Sekventerede behandlingsalternativer til at lindre depression (STAR*D)
24. september 2009 opdateret af: National Institute of Mental Health (NIMH)
Sekventerede behandlingsalternativer til at lindre depression
STAR*D fokuserer på ikke-psykotisk svær depressiv lidelse hos voksne, der ses i ambulante omgivelser.
Det primære formål med denne forskningsundersøgelse er at bestemme, hvilke behandlinger der virker bedst, hvis den første behandling med medicin ikke giver en acceptabel respons.
Deltagerne vil først modtage citalopram, en SSRI-medicin; hvis symptomerne forbliver efter 8-12 ugers behandling, tilbydes op til fire andre behandlingsniveauer, herunder kognitiv terapi og anden medicin.
Der er ingen placebobehandlinger.
Nogle patienter kan have behov for en kombination af to eller flere behandlinger for at opnå det fulde udbytte.
Deltagelsen kan vare fra 15 til 27 måneder og involvere op til 30 klinikbesøg.
Deltagerne vil gennem hele undersøgelsen blive interviewet telefonisk om deres symptomer, daglig funktion, behandlingsbivirkninger, brug af sundhedsvæsenet og tilfredshed med behandlingen.
Der vil være en etårig opfølgning for deltagerne, når deres depression er blevet behandlet med succes
Studieoversigt
Status
Afsluttet
Betingelser
Detaljeret beskrivelse
STAR*D-projektet vil indskrive 4.000 ambulante patienter (i alderen 18-75) diagnosticeret med ikke-psykotisk svær depressiv lidelse. Deltagerne vil initialt blive behandlet (åbent) med citalopram, niveau 1-behandlingen, i minimum 8 uger. Patienter, der oplever minimal fordel, vil kraftigt blive opfordret til at gennemføre 12 ugers behandling for at maksimere chancerne for symptomremission (medmindre der overhovedet ikke ses nogen fordel efter 8 uger). Alle deltagere vil også modtage et kort undervisningsprogram om depression.
Ved hver niveauændring vil deltagerne blive bedt om at angive uacceptabiliteten af de potentielle behandlingsstrategier (f.eks. at øge eller skifte medicin). Deltagerne vil derefter være berettiget til tilfældig tildeling til en af de acceptable og medicinsk sikre behandlingsmuligheder.
Niveau 2: Deltagere, som enten ikke havde en tilstrækkelig respons på eller ikke kunne tolerere citalopram, er kvalificerede til niveau 2. Niveau 2-behandlingsstrategierne er:
i) Medicin og psykoterapi Skift: Skift til sertralin, venlafaxinXR, bupropionSR eller kognitiv terapi (CT).
ii) Forøgelse af medicin og psykoterapi: tilføj til citalopram enten a) buspiron, b) bupropionSR eller c) CT.
iii) Muligheder for kun medicinskift eller kun medicinforøgelse er tilgængelige for deltagere, for hvem CT er uacceptabelt.
iv) Kun psykoterapi Switch eller Psychotherapy Only Augmentation muligheder er tilgængelige for deltagere, for hvem yderligere medicin er uacceptabel på dette tidspunkt i undersøgelsen (deltagere skal være villige til at fortsætte med citalopram)
Niveau 2A: Deltagere uden et tilfredsstillende svar på deres niveau 2-behandling er berettiget til tilfældig tildeling til yderligere behandling på niveau 2A (hvis medicinsk sikkert og acceptabelt). Niveau 2A er inkluderet, så alle deltagere på niveau 3 har haft mulighed for at reagere på mindst 2 medicin. Niveau 2A består af Medicin Skift til en af to antidepressiv medicin (venlafaxinXR eller bupropion SR).
Niveau 3: Deltagere uden tilfredsstillende respons på niveau 2 og, hvis det er relevant, niveau 2A, er berettiget til tilfældig tildeling til en af følgende behandlinger (hvis acceptabel og medicinsk sikker):
i) Medicin Skift til: a) mirtazapin eller b) nortriptylin, et tricyklisk antidepressivum.
ii) Medicinforøgelse: Tilføj (til nuværende niveau 2 eller niveau 2A medicin) enten: a) lithium eller b) thyreoideahormon (T3).
Niveau 4: Deltagere uden et tilstrækkeligt svar på niveau 3 er berettiget til tilfældig tildeling til niveau 4-behandling (hvis det er acceptabelt og medicinsk sikkert). Niveau 4 inkluderer to medicinskiftemuligheder: til tranylcypromin [en monoaminoxidasehæmmer (MAOI)] eller til mirtazapin plus venlafaxinXR.
Efter niveau 4 vil deltagere uden et tilstrækkeligt svar diskutere andre acceptable behandlingsmuligheder med deres læge.
Når et tilstrækkeligt svar er opnået på niveau 2, 2A, 3 eller 4, er deltagerne berettiget til at deltage i 12-måneders opfølgning, i hvilken tid de vil forblive på deres nuværende behandling(er) og vil blive spurgt om deres symptomer og anden relevant information månedligt telefonisk. KUN PATIENTER, DER BLIR BEHANDLET PÅ DE DELTAGENDE KLINIKER, ER KVALIFICEREDE TIL DENNE STUDIE.
Undersøgelsestype
Interventionel
Tilmelding
4000
Fase
- Fase 4
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Birmingham, Alabama, Forenede Stater, 35223
- Birmingham VA Medical Center
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Tuscaloosa, Alabama, Forenede Stater, 35404
- Tuscaloosa VA Mental Health Clinic - Veterans Only
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Tuscaloosa, Alabama, Forenede Stater, 35404
- Tuscaloosa VA Primary Care Center
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California
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Chula Vista, California, Forenede Stater, 91910
- Psychiatric Centers at San Diego
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Harbor City, California, Forenede Stater, 90710
- Harbor UCLA Family Health Care Center
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Los Angeles, California, Forenede Stater, 90024
- UCLA Internal Medicine Clinic
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Los Angeles, California, Forenede Stater, 90024
- UCLA General Outpatient Psychiatry Clinic
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San Diego, California, Forenede Stater, 92103
- UCSD Outpatient Psychiatric Services
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San Diego, California, Forenede Stater, 92161
- Veterans Affairs Medical Center/FIRM Primary Care Clinic
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Torrance, California, Forenede Stater, 90509
- Harbor UCLA Medical Center
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Illinois
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern Outpatient Treatment Care Center
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Chicago, Illinois, Forenede Stater, 60612
- University of Illinois at Chicago Clinic
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Evanston, Illinois, Forenede Stater, 60201
- Evanston Outpatient Clinic
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Kansas
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Wichita, Kansas, Forenede Stater, 67203
- COMCARE of Sedgwick County
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Wichita, Kansas, Forenede Stater, 67214-2878
- Psychiatric Outpatient Clinic
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Massachusetts
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Boston, Massachusetts, Forenede Stater, 01907
- Swampscott Family Doctors
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Boston, Massachusetts, Forenede Stater, 02114
- Internal Medicine Associates
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Charlestown, Massachusetts, Forenede Stater, 02129
- MGH/Charlestown Clinic
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Salem, Massachusetts, Forenede Stater, 01970
- MGH/Salem Professional
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Michigan
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Ann Arbor, Michigan, Forenede Stater, 48105-0722
- General Psychiatric Ambulatory Clinic
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Ann Arbor, Michigan, Forenede Stater, 48109-0708
- Briarwood Family Practice Clinic
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New York
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Glen Oaks, New York, Forenede Stater, 11004
- LIJ/Zucker Hillside Adult Ambulatory Care Center
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Lake Success, New York, Forenede Stater, 11040
- LIJ North Shore Medical Group
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North Carolina
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Chapel Hill, North Carolina, Forenede Stater, 27599-7160
- UNC Chapel Hill Adult Diagnostic & Treatment Clinic
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Chapel Hill, North Carolina, Forenede Stater, 27599-7110
- UNC Chapel Hill General Medicine Clinic
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Chapel Hill, North Carolina, Forenede Stater, 27955
- UNC Chapel Hill Family Practice Clinic
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Oklahoma
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Tulsa, Oklahoma, Forenede Stater, 74135
- Springer Family Medicine
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Tulsa, Oklahoma, Forenede Stater, 74136
- Laureate Psychiatric Clinic & Hospital
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Tulsa, Oklahoma, Forenede Stater, 74136
- Warren Clinic
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Pennsylvania
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Pittsburgh, Pennsylvania, Forenede Stater, 15213
- Bellefield Clinic of WPIC
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Pittsburgh, Pennsylvania, Forenede Stater, 15062
- Diversified Human Services Clinic
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Pittsburgh, Pennsylvania, Forenede Stater, 15132
- Latterman Family Health Center
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Upper St. Clair, Pennsylvania, Forenede Stater, 15317
- AMPN Corkery, Heise & Dainesi
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Tennessee
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Nashville, Tennessee, Forenede Stater, 37212
- Vine Hill Community Clinic
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Nashville, Tennessee, Forenede Stater, 37203
- Psychiatric Consultants, P.C.
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Nashville, Tennessee, Forenede Stater, 37212
- Vanderbilt University Medical Center-Mental Health Center
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Nashville, Tennessee, Forenede Stater, 37217
- Centerstone/Luton Mental Health Services
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Texas
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Dallas, Texas, Forenede Stater, 75390
- UT Southwestern Family Medicine Clinic
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Dallas, Texas, Forenede Stater, 75230
- The Holiner Psychiatric Group
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Virginia
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Richmond, Virginia, Forenede Stater, 23220
- MCV Primary Care Clinic
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Richmond, Virginia, Forenede Stater, 23298-0268
- MCV Family Counseling
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
14 år til 71 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
- Ambulante patienter i alderen 18 til 75 år med ikke-psykotisk svær depressiv lidelse (HAMD-score 14 eller højere)
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Efterforskere
- Studieleder: A. John Rush, MD, University of Texas Southwestern Medical Center Department of Psychiatry
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Rush AJ, Trivedi MH, Wisniewski SR, Stewart JW, Nierenberg AA, Thase ME, Ritz L, Biggs MM, Warden D, Luther JF, Shores-Wilson K, Niederehe G, Fava M; STAR*D Study Team. Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. N Engl J Med. 2006 Mar 23;354(12):1231-42. doi: 10.1056/NEJMoa052963.
- Callan JA, Kazantzis N, Park SY, Moore CG, Thase ME, Minhajuddin A, Kornblith S, Siegle GJ. A Propensity Score Analysis of Homework Adherence-Outcome Relations in Cognitive Behavioral Therapy for Depression. Behav Ther. 2019 Mar;50(2):285-299. doi: 10.1016/j.beth.2018.05.010. Epub 2018 Jun 5.
- Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR. Cross-trial prediction of treatment outcome in depression: a machine learning approach. Lancet Psychiatry. 2016 Mar;3(3):243-50. doi: 10.1016/S2215-0366(15)00471-X. Epub 2016 Jan 21.
- Perlis RH, Fraguas R, Fava M, Trivedi MH, Luther JF, Wisniewski SR, Rush AJ. Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study. J Clin Psychiatry. 2005 Feb;66(2):159-66; quiz 147, 273-4.
- Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006 Nov;163(11):1905-17. doi: 10.1176/ajp.2006.163.11.1905.
- Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramani GK, Fava M; STAR*D Study Team. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry. 2006 Jan;163(1):28-40. doi: 10.1176/appi.ajp.163.1.28.
- Adli M, Rush AJ, Moller HJ, Bauer M. Algorithms for optimizing the treatment of depression: making the right decision at the right time. Pharmacopsychiatry. 2003 Nov;36 Suppl 3:S222-9. doi: 10.1055/s-2003-45134.
- Fava M, Rush AJ, Trivedi MH, Nierenberg AA, Thase ME, Sackeim HA, Quitkin FM, Wisniewski S, Lavori PW, Rosenbaum JF, Kupfer DJ. Background and rationale for the sequenced treatment alternatives to relieve depression (STAR*D) study. Psychiatr Clin North Am. 2003 Jun;26(2):457-94, x. doi: 10.1016/s0193-953x(02)00107-7.
- Rush AJ, Trivedi M, Fava M. Depression, IV: STAR*D treatment trial for depression. Am J Psychiatry. 2003 Feb;160(2):237. doi: 10.1176/appi.ajp.160.2.237. No abstract available.
- Lavori PW, Rush AJ, Wisniewski SR, Alpert J, Fava M, Kupfer DJ, Nierenberg A, Quitkin FM, Sackeim HA, Thase ME, Trivedi M. Strengthening clinical effectiveness trials: equipoise-stratified randomization. Biol Psychiatry. 2001 Nov 15;50(10):792-801. doi: 10.1016/s0006-3223(01)01223-9.
- Rush AJ, Fava M, Wisniewski SR, Lavori PW, Trivedi MH, Sackeim HA, Thase ME, Nierenberg AA, Quitkin FM, Kashner TM, Kupfer DJ, Rosenbaum JF, Alpert J, Stewart JW, McGrath PJ, Biggs MM, Shores-Wilson K, Lebowitz BD, Ritz L, Niederehe G; STAR*D Investigators Group. Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design. Control Clin Trials. 2004 Feb;25(1):119-42. doi: 10.1016/s0197-2456(03)00112-0.
- Wisniewski SR, Stegman D, Trivedi M, Husain MM, Eng H, Shores-Wilson K, Luther J, Biggs MM, Burroughs D, Ritz AL, Fava M, Quitkin F, Rush AJ; STAR*D Investigators. Methods of testing feasibility for sequenced treatment alternatives to relieve depression (STAR*D). J Psychiatr Res. 2004 May-Jun;38(3):241-8. doi: 10.1016/j.jpsychires.2003.06.001.
- Wisniewski SR, Eng H, Meloro L, Gatt R, Ritz L, Stegman D, Trivedi M, Biggs MM, Friedman E, Shores-Wilson K, Warden D, Bartolowits D, Martin JP, Rush AJ. Web-based communications and management of a multi-center clinical trial: the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project. Clin Trials. 2004;1(4):387-98. doi: 10.1191/1740774504cn035oa.
- Nierenberg AA, Trivedi MH, Ritz L, Burroughs D, Greist J, Sackeim H, Kornstein S, Schwartz T, Stegman D, Fava M, Wisniewski SR. Suicide risk management for the sequenced treatment alternatives to relieve depression study: applied NIMH guidelines. J Psychiatr Res. 2004 Nov-Dec;38(6):583-9. doi: 10.1016/j.jpsychires.2004.03.004.
- Yates WR, Mitchell J, Rush AJ, Trivedi MH, Wisniewski SR, Warden D, Hauger RB, Fava M, Gaynes BN, Husain MM, Bryan C. Clinical features of depressed outpatients with and without co-occurring general medical conditions in STAR*D. Gen Hosp Psychiatry. 2004 Nov-Dec;26(6):421-9. doi: 10.1016/j.genhosppsych.2004.06.008.
- Fava M, Alpert JE, Carmin CN, Wisniewski SR, Trivedi MH, Biggs MM, Shores-Wilson K, Morgan D, Schwartz T, Balasubramani GK, Rush AJ. Clinical correlates and symptom patterns of anxious depression among patients with major depressive disorder in STAR*D. Psychol Med. 2004 Oct;34(7):1299-308. doi: 10.1017/s0033291704002612.
- Friedman EF, Thase ME, Biggs MM, Carmin C, Hollon SD, Kornblith SJ, Petersen T, Veenstra G, Wisniewski SR, and Rush AJ. The implementation of cognitive therapy in STAR*D. Cognitive Therapy and Research, 28:819-833, 2004.
- Zisook S, Rush AJ, Albala A, Alpert J, Balasubramani GK, Fava M, Husain M, Sackeim H, Trivedi M, Wisniewski S. Factors that differentiate early vs. later onset of major depression disorder. Psychiatry Res. 2004 Dec 15;129(2):127-40. doi: 10.1016/j.psychres.2004.07.004.
- Davis LL, Rush JA, Wisniewski SR, Rice K, Cassano P, Jewell ME, Biggs MM, Shores-Wilson K, Balasubramani GK, Husain MM, Quitkin FM, McGrath PJ. Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort. Compr Psychiatry. 2005 Mar-Apr;46(2):81-9. doi: 10.1016/j.comppsych.2004.07.025.
- Warden D, Rush AJ, Trivedi M, Ritz L, Stegman D, Wisniewski SR. Quality improvement methods as applied to a multicenter effectiveness trial--STAR*D. Contemp Clin Trials. 2005 Feb;26(1):95-112. doi: 10.1016/j.cct.2004.11.011. Epub 2005 Jan 27.
- Gaynes BN, Rush AJ, Trivedi M, Wisniewski SR, Balasubramani GK, Spencer DC, Petersen T, Klinkman M, Warden D, Schneider RK, Castro DB, Golden RN. A direct comparison of presenting characteristics of depressed outpatients from primary vs. specialty care settings: preliminary findings from the STAR*D clinical trial. Gen Hosp Psychiatry. 2005 Mar-Apr;27(2):87-96. doi: 10.1016/j.genhosppsych.2004.10.003.
- Kornstein SG, Harvey AT, Rush AJ, Wisniewski SR, Trivedi MH, Svikis DS, McKenzie ND, Bryan C, Harley R. Self-reported premenstrual exacerbation of depressive symptoms in patients seeking treatment for major depression. Psychol Med. 2005 May;35(5):683-92. doi: 10.1017/s0033291704004106.
- Rush AJ, Zimmerman M, Wisniewski SR, Fava M, Hollon SD, Warden D, Biggs MM, Shores-Wilson K, Shelton RC, Luther JF, Thomas B, Trivedi MH. Comorbid psychiatric disorders in depressed outpatients: demographic and clinical features. J Affect Disord. 2005 Jul;87(1):43-55. doi: 10.1016/j.jad.2005.03.005.
- Marcus SM, Young EA, Kerber KB, Kornstein S, Farabaugh AH, Mitchell J, Wisniewski SR, Balasubramani GK, Trivedi MH, Rush AJ. Gender differences in depression: findings from the STAR*D study. J Affect Disord. 2005 Aug;87(2-3):141-50. doi: 10.1016/j.jad.2004.09.008.
- Lesser IM, Leuchter AF, Trivedi MH, Davis LL, Wisniewski SR, Balasubramani GK, Petersen T, Stegman D, Rush AJ. Characteristics of insured and noninsured outpatients with depression in STAR(*)D. Psychiatr Serv. 2005 Aug;56(8):995-1004. doi: 10.1176/appi.ps.56.8.995.
- Novick JS, Stewart JW, Wisniewski SR, Cook IA, Manev R, Nierenberg AA, Rosenbaum JF, Shores-Wilson K, Balasubramani GK, Biggs MM, Zisook S, Rush AJ; STAR*D investigators. Clinical and demographic features of atypical depression in outpatients with major depressive disorder: preliminary findings from STAR*D. J Clin Psychiatry. 2005 Aug;66(8):1002-11. doi: 10.4088/jcp.v66n0807.
- Husain MM, Rush AJ, Sackeim HA, Wisniewski SR, McClintock SM, Craven N, Holiner J, Mitchell JR, Balasubramani GK, Hauger R. Age-related characteristics of depression: a preliminary STAR*D report. Am J Geriatr Psychiatry. 2005 Oct;13(10):852-60. doi: 10.1176/appi.ajgp.13.10.852.
- Gaynes, B.N., Davis, L., Rush A.J., Trivedi, M., Fava, M., Wisniewski, S.R. The aims and design of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Primary Psychiatry, 12(2):36-41, 2005.
- Friedman EF, Thase ME, Biggs MM, Carmin C, Hollon SD, Kornblith SJ, Petersen T, Veenstra G, Wisniewski SR, Rush AJ. The implementation of cognitive therapy in STAR*D. Cognit Ther Res 2004;28:819-33.
- Gaynes BN, Davis L, Rush AJ, Trivedi MH, Fava M, Wisniewski SR. The aims and design of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Primary Psychiatry 2005;12(2):36-41. http://www.primarypsychiatry.com/pdf/art_4845.pdf
- Gilmer WS, Trivedi MH, Rush AJ, Wisniewski SR, Luther J, Howland RH, Yohanna D, Khan A, Alpert J. Factors associated with chronic depressive episodes: a preliminary report from the STAR-D project. Acta Psychiatr Scand. 2005 Dec;112(6):425-33. doi: 10.1111/j.1600-0447.2005.00633.x.
- Hollon SD, Shelton RC, Wisniewski S, Warden D, Biggs MM, Friedman ES, Husain M, Kupfer DJ, Nierenberg AA, Petersen TJ, Shores-Wilson K, Rush AJ. Presenting characteristics of depressed outpatients as a function of recurrence: preliminary findings from the STAR*D clinical trial. J Psychiatr Res. 2006 Feb;40(1):59-69. doi: 10.1016/j.jpsychires.2005.07.008. Epub 2005 Oct 21.
- Rush AJ, Bernstein IH, Trivedi MH, Carmody TJ, Wisniewski S, Mundt JC, Shores-Wilson K, Biggs MM, Woo A, Nierenberg AA, Fava M. An evaluation of the quick inventory of depressive symptomatology and the hamilton rating scale for depression: a sequenced treatment alternatives to relieve depression trial report. Biol Psychiatry. 2006 Mar 15;59(6):493-501. doi: 10.1016/j.biopsych.2005.08.022. Epub 2005 Sep 30.
- Davis LL, Frazier E, Husain MM, Warden D, Trivedi M, Fava M, Cassano P, McGrath PJ, Balasubramani GK, Wisniewski SR, Rush AJ. Substance use disorder comorbidity in major depressive disorder: a confirmatory analysis of the STAR*D cohort. Am J Addict. 2006 Jul-Aug;15(4):278-85. doi: 10.1080/10550490600754317.
- Pilowsky DJ, Wickramaratne PJ, Rush AJ, Hughes CW, Garber J, Malloy E, King CA, Cerda G, Sood AB, Alpert JE, Wisniewski SR, Trivedi MH, Talati A, Carlson MM, Liu HH, Fava M, Weissman MM. Children of currently depressed mothers: a STAR*D ancillary study. J Clin Psychiatry. 2006 Jan;67(1):126-36. doi: 10.4088/jcp.v67n0119.
- Trivedi MH, Rush AJ, Wisniewski SR, Warden D, McKinney W, Downing M, Berman SR, Farabaugh A, Luther JF, Nierenberg AA, Callan JA, Sackeim HA. Factors associated with health-related quality of life among outpatients with major depressive disorder: a STAR*D report. J Clin Psychiatry. 2006 Feb;67(2):185-95. doi: 10.4088/jcp.v67n0203.
- Weissman MM, Pilowsky DJ, Wickramaratne PJ, Talati A, Wisniewski SR, Fava M, Hughes CW, Garber J, Malloy E, King CA, Cerda G, Sood AB, Alpert JE, Trivedi MH, Rush AJ; STAR*D-Child Team. Remissions in maternal depression and child psychopathology: a STAR*D-child report. JAMA. 2006 Mar 22;295(12):1389-98. doi: 10.1001/jama.295.12.1389. Erratum In: JAMA. 2006 Sep 13;296(10):1234.
- Trivedi MH, Fava M, Wisniewski SR, Thase ME, Quitkin F, Warden D, Ritz L, Nierenberg AA, Lebowitz BD, Biggs MM, Luther JF, Shores-Wilson K, Rush AJ; STAR*D Study Team. Medication augmentation after the failure of SSRIs for depression. N Engl J Med. 2006 Mar 23;354(12):1243-52. doi: 10.1056/NEJMoa052964.
- Fava M, Rush AJ, Wisniewski SR, Nierenberg AA, Alpert JE, McGrath PJ, Thase ME, Warden D, Biggs M, Luther JF, Niederehe G, Ritz L, Trivedi MH. A comparison of mirtazapine and nortriptyline following two consecutive failed medication treatments for depressed outpatients: a STAR*D report. Am J Psychiatry. 2006 Jul;163(7):1161-72. doi: 10.1176/ajp.2006.163.7.1161.
- McGrath PJ, Stewart JW, Fava M, Trivedi MH, Wisniewski SR, Nierenberg AA, Thase ME, Davis L, Biggs MM, Shores-Wilson K, Luther JF, Niederehe G, Warden D, Rush AJ. Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry. 2006 Sep;163(9):1531-41; quiz 1666. doi: 10.1176/ajp.2006.163.9.1531.
- Nierenberg AA, Fava M, Trivedi MH, Wisniewski SR, Thase ME, McGrath PJ, Alpert JE, Warden D, Luther JF, Niederehe G, Lebowitz B, Shores-Wilson K, Rush AJ. A comparison of lithium and T(3) augmentation following two failed medication treatments for depression: a STAR*D report. Am J Psychiatry. 2006 Sep;163(9):1519-30; quiz 1665. doi: 10.1176/ajp.2006.163.9.1519.
- McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJM, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet. 2006 May;78(5):804-814. doi: 10.1086/503820. Epub 2006 Mar 20.
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- Davis LL, Wisniewski SR, Howland RH, Trivedi MH, Husain MM, Fava M, McGrath PJ, Balasubramani GK, Warden D, Rush AJ. Does comorbid substance use disorder impair recovery from major depression with SSRI treatment? An analysis of the STAR*D level one treatment outcomes. Drug Alcohol Depend. 2010 Mar 1;107(2-3):161-70. doi: 10.1016/j.drugalcdep.2009.10.003. Epub 2009 Nov 28.
- Leuchter AF, Husain MM, Cook IA, Trivedi MH, Wisniewski SR, Gilmer WS, Luther JF, Fava M, Rush AJ. Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report. Psychol Med. 2010 Feb;40(2):239-51. doi: 10.1017/S0033291709006035. Epub 2009 Jun 3.
- Nierenberg AA, Husain MM, Trivedi MH, Fava M, Warden D, Wisniewski SR, Miyahara S, Rush AJ. Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR*D report. Psychol Med. 2010 Jan;40(1):41-50. doi: 10.1017/S0033291709006011. Epub 2009 May 22.
- Stewart JW, McGrath PJ, Fava M, Wisniewski SR, Zisook S, Cook I, Nierenberg AA, Trivedi MH, Balasubramani GK, Warden D, Lesser I, John Rush A. Do atypical features affect outcome in depressed outpatients treated with citalopram? Int J Neuropsychopharmacol. 2010 Feb;13(1):15-30. doi: 10.1017/S1461145709000182. Epub 2009 Apr 3.
- Wisniewski SR, Rush AJ, Nierenberg AA, Gaynes BN, Warden D, Luther JF, McGrath PJ, Lavori PW, Thase ME, Fava M, Trivedi MH. Can phase III trial results of antidepressant medications be generalized to clinical practice? A STAR*D report. Am J Psychiatry. 2009 May;166(5):599-607. doi: 10.1176/appi.ajp.2008.08071027. Epub 2009 Apr 1.
- Husain MM, Rush AJ, Wisniewski SR, McClintock SM, Fava M, Nierenberg AA, Davis L, Balasubramani GK, Young E, Albala AA, Trivedi MH. Family history of depression and therapeutic outcome: findings from STAR*D. J Clin Psychiatry. 2009 Feb;70(2):185-95. doi: 10.4088/jcp.07m03571. Epub 2008 Dec 2.
- McGrath PJ, Khan AY, Trivedi MH, Stewart JW, Morris DW, Wisniewski SR, Miyahara S, Nierenberg AA, Fava M, Rush AJ. Response to a selective serotonin reuptake inhibitor (citalopram) in major depressive disorder with melancholic features: a STAR*D report. J Clin Psychiatry. 2008 Dec;69(12):1847-55. doi: 10.4088/jcp.v69n1201. Epub 2008 Nov 18.
- Gilmer WS, Gollan JK, Wisniewski SR, Howland RH, Trivedi MH, Miyahara S, Fleck J, Thase ME, Alpert JE, Nierenberg AA, Warden D, Fava M, Rush AJ. Does the duration of index episode affect the treatment outcome of major depressive disorder? A STAR*D report. J Clin Psychiatry. 2008 Aug;69(8):1246-56. doi: 10.4088/jcp.v69n0807.
- Rush AJ, Wisniewski SR, Warden D, Luther JF, Davis LL, Fava M, Nierenberg AA, Trivedi MH. Selecting among second-step antidepressant medication monotherapies: predictive value of clinical, demographic, or first-step treatment features. Arch Gen Psychiatry. 2008 Aug;65(8):870-80. doi: 10.1001/archpsyc.65.8.870.
- Davis LL, Frazier EC, Gaynes BN, Trivedi MH, Wisniewski SR, Fava M, Barkin J, Kashner TM, Shelton RC, Alpert JE, Rush AJ. Are depressed outpatients with and without a family history of substance use disorder different? A baseline analysis of the STAR*D cohort. J Clin Psychiatry. 2007 Dec;68(12):1931-8. doi: 10.4088/jcp.v68n1214.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. juli 2001
Studieafslutning
1. september 2006
Datoer for studieregistrering
Først indsendt
20. juli 2001
Først indsendt, der opfyldte QC-kriterier
21. juli 2001
Først opslået (Skøn)
23. juli 2001
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
25. september 2009
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
24. september 2009
Sidst verificeret
1. september 2006
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Adfærdsmæssige symptomer
- Psykiske lidelser
- Stemningsforstyrrelser
- Depression
- Depressiv lidelse
- Lægemidlers fysiologiske virkninger
- Adrenerge antagonister
- Adrenerge midler
- Neurotransmittermidler
- Molekylære mekanismer for farmakologisk virkning
- Depressive midler til centralnervesystemet
- Enzymhæmmere
- Beroligende midler
- Psykotropiske stoffer
- Serotoninoptagelseshæmmere
- Neurotransmitter optagelseshæmmere
- Membrantransportmodulatorer
- Serotoninmidler
- Antidepressive midler
- Serotoninreceptoragonister
- Serotonin 5-HT2-receptorantagonister
- Serotonin-antagonister
- Anti-angst midler
- Antidepressive midler, anden generation
- Antidepressive midler, tricykliske
- Serotonin 5-HT3-receptorantagonister
- Monoaminoxidasehæmmere
- Histamin H1-antagonister
- Histaminantagonister
- Histaminmidler
- Adrenerge optagelseshæmmere
- Adrenerge alfa-antagonister
- Adrenerge alfa-2-receptorantagonister
- Buspiron
- Sertralin
- Citalopram
- Mirtazapin
- Nortriptylin
- Tranylcypromin
Andre undersøgelses-id-numre
- N01 MH90003
- DSIR AT (NCT00590863)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .