- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00005324
Genetic and Epidemiologic Studies of Premature Coronary Artery Disease - SCOR in Arteriosclerosis
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
BACKGROUND:
Preliminary work for this project was carried out as part of the Johns Hopkins Coronary Artery Disease study (R01-HL-34791) which provided extensive data on families ascertained through equal numbers of white male and female probands undergoing elective angiography.
DESIGN NARRATIVE:
The study, a subproject within an Arteriosclerosis SCOR, had three components. In Component 1, the group of 203 probands under study R01HL34791 was expanded with an additional 50 black patients undergoing angiography, meeting identical criteria. In Component 2, segregation analysis was carried out on lipoproteins, apolipoproteins, and selected non-traditional risk factors on families of all probands and the etiologic heterogeneity among different groups of families was tested. In Component 3, linkage was tested between putative Mendelian loci defined in Component 2 and markers in and around candidate loci involved in lipid metabolism. Preliminary results provided evidence of Mendelian control for apolipoprotein A1 and B, and the candidate loci examined included apo B, lipoprotein lipase, and the A1-CIII-A4 gene cluster. The major hypothesis was that these apolipoprotein levels and other non-traditional risk factors might be under genetic control. Genetic analysis of these risk factors was used to direct molecular studies to identify specific mutations.
The study completion date listed in this record was obtained from the "Completed Date" entered in the Query View Report System (QVR).
Undersøgelsestype
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Samarbejdspartnere og efterforskere
Publikationer og nyttige links
Generelle publikationer
- Mal'tsev VI, Kovalenko VM. [The main trends in the development of a therapeutic service in Ukraine]. Lik Sprava. 1994 Feb;(2):3-9. No abstract available. Ukrainian.
- Coresh J, Beaty TH, Prenger VL, Xu J, Kwiterovich PO Jr. Segregation analysis of HDL3-C levels in families of patients undergoing coronary arteriography at an early age. Arterioscler Thromb Vasc Biol. 1995 Sep;15(9):1307-13. doi: 10.1161/01.atv.15.9.1307.
Datoer for undersøgelser
Studer store datoer
Studiestart
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 4105
- 5P50HL047212-05 (U.S. NIH-bevilling/kontrakt)
- P50HL027341-15 (U.S. NIH-bevilling/kontrakt)
- P50HL014237 (U.S. NIH-bevilling/kontrakt)
- P50HL047151 (U.S. NIH-bevilling/kontrakt)
- P50HL014197 (U.S. NIH-bevilling/kontrakt)
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