Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Afprøvning af rollen af ​​DNA frigivet fra tumorceller ind i blodet i at vejlede brugen af ​​immunterapi efter kirurgisk fjernelse af blæren til blærekræftbehandling, MODERN undersøgelse

5. november 2026 opdateret af: National Cancer Institute (NCI)

MODERN: Et integreret fase 2/3 og fase 3 forsøg med MRD-baseret optimering af adjuverende terapi i urothelial kræft

This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or urethra, but require an additional treatment called immunotherapy to help prevent their urinary tract (urothelial) cancer from coming back, can be identified by a blood test. Many types of tumors tend to lose cells or release different types of cellular products including their DNA which is referred to as circulating tumor DNA (ctDNA) into the bloodstream before changes can be seen on scans. Health care providers can measure the level of ctDNA in blood or other bodily fluids to determine which patients are at higher risk for disease progression or relapse. In this study, a blood test is used to measure ctDNA and see if there is still cancer somewhere in the body after surgery and if giving a treatment will help eliminate the cancer. Immunotherapy with monoclonal antibodies, such as nivolumab and relatlimab, can help the body's immune system to attack the cancer, and can interfere with the ability of tumor cells to grow and spread. This trial may help doctors determine if ctDNA measurement in blood can better identify patients that need additional treatment, if treatment with nivolumab prolongs patients' life and whether the additional immunotherapy treatment with relatlimab extends time without disease progression or prolongs life of urothelial cancer patients who have undergone surgical removal of their bladder, kidney, ureter or urethra.

Studieoversigt

Status

Status

Angiver den aktuelle rekrutteringsstatus eller den udvidede adgangsstatus.
Rekruttering

Betingelser

Betingelser

Den sygdom, lidelse, syndrom, sygdom eller skade, der undersøges. På ClinicalTrials.gov kan tilstande også omfatte andre sundhedsrelaterede problemer, såsom levetid, livskvalitet og sundhedsrisici.

Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.

Detaljeret beskrivelse

PRIMARY OBJECTIVES:

I. To compare the ctDNA clearance proportion (i.e., ctDNA positive [+] --> ctDNA negative [-]) at 12 weeks in patients enrolled in Cohort A treated with adjuvant nivolumab versus nivolumab + relatlimab (phase 2 portion).

II. To compare overall survival in patients enrolled in Cohort A treated with adjuvant nivolumab versus nivolumab + relatlimab (phase 3 portion).

III. To compare disease-free survival in patients enrolled in Cohort B randomized to immediate treatment with nivolumab to those randomized to surveillance with subsequent treatment with nivolumab only upon converting to ctDNA(+)

SECONDARY OBJECTIVES:

I. To compare disease-free survival in patients enrolled in Cohort A treated with adjuvant nivolumab versus nivolumab + relatlimab.

II. To define the association between ctDNA clearance and disease-free survival and overall survival for Cohort A patients.

III. To compare overall survival in patients enrolled in Cohort B randomized to immediate treatment with nivolumab to those randomized to surveillance with subsequent treatment with nivolumab only upon converting to ctDNA(+).

IV. To determine the lead time from a ctDNA(+) assay to radiographic recurrence in patients initially ctDNA(-) post-definitive surgery enrolled in Cohort B.

V. To estimate the proportion of Cohort B patients on Arm 4 who become ctDNA(+) and receive nivolumab.

VI. To compare the cumulative incidence of Cohort B patients who become ctDNA(+) between Arms 3 and 4.

VII. To determine the safety of adjuvant nivolumab plus relatlimab. VIII. To compare disease-free survival and overall survival in patients enrolled in Cohort A treated with adjuvant nivolumab versus nivolumab + relatlimab according to receipt of neoadjuvant immune checkpoint blockade-containing therapy versus no neoadjuvant immune checkpoint blockade-containing therapy.

IX. To compare disease-free survival and overall survival in patients enrolled in Cohort B treated with adjuvant nivolumab versus nivolumab + relatlimab according to receipt of neoadjuvant immune checkpoint blockade-containing therapy versus no neoadjuvant immune checkpoint blockade-containing therapy.

EXPLORATORY OBJECTIVES:

I. To explore the kinetics of quantitative ctDNA levels (mean number of tumor molecules observed per mL of plasma or MTM/ml) over time and the association between ctDNA kinetics and time-to-event outcomes.

II. To estimate the costs and value of care in patients with a ctDNA(+) assay post-radical surgery treated with adjuvant nivolumab versus nivolumab + relatlimab.

III. To estimate the costs and value of care in patients with a ctDNA(-) assay post-radical surgery treated with adjuvant nivolumab versus surveillance with subsequent treatment with nivolumab at the time of conversion to ctDNA(+).

QUALITY OF LIFE OBJECTIVES:

I. Within each cohort, to compare quality-adjusted survival among randomized arms using European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L).

II. Within Cohort B, to compare overall quality of life (QOL) as measured by the European Organization for the Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 (QLQ-C30) between baseline and 42 months (calculated as the area under the curve) among randomized arms.

III. Within each cohort, to compare overall QOL as measured by the EORTC QLQ-C30 at each time point among randomized arms.

IV. Within each cohort, to compare bladder cancer-specific QOL as measured by the EORTC Bladder Cancer Muscle-Invasive 30 Questionnaire (QLQ-BLM30) at each time point among randomized arms.

V. Within each cohort, to compare patient-reported fatigue as measured by Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue at each time point among randomized arms.

OUTLINE: Patients are assigned to 1 of 2 cohorts based on ctDNA results.

COHORT A: Patients who are ctDNA(+) are randomized to 1 of 2 arms:

ARM I: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo computed tomography (CT) or magnetic resonance imaging (MRI) and may undergo cystoscopy throughout the trial.

ARM II: Patients receive nivolumab IV over 30 minutes and relatlimab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.

COHORT B: Patients who are ctDNA(-) are randomized to 1 of 2 arms:

ARM III: Patients receive nivolumab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.

ARM IV: Patients undergo ctDNA surveillance consisting of collection of tissue and blood during screening and collection of blood only on study and during follow up. Patients who convert to ctDNA(+) during surveillance then receive nivolumab IV over 30 minutes day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.

After completion of study treatment, patients are followed up at weeks 48, 60, 72, 84, 96, 120, 144, 196, and 248.

Undersøgelsestype

Undersøgelsestype

Beskriver karakteren af ​​en klinisk undersøgelse. Undersøgelsestyper omfatter interventionelle undersøgelser (også kaldet kliniske forsøg), observationsundersøgelser (herunder patientregistre) og udvidet adgang.
Interventionel

Tilmelding (Anslået)

Tilmelding

Antallet af deltagere i en klinisk undersøgelse. Den "forventede" tilmelding er det mål for antallet af deltagere, som forskerne skal bruge til undersøgelsen.
992

Fase

Fase

Stadiet af et klinisk forsøg, der studerer et lægemiddel eller et biologisk produkt, baseret på definitioner udviklet af U.S. Food and Drug Administration (FDA). Fasen tager udgangspunkt i undersøgelsens formål, antallet af deltagere og andre karakteristika. Der er fem faser: Tidlig fase 1 (tidligere opført som fase 0), fase 1, fase 2, fase 3 og fase 4. Ikke relevant bruges til at beskrive forsøg uden FDA-definerede faser, herunder forsøg med enheder eller adfærdsmæssige indgreb.
  • Fase 2
  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 5G2
        • Rekruttering
        • Arthur J E Child Comprehensive Cancer Centre
        • Kontakt:
        • Ledende efterforsker:
          • Nimira S. Alimohamed
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Rekruttering
        • Cross Cancer Institute
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 780-432-8500
        • Ledende efterforsker:
          • Scott A. North
    • British Columbia
      • Vancouver, British Columbia, Canada, V5Z 4E6
        • Rekruttering
        • BCCA-Vancouver Cancer Centre
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-939-3333
        • Ledende efterforsker:
          • Bernie (Bernhard) J. Eigl
    • Ontario
      • Kitchener, Ontario, Canada, N2G 1G3
        • Rekruttering
        • Waterloo Regional Health Network
        • Ledende efterforsker:
          • Anupam Batra
        • Kontakt:
      • London, Ontario, Canada, N6A 4L6
        • Rekruttering
        • London Regional Cancer Program
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 519-685-8600
        • Ledende efterforsker:
          • Melissa Huynh
      • Ottawa, Ontario, Canada, K1H 8L6
        • Rekruttering
        • Ottawa Hospital and Cancer Center-General Campus
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 613-761-4395
        • Ledende efterforsker:
          • Ana-Alicia Beltran-Bless
      • Toronto, Ontario, Canada, M4N 3M5
        • Rekruttering
        • Odette Cancer Centre- Sunnybrook Health Sciences Centre
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 416-480-5000
        • Ledende efterforsker:
          • Susanna Y. Cheng
      • Toronto, Ontario, Canada, M5G 2M9
        • Rekruttering
        • University Health Network-Princess Margaret Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Srikala S. Sridhar
    • Saskatchewan
      • Regina, Saskatchewan, Canada, S4T 7T1
        • Rekruttering
        • Allan Blair Cancer Centre
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 306-766-2213
        • Ledende efterforsker:
          • Osama Souied
      • Saskatoon, Saskatchewan, Canada, S7N 4H4
        • Rekruttering
        • Saskatoon Cancer Centre
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 306-655-2914
        • Ledende efterforsker:
          • Sunil K. Yadav
  • Forenede Stater
    • Arizona
      • Phoenix, Arizona, Forenede Stater, 85004
      • Phoenix, Arizona, Forenede Stater, 85054
        • Rekruttering
        • Mayo Clinic Hospital in Arizona
        • Ledende efterforsker:
          • Arnab Basu
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
      • Tucson, Arizona, Forenede Stater, 85719
        • Rekruttering
        • Banner University Medical Center - Tucson
        • Kontakt:
        • Ledende efterforsker:
          • Edward P. Gelmann
      • Tucson, Arizona, Forenede Stater, 85719
        • Rekruttering
        • University of Arizona Cancer Center-North Campus
        • Kontakt:
        • Ledende efterforsker:
          • Edward P. Gelmann
      • Tucson, Arizona, Forenede Stater, 85704
        • Suspenderet
        • University of Arizona Cancer Center-Orange Grove Campus
    • Arkansas
      • Fayetteville, Arkansas, Forenede Stater, 72703
        • Rekruttering
        • Highlands Oncology Group - Fayetteville
        • Ledende efterforsker:
          • Joseph T. Beck
        • Kontakt:
      • Rogers, Arkansas, Forenede Stater, 72758
        • Rekruttering
        • Highlands Oncology Group - Rogers
        • Ledende efterforsker:
          • Joseph T. Beck
        • Kontakt:
      • Springdale, Arkansas, Forenede Stater, 72762
        • Rekruttering
        • Highlands Oncology Group
        • Ledende efterforsker:
          • Joseph T. Beck
        • Kontakt:
    • California
      • Anaheim, California, Forenede Stater, 92806
        • Rekruttering
        • Kaiser Permanente-Anaheim
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Baldwin Park, California, Forenede Stater, 91706
        • Rekruttering
        • Kaiser Permanente-Baldwin Park
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Bellflower, California, Forenede Stater, 90706
        • Rekruttering
        • Kaiser Permanente-Bellflower
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Dublin, California, Forenede Stater, 94568
        • Rekruttering
        • Kaiser Permanente Dublin
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
      • Fontana, California, Forenede Stater, 92335
        • Rekruttering
        • Kaiser Permanente-Fontana
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Fremont, California, Forenede Stater, 94538
        • Rekruttering
        • Kaiser Permanente-Fremont
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Fresno, California, Forenede Stater, 93720
        • Rekruttering
        • Kaiser Permanente-Fresno
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Fresno, California, Forenede Stater, 93720
        • Rekruttering
        • Kaiser Permanente Fresno Orchard Plaza
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 833-574-2273
      • Harbor City, California, Forenede Stater, 90710
        • Rekruttering
        • Kaiser Permanente South Bay
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Irvine, California, Forenede Stater, 92618
        • Rekruttering
        • Kaiser Permanente-Irvine
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • La Jolla, California, Forenede Stater, 92093
        • Rekruttering
        • UC San Diego Moores Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Tyler Stewart
      • Los Angeles, California, Forenede Stater, 90095
        • Rekruttering
        • UCLA / Jonsson Comprehensive Cancer Center
        • Ledende efterforsker:
          • Alexandra Drakaki
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-798-0719
      • Los Angeles, California, Forenede Stater, 90027
        • Rekruttering
        • Kaiser Permanente Los Angeles Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Los Angeles, California, Forenede Stater, 90034
        • Rekruttering
        • Kaiser Permanente West Los Angeles
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Los Angeles, California, Forenede Stater, 90033
        • Aktiv, ikke rekrutterende
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90020
        • Aktiv, ikke rekrutterende
        • Keck Medicine of USC Koreatown
      • Los Angeles, California, Forenede Stater, 90033
        • Aktiv, ikke rekrutterende
        • Los Angeles General Medical Center
      • Modesto, California, Forenede Stater, 95356
        • Rekruttering
        • Kaiser Permanente-Modesto
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Modesto, California, Forenede Stater, 95356
        • Rekruttering
        • Kaiser Permanente- Modesto MOB II
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
      • Newport Beach, California, Forenede Stater, 92663
        • Aktiv, ikke rekrutterende
        • USC Norris Oncology/Hematology-Newport Beach
      • Oakland, California, Forenede Stater, 94611
        • Rekruttering
        • Kaiser Permanente-Oakland
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Ontario, California, Forenede Stater, 91761
        • Rekruttering
        • Kaiser Permanente-Ontario
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Palo Alto, California, Forenede Stater, 94304
        • Rekruttering
        • Stanford Cancer Institute Palo Alto
        • Ledende efterforsker:
          • Ali R. Khaki
        • Kontakt:
      • Panorama City, California, Forenede Stater, 91402
        • Rekruttering
        • Kaiser Permanente - Panorama City
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Riverside, California, Forenede Stater, 92505
        • Rekruttering
        • Kaiser Permanente-Riverside
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • Roseville, California, Forenede Stater, 95661
        • Rekruttering
        • Kaiser Permanente-Roseville
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Sacramento, California, Forenede Stater, 95817
        • Rekruttering
        • University of California Davis Comprehensive Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 916-734-3089
        • Ledende efterforsker:
          • Mamta Parikh
      • Sacramento, California, Forenede Stater, 95814
        • Rekruttering
        • Kaiser Permanente Downtown Commons
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: kpoct@kp.org
      • Sacramento, California, Forenede Stater, 95823
        • Rekruttering
        • Kaiser Permanente-South Sacramento
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • San Diego, California, Forenede Stater, 92120
        • Rekruttering
        • Kaiser Permanente-San Diego Zion
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • San Francisco, California, Forenede Stater, 94115
        • Rekruttering
        • Kaiser Permanente-San Francisco
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • San Jose, California, Forenede Stater, 95119
        • Rekruttering
        • Kaiser Permanente-Santa Teresa-San Jose
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • San Leandro, California, Forenede Stater, 94577
        • Rekruttering
        • Kaiser Permanente San Leandro
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • San Marcos, California, Forenede Stater, 92078
        • Rekruttering
        • Kaiser Permanente-San Marcos
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
      • San Rafael, California, Forenede Stater, 94903
        • Rekruttering
        • Kaiser San Rafael-Gallinas
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Santa Clara, California, Forenede Stater, 95051
        • Rekruttering
        • Kaiser Permanente Medical Center - Santa Clara
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Santa Monica, California, Forenede Stater, 90404
        • Rekruttering
        • Saint John's Cancer Institute
        • Ledende efterforsker:
          • Przemyslaw W. Twardowski
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 310-582-7448
      • Santa Rosa, California, Forenede Stater, 95403
        • Rekruttering
        • Kaiser Permanente-Santa Rosa
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • South San Francisco, California, Forenede Stater, 94080
        • Rekruttering
        • Kaiser Permanente-South San Francisco
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Vallejo, California, Forenede Stater, 94589
        • Rekruttering
        • Kaiser Permanente-Vallejo
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Walnut Creek, California, Forenede Stater, 94596
        • Rekruttering
        • Kaiser Permanente-Walnut Creek
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-642-4691
          • E-mail: Kpoct@kp.org
      • Woodland Hills, California, Forenede Stater, 91367
        • Rekruttering
        • Kaiser Permanente-Woodland Hills
        • Kontakt:
        • Ledende efterforsker:
          • Helen H. Moon
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • Rekruttering
        • UCHealth University of Colorado Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 720-848-0650
        • Ledende efterforsker:
          • Elizabeth R. Kessler
      • Denver, Colorado, Forenede Stater, 80205
        • Rekruttering
        • Kaiser Permanente-Franklin
        • Ledende efterforsker:
          • Matthew J. Eadens
        • Kontakt:
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Rekruttering
        • Poudre Valley Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 970-297-6150
        • Ledende efterforsker:
          • Elizabeth R. Kessler
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Rekruttering
        • Cancer Care and Hematology-Fort Collins
        • Kontakt:
        • Ledende efterforsker:
          • Elizabeth R. Kessler
      • Greeley, Colorado, Forenede Stater, 80631
        • Rekruttering
        • UCHealth Greeley Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elizabeth R. Kessler
      • Highlands Ranch, Colorado, Forenede Stater, 80129
        • Rekruttering
        • UCHealth Highlands Ranch Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 720-848-0650
        • Ledende efterforsker:
          • Elizabeth R. Kessler
      • Lafayette, Colorado, Forenede Stater, 80026
        • Rekruttering
        • Kaiser Permanente-Rock Creek
        • Ledende efterforsker:
          • Matthew J. Eadens
        • Kontakt:
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rekruttering
        • Kaiser Permanente-Lone Tree
        • Ledende efterforsker:
          • Matthew J. Eadens
        • Kontakt:
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rekruttering
        • UCHealth Lone Tree Health Center
        • Kontakt:
        • Ledende efterforsker:
          • Elizabeth R. Kessler
      • Loveland, Colorado, Forenede Stater, 80538
        • Rekruttering
        • Medical Center of the Rockies
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 970-203-7083
        • Ledende efterforsker:
          • Elizabeth R. Kessler
    • Connecticut
      • Avon, Connecticut, Forenede Stater, 06001
        • Rekruttering
        • Hartford HealthCare - Avon
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-972-4700
        • Ledende efterforsker:
          • Michael Sun
      • Bridgeport, Connecticut, Forenede Stater, 06606
        • Rekruttering
        • Hartford HealthCare - Saint Vincent's Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-972-4700
        • Ledende efterforsker:
          • Michael Sun
      • Derby, Connecticut, Forenede Stater, 06418
        • Rekruttering
        • Smilow Cancer Hospital-Derby Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Fairfield, Connecticut, Forenede Stater, 06824
        • Rekruttering
        • Smilow Cancer Hospital Care Center-Fairfield
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Fairfield, Connecticut, Forenede Stater, 06824
        • Rekruttering
        • Hartford Healthcare - Fairfield
        • Ledende efterforsker:
          • Michael Sun
        • Kontakt:
      • Glastonbury, Connecticut, Forenede Stater, 06033
        • Suspenderet
        • Smilow Cancer Hospital Care Center at Glastonbury
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Rekruttering
        • Smilow Cancer Hospital Care Center at Greenwich
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Guilford, Connecticut, Forenede Stater, 06437
        • Rekruttering
        • Smilow Cancer Hospital Care Center - Guilford
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Hartford, Connecticut, Forenede Stater, 06105
        • Suspenderet
        • Smilow Cancer Hospital Care Center at Saint Francis
      • Hartford, Connecticut, Forenede Stater, 06102
        • Rekruttering
        • Hartford Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-545-5363
        • Ledende efterforsker:
          • Michael Sun
      • Manchester, Connecticut, Forenede Stater, 06042
        • Rekruttering
        • Hartford HealthCare - Manchester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-972-4700
        • Ledende efterforsker:
          • Michael Sun
      • Meriden, Connecticut, Forenede Stater, 06451
        • Rekruttering
        • Midstate Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 866-662-5678
        • Ledende efterforsker:
          • Michael Sun
      • New Britain, Connecticut, Forenede Stater, 06050
        • Rekruttering
        • The Hospital of Central Connecticut
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 860-224-5660
        • Ledende efterforsker:
          • Michael Sun
      • New Haven, Connecticut, Forenede Stater, 06520
        • Rekruttering
        • Yale University
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • North Haven, Connecticut, Forenede Stater, 06473
        • Rekruttering
        • Yale-New Haven Hospital North Haven Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Stamford, Connecticut, Forenede Stater, 06902
        • Rekruttering
        • Smilow Cancer Hospital Care Center at Long Ridge
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Torrington, Connecticut, Forenede Stater, 06790
        • Rekruttering
        • Smilow Cancer Hospital-Torrington Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Trumbull, Connecticut, Forenede Stater, 06611
        • Rekruttering
        • Smilow Cancer Hospital Care Center-Trumbull
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Waterbury, Connecticut, Forenede Stater, 06708
        • Rekruttering
        • Smilow Cancer Hospital-Waterbury Care Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
      • Waterford, Connecticut, Forenede Stater, 06385
        • Rekruttering
        • Smilow Cancer Hospital Care Center - Waterford
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
    • Delaware
      • Newark, Delaware, Forenede Stater, 19713
        • Rekruttering
        • Helen F Graham Cancer Center
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
      • Newark, Delaware, Forenede Stater, 19713
        • Rekruttering
        • Medical Oncology Hematology Consultants PA
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
    • District of Columbia
      • Washington D.C., District of Columbia, Forenede Stater, 20016
        • Rekruttering
        • Sibley Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Jean H. Hoffman-Censits
      • Washington D.C., District of Columbia, Forenede Stater, 20007
        • Rekruttering
        • MedStar Georgetown University Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 202-444-2223
        • Ledende efterforsker:
          • Nicholas I. Simon
      • Washington D.C., District of Columbia, Forenede Stater, 20010
        • Rekruttering
        • MedStar Washington Hospital Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 202-877-8839
        • Ledende efterforsker:
          • Nicholas I. Simon
      • Washington D.C., District of Columbia, Forenede Stater, 20037
        • Rekruttering
        • George Washington University Medical Center
        • Ledende efterforsker:
          • Pavani Chalasani
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 202-741-2210
    • Florida
      • Aventura, Florida, Forenede Stater, 33180
        • Rekruttering
        • Mount Sinai Comprehensive Cancer Center at Aventura
        • Kontakt:
        • Ledende efterforsker:
          • Oleg Gligich
      • Aventura, Florida, Forenede Stater, 33180
        • Suspenderet
        • UM Sylvester Comprehensive Cancer Center at Aventura
      • Coral Gables, Florida, Forenede Stater, 33146
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Coral Gables
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Ledende efterforsker:
          • Janaki N. Sharma
      • Deerfield Beach, Florida, Forenede Stater, 33442
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Ledende efterforsker:
          • Janaki N. Sharma
      • Gainesville, Florida, Forenede Stater, 32610
        • Rekruttering
        • Malcom Randall Veterans Administration Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Jess DeLaune
      • Gainesville, Florida, Forenede Stater, 32610
        • Rekruttering
        • UF Health Cancer Institute - Gainesville
        • Kontakt:
        • Ledende efterforsker:
          • Daniel V. Araujo
      • Hollywood, Florida, Forenede Stater, 33021
        • Rekruttering
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 954-265-1847
          • E-mail: OHR@mhs.net
        • Ledende efterforsker:
          • Matthew P. Salzberg
      • Jacksonville, Florida, Forenede Stater, 32224-9980
        • Rekruttering
        • Mayo Clinic in Florida
        • Ledende efterforsker:
          • Arnab Basu
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
      • Miami, Florida, Forenede Stater, 33136
        • Rekruttering
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Ledende efterforsker:
          • Janaki N. Sharma
      • Miami, Florida, Forenede Stater, 33176
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Kendall
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Ledende efterforsker:
          • Janaki N. Sharma
      • Miami, Florida, Forenede Stater, 33176
        • Rekruttering
        • Miami Cancer Institute
        • Ledende efterforsker:
          • Rohan Garje
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 786-596-2000
      • Miami Beach, Florida, Forenede Stater, 33140
        • Rekruttering
        • Mount Sinai Medical Center
        • Ledende efterforsker:
          • Oleg Gligich
        • Kontakt:
      • North Miami, Florida, Forenede Stater, 33181
        • Rekruttering
        • University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
        • Ledende efterforsker:
          • Janaki N. Sharma
        • Kontakt:
      • Orlando, Florida, Forenede Stater, 32803
        • Rekruttering
        • AdventHealth Orlando
        • Kontakt:
        • Ledende efterforsker:
          • Guru P. Sonpavde
      • Pembroke Pines, Florida, Forenede Stater, 33028
        • Rekruttering
        • Memorial Hospital West
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 954-265-4325
        • Ledende efterforsker:
          • Matthew P. Salzberg
      • Plantation, Florida, Forenede Stater, 33324
        • Rekruttering
        • UM Sylvester Comprehensive Cancer Center at Plantation
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 305-243-2647
        • Ledende efterforsker:
          • Janaki N. Sharma
    • Georgia
      • Atlanta, Georgia, Forenede Stater, 30322
        • Rekruttering
        • Emory University Hospital/Winship Cancer Institute
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 404-778-1868
        • Ledende efterforsker:
          • Jacqueline T. Brown
      • Atlanta, Georgia, Forenede Stater, 30342
        • Rekruttering
        • Northside Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Louis C. Garrot
      • Atlanta, Georgia, Forenede Stater, 30303
        • Rekruttering
        • Grady Health System
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 404-778-1868
        • Ledende efterforsker:
          • Jacqueline T. Brown
      • Atlanta, Georgia, Forenede Stater, 30308
        • Rekruttering
        • Emory University Hospital Midtown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-946-7447
        • Ledende efterforsker:
          • Jacqueline T. Brown
      • Atlanta, Georgia, Forenede Stater, 30342
        • Rekruttering
        • Emory Saint Joseph's Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 404-851-7115
        • Ledende efterforsker:
          • Jacqueline T. Brown
      • Duluth, Georgia, Forenede Stater, 30096
        • Rekruttering
        • Northside Hospital - Duluth
        • Kontakt:
        • Ledende efterforsker:
          • Louis C. Garrot
      • Johns Creek, Georgia, Forenede Stater, 30097
        • Rekruttering
        • Emory Johns Creek Hospital
        • Ledende efterforsker:
          • Jacqueline T. Brown
        • Kontakt:
      • Lawrenceville, Georgia, Forenede Stater, 30046
        • Rekruttering
        • Northside Hospital - Gwinnett
        • Kontakt:
        • Ledende efterforsker:
          • Louis C. Garrot
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Rekruttering
        • Kaiser Permanente Moanalua Medical Center
        • Ledende efterforsker:
          • Andrea L. Harzstark
        • Kontakt:
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Boise
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Caldwell, Idaho, Forenede Stater, 83605
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Caldwell
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Rekruttering
        • Kootenai Health - Coeur d'Alene
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Nampa, Idaho, Forenede Stater, 83687
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Nampa
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Post Falls, Idaho, Forenede Stater, 83854
        • Rekruttering
        • Kootenai Clinic Cancer Services - Post Falls
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Rekruttering
        • Kootenai Clinic Cancer Services - Sandpoint
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
    • Illinois
      • Barrington, Illinois, Forenede Stater, 60010
        • Rekruttering
        • Advocate Good Shepherd Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-842-4847
        • Ledende efterforsker:
          • Adam P. Siegel
      • Bloomington, Illinois, Forenede Stater, 61704
        • Rekruttering
        • Illinois CancerCare-Bloomington
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Canton, Illinois, Forenede Stater, 61520
        • Rekruttering
        • Illinois CancerCare-Canton
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Carthage, Illinois, Forenede Stater, 62321
        • Rekruttering
        • Illinois CancerCare-Carthage
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Chicago, Illinois, Forenede Stater, 60637
        • Rekruttering
        • University of Chicago Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Randy F. Sweis
      • Chicago, Illinois, Forenede Stater, 60611
        • Rekruttering
        • Northwestern University
        • Kontakt:
        • Ledende efterforsker:
          • David VanderWeele
      • Chicago, Illinois, Forenede Stater, 60612
        • Rekruttering
        • University of Illinois
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-355-3046
        • Ledende efterforsker:
          • Natalie Reizine
      • Chicago, Illinois, Forenede Stater, 60657
        • Rekruttering
        • Advocate Illinois Masonic Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 773-296-5360
        • Ledende efterforsker:
          • Adam P. Siegel
      • Chicago, Illinois, Forenede Stater, 60625
        • Rekruttering
        • Swedish Covenant Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 773-878-8200
        • Ledende efterforsker:
          • Nicklas R. Pfanzelter
      • Crystal Lake, Illinois, Forenede Stater, 60014
        • Rekruttering
        • AMG Crystal Lake - Oncology
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Danville, Illinois, Forenede Stater, 61832
        • Rekruttering
        • Carle at The Riverfront
        • Ledende efterforsker:
          • Priyank P. Patel
        • Kontakt:
      • DeKalb, Illinois, Forenede Stater, 60115
        • Rekruttering
        • Northwestern Medicine Cancer Center Kishwaukee
        • Kontakt:
        • Ledende efterforsker:
          • David VanderWeele
      • Decatur, Illinois, Forenede Stater, 62526
        • Rekruttering
        • Cancer Care Specialists of Illinois - Decatur
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Decatur, Illinois, Forenede Stater, 62526
        • Rekruttering
        • Decatur Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Dixon, Illinois, Forenede Stater, 61021
        • Rekruttering
        • Illinois CancerCare-Dixon
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 815-285-7800
      • Downers Grove, Illinois, Forenede Stater, 60515
        • Rekruttering
        • Advocate Good Samaritan Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Effingham, Illinois, Forenede Stater, 62401
        • Rekruttering
        • Carle Physician Group-Effingham
        • Kontakt:
        • Ledende efterforsker:
          • Priyank P. Patel
      • Effingham, Illinois, Forenede Stater, 62401
        • Rekruttering
        • Crossroads Cancer Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Elgin, Illinois, Forenede Stater, 60123
        • Rekruttering
        • Advocate Sherman Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-429-2907
        • Ledende efterforsker:
          • Adam P. Siegel
      • Elmhurst, Illinois, Forenede Stater, 60126
        • Aktiv, ikke rekrutterende
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, Forenede Stater, 61530
        • Rekruttering
        • Illinois CancerCare-Eureka
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Evanston, Illinois, Forenede Stater, 60201
        • Rekruttering
        • NorthShore University HealthSystem-Evanston Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
        • Ledende efterforsker:
          • Nicklas R. Pfanzelter
      • Galesburg, Illinois, Forenede Stater, 61401
        • Rekruttering
        • Illinois CancerCare-Galesburg
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Geneva, Illinois, Forenede Stater, 60134
        • Rekruttering
        • Northwestern Medicine Cancer Center Delnor
        • Kontakt:
        • Ledende efterforsker:
          • David VanderWeele
      • Glenview, Illinois, Forenede Stater, 60026
        • Rekruttering
        • NorthShore University HealthSystem-Glenbrook Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
        • Ledende efterforsker:
          • Nicklas R. Pfanzelter
      • Glenview, Illinois, Forenede Stater, 60026
        • Rekruttering
        • Northwestern Medicine Glenview Outpatient Center
        • Ledende efterforsker:
          • David VanderWeele
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-695-1102
      • Grayslake, Illinois, Forenede Stater, 60030
        • Rekruttering
        • Northwestern Medicine Grayslake Outpatient Center
        • Ledende efterforsker:
          • David VanderWeele
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-695-1102
      • Harvey, Illinois, Forenede Stater, 60426
        • Rekruttering
        • Ingalls Memorial Hospital
        • Ledende efterforsker:
          • James A. Wallace
        • Kontakt:
      • Hazel Crest, Illinois, Forenede Stater, 60429
        • Rekruttering
        • Advocate South Suburban Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 708-799-9995
        • Ledende efterforsker:
          • Adam P. Siegel
      • Highland Park, Illinois, Forenede Stater, 60035
        • Rekruttering
        • NorthShore University HealthSystem-Highland Park Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-570-2109
        • Ledende efterforsker:
          • Nicklas R. Pfanzelter
      • Kewanee, Illinois, Forenede Stater, 61443
        • Rekruttering
        • Illinois CancerCare-Kewanee Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Rekruttering
        • Northwestern Medicine Lake Forest Hospital
        • Kontakt:
        • Ledende efterforsker:
          • David VanderWeele
      • Libertyville, Illinois, Forenede Stater, 60048
        • Rekruttering
        • AMG Libertyville - Oncology
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Libertyville, Illinois, Forenede Stater, 60048
        • Rekruttering
        • Condell Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Macomb, Illinois, Forenede Stater, 61455
        • Rekruttering
        • Illinois CancerCare-Macomb
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Mattoon, Illinois, Forenede Stater, 61938
        • Rekruttering
        • Carle Physician Group-Mattoon/Charleston
        • Kontakt:
        • Ledende efterforsker:
          • Priyank P. Patel
      • Naperville, Illinois, Forenede Stater, 60540
        • Aktiv, ikke rekrutterende
        • Edward Hospital/Cancer Center
      • New Lenox, Illinois, Forenede Stater, 60451
        • Rekruttering
        • UC Comprehensive Cancer Center at Silver Cross
        • Kontakt:
        • Ledende efterforsker:
          • Randy F. Sweis
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Rekruttering
        • Cancer Care Center of O'Fallon
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Oak Brook, Illinois, Forenede Stater, 60523
      • Oak Lawn, Illinois, Forenede Stater, 60453-2699
        • Rekruttering
        • Advocate Christ Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-323-8622
        • Ledende efterforsker:
          • Adam P. Siegel
      • Orland Park, Illinois, Forenede Stater, 60462
        • Rekruttering
        • University of Chicago Medicine-Orland Park
        • Kontakt:
        • Ledende efterforsker:
          • Randy F. Sweis
      • Orland Park, Illinois, Forenede Stater, 60462
      • Ottawa, Illinois, Forenede Stater, 61350
        • Rekruttering
        • Illinois CancerCare-Ottawa Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Park Ridge, Illinois, Forenede Stater, 60068
        • Rekruttering
        • Advocate Lutheran General Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 847-384-3621
        • Ledende efterforsker:
          • Adam P. Siegel
      • Pekin, Illinois, Forenede Stater, 61554
        • Rekruttering
        • Illinois CancerCare-Pekin
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Peoria, Illinois, Forenede Stater, 61615
        • Rekruttering
        • Illinois CancerCare-Peoria
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Peru, Illinois, Forenede Stater, 61354
        • Rekruttering
        • Illinois CancerCare-Peru
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Plainfield, Illinois, Forenede Stater, 60585
        • Aktiv, ikke rekrutterende
        • Edward Hospital/Cancer Center?Plainfield
      • Princeton, Illinois, Forenede Stater, 61356
        • Rekruttering
        • Illinois CancerCare-Princeton
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
      • Rockford, Illinois, Forenede Stater, 61114
        • Rekruttering
        • UW Health Carbone Cancer Center Rockford
        • Kontakt:
        • Ledende efterforsker:
          • Fahrettin Covut
      • Shiloh, Illinois, Forenede Stater, 62269
        • Rekruttering
        • Memorial Hospital East
        • Kontakt:
        • Ledende efterforsker:
          • Melissa A. Reimers
      • Springfield, Illinois, Forenede Stater, 62702
        • Rekruttering
        • Southern Illinois University School of Medicine
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 217-545-7929
      • Springfield, Illinois, Forenede Stater, 62702
        • Rekruttering
        • Springfield Clinic
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-444-7541
      • Springfield, Illinois, Forenede Stater, 62781
        • Rekruttering
        • Springfield Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Urbana, Illinois, Forenede Stater, 61801
        • Rekruttering
        • Carle Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Priyank P. Patel
      • Warrenville, Illinois, Forenede Stater, 60555
        • Rekruttering
        • Northwestern Medicine Cancer Center Warrenville
        • Kontakt:
        • Ledende efterforsker:
          • David VanderWeele
      • Washington, Illinois, Forenede Stater, 61571
        • Rekruttering
        • Illinois CancerCare - Washington
        • Kontakt:
        • Ledende efterforsker:
          • Bryan A. Faller
    • Indiana
      • Crown Point, Indiana, Forenede Stater, 46307
        • Rekruttering
        • UChicago Medicine Northwest Indiana
        • Ledende efterforsker:
          • Randy F. Sweis
        • Kontakt:
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Rekruttering
        • Indiana University/Melvin and Bren Simon Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Tareq Salous
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • Rekruttering
        • Mary Greeley Medical Center
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Ames, Iowa, Forenede Stater, 50010
        • Rekruttering
        • McFarland Clinic - Ames
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
      • Ankeny, Iowa, Forenede Stater, 50023
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Ankeny Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Richard L. Deming
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Suspenderet
        • University of Iowa Healthcare Cancer Services Quad Cities
      • Boone, Iowa, Forenede Stater, 50036
        • Suspenderet
        • McFarland Clinic - Boone
      • Clive, Iowa, Forenede Stater, 50325
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50314
        • Rekruttering
        • Mercy Medical Center - Des Moines
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Richard L. Deming
      • Des Moines, Iowa, Forenede Stater, 50309
        • Rekruttering
        • Iowa Methodist Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-6727
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50309
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50314
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • Rekruttering
        • McFarland Clinic - Trinity Cancer Center
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Iowa City, Iowa, Forenede Stater, 52242
        • Rekruttering
        • University of Iowa/Holden Comprehensive Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-237-1225
        • Ledende efterforsker:
          • Vitor Fiorin De Vasconcellos
      • Jefferson, Iowa, Forenede Stater, 50129
        • Suspenderet
        • McFarland Clinic - Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • Rekruttering
        • McFarland Clinic - Marshalltown
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Waukee, Iowa, Forenede Stater, 50263
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Waukee Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
    • Kansas
      • Hays, Kansas, Forenede Stater, 67601
        • Rekruttering
        • HaysMed
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 785-623-5774
      • Kansas City, Kansas, Forenede Stater, 66160
        • Rekruttering
        • University of Kansas Cancer Center
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • Lawrence, Kansas, Forenede Stater, 66044
        • Rekruttering
        • Lawrence Memorial Hospital
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • Olathe, Kansas, Forenede Stater, 66061
        • Rekruttering
        • The University of Kansas Cancer Center - Olathe
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • Overland Park, Kansas, Forenede Stater, 66210
        • Rekruttering
        • University of Kansas Cancer Center-Overland Park
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • Salina, Kansas, Forenede Stater, 67401
        • Rekruttering
        • Salina Regional Health Center
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • Topeka, Kansas, Forenede Stater, 66606
        • Rekruttering
        • University of Kansas Health System Saint Francis Campus
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 785-295-8000
      • Westwood, Kansas, Forenede Stater, 66205
        • Rekruttering
        • University of Kansas Hospital-Westwood Cancer Center
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40536
        • Rekruttering
        • University of Kentucky/Markey Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 859-257-3379
        • Ledende efterforsker:
          • Patrick J. Hensley
      • Louisville, Kentucky, Forenede Stater, 40202
        • Rekruttering
        • The James Graham Brown Cancer Center at University of Louisville
        • Ledende efterforsker:
          • Rohit Kumar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 502-562-3429
      • Louisville, Kentucky, Forenede Stater, 40245
        • Rekruttering
        • UofL Health Medical Center Northeast
        • Ledende efterforsker:
          • Rohit Kumar
        • Kontakt:
      • Louisville, Kentucky, Forenede Stater, 40207
        • Aktiv, ikke rekrutterende
        • Baptist Health Louisville
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Rekruttering
        • Louisiana Hematology Oncology Associates LLC
        • Kontakt:
        • Ledende efterforsker:
          • Scott E. Delacroix
      • Metairie, Louisiana, Forenede Stater, 70002
        • Rekruttering
        • Mary Bird Perkins Cancer Center - Metairie
        • Ledende efterforsker:
          • Scott E. Delacroix
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 504-584-6990
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Rekruttering
        • Ochsner Medical Center Jefferson
        • Kontakt:
        • Ledende efterforsker:
          • Brian T. Halbert
    • Maine
      • Brewer, Maine, Forenede Stater, 04412
        • Rekruttering
        • Lafayette Family Cancer Center-EMMC
        • Ledende efterforsker:
          • Sarah J. Sinclair
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-987-3005
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21287
        • Rekruttering
        • Johns Hopkins University/Sidney Kimmel Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Jean H. Hoffman-Censits
      • Baltimore, Maryland, Forenede Stater, 21201
        • Rekruttering
        • University of Maryland/Greenebaum Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-888-8823
        • Ledende efterforsker:
          • Heather D. Mannuel
      • Cumberland, Maryland, Forenede Stater, 21502
        • Rekruttering
        • UPMC Western Maryland
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 240-964-1400
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Frederick, Maryland, Forenede Stater, 21702
        • Rekruttering
        • FMH James M Stockman Cancer Institute
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 301-668-7043
        • Ledende efterforsker:
          • Saro Sarkisian
    • Massachusetts
      • Beverly, Massachusetts, Forenede Stater, 01915
        • Rekruttering
        • Beverly Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 2405 978-922-3000
        • Ledende efterforsker:
          • Brett Dumas
      • Boston, Massachusetts, Forenede Stater, 02215
        • Rekruttering
        • Dana-Farber Cancer Institute
        • Ledende efterforsker:
          • Stephanie A. Berg
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-442-3324
      • Boston, Massachusetts, Forenede Stater, 02215
        • Rekruttering
        • Beth Israel Deaconess Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 617-667-9925
        • Ledende efterforsker:
          • David Einstein
      • Brighton, Massachusetts, Forenede Stater, 02135
        • Rekruttering
        • Dana-Farber Cancer Institute at Boston Medical Center - Brighton
        • Ledende efterforsker:
          • Olga Kozyreva
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 617-789-2903
      • Burlington, Massachusetts, Forenede Stater, 01805
      • Foxborough, Massachusetts, Forenede Stater, 02035
        • Rekruttering
        • Dana-Farber Cancer Institute at Foxborough
        • Ledende efterforsker:
          • Daniel Roberts
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-338-7425
      • Gloucester, Massachusetts, Forenede Stater, 01930
        • Rekruttering
        • Addison Gilbert Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 559 978-283-4000
        • Ledende efterforsker:
          • Brett Dumas
      • Milford, Massachusetts, Forenede Stater, 01757
        • Rekruttering
        • Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-332-4294
        • Ledende efterforsker:
          • Daniel E. Fein
      • Peabody, Massachusetts, Forenede Stater, 01960
      • South Weymouth, Massachusetts, Forenede Stater, 02190
        • Rekruttering
        • Dana-Farber/Brigham and Women's Cancer Center at South Shore
        • Ledende efterforsker:
          • Shail Maingi
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 781-624-5000
      • Winchester, Massachusetts, Forenede Stater, 01890
        • Aktiv, ikke rekrutterende
        • Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • Rekruttering
        • University of Michigan Rogel Cancer Center
        • Ledende efterforsker:
          • Irene Tsung
        • Kontakt:
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Rekruttering
        • Bronson Battle Creek
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Bay City, Michigan, Forenede Stater, 48706
        • Rekruttering
        • McLaren Cancer Institute-Bay City
        • Kontakt:
        • Ledende efterforsker:
          • Yusra F. Shao
      • Brighton, Michigan, Forenede Stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Brighton, Michigan, Forenede Stater, 48116
        • Rekruttering
        • University of Michigan - Brighton Center for Specialty Care
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-865-1125
        • Ledende efterforsker:
          • Irene Tsung
      • Brownstown, Michigan, Forenede Stater, 48183
        • Rekruttering
        • Henry Ford Cancer Institute-Downriver
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Canton, Michigan, Forenede Stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Chelsea, Michigan, Forenede Stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Clinton Township, Michigan, Forenede Stater, 48038
        • Rekruttering
        • Henry Ford Macomb Hospital-Clinton Township
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Dearborn, Michigan, Forenede Stater, 48126
        • Rekruttering
        • Henry Ford Medical Center-Fairlane
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Detroit, Michigan, Forenede Stater, 48201
        • Rekruttering
        • Wayne State University/Karmanos Cancer Institute
        • Ledende efterforsker:
          • Yusra F. Shao
        • Kontakt:
      • Detroit, Michigan, Forenede Stater, 48202
        • Rekruttering
        • Henry Ford Hospital
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Escanaba, Michigan, Forenede Stater, 49829
        • Rekruttering
        • OSF Saint Francis Hospital and Medical Group
        • Ledende efterforsker:
          • Anthony J. Jaslowski
        • Kontakt:
      • Farmington Hills, Michigan, Forenede Stater, 48334
        • Rekruttering
        • Weisberg Cancer Treatment Center
        • Kontakt:
        • Ledende efterforsker:
          • Yusra F. Shao
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Genesys Hurley Cancer Institute
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Hurley Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Flint, Michigan, Forenede Stater, 48503
        • Suspenderet
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Rekruttering
        • Cancer Hematology Centers - Flint
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Rekruttering
        • Trinity Health Grand Rapids Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Rekruttering
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Jackson, Michigan, Forenede Stater, 49201
        • Rekruttering
        • Allegiance Health
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Rekruttering
        • Bronson Methodist Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Rekruttering
        • West Michigan Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Lansing, Michigan, Forenede Stater, 48910
        • Rekruttering
        • Karmanos Cancer Institute at McLaren Greater Lansing
        • Kontakt:
        • Ledende efterforsker:
          • Yusra F. Shao
      • Lansing, Michigan, Forenede Stater, 48912
        • Rekruttering
        • University of Michigan Health - Sparrow Lansing
        • Ledende efterforsker:
          • Elie G. Dib
        • Kontakt:
      • Livonia, Michigan, Forenede Stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Muskegon, Michigan, Forenede Stater, 49444
        • Rekruttering
        • Trinity Health Muskegon Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Niles, Michigan, Forenede Stater, 49120
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Niles Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 616-391-1230
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Norton Shores, Michigan, Forenede Stater, 49444
        • Rekruttering
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Novi, Michigan, Forenede Stater, 48377
        • Rekruttering
        • Henry Ford Medical Center-Columbus
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Petoskey, Michigan, Forenede Stater, 49770
        • Rekruttering
        • McLaren Cancer Institute-Northern Michigan
        • Kontakt:
        • Ledende efterforsker:
          • Yusra F. Shao
      • Pontiac, Michigan, Forenede Stater, 48341
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Oakland Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Reed City, Michigan, Forenede Stater, 49677
        • Rekruttering
        • Corewell Health Reed City Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Saginaw, Michigan, Forenede Stater, 48604
        • Suspenderet
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forenede Stater, 48601
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Rekruttering
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Tawas City, Michigan, Forenede Stater, 48764
      • Traverse City, Michigan, Forenede Stater, 49684
        • Rekruttering
        • Munson Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • West Bloomfield, Michigan, Forenede Stater, 48322
        • Rekruttering
        • Henry Ford West Bloomfield Hospital
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • West Branch, Michigan, Forenede Stater, 48661
        • Suspenderet
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Wyandotte, Michigan, Forenede Stater, 48192
        • Rekruttering
        • Henry Ford Wyandotte Hospital
        • Ledende efterforsker:
          • Clara Hwang
        • Kontakt:
      • Wyoming, Michigan, Forenede Stater, 49519
        • Rekruttering
        • University of Michigan Health - West
        • Kontakt:
        • Ledende efterforsker:
          • Kathleen Y. Butler
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Rekruttering
        • Mercy Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Edina, Minnesota, Forenede Stater, 55435
        • Rekruttering
        • Fairview Southdale Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Edina, Minnesota, Forenede Stater, 55435
        • Rekruttering
        • Minnesota Oncology - Edina
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Rekruttering
        • Hennepin County Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Rekruttering
        • Coborn Cancer Center at Saint Cloud Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Donald J. Jurgens
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Rekruttering
        • Park Nicollet Clinic - Saint Louis Park
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Rekruttering
        • Regions Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • Rekruttering
        • United Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Yan Ji
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • Rekruttering
        • University of Mississippi Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 601-815-6700
        • Ledende efterforsker:
          • John C. Henegan
    • Missouri
      • Ballwin, Missouri, Forenede Stater, 63011
        • Rekruttering
        • Mercy Oncology and Hematology - Clayton-Clarkson
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-446-3729
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Rekruttering
        • Saint Francis Medical Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 573-334-2230
          • E-mail: sfmc@sfmc.net
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Rekruttering
        • Siteman Cancer Center at Saint Peters Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Melissa A. Reimers
      • Columbia, Missouri, Forenede Stater, 65212
        • Rekruttering
        • MU Health - University Hospital/Ellis Fischel Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 573-882-7440
        • Ledende efterforsker:
          • Mark R. Wakefield
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Siteman Cancer Center at West County Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Melissa A. Reimers
      • Farmington, Missouri, Forenede Stater, 63640
        • Rekruttering
        • Parkland Health Center - Farmington
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Aktiv, ikke rekrutterende
        • MU Health Care Goldschmidt Cancer Center
      • Kansas City, Missouri, Forenede Stater, 64154
        • Rekruttering
        • University of Kansas Cancer Center - North
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • Kansas City, Missouri, Forenede Stater, 64108
        • Rekruttering
        • University Health Truman Medical Center
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 816-404-4375
      • Kansas City, Missouri, Forenede Stater, 64128
        • Suspenderet
        • Kansas City Veterans Affairs Medical Center
      • Kansas City, Missouri, Forenede Stater, 64116
        • Rekruttering
        • University of Kansas Cancer Center - Briarcliff
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 913-588-3671
      • Lee's Summit, Missouri, Forenede Stater, 64064
        • Rekruttering
        • University of Kansas Cancer Center - Lee's Summit
        • Ledende efterforsker:
          • Saqib Abbasi
        • Kontakt:
      • North Kansas City, Missouri, Forenede Stater, 64116
        • Suspenderet
        • University of Kansas Cancer Center at North Kansas City Hospital
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Rekruttering
        • Sainte Genevieve County Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • Springfield, Missouri, Forenede Stater, 65804
        • Rekruttering
        • Mercy Hospital Springfield
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 417-269-4520
      • St Louis, Missouri, Forenede Stater, 63110
        • Rekruttering
        • Washington University School of Medicine
        • Kontakt:
        • Ledende efterforsker:
          • Melissa A. Reimers
      • St Louis, Missouri, Forenede Stater, 63128
        • Rekruttering
        • Mercy Hospital South
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
      • St Louis, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Mercy Hospital Saint Louis
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-251-7066
      • St Louis, Missouri, Forenede Stater, 63129
        • Rekruttering
        • Siteman Cancer Center-South County
        • Kontakt:
        • Ledende efterforsker:
          • Melissa A. Reimers
      • St Louis, Missouri, Forenede Stater, 63136
        • Rekruttering
        • Siteman Cancer Center at Christian Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Melissa A. Reimers
      • St Louis, Missouri, Forenede Stater, 63131
        • Rekruttering
        • Missouri Baptist Medical Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
      • St Louis, Missouri, Forenede Stater, 63125
        • Rekruttering
        • Veteran's Affairs Medical Center - Saint Louis
        • Kontakt:
        • Ledende efterforsker:
          • Eric M. Knoche
      • Sullivan, Missouri, Forenede Stater, 63080
        • Rekruttering
        • Missouri Baptist Sullivan Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-996-5569
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Rekruttering
        • Community Hospital of Anaconda
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Billings, Montana, Forenede Stater, 59101
        • Rekruttering
        • Billings Clinic Cancer Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Bozeman, Montana, Forenede Stater, 59715
        • Rekruttering
        • Bozeman Health Deaconess Hospital
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Great Falls, Montana, Forenede Stater, 59405
        • Rekruttering
        • Benefis Sletten Cancer Institute
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Kalispell, Montana, Forenede Stater, 59901
        • Rekruttering
        • Logan Health Medical Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
      • Missoula, Montana, Forenede Stater, 59804
        • Rekruttering
        • Community Medical Center
        • Ledende efterforsker:
          • John M. Schallenkamp
        • Kontakt:
    • Nebraska
      • Bellevue, Nebraska, Forenede Stater, 68123
        • Rekruttering
        • Nebraska Medicine-Bellevue
        • Kontakt:
        • Ledende efterforsker:
          • Harshraj Leuva
      • Omaha, Nebraska, Forenede Stater, 68198
        • Rekruttering
        • University of Nebraska Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Harshraj Leuva
      • Omaha, Nebraska, Forenede Stater, 68118
        • Rekruttering
        • Nebraska Medicine-Village Pointe
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 402-559-5600
        • Ledende efterforsker:
          • Harshraj Leuva
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89102
        • Suspenderet
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Forenede Stater, 89183
        • Suspenderet
        • OptumCare Cancer Care at Fort Apache
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • Aktiv, ikke rekrutterende
        • New Hampshire Oncology Hematology PA-Concord
      • Manchester, New Hampshire, Forenede Stater, 03103
        • Aktiv, ikke rekrutterende
        • Solinsky Center for Cancer Care
    • New Jersey
      • Basking Ridge, New Jersey, Forenede Stater, 07920
        • Rekruttering
        • Memorial Sloan Kettering Basking Ridge
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • Cherry Hill, New Jersey, Forenede Stater, 08002
        • Rekruttering
        • Jefferson Cherry Hill Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Patrick Mille
      • Hackensack, New Jersey, Forenede Stater, 07601
        • Rekruttering
        • Hackensack University Medical Center
        • Ledende efterforsker:
          • Robert S. Alter
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 551-996-2897
      • Jersey City, New Jersey, Forenede Stater, 07302
        • Rekruttering
        • Jersey City Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Biren Saraiya
      • Lakewood, New Jersey, Forenede Stater, 08701
        • Rekruttering
        • Monmouth Medical Center Southern Campus
        • Kontakt:
        • Ledende efterforsker:
          • Biren Saraiya
      • Livingston, New Jersey, Forenede Stater, 07039
        • Rekruttering
        • Cooperman Barnabas Medical Center
        • Ledende efterforsker:
          • Biren Saraiya
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 973-322-5200
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Rekruttering
        • Monmouth Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Biren Saraiya
      • Manahawkin, New Jersey, Forenede Stater, 08050
        • Rekruttering
        • Southern Ocean County Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 609-978-3429
        • Ledende efterforsker:
          • Evan C. Naylor
      • Middletown, New Jersey, Forenede Stater, 07748
        • Rekruttering
        • Memorial Sloan Kettering Monmouth
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • Montvale, New Jersey, Forenede Stater, 07645
        • Rekruttering
        • Memorial Sloan Kettering Bergen
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rekruttering
        • Rutgers Cancer Institute of New Jersey
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 732-235-7356
        • Ledende efterforsker:
          • Biren Saraiya
      • Sewell, New Jersey, Forenede Stater, 08080
        • Rekruttering
        • Sidney Kimmel Cancer Center Washington Township
        • Kontakt:
        • Ledende efterforsker:
          • Patrick Mille
      • Somerville, New Jersey, Forenede Stater, 08876
        • Rekruttering
        • Robert Wood Johnson University Hospital Somerset
        • Ledende efterforsker:
          • Biren Saraiya
        • Kontakt:
      • Toms River, New Jersey, Forenede Stater, 08755
        • Rekruttering
        • Community Medical Center
        • Ledende efterforsker:
          • Biren Saraiya
        • Kontakt:
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87110
        • Rekruttering
        • Presbyterian Kaseman Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Amy C. Tarnower
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Rekruttering
        • University of New Mexico Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Amy C. Tarnower
      • Rio Rancho, New Mexico, Forenede Stater, 87124
        • Rekruttering
        • Presbyterian Rust Medical Center/Jorgensen Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Amy C. Tarnower
    • New York
      • Brooklyn, New York, Forenede Stater, 11219
        • Rekruttering
        • Maimonides Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 718-765-2500
        • Ledende efterforsker:
          • Abhigna Kodali
      • Buffalo, New York, Forenede Stater, 14263
        • Aktiv, ikke rekrutterende
        • Roswell Park Cancer Institute
      • Commack, New York, Forenede Stater, 11725
        • Rekruttering
        • Memorial Sloan Kettering Commack
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • Flushing, New York, Forenede Stater, 11355
        • Rekruttering
        • The New York Hospital Medical Center of Queens
        • Kontakt:
        • Ledende efterforsker:
          • Leen Khoury
      • Glens Falls, New York, Forenede Stater, 12801
        • Rekruttering
        • Glens Falls Hospital
        • Ledende efterforsker:
          • Steven Ades
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 518-926-6700
      • Harrison, New York, Forenede Stater, 10604
        • Rekruttering
        • Memorial Sloan Kettering Westchester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • Mineola, New York, Forenede Stater, 11501
        • Aktiv, ikke rekrutterende
        • NYU Langone Hospital - Long Island
      • New York, New York, Forenede Stater, 10065
        • Rekruttering
        • Memorial Sloan Kettering Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • New York, New York, Forenede Stater, 10011
        • Rekruttering
        • Mount Sinai Chelsea
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-mail: CCTO@mssm.edu
        • Ledende efterforsker:
          • Matthew D. Galsky
      • New York, New York, Forenede Stater, 10029
        • Rekruttering
        • Mount Sinai Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-824-7309
          • E-mail: CCTO@mssm.edu
        • Ledende efterforsker:
          • Matthew D. Galsky
      • New York, New York, Forenede Stater, 10065
        • Rekruttering
        • NYP/Weill Cornell Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-746-1848
        • Ledende efterforsker:
          • Cora N. Sternberg
      • New York, New York, Forenede Stater, 10016
        • Aktiv, ikke rekrutterende
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
      • Rochester, New York, Forenede Stater, 14642
        • Rekruttering
        • University of Rochester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 585-275-5830
        • Ledende efterforsker:
          • Brendan J. Guercio
      • Rochester, New York, Forenede Stater, 14621
        • Rekruttering
        • Rochester General Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Maria M. Sbenghe
      • Rochester, New York, Forenede Stater, 14626
        • Rekruttering
        • Unity Park Ridge Campus
        • Kontakt:
        • Ledende efterforsker:
          • Maria M. Sbenghe
      • Stony Brook, New York, Forenede Stater, 11794
        • Rekruttering
        • Stony Brook University Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-862-2215
        • Ledende efterforsker:
          • Judy Huang
      • The Bronx, New York, Forenede Stater, 10461
        • Rekruttering
        • Montefiore Medical Center-Einstein Campus
        • Kontakt:
        • Ledende efterforsker:
          • Benjamin A. Gartrell
      • Uniondale, New York, Forenede Stater, 11553
        • Rekruttering
        • Memorial Sloan Kettering Nassau
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • David H. Aggen
      • Webster, New York, Forenede Stater, 14580
    • North Carolina
      • Albemarle, North Carolina, Forenede Stater, 28002
        • Rekruttering
        • Atrium Health Stanly/LCI-Albemarle
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Cary, North Carolina, Forenede Stater, 27518
        • Suspenderet
        • Duke Cancer Center Cary
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • Rekruttering
        • UNC Lineberger Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Matthew I. Milowsky
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Rekruttering
        • Carolinas Medical Center/Levine Cancer Institute
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Charlotte, North Carolina, Forenede Stater, 28210
        • Rekruttering
        • Atrium Health Pineville/LCI-Pineville
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-2000
      • Charlotte, North Carolina, Forenede Stater, 28211
        • Rekruttering
        • Levine Cancer Institute-SouthPark
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-2000
      • Charlotte, North Carolina, Forenede Stater, 28262
        • Rekruttering
        • Atrium Health University City/LCI-University
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Charlotte, North Carolina, Forenede Stater, 28277
        • Rekruttering
        • Levine Cancer Institute-Ballantyne
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Clemmons, North Carolina, Forenede Stater, 27012
        • Rekruttering
        • Wake Forest University at Clemmons
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-716-9259
        • Ledende efterforsker:
          • Michael McCormack
      • Concord, North Carolina, Forenede Stater, 28025
        • Rekruttering
        • Atrium Health Cabarrus/LCI-Concord
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Durham, North Carolina, Forenede Stater, 27710
        • Rekruttering
        • Duke University Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-275-3853
        • Ledende efterforsker:
          • Hannah D. McManus
      • Durham, North Carolina, Forenede Stater, 27713
        • Rekruttering
        • Duke Cancer Center Southpoint
        • Kontakt:
        • Ledende efterforsker:
          • Hannah D. McManus
      • Forest City, North Carolina, Forenede Stater, 28043
        • Rekruttering
        • Levine Cancer Institute - Rutherford
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Gastonia, North Carolina, Forenede Stater, 28054
        • Rekruttering
        • Levine Cancer Institute-Gaston
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Huntersville, North Carolina, Forenede Stater, 28078
        • Rekruttering
        • Levine Cancer Institute - Huntersville
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-2000
      • Lincolnton, North Carolina, Forenede Stater, 28092
        • Rekruttering
        • Atrium Health Lincoln/LCI-Lincolnton
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Matthews, North Carolina, Forenede Stater, 28104
        • Rekruttering
        • Levine Cancer Institute - Union West
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-0600
        • Ledende efterforsker:
          • Landon C. Brown
      • Monroe, North Carolina, Forenede Stater, 28112
        • Rekruttering
        • Atrium Health Union/LCI-Union
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-2000
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • Rekruttering
        • FirstHealth of the Carolinas-Moore Regional Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Charles S. Kuzma
      • Raleigh, North Carolina, Forenede Stater, 27609
        • Rekruttering
        • Duke Cancer Center Raleigh
        • Kontakt:
        • Ledende efterforsker:
          • Hannah D. McManus
      • Shelby, North Carolina, Forenede Stater, 28150
        • Rekruttering
        • Atrium Health Cleveland/LCI-Cleveland
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Rekruttering
        • Wake Forest University Health Sciences
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 336-713-6771
        • Ledende efterforsker:
          • Michael McCormack
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
      • Fargo, North Dakota, Forenede Stater, 58122
      • Fargo, North Dakota, Forenede Stater, 58122
    • Ohio
      • Athens, Ohio, Forenede Stater, 45701
        • Aktiv, ikke rekrutterende
        • OhioHealth O'Bleness Hospital
      • Cincinnati, Ohio, Forenede Stater, 45219
        • Rekruttering
        • University of Cincinnati Cancer Center-UC Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Robert A. Franklin
      • Columbus, Ohio, Forenede Stater, 43210
        • Rekruttering
        • Ohio State University Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Lingbin Meng
      • Columbus, Ohio, Forenede Stater, 43215
        • Aktiv, ikke rekrutterende
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43228
        • Aktiv, ikke rekrutterende
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43214
        • Aktiv, ikke rekrutterende
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forenede Stater, 43214
        • Aktiv, ikke rekrutterende
        • Riverside Methodist Hospital
      • Delaware, Ohio, Forenede Stater, 43015
        • Aktiv, ikke rekrutterende
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Aktiv, ikke rekrutterende
        • Grady Memorial Hospital
      • Dublin, Ohio, Forenede Stater, 43016
        • Aktiv, ikke rekrutterende
        • Dublin Methodist Hospital
      • Dublin, Ohio, Forenede Stater, 43016
        • Aktiv, ikke rekrutterende
        • Columbus Oncology and Hematology Associates
      • Mansfield, Ohio, Forenede Stater, 44903
        • Aktiv, ikke rekrutterende
        • OhioHealth Mansfield Hospital
      • Marion, Ohio, Forenede Stater, 43302
        • Aktiv, ikke rekrutterende
        • OhioHealth Marion General Hospital
      • Pickerington, Ohio, Forenede Stater, 43147
        • Aktiv, ikke rekrutterende
        • OhioHealth Pickerington Methodist Hospital
      • Sylvania, Ohio, Forenede Stater, 43560
        • Rekruttering
        • ProMedica Flower Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Jeffrey H. Muler
      • West Chester, Ohio, Forenede Stater, 45069
        • Rekruttering
        • University of Cincinnati Cancer Center-West Chester
        • Kontakt:
        • Ledende efterforsker:
          • Robert A. Franklin
      • Westerville, Ohio, Forenede Stater, 43082
        • Aktiv, ikke rekrutterende
        • OhioHealth Westerville Medical Campus/Westerville Cancer Center
    • Oklahoma
      • Lawton, Oklahoma, Forenede Stater, 73505
        • Rekruttering
        • Cancer Centers of Southwest Oklahoma Research
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-231-4440
        • Ledende efterforsker:
          • Adanma Anji Ayanambakkam Attanathi
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Kontakt:
        • Ledende efterforsker:
          • Adanma Anji Ayanambakkam Attanathi
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Aktiv, ikke rekrutterende
        • Oklahoma Cancer Specialists and Research Institute-Tulsa
    • Oregon
      • Ontario, Oregon, Forenede Stater, 97914
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Ontario
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Oregon City, Oregon, Forenede Stater, 97045
        • Rekruttering
        • Providence Willamette Falls Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Portland, Oregon, Forenede Stater, 97239
        • Rekruttering
        • Oregon Health and Science University
        • Kontakt:
        • Ledende efterforsker:
          • Ronald Ng
      • Portland, Oregon, Forenede Stater, 97213
        • Rekruttering
        • Providence Portland Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
      • Portland, Oregon, Forenede Stater, 97225
        • Rekruttering
        • Providence Saint Vincent Medical Center
        • Ledende efterforsker:
          • Alison K. Conlin
        • Kontakt:
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Rekruttering
        • Lehigh Valley Hospital-Cedar Crest
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Altoona, Pennsylvania, Forenede Stater, 16601
        • Rekruttering
        • UPMC Altoona
        • Kontakt:
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Beaver, Pennsylvania, Forenede Stater, 15009
        • Rekruttering
        • UPMC-Heritage Valley Health System Beaver
        • Kontakt:
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Rekruttering
        • Lehigh Valley Hospital - Muhlenberg
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Rekruttering
        • Pocono Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Elie G. Dib
      • Erie, Pennsylvania, Forenede Stater, 16505
        • Rekruttering
        • UPMC Hillman Cancer Center Erie
        • Ledende efterforsker:
          • Leonard J. Appleman
        • Kontakt:
      • Greensburg, Pennsylvania, Forenede Stater, 15601
        • Rekruttering
        • UPMC Cancer Centers - Arnold Palmer Pavilion
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 724-838-1900
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Harrisburg, Pennsylvania, Forenede Stater, 17109
        • Rekruttering
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
        • Kontakt:
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Lancaster, Pennsylvania, Forenede Stater, 17601
        • Aktiv, ikke rekrutterende
        • Lancaster General Ann B Barshinger Cancer Institute
      • Mechanicsburg, Pennsylvania, Forenede Stater, 17050
        • Rekruttering
        • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
        • Kontakt:
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • Rekruttering
        • UPMC Hillman Cancer Center - Monroeville
        • Ledende efterforsker:
          • Leonard J. Appleman
        • Kontakt:
      • New Castle, Pennsylvania, Forenede Stater, 16105
        • Rekruttering
        • UPMC Hillman Cancer Center - New Castle
        • Kontakt:
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Rekruttering
        • Thomas Jefferson University Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Patrick Mille
      • Philadelphia, Pennsylvania, Forenede Stater, 19114
        • Rekruttering
        • Jefferson Torresdale Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Patrick Mille
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • Aktiv, ikke rekrutterende
        • University of Pennsylvania/Abramson Cancer Center
      • Pittsburgh, Pennsylvania, Forenede Stater, 15215
        • Rekruttering
        • UPMC-Saint Margaret
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-784-4900
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Pittsburgh, Pennsylvania, Forenede Stater, 15237
        • Rekruttering
        • UPMC-Passavant Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-367-6454
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Pittsburgh, Pennsylvania, Forenede Stater, 15243
        • Rekruttering
        • UPMC-Saint Clair Hospital Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-502-3920
        • Ledende efterforsker:
          • Leonard J. Appleman
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • Rekruttering
        • UPMC Hillman Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-647-8073
        • Ledende efterforsker:
          • Leonard J. Appleman
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Rekruttering
        • Reading Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 610-988-9323
        • Ledende efterforsker:
          • Terrence P. Cescon
      • Willow Grove, Pennsylvania, Forenede Stater, 19090
        • Rekruttering
        • Asplundh Cancer Pavilion
        • Kontakt:
        • Ledende efterforsker:
          • Patrick Mille
    • Rhode Island
      • Westerly, Rhode Island, Forenede Stater, 02891
        • Rekruttering
        • Smilow Cancer Hospital Care Center - Westerly
        • Kontakt:
        • Ledende efterforsker:
          • Joseph W. Kim
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • Rekruttering
        • AnMed Health Cancer Center
        • Ledende efterforsker:
          • Jay B. Nayak
        • Kontakt:
      • Boiling Springs, South Carolina, Forenede Stater, 29316
        • Rekruttering
        • Prisma Health Cancer Institute - Spartanburg
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Charleston, South Carolina, Forenede Stater, 29425
        • Rekruttering
        • Medical University of South Carolina
        • Kontakt:
        • Ledende efterforsker:
          • Theodore S. Gourdin
      • Easley, South Carolina, Forenede Stater, 29640
        • Rekruttering
        • Prisma Health Cancer Institute - Easley
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Gaffney, South Carolina, Forenede Stater, 29341
        • Rekruttering
        • Gibbs Cancer Center-Gaffney
        • Kontakt:
        • Ledende efterforsker:
          • Michael Humeniuk
      • Greenville, South Carolina, Forenede Stater, 29605
        • Rekruttering
        • Prisma Health Cancer Institute - Faris
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29605
        • Rekruttering
        • Prisma Health Cancer Institute - Butternut
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29615
        • Rekruttering
        • Prisma Health Cancer Institute - Eastside
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greenville, South Carolina, Forenede Stater, 29605
        • Rekruttering
        • Prisma Health Greenville Memorial Hospital
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greer, South Carolina, Forenede Stater, 29650
        • Rekruttering
        • Prisma Health Cancer Institute - Greer
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Greer, South Carolina, Forenede Stater, 29651
        • Rekruttering
        • Gibbs Cancer Center-Pelham
        • Kontakt:
        • Ledende efterforsker:
          • Michael Humeniuk
      • Rock Hill, South Carolina, Forenede Stater, 29732
        • Rekruttering
        • Levine Cancer Institute-Rock Hill
        • Ledende efterforsker:
          • Landon C. Brown
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
      • Seneca, South Carolina, Forenede Stater, 29672
        • Rekruttering
        • Prisma Health Cancer Institute - Seneca
        • Ledende efterforsker:
          • Ki Y. Chung
        • Kontakt:
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Rekruttering
        • Spartanburg Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Michael Humeniuk
      • Union, South Carolina, Forenede Stater, 29379
        • Rekruttering
        • SMC Center for Hematology Oncology Union
        • Kontakt:
        • Ledende efterforsker:
          • Michael Humeniuk
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57104
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    • Tennessee
      • Germantown, Tennessee, Forenede Stater, 38138
        • Aktiv, ikke rekrutterende
        • The West Clinic - Wolf River
      • Nashville, Tennessee, Forenede Stater, 37232
        • Rekruttering
        • Vanderbilt University/Ingram Cancer Center
        • Ledende efterforsker:
          • Kerry R. Schaffer
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-811-8480
    • Texas
      • Dallas, Texas, Forenede Stater, 75390
        • Rekruttering
        • UT Southwestern/Simmons Cancer Center-Dallas
        • Ledende efterforsker:
          • Tian Zhang
        • Kontakt:
      • Dallas, Texas, Forenede Stater, 75237
        • Rekruttering
        • UT Southwestern Simmons Cancer Center - RedBird
        • Ledende efterforsker:
          • Tian Zhang
        • Kontakt:
      • Fort Worth, Texas, Forenede Stater, 76104
        • Rekruttering
        • UT Southwestern/Simmons Cancer Center-Fort Worth
        • Ledende efterforsker:
          • Tian Zhang
        • Kontakt:
      • Houston, Texas, Forenede Stater, 77030
        • Rekruttering
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 713-798-1354
          • E-mail: burton@bcm.edu
        • Ledende efterforsker:
          • Aihua E. Yen
      • Houston, Texas, Forenede Stater, 77030
        • Rekruttering
        • Ben Taub General Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 713-873-2000
        • Ledende efterforsker:
          • Aihua E. Yen
      • Houston, Texas, Forenede Stater, 77026-1967
        • Rekruttering
        • Lyndon Baines Johnson General Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 713-566-5000
        • Ledende efterforsker:
          • Debanjan Pain
      • Houston, Texas, Forenede Stater, 77030
        • Rekruttering
        • Michael E DeBakey VA Medical Center
        • Ledende efterforsker:
          • Aihua E. Yen
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-553-2278
      • Richardson, Texas, Forenede Stater, 75080
        • Rekruttering
        • UT Southwestern Clinical Center at Richardson/Plano
        • Ledende efterforsker:
          • Tian Zhang
        • Kontakt:
    • Utah
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Rekruttering
        • Huntsman Cancer Institute/University of Utah
        • Kontakt:
        • Ledende efterforsker:
          • Bogdana Schmidt
    • Vermont
      • Berlin Corners, Vermont, Forenede Stater, 05602
        • Rekruttering
        • Central Vermont Medical Center/National Life Cancer Treatment
        • Ledende efterforsker:
          • Steven Ades
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 802-225-5400
      • Burlington, Vermont, Forenede Stater, 05401
        • Rekruttering
        • University of Vermont Medical Center
        • Ledende efterforsker:
          • Steven Ades
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 802-656-4101
          • E-mail: rpo@uvm.edu
      • Burlington, Vermont, Forenede Stater, 05405
        • Rekruttering
        • University of Vermont and State Agricultural College
        • Ledende efterforsker:
          • Steven Ades
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 802-656-8990
          • E-mail: rpo@uvm.edu
    • Virginia
      • Charlottesville, Virginia, Forenede Stater, 22908
      • Mechanicsville, Virginia, Forenede Stater, 23116
        • Rekruttering
        • Bon Secours Memorial Regional Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph D. Pennington
      • Midlothian, Virginia, Forenede Stater, 23114
        • Rekruttering
        • Bon Secours Saint Francis Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph D. Pennington
      • Richmond, Virginia, Forenede Stater, 23235
        • Rekruttering
        • VCU Massey Cancer Center at Stony Point
        • Kontakt:
        • Ledende efterforsker:
          • John Melson
      • Richmond, Virginia, Forenede Stater, 23226
        • Rekruttering
        • Bon Secours Saint Mary's Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Joseph D. Pennington
      • Richmond, Virginia, Forenede Stater, 23223
        • Rekruttering
        • Bon Secours Richmond Community Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Joseph D. Pennington
      • Richmond, Virginia, Forenede Stater, 23298
        • Rekruttering
        • VCU Massey Comprehensive Cancer Center
        • Ledende efterforsker:
          • John Melson
        • Kontakt:
      • South Hill, Virginia, Forenede Stater, 23970
        • Rekruttering
        • VCU Community Memorial Health Center
        • Kontakt:
        • Ledende efterforsker:
          • John Melson
    • Washington
      • Seattle, Washington, Forenede Stater, 98101
        • Rekruttering
        • Virginia Mason Medical Center
        • Ledende efterforsker:
          • Huong T. Pham
        • Kontakt:
    • West Virginia
      • Charleston, West Virginia, Forenede Stater, 25304
        • Rekruttering
        • Vandalia Health/CAMC Institute for Academic Medicine
        • Ledende efterforsker:
          • Kok Hoe Chan
        • Kontakt:
      • Morgantown, West Virginia, Forenede Stater, 26506
        • Rekruttering
        • West Virginia University Healthcare
        • Kontakt:
        • Ledende efterforsker:
          • Raheel S. Siddiqui
    • Wisconsin
      • Appleton, Wisconsin, Forenede Stater, 54911
        • Rekruttering
        • ThedaCare Regional Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Joyce Philip
      • Cudahy, Wisconsin, Forenede Stater, 53110
        • Rekruttering
        • Aurora Saint Luke's South Shore
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Eau Claire, Wisconsin, Forenede Stater, 54701
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Rekruttering
        • Aurora Cancer Care-Grafton
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Rekruttering
        • Aurora BayCare Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Rekruttering
        • Saint Vincent Hospital Cancer Center Green Bay
        • Ledende efterforsker:
          • Anthony J. Jaslowski
        • Kontakt:
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Saint Mary's
        • Ledende efterforsker:
          • Anthony J. Jaslowski
        • Kontakt:
      • Madison, Wisconsin, Forenede Stater, 53792
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - University Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Anthony Serritella
      • Madison, Wisconsin, Forenede Stater, 53718
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Anthony Serritella
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Rekruttering
        • Aurora Bay Area Medical Group-Marinette
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Marshfield, Wisconsin, Forenede Stater, 54449
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Rekruttering
        • Aurora Saint Luke's Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Rekruttering
        • Medical College of Wisconsin
        • Ledende efterforsker:
          • Kathryn A. Bylow
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 414-805-3666
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Rekruttering
        • Aurora Sinai Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • Rekruttering
        • ProHealth D N Greenwald Center
        • Kontakt:
        • Ledende efterforsker:
          • Timothy R. Wassenaar
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Rekruttering
        • ProHealth Oconomowoc Memorial Hospital
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 262-928-7878
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Oconto Falls
        • Ledende efterforsker:
          • Anthony J. Jaslowski
        • Kontakt:
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Rekruttering
        • Vince Lombardi Cancer Clinic - Oshkosh
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Rice Lake, Wisconsin, Forenede Stater, 54868
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Rekruttering
        • Vince Lombardi Cancer Clinic-Sheboygan
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Sheboygan
        • Ledende efterforsker:
          • Anthony J. Jaslowski
        • Kontakt:
      • Stevens Point, Wisconsin, Forenede Stater, 54482
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
        • Ledende efterforsker:
          • Anthony J. Jaslowski
        • Kontakt:
      • Summit, Wisconsin, Forenede Stater, 53066
        • Rekruttering
        • Aurora Medical Center in Summit
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Rekruttering
        • Vince Lombardi Cancer Clinic-Two Rivers
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Rekruttering
        • ProHealth Waukesha Memorial Hospital
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 262-928-7632
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Rekruttering
        • UW Cancer Center at ProHealth Care
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Rekruttering
        • Aurora Cancer Care-Milwaukee West
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Rekruttering
        • Aurora West Allis Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Adam P. Siegel
      • Weston, Wisconsin, Forenede Stater, 54476

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Berettigelseskriterier

De nøglekrav, som personer, der ønsker at deltage i et klinisk studie, skal opfylde eller de egenskaber, de skal have. Kvalifikationskriterier består af både inklusionskriterier (som er nødvendige for at en person kan deltage i undersøgelsen) og eksklusionskriterier (som forhindrer en person i at deltage). Typer af berettigelseskriterier omfatter, om en undersøgelse accepterer raske frivillige, har alders- eller aldersgruppekrav eller er begrænset af køn.

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • PRE-REGISTRATION (STEP 0): Histologically confirmed muscle-invasive urothelial carcinoma of the urethra, bladder, ureter or renal pelvis

  • PRE-REGISTRATION (STEP 0): Variant histology, including neuroendocrine differentiation, sarcomatoid, micropapillary, glandular, trophoblastic, Mullerian, is allowed if urothelial cancer is predominant histology (any amount of squamous differentiation is allowed provided the tumor is not a pure squamous cell cancer)

  • PRE-REGISTRATION (STEP 0): Radical surgery (cystectomy with lymph node dissection or nephroureterectomy or ureterectomy) must be ≥ 3 weeks and ≤ 12 weeks (central Signatera pathway) or ≤ 16 weeks (commercial Signatera pathwary) prior to pre-registration. Patients who have had a partial cystectomy as definitive therapy are not eligible

  • PRE-REGISTRATION (STEP 0): Patients who have had a partial cystectomy as definitive therapy are not eligible

  • PRE-REGISTRATION (STEP 0): No gross cancer at the surgical margins. Microscopic invasive urothelial carcinoma at the surgical margins (i.e., "positive margins") are allowed. Carcinoma in situ (CIS) at margins is considered negative margins

  • PRE-REGISTRATION (STEP 0): No evidence of residual cancer or metastasis after radical cystectomy or nephroureterectomy or ureterectomy (imaging is not required prior to pre-registration but is required prior to registration)

  • PRE-REGISTRATION (STEP 0): Have undergone a radical cystectomy nephroureterectomy, or ureterectomy with pathological evidence of urothelial carcinoma at high risk of recurrence as described in one of the two scenarios below (i or ii). The 7th edition of American Joint Committee on Cancer (AJCC) staging will be utilized.:

    • (i) Patients who have not received neoadjuvant systemic therapy: pT4N0 or pTanyN+ on radical surgery pathology specimen (i.e., cystectomy, nephroureterectomy, or ureterectomy) and are not eligible for adjuvant cisplatin chemotherapy

      • (i) Patients ineligible for cisplatin due to at least one of the following criteria and reason for ineligibility should be documented:

        • (i) Creatinine Clearance (using Cockcroft-Gault): < 60 mL/min
        • (i) Common Terminology Criteria for Adverse Events (CTCAE) version 5, grade >= 2 audiometric hearing loss
        • (i) CTCAE version 5, grade >= 2 or above peripheral neuropathy
        • New York Heart Association Class III heart failure
        • (i) Eastern Cooperative Oncology Group (ECOG) performance status = 2

      • (i) Patients who are eligible for adjuvant cisplatin may be candidates if they refuse adjuvant cisplatin-based chemotherapy, despite being informed by the investigator about the treatment options. The patient's refusal must be documented.

        • (i) Patients with pT2N0 urothelial cancer on radical surgery specimen (without prior neoadjuvant systemic therapy) with ctDNA(+) Signatera results are eligible only if the result was obtained via commercial testing (central testing is not permitted for this population) (Note: this is distinct from patients with ypT2N0 who are eligible based on ii).

    • (ii) Patients who received neoadjuvant systemic therapy: ypT2-T4N0 or Nx or ypTanyN+ on radical surgery (i.e., cystectomy. , nephroureterectomy, or ureterectomy) pathology specimen. Neoadjuvant systemic therapy may have included cisplatin-based chemotherapy, cisplatin-based chemotherapy plus PD-1/PD-L1 blockade, or enfortumab vedotin plus PD-1/PD-L1 blockade

  • PRE-REGISTRATION (STEP 0): Patients are required to meet criteria for one of two criteria:

    • 1) Commercial Signatera pathway:

      • Available commercial Signatera testing result (i.e., ctDNA+ or ctDNA-) from blood sample obtained ≥ 3 weeks and ≤ 16 weeks from time of radical surgery performed as part of standard care

        • Sites are required to verify that the commercial Signatera report demonstrates a complete 16 target assay design and that the test was designed on exome. This verification is conducted at the site level during the eligibility review. OR

    • Central Signatera pathway:

      • Pre-registration samples are to be submitted after pre-registration, at ≥ 3 weeks but ≤ 12 weeks from the time of radical surgery

        • Ineligible patients for the commercial pathway must use the central Signatera pathway and provide tumor tissue as part of the A032103 study
        • For patients who have not had neoadjuvant chemotherapy, tumor tissue is preferred from the radical surgery specimen
        • For patients who have had neoadjuvant therapy, tissue is preferred from the pre-chemotherapy specimen diagnosing muscle-invasive disease (e.g., transurethral resection of bladder tumor specimen)

  • PRE-REGISTRATION (STEP 0): Age >= 18 years

  • PRE-REGISTRATION (STEP 0): ECOG performance status 0-2

  • PRE-REGISTRATION (STEP 0): Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects

  • PRE-REGISTRATION (STEP 0): No postoperative adjuvant systemic therapy after radical surgery

  • PRE-REGISTRATION (STEP 0): No adjuvant radiation after radical surgery

  • PRE-REGISTRATION (STEP 0): No treatment with any other type of investigational agent =< 4 weeks before pre-registration

  • PRE-REGISTRATION (STEP 0): No previous treatment with LAG-3 blockade therapy

  • PRE-REGISTRATION (STEP 0): Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

  • PRE-REGISTRATION (STEP 0): Absolute neutrophil count (ANC) >= 1,200/mm^3

  • PRE-REGISTRATION (STEP 0): Platelet count >= 100,000/mm^3

  • PRE-REGISTRATION (STEP 0): Hemoglobin >= 8 g/dL

  • PRE-REGISTRATION (STEP 0): Creatinine =< 1.5 x upper limit of normal (ULN) or calculated (calc.) creatinine clearance > 30 mL/min (using either Cockcroft-Gault formula or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation

  • PRE-REGISTRATION (STEP 0): Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN

  • PRE-REGISTRATION (STEP 0): Total bilirubin =< 1.5 x upper limit of normal (ULN) (except in patients with Gilbert Syndrome, who can have total bilirubin < 3.0 mg/dL)

  • PRE-REGISTRATION (STEP 0): For women of childbearing potential only: A negative urine or serum pregnancy test done =< 14 days prior to pre-registration is required

  • PRE-REGISTRATION (STEP 0): Not currently requiring hemodialysis

  • PRE-REGISTRATION (STEP 0): No current or prior history of myocarditis

  • PRE-REGISTRATION (STEP 0): No history of a grade ≥ 3 immune related adverse event with prior PD-1/PD-L1 blockade in the neoadjuvant setting

  • PRE-REGISTRATION (STEP 0): No active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids. These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens- Johnson syndrome, or phospholipid syndrome because of the risk of recurrence or exacerbation of disease.

  • PRE-REGISTRATION (STEP 0): Patients with vitiligo, endocrine deficiencies including type I diabetes mellitus, thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible.

  • PRE-REGISTRATION (STEP 0): Patients with rheumatoid arthritis and other arthropathies, Sjögren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible.

  • PRE-REGISTRATION (STEP 0): No current pneumonitis or prior history of non-infectious pneumonitis that required steroids within the previous 5 years.

  • PRE-REGISTRATION (STEP 0): No known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [RNA] [qualitative] is detected).

  • PRE-REGISTRATION (STEP 0): For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load.

  • PRE-REGISTRATION (STEP 0): Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible.

  • PRE-REGISTRATION (STEP 0): No concurrent antineoplastic therapy including anti-hormonal treatments used for cancer therapy (e.g., leuprolide, antiandrogens)

  • PRE-REGISTRATION (STEP 0): No current immunosuppressive agents (except for corticosteroids as described below).

  • PRE-REGISTRATION (STEP 0): No condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of pre-registration (with the exception of steroid pre-medications for contrast allergies). Inhaled or topical steroids and adrenal replacement doses < 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease.

  • REGISTRATION (STEP 1): Patient must have had radical cystectomy and lymph node dissection or nephroureterectomy or ureterectomy =< 18 weeks prior to registration.

  • REGISTRATION (STEP 1): Must have evaluable ctDNA Signatera assay result (i.e., ctDNA+ or ctDNA-) based on either:

    • Commercial Signatera result OR
    • Central Signatera testing result (i.e. testing that was performed as part of A032103.)

  • REGISTRATION (STEP 1): All patients must have confirmed disease-free status defined as no measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1, or definitive non-measurable radiographic metastatic disease, within 60 days prior to registration. Patients with equivocal lymph nodes less than 15 mm in short axis, or < 10 mm in long axis for non-lymph node lesions, not considered by the investigator to represent malignant disease will be eligible. Attempts should be made to resolve the etiology of equivocal lesions with complementary imaging (e.g., PET scan) or biopsy.

  • REGISTRATION (STEP 1): No major surgery =< 3 weeks before registration.

  • REGISTRATION (STEP 1): No live vaccine within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette- Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist [registered trademark]) are live attenuated vaccines and are not allowed. Coronavirus disease 2019 (COVID-19) vaccines are not live vaccines and are allowed

  • REGISTRATION (STEP 1): No change since Step 0 pre-registration in clinical condition and/or laboratory tests that would impact the safety of nivolumab +/- relatlimab administration in the opinion of the treating investigator

  • REGISTRATION (STEP 1): No evidence of high grade urothelial cancer in the bladder for patients with primary urothelial cancers of the upper urinary tract

  • RE-REGISTRATION (STEP 2) COHORT B, ARM 4 PATIENTS INITIATING NIVOLUMAB AFTER CONVERSION OF ctDNA ASSAY FROM ctDNA(-) to ctDNA (+):

    • Patient must have converted to ctDNA(+) during serial monitoring performed centrally as part of A032103

  • RE-REGISTRATION (STEP 2) COHORT B, ARM 4 PATIENTS INITIATING NIVOLUMAB AFTER CONVERSION OF ctDNA ASSAY FROM ctDNA(-) to ctDNA (+):

    • No evidence of metastatic disease on the most recent scheduled imaging assessment as outlined in the study calendar (no repeat imaging is necessary specifically at the time of the conversion from ctDNA[-] to ctDNA[+]).

  • RE-REGISTRATION (STEP 2) COHORT B, ARM 4 PATIENTS INITIATING NIVOLUMAB AFTER CONVERSION OF ctDNA ASSAY FROM ctDNA(-) to ctDNA (+):

    • In the opinion of the treating investigator, patient clinical condition and laboratory tests would not impact the safety of nivolumab administration in the opinion of the treating investigator

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm

Deltagergruppe / Arm

En gruppe eller undergruppe af deltagere i et klinisk forsøg, der modtager en specifik intervention/behandling eller ingen intervention i henhold til forsøgets protokol.
Intervention / Behandling

Intervention / Behandling

En proces eller handling, der er i fokus for en klinisk undersøgelse. Interventioner omfatter lægemidler, medicinsk udstyr, procedurer, vacciner og andre produkter, der enten er til undersøgelse eller allerede er tilgængelige. Interventioner kan også omfatte ikke-invasive tilgange, såsom uddannelse eller ændring af kost og motion.
Aktiv komparator: Cohort A, Arm I (nivolumab)

Patients in Cohort A, Arm I receive nivolumab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.
Procedure: Computed Tomography

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type
Procedure: Magnetic Resonance Imaging

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR
Andet: Questionnaire Administration

Ancillary studies

Biologisk: Nivolumab

Given IV

Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Procedure: Cystoscopy

Undergo cystoscopy

Andre navne:
  • CS
Procedure: Biospecimen Collection

Undergo collection of tissue and blood

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion
Eksperimentel: Cohort A, Arm II (nivolumab, relatlimab)

Patients in Cohort A, Arm II receive nivolumab IV over 30 minutes and relatlimab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.
Procedure: Computed Tomography

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type
Procedure: Magnetic Resonance Imaging

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR
Andet: Questionnaire Administration

Ancillary studies

Biologisk: Nivolumab

Given IV

Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Biologisk: Relatlimab

Given IV

Andre navne:
  • BMS-986016
  • BMS986016
  • Immunoglobulin G4, Anti-(humant lymfocytaktiveringsgen-3-protein) (Human Heavy Chain), Disulfid med Human Light Chain, Dimer
  • BMS 986016
Procedure: Cystoscopy

Undergo cystoscopy

Andre navne:
  • CS
Procedure: Biospecimen Collection

Undergo collection of tissue and blood

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion
Aktiv komparator: Cohort B, Arm III (nivolumab)

Patients in Cohort B, Arm III receive nivolumab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.
Procedure: Computed Tomography

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type
Procedure: Magnetic Resonance Imaging

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR
Andet: Questionnaire Administration

Ancillary studies

Biologisk: Nivolumab

Given IV

Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Procedure: Biospecimen Collection

Undergo collection of tissue and blood

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion
Eksperimentel: Cohort B, Arm IV (ctDNA surveillance, nivolumab)

Patients in Cohort B, Arm IV undergo ctDNA surveillance consisting of collection of tissue and blood during screening and collection of blood only on study and during follow up. Patients who convert to ctDNA(+) during surveillance then receive nivolumab IV over 30 minutes on day 1 of each cycle. Treatment repeats every 28 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of tissue during screening and collection of blood throughout the trial. Patients also undergo CT or MRI and may undergo cystoscopy throughout the trial.
Procedure: Computed Tomography

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type
Procedure: Magnetic Resonance Imaging

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR
Andet: Questionnaire Administration

Ancillary studies

Biologisk: Nivolumab

Given IV

Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Procedure: Cystoscopy

Undergo cystoscopy

Andre navne:
  • CS
Procedure: Biospecimen Collection

Undergo collection of tissue and blood

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion
Andet: cfDNA or ctDNA Measurement

Undergo ctDNA surveillance

Andre navne:
  • Cellefri DNA/DNA-måling i cirkulerende tumor
  • cfDNA/ctdDNA-måling
  • cfDNA/ctDNA
  • cfDNA/ctDNA-måling
  • Cirkulerende cellefrit DNA/Cirkulerende tumorafledt DNA-måling

Hvad måler undersøgelsen?

Primære resultatmål

Primære resultatmål

I et klinisk studies protokol er det planlagte resultatmål, der er det vigtigste for at evaluere effekten af ​​en intervention/behandling. De fleste kliniske undersøgelser har ét primært resultatmål, men nogle har mere end ét.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Proportion of patients who are circulating tumor DNA negative (ctDNA[-]) (Cohort A Phase II)
Tidsramme: At week 12 from treatment start date

Will be determined for each treatment arm as the number of patients who are ctDNA(-) after 12 weeks of treatment divided by the total number of patients on the treatment arm. Patients who do not have a 12-week ctDNA result will be deemed to be ctDNA(+). The comparison of the proportions of patients who are ctDNA(-) after 12 weeks of treatment between the two arms will be performed with a chi-square test.
At week 12 from treatment start date
Overall survival (OS) (Cohort A Phase III)
Tidsramme: From randomization until death due to any cause, assessed up to 5 years after completion of study treatment

The analysis will be performed using a stratified log-rank test that uses the specified stratification variables. An additional analysis will be perform using a stratified Cox regression model to generate the point estimate and 90% confidence interval for the hazard ratio (HR) (comparing Arm 2 to Arm 1).
From randomization until death due to any cause, assessed up to 5 years after completion of study treatment
Disease-Free Survival (DFS) (Cohort B)
Tidsramme: From randomization until confirmed disease recurrence as assessed by the treating physician or death due to any cause, assessed up to 5 years after completion of study treatment

A stratified Cox model (using the randomization stratification variables will be used to generate a 90% confidence interval (CI) for the HR. If the 90% CI does not contain 1.39, Arm 4 (surveillance with ctDNA serial testing to determine whether patient is treated with nivolumab) will be deemed to be non-inferior to treating patients immediately with nivolumab.
From randomization until confirmed disease recurrence as assessed by the treating physician or death due to any cause, assessed up to 5 years after completion of study treatment

Sekundære resultatmål

Sekundære resultatmål

I en klinisk undersøgelses protokol er et planlagt resultatmål, der ikke er lige så vigtigt som det primære resultatmål for at evaluere effekten af ​​en intervention, men som stadig er af interesse. De fleste kliniske undersøgelser har mere end ét sekundært resultatmål.
Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
OS (kohorte B)
Tidsramme: Fra randomisering til død på grund af enhver årsag, vurderet op til 5 år efter afsluttet undersøgelsesbehandling
Fra randomisering til død på grund af enhver årsag, vurderet op til 5 år efter afsluttet undersøgelsesbehandling
Kumulativ forekomst af ctDNA(+)-konvertering (kohorte B)
Tidsramme: Fra randomisering til en patient bliver ctDNA(+), vurderet op til 5 år efter afsluttet undersøgelsesbehandling
Fra randomisering til en patient bliver ctDNA(+), vurderet op til 5 år efter afsluttet undersøgelsesbehandling
Gennemløbstid for ctDNA(+)-konvertering (kohorte B)
Tidsramme: Fra en patient bliver ctDNA(+) til en bekræftet radiografisk sygdomsgentagelse, vurderet op til 5 år efter afsluttet undersøgelsesbehandling
Fra en patient bliver ctDNA(+) til en bekræftet radiografisk sygdomsgentagelse, vurderet op til 5 år efter afsluttet undersøgelsesbehandling
Proportion of patients who are ctDNA(-) (Cohort A Phase III) from treatment start date
Tidsramme: At week 12

Will be determined for each treatment arm as the number of patients who are ctDNA(-) after 12 weeks of treatment divided by the total number of patients on the treatment arm. Patients who do not have a 12-week ctDNA result will be deemed to be ctDNA(+).
At week 12
OS (Cohort A Phase II)
Tidsramme: From randomization until death due to any cause, assessed up to 5 years after completion of study treatment

If the trial does not continue to phase III, OS will be a secondary endpoint.
From randomization until death due to any cause, assessed up to 5 years after completion of study treatment
DFS (Cohort A Phase II or III)
Tidsramme: From randomization until confirmed disease recurrence as assessed by the treating physician or death due to any cause, assessed up to 5 years after completion of study treatment

This will be a secondary endpoint for the phase III trial, if completed, or for the phase II trial if the phase III trial is not performed.
From randomization until confirmed disease recurrence as assessed by the treating physician or death due to any cause, assessed up to 5 years after completion of study treatment
Incidence of adverse events (Cohort A)
Tidsramme: Up to 5 years after completion of study treatment

Will be assessed using Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0. Adverse events (AEs) will be summarized with frequencies and relative frequencies. The maximum grade for an AE will be recorded for each patient by treatment arm. The number (percent) of patients that experience each observed adverse event will be summarized by treatment arm. In addition, the proportion of patients that experience a grade 3+, grade 4+, and grade 5 adverse event will be summarized as the number and percent of patients by treatment arm. The primary summary will be regardless of attribution.
Up to 5 years after completion of study treatment
Incidence of adverse events (Cohort B)
Tidsramme: Up to 5 years after completion of study treatment

Will be assessed using CTCAE v5.0. Adverse events will be summarized with frequencies and relative frequencies. The maximum grade for an AE will be recorded for each patient by treatment arm. The number (percent) of patients that experience each observed adverse event will be summarized by treatment arm. In addition, the proportion of patients that experience a grade 3+, grade 4+, and grade 5 adverse event will be summarized as the number and percent of patients by treatment arm. The primary summary will be regardless of attribution.
Up to 5 years after completion of study treatment

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Sponsor

Den organisation eller person, der igangsætter undersøgelsen, og som har myndighed og kontrol over undersøgelsen.
National Cancer Institute (NCI)

Efterforskere

Efterforskere

En forsker involveret i et klinisk studie. Beslægtede termer omfatter stedets principal investigator, site sub-investigator, studieformand, undersøgelsesleder og undersøgelseshovedinvestigator.
  • Ledende efterforsker: Matthew D Galsky, Alliance for Clinical Trials in Oncology

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

Studiestart

Den faktiske dato, hvor den første deltager blev tilmeldt en klinisk undersøgelse. Den "forventede" undersøgelses startdato er den dato, som forskerne tror vil være undersøgelsens startdato.
2. februar 2024

Primær færdiggørelse (Anslået)

Primær færdiggørelse

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention for at indsamle endelige data for det primære resultatmål. Hvorvidt det kliniske studie sluttede i henhold til protokollen eller blev afsluttet, påvirker ikke denne dato. For kliniske undersøgelser med mere end ét primært resultatmål med forskellige afslutningsdatoer refererer dette udtryk til den dato, hvor dataindsamlingen er afsluttet for alle de primære resultatmål. Den "forventede" primære afslutningsdato er den dato, som forskerne tror vil være den primære afslutningsdato for undersøgelsen.
2. september 2030

Studieafslutning (Anslået)

Studieafslutning

Den dato, hvor den sidste deltager i et klinisk studie blev undersøgt eller modtog en intervention/behandling for at indsamle endelige data for de primære resultatmål, sekundære udfaldsmål og uønskede hændelser (det vil sige den sidste deltagers sidste besøg). Den "forventede" undersøgelses afslutningsdato er den dato, som forskerne tror vil være undersøgelsens afslutningsdato.
2. september 2030

Datoer for studieregistrering

Først indsendt

Først indsendt

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsendte en undersøgelsespost til ClinicalTrials.gov. Der er typisk en forsinkelse på et par dage mellem den første indsendte dato og postens tilgængelighed på ClinicalTrials.gov (den første offentliggjorte dato).
10. august 2023

Først indsendt, der opfyldte QC-kriterier

Først indsendt, der opfyldte QC-kriterier

Den dato, hvor undersøgelsens sponsor eller investigator første gang indsender en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Sponsoren eller investigatoren skal muligvis revidere og indsende en undersøgelsespost en eller flere gange, før NLM's kvalitetskontrolkriterier er opfyldt. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
10. august 2023

Først opslået (Faktiske)

Først opslået

Datoen, hvor undersøgelsesposten først var tilgængelig på ClinicalTrials.gov efter National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgang er afsluttet. Der er typisk en forsinkelse på et par dage mellem den dato, hvor undersøgelsens sponsor eller investigator indsendte undersøgelsesposten, og den første offentliggjorte dato.
14. august 2023

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering sendt

Den seneste dato, hvor ændringer i en undersøgelsespost blev gjort tilgængelig på ClinicalTrials.gov. Der kan være en forsinkelse mellem det tidspunkt, hvornår ændringerne blev indsendt til ClinicalTrials.gov af undersøgelsens sponsor eller investigator (datoen for sidste opdatering afsendt) og den sidste opdatering, der blev sendt.
6. november 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Den seneste dato, hvor undersøgelsens sponsor eller investigator indsendte ændringer til en undersøgelsespost, der er i overensstemmelse med National Library of Medicine (NLM) kvalitetskontrol (QC) gennemgangskriterier. Det er sponsorens eller investigatorens ansvar at sikre, at undersøgelsesposten er i overensstemmelse med NLM QC-gennemgangskriterierne.
5. november 2026

Sidst verificeret

Sidst verificeret

Den seneste dato, hvor undersøgelsens sponsor eller investigator bekræftede oplysningerne om en klinisk undersøgelse på ClinicalTrials.gov som nøjagtige og aktuelle. Hvis en undersøgelse med rekrutteringsstatus som rekruttering; rekrutterer endnu ikke; eller aktiv, ikke rekruttering er ikke blevet bekræftet inden for de seneste 2 år, er undersøgelsens rekrutteringsstatus vist som ukendt.
1. oktober 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Andre undersøgelses-id-numre

Andre identifikatorer eller ID-numre end NCT-nummeret, der er tildelt til en klinisk undersøgelse af undersøgelsens sponsor, finansieringsgivere eller andre. Disse numre kan omfatte unikke identifikatorer fra andre forsøgsregistre og National Institutes of Health-bevillingsnumre.
  • NCI-2023-05980
  • U10CA180821 (U.S. NIH-bevilling/kontrakt)
  • NCI-2023-05980 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • A032103 (Anden identifikator: CTEP)
  • A032103 (Anden identifikator: Alliance for Clinical Trials in Oncology)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Cookieindstillinger

Vi bruger cookies for at sikre, at vi giver dig den bedste oplevelse på vores hjemmeside. For flere detaljer skal du læse omhyggeligt vores Politik om beskyttelse af personlige oplysninger og cookies. ...>>>Du kan når som helst ændre dine præferencer eller trække dit samtykke tilbage ved at slette cookies fra din hjemmeside eller computer som beskrevet i politikken. Accepter det og vælg dine præferencer ved at markere de tilsvarende felter i afsnittet "Administrer indstillinger" nedenfor. Læs vores servicevilkår omhyggeligt, inden du fortsætter med at bruge nogen del af dette websted.
«Administrer indstillinger