomb
      • Macomb, Michigan, Forenede Stater, 48044
        • Rekruttering
        • Henry Ford Saint John Hospital - Macomb Medical
        • Ledende efterforsker:
          • Tareq Al baghdadi
        • Kontakt:
      • Marlette, Michigan, Forenede Stater, 48453
        • Suspenderet
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Muskegon, Michigan, Forenede Stater, 49444
        • Suspenderet
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, Forenede Stater, 49120
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Niles Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 616-391-1230
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Norton Shores, Michigan, Forenede Stater, 49444
        • Suspenderet
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Pontiac, Michigan, Forenede Stater, 48341
        • Suspenderet
        • Hope Cancer Center
      • Pontiac, Michigan, Forenede Stater, 48341
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Oakland Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Pontiac, Michigan, Forenede Stater, 48341
        • Suspenderet
        • Michigan Healthcare Professionals Pontiac
      • Pontiac, Michigan, Forenede Stater, 48341
        • Suspenderet
        • Trinity Health IHA Medical Group-Alice Gustafson Center
      • Reed City, Michigan, Forenede Stater, 49677
        • Rekruttering
        • Corewell Health Reed City Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Rochester Hills, Michigan, Forenede Stater, 48309
        • Suspenderet
        • Henry Ford Rochester Hospital
      • Saginaw, Michigan, Forenede Stater, 48604
        • Suspenderet
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forenede Stater, 48601
        • Suspenderet
        • MyMichigan Medical Center Saginaw
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Suspenderet
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Sterling Heights, Michigan, Forenede Stater, 48312
        • Suspenderet
        • Bhadresh Nayak MD PC-Sterling Heights
      • Tawas City, Michigan, Forenede Stater, 48764
        • Suspenderet
        • MyMichigan Medical Center Tawas
      • Traverse City, Michigan, Forenede Stater, 49684
        • Rekruttering
        • Munson Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Warren, Michigan, Forenede Stater, 48088
        • Suspenderet
        • Advanced Breast Care Center PLLC
      • Warren, Michigan, Forenede Stater, 48093
        • Suspenderet
        • Macomb Hematology Oncology PC
      • Warren, Michigan, Forenede Stater, 48093
        • Suspenderet
        • Henry Ford Madison Heights Hospital - Breast
      • Warren, Michigan, Forenede Stater, 48093
        • Suspenderet
        • Henry Ford Health Warren Hospital
      • Warren, Michigan, Forenede Stater, 48093
        • Suspenderet
        • Henry Ford Warren Hospital - GLCMS
      • West Branch, Michigan, Forenede Stater, 48661
        • Suspenderet
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Wyoming, Michigan, Forenede Stater, 49519
        • Rekruttering
        • University of Michigan Health - West
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Ypsilanti, Michigan, Forenede Stater, 48106
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
    • Minnesota
      • Aitkin, Minnesota, Forenede Stater, 56431
        • Suspenderet
        • Riverwood Healthcare Center
      • Brainerd, Minnesota, Forenede Stater, 56401
        • Suspenderet
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Suspenderet
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Suspenderet
        • Minnesota Oncology - Burnsville
      • Cambridge, Minnesota, Forenede Stater, 55008
        • Suspenderet
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Suspenderet
        • Mercy Hospital
      • Deer River, Minnesota, Forenede Stater, 56636
        • Suspenderet
        • Essentia Health - Deer River Clinic
      • Detroit Lakes, Minnesota, Forenede Stater, 56501
        • Suspenderet
        • Essentia Health Saint Mary's - Detroit Lakes Clinic
      • Duluth, Minnesota, Forenede Stater, 55805
        • Rekruttering
        • Essentia Health Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Duluth, Minnesota, Forenede Stater, 55805
        • Suspenderet
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Suspenderet
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Suspenderet
        • Fairview Southdale Hospital
      • Fergus Falls, Minnesota, Forenede Stater, 56537
        • Suspenderet
        • Lake Region Healthcare Corporation-Cancer Care
      • Fosston, Minnesota, Forenede Stater, 56542
        • Suspenderet
        • Essentia Health - Fosston
      • Fridley, Minnesota, Forenede Stater, 55432
        • Aktiv, ikke rekrutterende
        • Unity Hospital
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Suspenderet
        • Essentia Health Hibbing Clinic
      • Maple Grove, Minnesota, Forenede Stater, 55369
        • Suspenderet
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Suspenderet
        • Minnesota Oncology Hematology PA-Maplewood
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Suspenderet
        • Saint John's Hospital - Healtheast
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Suspenderet
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Suspenderet
        • Health Partners Inc
      • Monticello, Minnesota, Forenede Stater, 55362
        • Suspenderet
        • Monticello Cancer Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • Suspenderet
        • New Ulm Medical Center
      • Park Rapids, Minnesota, Forenede Stater, 56470
        • Suspenderet
        • Essentia Health - Park Rapids
      • Princeton, Minnesota, Forenede Stater, 55371
        • Suspenderet
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • Suspenderet
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Rekruttering
        • Mayo Clinic in Rochester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
        • Ledende efterforsker:
          • Aasiya Matin
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Suspenderet
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • Suspenderet
        • United Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Suspenderet
        • Regions Hospital
      • Sandstone, Minnesota, Forenede Stater, 55072
        • Suspenderet
        • Essentia Health Sandstone
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Suspenderet
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Suspenderet
        • Lakeview Hospital
      • Virginia, Minnesota, Forenede Stater, 55792
        • Suspenderet
        • Essentia Health Virginia Clinic
      • Waconia, Minnesota, Forenede Stater, 55387
        • Suspenderet
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Suspenderet
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Suspenderet
        • Minnesota Oncology Hematology PA-Woodbury
      • Wyoming, Minnesota, Forenede Stater, 55092
        • Suspenderet
        • Fairview Lakes Medical Center
    • Missouri
      • Ballwin, Missouri, Forenede Stater, 63011
        • Suspenderet
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Forenede Stater, 65613
        • Suspenderet
        • Central Care Cancer Center - Bolivar
      • Branson, Missouri, Forenede Stater, 65616
        • Suspenderet
        • Cox Cancer Center Branson
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Rekruttering
        • Siteman Cancer Center at Saint Peters Hospital
        • Ledende efterforsker:
          • Geoffrey L. Uy
        • Kontakt:
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Siteman Cancer Center at West County Hospital
        • Ledende efterforsker:
          • Geoffrey L. Uy
        • Kontakt:
      • Joplin, Missouri, Forenede Stater, 64804
        • Suspenderet
        • Freeman Health System
      • Joplin, Missouri, Forenede Stater, 64804
        • Suspenderet
        • Mercy Hospital Joplin
      • Rolla, Missouri, Forenede Stater, 65401
        • Suspenderet
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Forenede Stater, 65401
        • Suspenderet
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Suspenderet
        • Heartland Regional Medical Center
      • Springfield, Missouri, Forenede Stater, 65804
        • Suspenderet
        • Mercy Hospital Springfield
      • Springfield, Missouri, Forenede Stater, 65807
        • Suspenderet
        • CoxHealth South Hospital
      • St Louis, Missouri, Forenede Stater, 63110
        • Rekruttering
        • Washington University School of Medicine
        • Ledende efterforsker:
          • Geoffrey L. Uy
        • Kontakt:
      • St Louis, Missouri, Forenede Stater, 63128
        • Rekruttering
        • Mercy Hospital South
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
      • St Louis, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Mercy Hospital Saint Louis
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-251-7066
      • St Louis, Missouri, Forenede Stater, 63129
        • Rekruttering
        • Siteman Cancer Center-South County
        • Ledende efterforsker:
          • Geoffrey L. Uy
        • Kontakt:
      • St Louis, Missouri, Forenede Stater, 63109
        • Suspenderet
        • Mercy Infusion Center - Chippewa
      • Washington, Missouri, Forenede Stater, 63090
        • Suspenderet
        • Mercy Hospital Washington
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Rekruttering
        • Community Hospital of Anaconda
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Billings, Montana, Forenede Stater, 59101
        • Rekruttering
        • Billings Clinic Cancer Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Billings, Montana, Forenede Stater, 59101
        • Suspenderet
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59102
        • Suspenderet
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, Forenede Stater, 59715
        • Rekruttering
        • Bozeman Health Deaconess Hospital
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Butte, Montana, Forenede Stater, 59701
        • Suspenderet
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Suspenderet
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Rekruttering
        • Benefis Sletten Cancer Institute
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Kalispell, Montana, Forenede Stater, 59901
        • Rekruttering
        • Logan Health Medical Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Missoula, Montana, Forenede Stater, 59802
        • Suspenderet
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59804
        • Rekruttering
        • Community Medical Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
    • Nebraska
      • Bellevue, Nebraska, Forenede Stater, 68123
        • Rekruttering
        • Nebraska Medicine-Bellevue
        • Ledende efterforsker:
          • Krishna Gundabolu
        • Kontakt:
      • Omaha, Nebraska, Forenede Stater, 68198
        • Rekruttering
        • University of Nebraska Medical Center
        • Ledende efterforsker:
          • Krishna Gundabolu
        • Kontakt:
      • Omaha, Nebraska, Forenede Stater, 68118
        • Rekruttering
        • Nebraska Medicine-Village Pointe
        • Ledende efterforsker:
          • Krishna Gundabolu
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 402-559-5600
    • Nevada
      • Carson City, Nevada, Forenede Stater, 89703
        • Suspenderet
        • Carson Tahoe Regional Medical Center
      • Henderson, Nevada, Forenede Stater, 89052
        • Suspenderet
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada-Horizon Ridge
      • Henderson, Nevada, Forenede Stater, 89052
        • Suspenderet
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • Suspenderet
        • Las Vegas Urology - Green Valley
      • Henderson, Nevada, Forenede Stater, 89074
        • Suspenderet
        • Las Vegas Urology - Pebble
      • Henderson, Nevada, Forenede Stater, 89074
        • Suspenderet
        • Urology Specialists of Nevada - Green Valley
      • Henderson, Nevada, Forenede Stater, 89074
        • Suspenderet
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, Forenede Stater, 89102
        • Suspenderet
        • Desert West Surgery
      • Las Vegas, Nevada, Forenede Stater, 89074
        • Suspenderet
        • Las Vegas Urology - Pecos
      • Las Vegas, Nevada, Forenede Stater, 89102
        • Suspenderet
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89103
        • Suspenderet
        • Hope Cancer Care of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Suspenderet
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Suspenderet
        • Urology Specialists of Nevada - Central
      • Las Vegas, Nevada, Forenede Stater, 89109
        • Suspenderet
        • Sunrise Hospital and Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Suspenderet
        • Las Vegas Prostate Cancer Center
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Suspenderet
        • Las Vegas Urology - Sunset
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Suspenderet
        • Urology Specialists of Nevada - Southwest
      • Las Vegas, Nevada, Forenede Stater, 89119
        • Suspenderet
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • Ann M Wierman MD LTD
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • Las Vegas Urology - Cathedral Rock
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • Las Vegas Urology - Smoke Ranch
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • Urology Specialists of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89135
        • Suspenderet
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Suspenderet
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89148-2405
        • Suspenderet
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Suspenderet
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Suspenderet
        • University Cancer Center
      • Las Vegas, Nevada, Forenede Stater, 89102
        • Suspenderet
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Suspenderet
        • Oncology Las Vegas - Tenaya
      • Las Vegas, Nevada, Forenede Stater, 89183
        • Suspenderet
        • OptumCare Cancer Care at Fort Apache
      • Pahrump, Nevada, Forenede Stater, 89048
        • Suspenderet
        • Hope Cancer Care of Nevada-Pahrump
      • Reno, Nevada, Forenede Stater, 89502
        • Suspenderet
        • Renown Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89503
        • Suspenderet
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89509
        • Suspenderet
        • Radiation Oncology Associates
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Aktiv, ikke rekrutterende
        • University of New Mexico Cancer Center
    • New York
      • Buffalo, New York, Forenede Stater, 14263
        • Rekruttering
        • Roswell Park Cancer Institute
        • Ledende efterforsker:
          • Eunice S. Wang
        • Kontakt:
      • Lake Success, New York, Forenede Stater, 11042
        • Rekruttering
        • Northwell Health/Center for Advanced Medicine
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Bradley H. Goldberg
      • Manhasset, New York, Forenede Stater, 11030
        • Rekruttering
        • North Shore University Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Bradley H. Goldberg
      • New Hyde Park, New York, Forenede Stater, 11040
        • Rekruttering
        • Long Island Jewish Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Bradley H. Goldberg
      • New York, New York, Forenede Stater, 10029
        • Rekruttering
        • Mount Sinai Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-mail: CCTO@mssm.edu
        • Ledende efterforsker:
          • Hannah Levavi
      • New York, New York, Forenede Stater, 10065
        • Rekruttering
        • NYP/Weill Cornell Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-746-1848
        • Ledende efterforsker:
          • Gail J. Roboz
      • Rochester, New York, Forenede Stater, 14642
        • Rekruttering
        • University of Rochester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 585-275-5830
        • Ledende efterforsker:
          • Kristen M. O'Dwyer
      • Stony Brook, New York, Forenede Stater, 11794
        • Aktiv, ikke rekrutterende
        • Stony Brook University Medical Center
      • Syracuse, New York, Forenede Stater, 13210
        • Aktiv, ikke rekrutterende
        • State University of New York Upstate Medical University
      • Verona, New York, Forenede Stater, 13478
        • Aktiv, ikke rekrutterende
        • Upstate Cancer Center at Verona
    • North Carolina
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • Rekruttering
        • UNC Lineberger Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Daniel R. Richardson
      • Durham, North Carolina, Forenede Stater, 27710
        • Aktiv, ikke rekrutterende
        • Duke University Medical Center
      • Greenville, North Carolina, Forenede Stater, 27834
        • Rekruttering
        • East Carolina University
        • Ledende efterforsker:
          • Darla K. Liles
        • Kontakt:
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Rekruttering
        • Wake Forest University Health Sciences
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 336-713-6771
        • Ledende efterforsker:
          • Bayard L. Powell
    • North Dakota
      • Fargo, North Dakota, Forenede Stater, 58103
        • Suspenderet
        • Essentia Health Cancer Center-South University Clinic
      • Jamestown, North Dakota, Forenede Stater, 58401
        • Suspenderet
        • Essentia Health - Jamestown Clinic
    • Ohio
      • Cincinnati, Ohio, Forenede Stater, 45219
        • Rekruttering
        • University of Cincinnati Cancer Center-UC Medical Center
        • Ledende efterforsker:
          • Emily K. Curran
        • Kontakt:
      • Cleveland, Ohio, Forenede Stater, 44195
        • Rekruttering
        • Cleveland Clinic Foundation
        • Kontakt:
        • Ledende efterforsker:
          • Anjali S. Advani
      • Cleveland, Ohio, Forenede Stater, 44106
        • Rekruttering
        • Case Western Reserve University
        • Ledende efterforsker:
          • Brenda W. Cooper
        • Kontakt:
      • Columbus, Ohio, Forenede Stater, 43210
        • Rekruttering
        • Ohio State University Comprehensive Cancer Center
        • Ledende efterforsker:
          • Meixiao Long
        • Kontakt:
      • West Chester, Ohio, Forenede Stater, 45069
        • Rekruttering
        • University of Cincinnati Cancer Center-West Chester
        • Ledende efterforsker:
          • Emily K. Curran
        • Kontakt:
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Kontakt:
        • Ledende efterforsker:
          • Mohamad Khawandanah
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Suspenderet
        • Mercy Hospital Oklahoma City
    • Oregon
      • Baker City, Oregon, Forenede Stater, 97814
        • Suspenderet
        • Saint Alphonsus Cancer Care Center-Baker City
      • Bend, Oregon, Forenede Stater, 97701
        • Suspenderet
        • Saint Charles Health System
      • Clackamas, Oregon, Forenede Stater, 97015
        • Suspenderet
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Forenede Stater, 97015
        • Suspenderet
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Forenede Stater, 97420
        • Suspenderet
        • Bay Area Hospital
      • Newberg, Oregon, Forenede Stater, 97132
        • Rekruttering
        • Providence Newberg Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Ontario, Oregon, Forenede Stater, 97914
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Ontario
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Portland, Oregon, Forenede Stater, 97239
        • Rekruttering
        • Oregon Health and Science University
        • Kontakt:
        • Ledende efterforsker:
          • Brandon M. Hayes-Lattin
      • Portland, Oregon, Forenede Stater, 97213
        • Rekruttering
        • Providence Portland Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Portland, Oregon, Forenede Stater, 97225
        • Rekruttering
        • Providence Saint Vincent Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Redmond, Oregon, Forenede Stater, 97756
        • Suspenderet
        • Saint Charles Health System-Redmond
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Rekruttering
        • Lehigh Valley Hospital-Cedar Crest
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Rekruttering
        • Lehigh Valley Hospital - Muhlenberg
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Al baghdadi
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Suspenderet
        • Pocono Medical Center
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Suspenderet
        • Lehigh Valley Hospital-Hazleton
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Rekruttering
        • Thomas Jefferson University Hospital
        • Ledende efterforsker:
          • Lindsay Wilde
        • Kontakt:
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • Rekruttering
        • University of Pennsylvania/Abramson Cancer Center
        • Ledende efterforsker:
          • Keith W. Pratz
        • Kontakt:
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • Aktiv, ikke rekrutterende
        • UPMC Hillman Cancer Center
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02903
        • Rekruttering
        • Rhode Island Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 401-444-1488
        • Ledende efterforsker:
          • Rabin Niroula
      • Providence, Rhode Island, Forenede Stater, 02906
        • Suspenderet
        • Miriam Hospital
    • South Carolina
      • Boiling Springs, South Carolina, Forenede Stater, 29316
        • Rekruttering
        • Prisma Health Cancer Institute - Spartanburg
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Clinton, South Carolina, Forenede Stater, 29325
        • Suspenderet
        • Prisma Health Cancer Institute - Laurens
      • Columbia, South Carolina, Forenede Stater, 29203
        • Rekruttering
        • Prisma Health Richland Hospital
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Easley, South Carolina, Forenede Stater, 29640
        • Rekruttering
        • Prisma Health Cancer Institute - Easley
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29601
        • Rekruttering
        • Saint Francis Hospital
        • Ledende efterforsker:
          • Stephen H. Dyar
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29605
        • Rekruttering
        • Prisma Health Cancer Institute - Faris
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29607
        • Rekruttering
        • Saint Francis Cancer Center
        • Ledende efterforsker:
          • Stephen H. Dyar
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29605
        • Rekruttering
        • Prisma Health Cancer Institute - Butternut
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29615
        • Rekruttering
        • Prisma Health Cancer Institute - Eastside
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29605
        • Rekruttering
        • Prisma Health Greenville Memorial Hospital
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29605
        • Suspenderet
        • BI-LO Charities Children's Cancer Center
      • Greer, South Carolina, Forenede Stater, 29650
        • Rekruttering
        • Prisma Health Cancer Institute - Greer
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Seneca, South Carolina, Forenede Stater, 29672
        • Rekruttering
        • Prisma Health Cancer Institute - Seneca
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
    • Texas
      • Houston, Texas, Forenede Stater, 77030
        • Rekruttering
        • Houston Methodist Hospital
        • Ledende efterforsker:
          • Siddhartha Ganguly
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 713-790-2700
      • Lubbock, Texas, Forenede Stater, 79410
        • Aktiv, ikke rekrutterende
        • Covenant Medical Center-Lakeside
    • Utah
      • American Fork, Utah, Forenede Stater, 84003
        • Suspenderet
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, Forenede Stater, 84720
        • Suspenderet
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forenede Stater, 84321
        • Suspenderet
        • Logan Regional Hospital
      • Murray, Utah, Forenede Stater, 84107
        • Suspenderet
        • Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • Suspenderet
        • McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Suspenderet
        • Utah Valley Regional Medical Center
      • Riverton, Utah, Forenede Stater, 84065
        • Suspenderet
        • Riverton Hospital
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Rekruttering
        • Huntsman Cancer Institute/University of Utah
        • Kontakt:
        • Ledende efterforsker:
          • Paul J. Shami
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Suspenderet
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84143
        • Suspenderet
        • LDS Hospital
      • St. George, Utah, Forenede Stater, 84770
        • Suspenderet
        • Saint George Regional Medical Center
    • Virginia
      • Fairfax, Virginia, Forenede Stater, 22031
        • Aktiv, ikke rekrutterende
        • Inova Schar Cancer Institute
      • Falls Church, Virginia, Forenede Stater, 22042
        • Aktiv, ikke rekrutterende
        • Inova Fairfax Hospital
      • Richmond, Virginia, Forenede Stater, 23298
        • Rekruttering
        • VCU Massey Comprehensive Cancer Center
        • Ledende efterforsker:
          • Keri R. Maher
        • Kontakt:
    • Washington
      • Aberdeen, Washington, Forenede Stater, 98520
        • Suspenderet
        • Providence Regional Cancer System-Aberdeen
      • Bellevue, Washington, Forenede Stater, 98004
        • Suspenderet
        • Overlake Medical Center
      • Bellingham, Washington, Forenede Stater, 98225
        • Suspenderet
        • PeaceHealth Saint Joseph Medical Center
      • Centralia, Washington, Forenede Stater, 98531
        • Suspenderet
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Forenede Stater, 98026
        • Rekruttering
        • Swedish Cancer Institute-Edmonds
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Everett, Washington, Forenede Stater, 98201
        • Suspenderet
        • Providence Regional Cancer Partnership
      • Issaquah, Washington, Forenede Stater, 98029
        • Suspenderet
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forenede Stater, 99336
        • Suspenderet
        • Kadlec Clinic Hematology and Oncology
      • Lacey, Washington, Forenede Stater, 98503
        • Suspenderet
        • Providence Regional Cancer System-Lacey
      • Longview, Washington, Forenede Stater, 98632
        • Suspenderet
        • PeaceHealth Saint John Medical Center
      • Port Townsend, Washington, Forenede Stater, 98368
        • Aktiv, ikke rekrutterende
        • Jefferson Healthcare
      • Renton, Washington, Forenede Stater, 98055
        • Suspenderet
        • Valley Medical Center
      • Seattle, Washington, Forenede Stater, 98104
        • Suspenderet
        • Pacific Gynecology Specialists
      • Seattle, Washington, Forenede Stater, 98107
        • Suspenderet
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forenede Stater, 98122-5711
        • Suspenderet
        • Swedish Medical Center-Cherry Hill
      • Seattle, Washington, Forenede Stater, 98122
        • Rekruttering
        • Swedish Medical Center-First Hill
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Seattle, Washington, Forenede Stater, 98112
        • Aktiv, ikke rekrutterende
        • Kaiser Permanente Washington
      • Sedro-Woolley, Washington, Forenede Stater, 98284
        • Suspenderet
        • PeaceHealth United General Medical Center
      • Shelton, Washington, Forenede Stater, 98584
        • Suspenderet
        • Providence Regional Cancer System-Shelton
      • Vancouver, Washington, Forenede Stater, 98664
        • Suspenderet
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Forenede Stater, 99362
        • Suspenderet
        • Providence Saint Mary Regional Cancer Center
      • Yakima, Washington, Forenede Stater, 98902
        • Suspenderet
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
      • Yelm, Washington, Forenede Stater, 98597
        • Suspenderet
        • Providence Regional Cancer System-Yelm
    • Wisconsin
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Suspenderet
        • Northwest Wisconsin Cancer Center
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Suspenderet
        • Duluth Clinic Ashland
      • Hayward, Wisconsin, Forenede Stater, 54843
        • Suspenderet
        • Essentia Health-Hayward Clinic
      • Madison, Wisconsin, Forenede Stater, 53792
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - University Hospital
        • Ledende efterforsker:
          • Ryan J. Mattison
        • Kontakt:
      • Madison, Wisconsin, Forenede Stater, 53718
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
        • Ledende efterforsker:
          • Ryan J. Mattison
        • Kontakt:
      • Marshfield, Wisconsin, Forenede Stater, 54449
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Rekruttering
        • Medical College of Wisconsin
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 414-805-3666
        • Ledende efterforsker:
          • Guru Subramanian Guru Murthy
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Suspenderet
        • Cancer Center of Western Wisconsin
      • Spooner, Wisconsin, Forenede Stater, 54801
        • Suspenderet
        • Essentia Health-Spooner Clinic
      • Superior, Wisconsin, Forenede Stater, 54880
        • Suspenderet
        • Essentia Health Saint Mary's Hospital - Superior
    • Wyoming
      • Cheyenne, Wyoming, Forenede Stater, 82001
        • Aktiv, ikke rekrutterende
        • Cheyenne Regional Medical Center-West
      • Cody, Wyoming, Forenede Stater, 82414
        • Suspenderet
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Suspenderet
        • Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Berettigelseskriterier

De nøglekrav, som personer, der ønsker at deltage i et klinisk studie, skal opfylde eller de egenskaber, de skal have. Kvalifikationskriterier består af både inklusionskriterier (som er nødvendige for at en person kan deltage i undersøgelsen) og eksklusionskriterier (som forhindrer en person i at deltage). Typer af berettigelseskriterier omfatter, om en undersøgelse accepterer raske frivillige, har alders- eller aldersgruppekrav eller er begrænset af køn.

Aldre berettiget til at studere

18 år til 39 år (Voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

REGISTRATION ELIGIBILITY CRITERIA (STEP 1)

  • Newly diagnosed patients with CD-22 positive B-cell acute lymphoblastic leukemia (WHO criteria) are eligible. Patients with Burkitt type ALL are NOT eligible

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Single-dose intrathecal cytarabine is allowed prior to registration or prior to initiation of systematic therapy for patient convenience; this is usually done at the time of the diagnostic bone marrow or venous line placement to avoid a second lumbar puncture; systemic chemotherapy must begin within 72 hours of this intrathecal therapy

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Age >= 18 years and < 40 years

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Eastern Cooperative Oncology Group (ECOG) performance status 0-2

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Direct bilirubin =< 3 x upper limit of normal (ULN), unless suspected leukemic involvement of the liver

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Calculated (calc.) creatinine clearance >= 50 mL/min by Cockcroft-Gault

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Completion of remission induction therapy

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) CONFIRMATION OF TOLERABILITY AND PHASE III ONLY):Patients with M2 marrow or better are eligible; patients with M3 or M4 marrow (greater than 25% lymphoblasts) will not be eligible to be randomized

    • Rating: M0, M1; Blast Cells (%): 0-5.0
    • Rating: M2; Blast Cells (%): 5.1-25.0
    • Rating: M3; Blast Cells (%): > 25-50
    • Rating: M4; Blast Cells (%): > 50.0
    • The term "blast cell" includes any cell that cannot be classified as a more mature normal element, and includes "leukemic cells," pathologic lymphocytes, and stem cells

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Absolute neutrophil count (ANC) >= 750/mm^3

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Platelet count >= 75,000/mm^3

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Total bilirubin =< 1.5 x upper limit of normal (ULN), except for patients with known Gilbert's syndrome

  • RANDOMIZATION ELIGIBILITY CRITERIA (STEP 2) (CONFIRMATION OF TOLERABILITY AND PHASE III ONLY): Aspartate aminotransferase (AST) =< 8 x upper limit of normal (ULN)

EXCLUSION CRITERIA

  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients who have BCR-ABL fusion transcript determined by fluorescence in situ hybridization (FISH) or real time-polymerase chain reaction (RT-PCR) or t(9;22)(q34;q11) by cytogenetics are not eligible and should be considered for enrollment on studies that incorporate imatinib during induction; please note: patients must also be assessed for CD20 positivity and other markers; positivity for CD22 and CD20 is defined as baseline expression of the CD22 or CD20 antigen in more than 20% of leukemic cells using local multiparameter flow-cytometric immunophenotyping with the use of CD45 expression as a marker to gate the ALL blast population, according to recommendations from the European LeukemiaNet
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior therapy for ALL except for limited treatment (=< 7 days) with corticosteroids or hydroxyurea and a single dose of intrathecal cytarabine; however, patients who are being treated with chronic steroids for other reasons (for example, to treat asthma, autoimmune disorders, lupus, etc.) are eligible
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): No prior therapy for acute leukemia except emergency therapy (corticosteroids or hydroxyurea) for blast cell crisis, superior vena cava syndrome, or renal failure due to leukemic infiltration of the kidneys; when indicated, leukapheresis or exchange transfusion is recommended to reduce the WBC
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Not pregnant and not nursing, because this study involves agents that have known genotoxic, mutagenic and teratogenic effects; therefore, for women of childbearing potential only, a negative urine or serum pregnancy test done =< 8 days prior to registration is required
  • REGISTRATION ELIGIBILITY CRITERIA (STEP 1): Patients with down syndrome are excluded from this study due to the likelihood of excessive toxicity resulting; these patients should be treated in consultation with a pediatric oncologist

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm

Deltagergruppe / Arm

En gruppe eller undergruppe af deltagere i et klinisk forsøg, der modtager en specifik intervention/behandling eller ingen intervention i henhold til forsøgets protokol.
Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.
Aktiv komparator: Arm I (frontline chemotherapy)

See detailed description.
Andet: Laboratory Biomarker Analysis

Correlative studies

Medicin: Cyclophosphamide

Given IV

Biologisk: Rituximab

Given IV

Medicin: Vincristine Sulfate

Given IV

Medicin: Daunorubicin Hydrochloride

Given IV

Medicin: Mercaptopurine

Given PO

Medicin: Dexamethasone

Given PO or IV

Medicin: Thioguanine

Given PO

Medicin: Allopurinol

Given PO

Medicin: Cytarabine

Given IT, IV, SC

Medicin: Pegylated L-Asparaginase

Given IV

Medicin: Methotrexate

Given IT, IV, PO

Procedure: Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration and biopsy
Eksperimentel: Arm II (frontline chemotherapy, inotuzumab ozogamicin)

Patients receive inotuzumab ozogamicin IV on days 1, 8, and 15 and undergo bone marrow aspirate and biopsy on day 28. Treatment repeats every 28 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity. Patients who are MRD+ and CD19+ after completion of 2 cycles of inotuzumab ozogamicin receive dexamethasone IV or PO on day 1 and blinatumomab IV via continuous infusion on days 1-28, followed by a 14 day break. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive remission consolidated chemotherapy, interim maintenance chemotherapy, delayed intensification, and maintenance therapy as in Arm I. Patients undergo MUGA or echocardiography and x ray imaging during screening, bone marrow aspiration and biopsy and lumbar puncture and blood sample collection throughout the study.
Andet: Laboratory Biomarker Analysis

Correlative studies

Medicin: Cyclophosphamide

Given IV

Medicin: Doxorubicin

Given IV

Biologisk: Rituximab

Given IV

Medicin: Vincristine Sulfate

Given IV

Medicin: Daunorubicin Hydrochloride

Given IV

Medicin: Mercaptopurine

Given PO

Biologisk: Inotuzumab Ozogamicin

Given IV

Medicin: Dexamethasone

Given PO or IV

Medicin: Thioguanine

Given PO

Medicin: Allopurinol

Given PO

Medicin: Cytarabine

Given IT, IV, SC

Medicin: Pegylated L-Asparaginase

Given IV

Medicin: Methotrexate

Given IT, IV, PO

Procedure: Bone Marrow Aspiration and Biopsy

Undergo bone marrow aspiration and biopsy

Hvad måler undersøgelsen?

Primære resultatmål

Primære resultatmål

I et klinisk studies protokol er det planlagte resultatmål, der er det vigtigste for at evaluere effekten af ​​en intervention/behandling. De fleste kliniske undersøgelser har ét primært resultatmål, men nogle har mere end ét.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Event-free survival (EFS)
Tidsramme: Time from induction response to the time of progressive-disease, secondary malignancy, or death, assessed up to 3 years

The EFS distributions between the two arms will be compared using non-stratified log-rank tests. EFS curves will be constructed using the Kaplan-Meier product limit method, and additional analyses will be done using the Cox proportional hazards model. with diagnostics test on proportional hazard assumptions first. The corresponding hazard ratio, 2- and 3-year EFS estimates will be assessed, and EFS medians along with their 95% confidence intervals for the two treatment arms.
Time from induction response to the time of progressive-disease, secondary malignancy, or death, assessed up to 3 years

Sekundære resultatmål

Sekundære resultatmål

I en klinisk undersøgelses protokol er et planlagt resultatmål, der ikke er lige så vigtigt som det primære resultatmål for at evaluere effekten af ​​en intervention, men som stadig er af interesse. De fleste kliniske undersøgelser har mere end ét sekundært resultatmål.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Disease-free survival (DFS)
Tidsramme: Time from achievement of complete response (CR) to the time of relapse and/or death, assessed up to 10 years
Time from achievement of complete response (CR) to the time of relapse and/or death, assessed up to 10 years
Overall Survival (OS)
Tidsramme: Time from randomization to the time of death due to any cause, assessed up to 10 years

Will be evaluated using Kaplan-Meier as well as Cox regression models.
Time from randomization to the time of death due to any cause, assessed up to 10 years
Proportion of patients who achieve CR or any response to induction therapy
Tidsramme: Up to 10 years

Will be summarized as the proportion of patients who achieve any type of response to induction therapy divided by the number of all evaluable patients registered to this trial and who received at least one dose of induction therapy. Corresponding 95% binomial confidence intervals will also be calculated.
Up to 10 years
Overall induction response rates
Tidsramme: Up to 10 years

Will be summarized as the proportion of patients who achieve any type of response to induction therapy divided by the number of all evaluable patients registered to this trial and who received at least one dose of induction therapy. Corresponding 95% binomial confidence intervals will also be calculated.
Up to 10 years
Incidence of adverse events as assessed by Common Terminology Criteria for Adverse Events version 5.0
Tidsramme: Up to 10 years

The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns. In addition, all adverse event data that is graded as 3, 4, or 5 will be reviewed and classified as either "unrelated" or "unlikely to be related" to study treatment in the event of an actual relationship developing. The incidence of severe (grade 3+) adverse events or toxicities will be described for each treatment arm, but will also be compared between the arms. Fisher's exact tests will be used to quantitatively compare the incidence of severe as well as specific toxicities of interest between the treatment arms and we will graphically assess differences in maximum grades observed for toxicities between the arms. Tolerability of the treatment arms will be assessed through assessing the number of patients who required dose modifications and/or dose delays.
Up to 10 years
Proportion of patients who go off treatment due to adverse reactions
Tidsramme: Up to 10 years

Will be assessed within each of the treatment arms and differences explores in these measures between the arms.
Up to 10 years
Proportion of patients who refuse further treatment for lesser toxicities that inhibit their willingness to continue participation on the trial
Tidsramme: Up to 10 years

Will be assessed within each of the treatment arms and differences explores in these measures between the arms.
Up to 10 years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Sponsor

Den organisation eller person, der igangsætter undersøgelsen, og som har myndighed og kontrol over undersøgelsen.
Alliance for Clinical Trials in Oncology

Samarbejdspartnere

Samarbejdspartnere

En anden organisation end sponsoren, der yder støtte til en klinisk undersøgelse. Denne støtte kan omfatte aktiviteter relateret til finansiering, design, implementering, dataanalyse eller rapportering.
National Cancer Institute (NCI)

Efterforskere

Efterforskere

En forsker involveret i et klinisk studie. Beslægtede termer omfatter stedets principal investigator, site sub-investigator, studieformand, undersøgelsesleder og undersøgelseshovedinvestigator.
  • Studiestol: daniel_deangelo@dfci.harvard.edu J. DeAngelo, MD, PhD, Dana-Farber Cancer Institute

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

Studiestart

Den faktiske dato, hvor den første deltager blev tilmeldt en klinisk undersøgelse. Den "forventede" undersøgelses startdato er den dato, som forskerne tror vil være undersøgelsens startdato.
20. september 2017

Primær færdiggørelse (Anslået)

Primær færdiggørelse

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention for at indsamle endelige data for det primære resultatmål. Hvorvidt det kliniske studie sluttede i henhold til protokollen eller blev afsluttet, påvirker ikke denne dato. For kliniske undersøgelser med mere end ét primært resultatmål med forskellige afslutningsdatoer refererer dette udtryk til den dato, hvor dataindsamlingen er afsluttet for alle de primære resultatmål. Den "forventede" primære afslutningsdato er den dato, som forskerne tror vil være den primære afslutningsdato for undersøgelsen.
1. november 2027

Studieafslutning (Anslået)

Studieafslutning

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention/behandling for at indsamle endelige data for de primære resultatmål, sekundære udfaldsmål og uønskede hændelser (det vil sige den sidste deltagers sidste besøg). Den "forventede" undersøgelses afslutningsdato er den dato, som forskerne tror vil være undersøgelsens afslutningsdato.
1. april 2028

Datoer for studieregistrering

Først indsendt

Først indsendt

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsendte en undersøgelsespost til ClinicalTrials.gov. Der er typisk en forsinkelse på et par dage mellem den første indsendte dato og postens tilgængelighed på ClinicalTrials.gov (den første offentliggjorte dato).
9. maj 2017

Først indsendt, der opfyldte QC-kriterier

Først indsendt, der opfyldte QC-kriterier

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsender en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Sponsoren eller investigatoren skal muligvis revidere og indsende en undersøgelsespost en eller flere gange, før NLM's kvalitetskontrolkriterier er opfyldt. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
10. maj 2017

Først opslået (Faktiske)

Først opslået

Datoen, hvor undersøgelsesposten først var tilgængelig på ClinicalTrials.gov efter National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgang er afsluttet. Der er typisk en forsinkelse på et par dage mellem den dato, hvor undersøgelsens sponsor eller investigator indsendte undersøgelsesposten, og den første offentliggjorte dato.
12. maj 2017

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering sendt

Den seneste dato, hvor ændringer i en undersøgelsespost blev gjort tilgængelig på ClinicalTrials.gov. Der kan være en forsinkelse mellem det tidspunkt, hvornår ændringerne blev indsendt til ClinicalTrials.gov af undersøgelsens sponsor eller investigator (datoen for sidste opdatering afsendt) og den sidste opdatering, der blev sendt.
3. november 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Den seneste dato, hvor undersøgelsens sponsor eller investigator indsendte ændringer til en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
2. november 2026

Sidst verificeret

Sidst verificeret

Den seneste dato, hvor undersøgelsens sponsor eller investigator bekræftede oplysningerne om en klinisk undersøgelse på ClinicalTrials.gov som nøjagtige og aktuelle. Hvis en undersøgelse med rekrutteringsstatus som rekruttering; rekrutterer endnu ikke; eller aktiv, ikke rekruttering er ikke blevet bekræftet inden for de seneste 2 år, er undersøgelsens rekrutteringsstatus vist som ukendt.
1. november 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Andre undersøgelses-id-numre

Andre identifikatorer eller ID-numre end NCT-nummeret, der er tildelt til en klinisk undersøgelse af undersøgelsens sponsor, finansieringsgivere eller andre. Disse numre kan omfatte unikke identifikatorer fra andre forsøgsregistre og National Institutes of Health-bevillingsnumre.
  • A041501
  • U10CA180821 (U.S. NIH-bevilling/kontrakt)
  • NCI-2016-01981 (Registry Identifier: Clinical Trial Reporting Program)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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