Generisk database over spædbørn med meget lav fødselsvægt (GDB)
12. marts 2026 opdateret af: NICHD Neonatal Research Network
Generisk database: En undersøgelse af morbiditet og dødelighed hos spædbørn med meget lav fødselsvægt
Den generiske database (GDB) er et register over spædbørn med meget lav fødselsvægt født i live i NICHD Neonatal Research Network (NRN) centre.
GDB indsamler observationsbaselinedata om både mødre og spædbørn og de anvendte terapier og resultaterne af spædbørnene.
De indsamlede oplysninger er ikke specifikke for en sygdom eller behandling (dvs. de er "generiske").
Data analyseres for at finde sammenhænge og tendenser mellem baseline-information, behandlinger og spædbørnsresultater og for at udvikle fremtidige NRN-forsøg.
Studieoversigt
Status
Rekruttering
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Den generiske database (GDB) er et register over spædbørn med meget lav fødselsvægt født i live i NICHD Neonatal Research Network (NRN) centre. Formålet er at indsamle baseline- og resultatdata på en ensartet måde på en stor kohorte af VLBW og andre syge spædbørn indlagt på neonatale intensivafdelinger.
GDB indsamler observationsbaselinedata om både mødre og spædbørn og de anvendte terapier og resultaterne af spædbørnene. De indsamlede oplysninger er ikke specifikke for en sygdom eller behandling (dvs. de er "generiske"). Baseline data indsamles kort efter indlæggelse på NICU; udfaldsdata indsamles på tidspunktet for dødsfald eller udskrivelse fra hospitalet. De indsamlede data omfatter oplysninger om:
- Demografi af mor og spædbarn
- Mors helbred (f.eks. graviditetshistorie og komplikationer)
- Fødsel og fødsel (f.eks. brud på membranerne, givet steroider og antibiotika, leveringsmåde)
- Spædbørns helbred (gestationsalder, Apgar-score, vægt, længde, genoplivning på fødestue, åndedrætsstøtte osv.)
- Spædbarns medicinske udfald (hjerte, lunge, nervesystem, mave-tarmsystem, hørelse og syn, kendte infektioner og større misdannelser/syndromer og dødelighed eller antal dage indlagt).
Disse data bruges: til at undersøge sammenhænge mellem baseline karakteristika, behandlinger og resultater; at spore tendenser i forekomster af sygdom og effektiviteten af terapier; og at identificere spørgsmål, der kræver yderligere dybdegående forskning.
Informeret samtykke: Som krævet af lokale IRB'er.
Sekundære studier omfatter:
A. All Birth Cohort (ABC) undersøgelsen. Et tidsbegrænset observationsregister til at bestemme forekomsten af intrapartum dødfødsel ved 20 0/7 - 28 6/7 ugers svangerskab og dets tilknyttede faktorer på netværkssteder.
Undersøgelsestype
Observationel
Tilmelding (Anslået)
80000
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Abhik Das, PhD
- Telefonnummer: 301-230-4640
- E-mail: adas@rti.org
Undersøgelse Kontakt Backup
- Navn: Ravi M Patal, MD
- Telefonnummer: 404-727-5905
- E-mail: rmpatel@emory.edu
Studiesteder
-
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Alabama
-
Birmingham, Alabama, Forenede Stater, 35233
- Rekruttering
- University of Alabama at Birmingham
-
Kontakt:
- Waldemar A. Carlo, MD
-
Ledende efterforsker:
- Waldemar A. Carlo, MD
-
-
California
-
Los Angeles, California, Forenede Stater, 90025
- Afsluttet
- University of California - Los Angeles
-
Palo Alto, California, Forenede Stater, 94304
- Rekruttering
- Stanford University
-
Kontakt:
- Krisa P. Van Meurs, MD
-
Ledende efterforsker:
- Krisa P. Van Meurs, MD
-
San Diego, California, Forenede Stater, 92103-8774
- Afsluttet
- University of California at San Diego
-
San Diego, California, Forenede Stater, 92123
- Rekruttering
- Sharp Mary Birch Hospital for Women & Newborns
-
Kontakt:
- Anup Katheria, MD
-
Ledende efterforsker:
- Anup Katheria, MD
-
-
Connecticut
-
New Haven, Connecticut, Forenede Stater, 06504
- Afsluttet
- Yale University
-
-
District of Columbia
-
Washington D.C., District of Columbia, Forenede Stater, 20052
- Afsluttet
- George Washington University
-
-
Florida
-
Miami, Florida, Forenede Stater, 33136
- Afsluttet
- University of Miami
-
-
Georgia
-
Atlanta, Georgia, Forenede Stater, 30303
- Rekruttering
- Emory University
-
Kontakt:
- David P Carlton, MD
-
Ledende efterforsker:
- David P Carlton, MD
-
-
Illinois
-
Chicago, Illinois, Forenede Stater, 60611
- Ikke rekrutterer endnu
- Northwestern Lurie Children's Hospital of Chicago
-
Kontakt:
- Aaron Hamvas, MD
-
Ledende efterforsker:
- Aaron Hamvas, MD
-
-
Indiana
-
Indianapolis, Indiana, Forenede Stater, 46202
- Afsluttet
- Indiana University
-
-
Iowa
-
Iowa City, Iowa, Forenede Stater, 52242
- Rekruttering
- University of Iowa
-
Kontakt:
- Edward F. Bell, MD
-
Ledende efterforsker:
- Edward F. Bell, MD
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02111
- Afsluttet
- Tufts Medical Center
-
Cambridge, Massachusetts, Forenede Stater, 02138
- Afsluttet
- Harvard University
-
-
Michigan
-
Detroit, Michigan, Forenede Stater, 48201
- Afsluttet
- Wayne State University
-
-
Mississippi
-
Jackson, Mississippi, Forenede Stater, 39216
- Ikke rekrutterer endnu
- University of Mississippi Medical Center - Children's of Mississippi
-
Ledende efterforsker:
- Abhay Bhatt, MD
-
Kontakt:
- Abhay Bhatt, MD
-
-
Missouri
-
Kansas City, Missouri, Forenede Stater, 64108
- Afsluttet
- Children's Mercy Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87131
- Rekruttering
- University of New Mexico
-
Kontakt:
- Kristi L. Watterberg, MD
-
Ledende efterforsker:
- Kristi L. Watterberg, MD
-
-
New York
-
Rochester, New York, Forenede Stater, 14642
- Aktiv, ikke rekrutterende
- University of Rochester
-
-
North Carolina
-
Durham, North Carolina, Forenede Stater, 27710
- Rekruttering
- Duke University
-
Kontakt:
- C. Michael Cotten, MD, MHS
-
Ledende efterforsker:
- C. Michael Cotten, MD, MHS
-
Durham, North Carolina, Forenede Stater, 27705
- Aktiv, ikke rekrutterende
- RTI International
-
-
Ohio
-
Cincinnati, Ohio, Forenede Stater, 45267
- Rekruttering
- Cincinnati Children's Medical Center
-
Kontakt:
- Brenda Poindexter, MD MS
-
Ledende efterforsker:
- Brenda Poindexter, MD MS
-
Cleveland, Ohio, Forenede Stater, 44106
- Rekruttering
- Case Western Reserve University, Rainbow Babies and Children's Hospital
-
Kontakt:
- Michele C. Walsh, MD MS
-
Ledende efterforsker:
- Michele C. Walsh, MD MS
-
Columbus, Ohio, Forenede Stater, 43205
- Aktiv, ikke rekrutterende
- Research Institute at Nationwide Children's Hospital
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Pennsylvania
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- Rekruttering
- Univeristy of Pennsylvania
-
Kontakt:
- Eric Eichenwald, MD
-
Ledende efterforsker:
- Eric Eichenwald, MD
-
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Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02905
- Aktiv, ikke rekrutterende
- Brown University, Women & Infants Hospital of Rhode Island
-
-
Tennessee
-
Memphis, Tennessee, Forenede Stater, 38163
- Afsluttet
- University of Tennessee
-
-
Texas
-
Dallas, Texas, Forenede Stater, 75235
- Rekruttering
- University of Texas Southwestern Medical Center at Dallas
-
Kontakt:
- Myra H Wyckoff, MD
-
Ledende efterforsker:
- Myra H Wyckoff, MD
-
Houston, Texas, Forenede Stater, 77030
- Rekruttering
- University of Texas Health Science Center at Houston
-
Kontakt:
- Jon E. Tyson, MD MPH
-
Ledende efterforsker:
- Jon E. Tyson, MD MPH
-
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Utah
-
Salt Lake City, Utah, Forenede Stater, 84108
- Rekruttering
- University of Utah
-
Kontakt:
- Bradley Yoder, MD
-
Ledende efterforsker:
- Bradley Yoder, MD
-
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Vermont
-
Burlington, Vermont, Forenede Stater, 05405
- Afsluttet
- University of Vermont
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
Ikke ældre end 2 uger (Barn)
Tager imod sunde frivillige
Ingen
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
Spædbørn, der er født på NICHD NRN-centre, der vejer 401-1000 gram fødselsvægt og/eller <29 ugers gestationsalder, ELLER spædbørn, der er tilmeldt en eller flere yderligere NICHD NRN-undersøgelser.
Beskrivelse
Inklusionskriterier:
- Spædbørn, der er født på NICHD NRN-centre, der er:
- 401-1000 gram fødselsvægt, og/eller
- 20 0/7 til 28 6/7 uger (<29 uger) gestationsalder
- Spædbørn tilmeldt et eller flere yderligere NICHD NRN-interventionsforsøg eller tidsbegrænsede observationsstudier. For spædbørn, der ikke opfylder inklusionskriterierne ovenfor, bestemmes inklusions- og eksklusionskriterier for den generiske database af kriterierne for de yderligere forsøg. I disse tilfælde kan spædbørn, der er større end 1.000 gram og/eller ældre end 29 uger, indgå i GDB.
Ekskluderingskriterier:
- Spædbørn >1.000 gram fødselsvægt og/eller >29 ugers svangerskabsalder
Bemærk: Disse inklusionskriterier blev ændret pr. 1/1/2008. Før denne dato var alle spædbørn med fødselsvægte mellem 401 og 1500 gram, som er indlagt på NRN NICU'er inden for 14 dage efter fødslen, inkluderet i databasen.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: Kohorte
- Tidsperspektiver: Fremadrettet
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
Registreringskohort
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
For at opretholde et register over baseline og udfaldsdata for VLBW -spædbørn med data indsamlet på en ensartet måde
Tidsramme: Langsgående database, der i øjeblikket er finansieret gennem 31-10-2030
|
For at opretholde et register over baseline og udfaldsdata for VLBW -spædbørn med indsamlet data
|
Langsgående database, der i øjeblikket er finansieret gennem 31-10-2030
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
At undersøge sammenhængen mellem baseline-karakteristika og resultat
Tidsramme: Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
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At overvåge tendenser i forekomst af forskellige sygdomsenheder
Tidsramme: Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
|
For at overvåge ændringer i VLBW og overlevelse i tidlig gestationsalder
Tidsramme: Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
|
At levere data til hypoteseformulering og beregning af stikprøvestørrelse til netværks multicenterundersøgelser
Tidsramme: Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
Longitudinel database finansieret i øjeblikket til og med 31/3/2021
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Jon E Tyson, MD MPH, The University of Texas Health Science Center, Houston
- Ledende efterforsker: Carl D'Angio, MD, University of Rochester
- Ledende efterforsker: Robin Ohls, MD, University of Utah
- Ledende efterforsker: Waldemar A Carlo, MD, University of Alabama at Birmingham
- Ledende efterforsker: Abhik Das, PhD, RTI International
- Ledende efterforsker: Abbot R Laptook, MD, Brown University, Women & Infants Hospital of Rhode Island
- Ledende efterforsker: Anna Maria Hibbs, MD, MSCE, FAAP, Case Western Reserve University, Rainbow Babies and Children's Hospital
- Ledende efterforsker: C. Michael Cotten, MD, Duke University
- Studiestol: Ravi M Patel, MD, MSc, Emory University
- Ledende efterforsker: Krisa P Van Meurs, MD, Stanford University
- Ledende efterforsker: Stephanie Merhar, MD MS, Children's Hospital Medical Center, Cincinnati
- Ledende efterforsker: Tarah Colaizy, MD, MPH, University of Iowa
- Ledende efterforsker: Kristi L Watterberg, MD, University of New Mexico
- Ledende efterforsker: Myra Wyckoff, MD, University of Texas, Southwestern Medical Center at Dallas
- Ledende efterforsker: Sara DeMauro, MD, MSCE, University of Pennsylvania
- Ledende efterforsker: Pablo Sanchez, MD, Research Institute at Nationwide Children's Hospital
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Malcolm WF, Gantz M, Martin RJ, Goldstein RF, Goldberg RN, Cotten CM; National Institute of Child Health and Human Development Neonatal Research Network. Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. Pediatrics. 2008 Jan;121(1):22-7. doi: 10.1542/peds.2007-0381.
- Strand M, Jobe AH. The multiple negative randomized controlled trials in perinatology--why? Semin Perinatol. 2003 Aug;27(4):343-50. doi: 10.1016/s0146-0005(03)00042-9.
- Tyson JE, Stoll BJ. Evidence-based ethics and the care and outcome of extremely premature infants. Clin Perinatol. 2003 Jun;30(2):363-87. doi: 10.1016/s0095-5108(03)00028-9.
- Wright LL. How to develop and manage a successful research network. Semin Pediatr Surg. 2002 Aug;11(3):175-80; discussion 180. doi: 10.1053/spsu.2002.33740. No abstract available.
- Wright LL, McNellis D. National Institute of Child Health and Human Development (NICHD)-sponsored Perinatal Research Networks. Semin Perinatol. 1995 Apr;19(2):112-23. doi: 10.1016/s0146-0005(05)80031-x. No abstract available.
- Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD Research Network. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008 May;121(5):e1167-77. doi: 10.1542/peds.2007-0423. Epub 2008 Apr 7.
- Ambalavanan N, Carlo WA, Bobashev G, Mathias E, Liu B, Poole K, Fanaroff AA, Stoll BJ, Ehrenkranz R, Wright LL; National Institute of Child Health and Human Development Neonatal Research Network. Prediction of death for extremely low birth weight neonates. Pediatrics. 2005 Dec;116(6):1367-73. doi: 10.1542/peds.2004-2099.
- Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R; National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. doi: 10.1542/peds.2004-2292.
- Broitman E, Ambalavanan N, Higgins RD, Vohr BR, Das A, Bhaskar B, Murray K, Hintz SR, Carlo WA; National Institute of Child Health and Human Development Neonatal Research Network. Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants. J Pediatr. 2007 Nov;151(5):500-5, 505.e1-2. doi: 10.1016/j.jpeds.2007.04.013. Epub 2007 Jul 12.
- Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10. doi: 10.1542/peds.114.2.404.
- Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ; Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics. 2008 Sep;122(3):e573-82. doi: 10.1542/peds.2007-3449.
- Cotten CM, Oh W, McDonald S, Carlo W, Fanaroff AA, Duara S, Stoll B, Laptook A, Poole K, Wright LL, Goldberg RN; NICHD Neonatal Research Network. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol. 2005 Oct;25(10):650-5. doi: 10.1038/sj.jp.7211369.
- Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, Ambalavanan N, Benjamin DK Jr; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66. doi: 10.1542/peds.2007-3423.
- Da Costa D, Bann CM, Hansen NI, Shankaran S, Delaney-Black V; National Institute of Child Health and Human Development Neonatal Research Network. Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants. Dev Med Child Neurol. 2009 Jul;51(7):536-44. doi: 10.1111/j.1469-8749.2009.03318.x.
- Demarini S, Dollberg S, Hoath SB, Ho M, Donovan EF. Effects of antenatal corticosteroids on blood pressure in very low birth weight infants during the first 24 hours of life. J Perinatol. 1999 Sep;19(6 Pt 1):419-25. doi: 10.1038/sj.jp.7200245.
- Dollberg S, Demarini S, Donovan EF, Hoath SB. Maturation of thermal capabilities in preterm infants. Am J Perinatol. 2000;17(1):47-51. doi: 10.1055/s-2000-7293.
- Donovan EF, Ehrenkranz RA, Shankaran S, Stevenson DK, Wright LL, Younes N, Fanaroff AA, Korones SB, Stoll BJ, Tyson JE, Bauer CR, Lemons JA, Oh W, Papile LA. Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units. Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):742-9. doi: 10.1016/s0002-9378(98)70075-4.
- Doyle NM, Gardner MO, Wells L, Qualls C, Papile LA. Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis. J Perinatol. 2005 May;25(5):336-40. doi: 10.1038/sj.jp.7211256.
- Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K; National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005 Dec;116(6):1353-60. doi: 10.1542/peds.2005-0249.
- Ehrenkranz RA, Wright LL. NICHD neonatal research network: contributions and future challenges. Semin Perinatol. 2003 Aug;27(4):264-80. doi: 10.1016/s0146-0005(03)00041-7.
- Fanaroff AA, Hack M, Walsh MC. The NICHD neonatal research network: changes in practice and outcomes during the first 15 years. Semin Perinatol. 2003 Aug;27(4):281-7. doi: 10.1016/s0146-0005(03)00055-7.
- Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK; NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007 Feb;196(2):147.e1-8. doi: 10.1016/j.ajog.2006.09.014.
- Fanaroff AA, Wright LL, Stevenson DK, Shankaran S, Donovan EF, Ehrenkranz RA, Younes N, Korones SB, Stoll BJ, Tyson JE, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol. 1995 Nov;173(5):1423-31. doi: 10.1016/0002-9378(95)90628-2.
- Gardner MO, Papile LA, Wright LL. Antenatal corticosteroids in pregnancies complicated by preterm premature rupture of membranes. Obstet Gynecol. 1997 Nov;90(5):851-3. doi: 10.1016/S0029-7844(97)00404-3.
- Gargus RA, Vohr BR, Tyson JE, High P, Higgins RD, Wrage LA, Poole K. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics. 2009 Jul;124(1):112-21. doi: 10.1542/peds.2008-2742.
- Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL; National Institute of Child Health and Human Development Neonatal Research Network. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb;117(2):e137-42. doi: 10.1542/peds.2005-1543. Epub 2006 Jan 3.
- Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Network. Pediatrics. 1991 May;87(5):587-97.
- Heller CD, O'Shea M, Yao Q, Langer J, Ehrenkranz RA, Phelps DL, Poole WK, Stoll B, Duara S, Oh W, Lemons J, Poindexter B; NICHD Neonatal Research Network. Human milk intake and retinopathy of prematurity in extremely low birth weight infants. Pediatrics. 2007 Jul;120(1):1-9. doi: 10.1542/peds.2006-1465.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood. Arch Pediatr Adolesc Med. 2008 Aug;162(8):748-55. doi: 10.1001/archpedi.162.8.748.
- Hintz SR, Bann CM, Ambalavanan N, Cotten CM, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predicting time to hospital discharge for extremely preterm infants. Pediatrics. 2010 Jan;125(1):e146-54. doi: 10.1542/peds.2009-0810. Epub 2009 Dec 14.
- Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, Poole WK, Blakely ML, Wright L, Higgins R; NICHD Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005 Mar;115(3):696-703. doi: 10.1542/peds.2004-0569.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics. 2005 Jun;115(6):1645-51. doi: 10.1542/peds.2004-2215.
- Hintz SR, Kendrick DE, Vohr BR, Kenneth Poole W, Higgins RD; Nichd Neonatal Research Network. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants. Acta Paediatr. 2006 Oct;95(10):1239-48. doi: 10.1080/08035250600599727.
- Hintz SR, Poole WK, Wright LL, Fanaroff AA, Kendrick DE, Laptook AR, Goldberg R, Duara S, Stoll BJ, Oh W; NICHD Neonatal Research Network. Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F128-33. doi: 10.1136/adc.2003.046268.
- Horbar JD, Onstad L, Wright E. Predicting mortality risk for infants weighing 501 to 1500 grams at birth: a National Institutes of Health Neonatal Research Network report. Crit Care Med. 1993 Jan;21(1):12-8. doi: 10.1097/00003246-199301000-00008.
- Horbar JD, Wright EC, Onstad L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. The Members of the National Institute of Child Health and Human Development Neonatal Research Network. Pediatrics. 1993 Aug;92(2):191-6.
- Lainwala S, Perritt R, Poole K, Vohr B; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants who are transferred from neonatal intensive care units to level I or II nurseries. Pediatrics. 2007 May;119(5):e1079-87. doi: 10.1542/peds.2006-0899. Epub 2007 Apr 2.
- Laptook AR, O'Shea TM, Shankaran S, Bhaskar B; NICHD Neonatal Network. Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents. Pediatrics. 2005 Mar;115(3):673-80. doi: 10.1542/peds.2004-0667.
- Laptook AR, Salhab W, Bhaskar B; Neonatal Research Network. Admission temperature of low birth weight infants: predictors and associated morbidities. Pediatrics. 2007 Mar;119(3):e643-9. doi: 10.1542/peds.2006-0943. Epub 2007 Feb 12.
- Lemons JA, Bauer CR, Oh W, Korones SB, Papile LA, Stoll BJ, Verter J, Temprosa M, Wright LL, Ehrenkranz RA, Fanaroff AA, Stark A, Carlo W, Tyson JE, Donovan EF, Shankaran S, Stevenson DK. Very low birth weight outcomes of the National Institute of Child health and human development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network. Pediatrics. 2001 Jan;107(1):E1. doi: 10.1542/peds.107.1.e1.
- Lowe J, Woodward B, Papile LA. Emotional regulation and its impact on development in extremely low birth weight infants. J Dev Behav Pediatr. 2005 Jun;26(3):209-13. doi: 10.1097/00004703-200506000-00008.
- Madan JC, Kendrick D, Hagadorn JI, Frantz ID 3rd; National Institute of Child Health and Human Development Neonatal Research Network. Patent ductus arteriosus therapy: impact on neonatal and 18-month outcome. Pediatrics. 2009 Feb;123(2):674-81. doi: 10.1542/peds.2007-2781.
- Malloy MH, Onstad L, Wright E. The effect of cesarean delivery on birth outcome in very low birth weight infants. National Institute of Child Health and Human Development Neonatal Research Network. Obstet Gynecol. 1991 Apr;77(4):498-503.
- Morris BH, Gard CC, Kennedy K; NICHD Neonatal Research Network. Rehospitalization of extremely low birth weight (ELBW) infants: are there racial/ethnic disparities? J Perinatol. 2005 Oct;25(10):656-63. doi: 10.1038/sj.jp.7211361.
- Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ, Ehrenkranz RA, Carlo WA, Shankaran S, Poole K, Wright LL; National Institute of Child Health and Human Development Neonatal Research Network. Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics. 2003 Oct;112(4):773-9. doi: 10.1542/peds.112.4.773.
- Shankaran S, Bauer CR, Bain R, Wright LL, Zachary J. Prenatal and perinatal risk and protective factors for neonatal intracranial hemorrhage. National Institute of Child Health and Human Development Neonatal Research Network. Arch Pediatr Adolesc Med. 1996 May;150(5):491-7. doi: 10.1001/archpedi.1996.02170300045009.
- Shankaran S, Bauer CR, Bain R, Wright LL, Zachary J. Relationship between antenatal steroid administration and grades III and IV intracranial hemorrhage in low birth weight infants. The NICHD Neonatal Research Network. Am J Obstet Gynecol. 1995 Jul;173(1):305-12. doi: 10.1016/0002-9378(95)90219-8. No abstract available.
- Shankaran S, Johnson Y, Langer JC, Vohr BR, Fanaroff AA, Wright LL, Poole WK. Outcome of extremely-low-birth-weight infants at highest risk: gestational age < or =24 weeks, birth weight < or =750 g, and 1-minute Apgar < or =3. Am J Obstet Gynecol. 2004 Oct;191(4):1084-91. doi: 10.1016/j.ajog.2004.05.032.
- Shankaran S, Fanaroff AA, Wright LL, Stevenson DK, Donovan EF, Ehrenkranz RA, Langer JC, Korones SB, Stoll BJ, Tyson JE, Bauer CR, Lemons JA, Oh W, Papile LA. Risk factors for early death among extremely low-birth-weight infants. Am J Obstet Gynecol. 2002 Apr;186(4):796-802. doi: 10.1067/mob.2002.121652.
- St John EB, Carlo WA. Respiratory distress syndrome in VLBW infants: changes in management and outcomes observed by the NICHD Neonatal Research Network. Semin Perinatol. 2003 Aug;27(4):288-92. doi: 10.1016/s0146-0005(03)00056-9.
- Stephens BE, Bann CM, Poole WK, Vohr BR. NEURODEVELOPMENTAL IMPAIRMENT: PREDICTORS OF ITS IMPACT ON THE FAMILIES OF EXTREMELY LOW BIRTH WEIGHT INFANTS AT 18 MONTHS. Infant Ment Health J. 2008 Nov 1;29(6):570-587. doi: 10.1002/imhj.20196.
- Stevenson DK, Verter J, Fanaroff AA, Oh W, Ehrenkranz RA, Shankaran S, Donovan EF, Wright LL, Lemons JA, Tyson JE, Korones SB, Bauer CR, Stoll BJ, Papile LA. Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage. Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F182-5. doi: 10.1136/fn.83.3.f182.
- Stevenson DK, Wright LL, Lemons JA, Oh W, Korones SB, Papile LA, Bauer CR, Stoll BJ, Tyson JE, Shankaran S, Fanaroff AA, Donovan EF, Ehrenkranz RA, Verter J. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994. Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1632-9. doi: 10.1016/s0002-9378(98)70037-7.
- Stoll BJ, Gordon T, Korones SB, Shankaran S, Tyson JE, Bauer CR, Fanaroff AA, Lemons JA, Donovan EF, Oh W, Stevenson DK, Ehrenkranz RA, Papile LA, Verter J, Wright LL. Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1996 Jul;129(1):72-80. doi: 10.1016/s0022-3476(96)70192-0.
- Stoll BJ, Gordon T, Korones SB, Shankaran S, Tyson JE, Bauer CR, Fanaroff AA, Lemons JA, Donovan EF, Oh W, Stevenson DK, Ehrenkranz RA, Papile LA, Verter J, Wright LL. Late-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1996 Jul;129(1):63-71. doi: 10.1016/s0022-3476(96)70191-9.
- Stoll BJ, Hansen N. Infections in VLBW infants: studies from the NICHD Neonatal Research Network. Semin Perinatol. 2003 Aug;27(4):293-301. doi: 10.1016/s0146-0005(03)00046-6.
- Stoll BJ, Hansen N, Fanaroff AA, Lemons JA. Enterobacter sakazakii is a rare cause of neonatal septicemia or meningitis in VLBW infants. J Pediatr. 2004 Jun;144(6):821-3. doi: 10.1016/j.jpeds.2004.02.045.
- Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, Lemons JA, Donovan EF, Stark AR, Tyson JE, Oh W, Bauer CR, Korones SB, Shankaran S, Laptook AR, Stevenson DK, Papile LA, Poole WK. To tap or not to tap: high likelihood of meningitis without sepsis among very low birth weight infants. Pediatrics. 2004 May;113(5):1181-6. doi: 10.1542/peds.113.5.1181.
- Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, Lemons JA, Donovan EF, Stark AR, Tyson JE, Oh W, Bauer CR, Korones SB, Shankaran S, Laptook AR, Stevenson DK, Papile LA, Poole WK. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N Engl J Med. 2002 Jul 25;347(4):240-7. doi: 10.1056/NEJMoa012657.
- Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, Lemons JA, Donovan EF, Stark AR, Tyson JE, Oh W, Bauer CR, Korones SB, Shankaran S, Laptook AR, Stevenson DK, Papile LA, Poole WK. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002 Aug;110(2 Pt 1):285-91. doi: 10.1542/peds.110.2.285.
- Stoll BJ, Hansen NI, Higgins RD, Fanaroff AA, Duara S, Goldberg R, Laptook A, Walsh M, Oh W, Hale E; National Institute of Child Health and Human Development. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. Pediatr Infect Dis J. 2005 Jul;24(7):635-9. doi: 10.1097/01.inf.0000168749.82105.64.
- Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff AA, Hintz SR, Vohr B, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 2004 Nov 17;292(19):2357-65. doi: 10.1001/jama.292.19.2357.
- Tyson JE, Younes N, Verter J, Wright LL. Viability, morbidity, and resource use among newborns of 501- to 800-g birth weight. National Institute of Child Health and Human Development Neonatal Research Network. JAMA. 1996 Nov 27;276(20):1645-51.
- Tyson JE, Parikh NA, Langer J, Green C, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Intensive care for extreme prematurity--moving beyond gestational age. N Engl J Med. 2008 Apr 17;358(16):1672-81. doi: 10.1056/NEJMoa073059.
- Uauy RD, Fanaroff AA, Korones SB, Phillips EA, Phillips JB, Wright LL. Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 1991 Oct;119(4):630-8. doi: 10.1016/s0022-3476(05)82418-7.
- Vohr BR, Msall ME, Wilson D, Wright LL, McDonald S, Poole WK. Spectrum of gross motor function in extremely low birth weight children with cerebral palsy at 18 months of age. Pediatrics. 2005 Jul;116(1):123-9. doi: 10.1542/peds.2004-1810.
- Vohr BR, O'Shea M, Wright LL. Longitudinal multicenter follow-up of high-risk infants: why, who, when, and what to assess. Semin Perinatol. 2003 Aug;27(4):333-42. doi: 10.1016/s0146-0005(03)00045-4.
- Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, Simon NP, Wilson DC, Broyles S, Bauer CR, Delaney-Black V, Yolton KA, Fleisher BE, Papile LA, Kaplan MD. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993-1994. Pediatrics. 2000 Jun;105(6):1216-26. doi: 10.1542/peds.105.6.1216.
- Vohr BR, Wright LL, Poole WK, McDonald SA. Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998. Pediatrics. 2005 Sep;116(3):635-43. doi: 10.1542/peds.2004-2247.
- Vohr BR, Tyson JE, Wright LL, Perritt RL, Li L, Poole WK; NICHD Neonatal Research Network. Maternal age, multiple birth, and extremely low birth weight infants. J Pediatr. 2009 Apr;154(4):498-503.e2. doi: 10.1016/j.jpeds.2008.10.044. Epub 2008 Dec 25.
- Vohr BR, Wright LL, Dusick AM, Perritt R, Poole WK, Tyson JE, Steichen JJ, Bauer CR, Wilson-Costello DE, Mayes LC; Neonatal Research Network. Center differences and outcomes of extremely low birth weight infants. Pediatrics. 2004 Apr;113(4):781-9. doi: 10.1542/peds.113.4.781.
- Wadhawan R, Oh W, Perritt R, Laptook AR, Poole K, Wright LL, Fanaroff AA, Duara S, Stoll BJ, Goldberg R. Association between early postnatal weight loss and death or BPD in small and appropriate for gestational age extremely low-birth-weight infants. J Perinatol. 2007 Jun;27(6):359-64. doi: 10.1038/sj.jp.7211751. Epub 2007 Apr 19.
- Wadhawan R, Oh W, Perritt RL, McDonald SA, Das A, Poole WK, Vohr BR, Higgins RD. Twin gestation and neurodevelopmental outcome in extremely low birth weight infants. Pediatrics. 2009 Feb;123(2):e220-7. doi: 10.1542/peds.2008-1126. Epub 2009 Jan 12.
- Wadhawan R, Vohr BR, Fanaroff AA, Perritt RL, Duara S, Stoll BJ, Goldberg R, Laptook A, Poole K, Wright LL, Oh W. Does labor influence neonatal and neurodevelopmental outcomes of extremely-low-birth-weight infants who are born by cesarean delivery? Am J Obstet Gynecol. 2003 Aug;189(2):501-6. doi: 10.1067/s0002-9378(03)00360-0.
- Walden RV, Taylor SC, Hansen NI, Poole WK, Stoll BJ, Abuelo D, Vohr BR; National Institute of Child Health and Human Development Neonatal Research Network. Major congenital anomalies place extremely low birth weight infants at higher risk for poor growth and developmental outcomes. Pediatrics. 2007 Dec;120(6):e1512-9. doi: 10.1542/peds.2007-0354. Epub 2007 Nov 5.
- Walsh MC, Morris BH, Wrage LA, Vohr BR, Poole WK, Tyson JE, Wright LL, Ehrenkranz RA, Stoll BJ, Fanaroff AA; National Institutes of Child Health and Human Development Neonatal Research Network. Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomes. J Pediatr. 2005 Jun;146(6):798-804. doi: 10.1016/j.jpeds.2005.01.047.
- Walsh MC, Yao Q, Horbar JD, Carpenter JH, Lee SK, Ohlsson A. Changes in the use of postnatal steroids for bronchopulmonary dysplasia in 3 large neonatal networks. Pediatrics. 2006 Nov;118(5):e1328-35. doi: 10.1542/peds.2006-0359.
- Wright LL, Horbar JD, Gunkel H, Verter J, Younes N, Andrews EB, Long W. Evidence from multicenter networks on the current use and effectiveness of antenatal corticosteroids in low birth weight infants. Am J Obstet Gynecol. 1995 Jul;173(1):263-9. doi: 10.1016/0002-9378(95)90211-2. No abstract available.
- Wright LL, Verter J, Younes N, Stevenson D, Fanaroff AA, Shankaran S, Ehrenkranz RA, Donovan EF. Antenatal corticosteroid administration and neonatal outcome in very low birth weight infants: the NICHD Neonatal Research Network. Am J Obstet Gynecol. 1995 Jul;173(1):269-74. doi: 10.1016/0002-9378(95)90212-0. No abstract available.
- Wright LL; Papile LA. U.S. neonatal databases: methods and uses. Semin Neonatal 1997;2:159-69. (ancillary publication).
- Ambalavanan N, Carlo WA, Tyson JE, Langer JC, Walsh MC, Parikh NA, Das A, Van Meurs KP, Shankaran S, Stoll BJ, Higgins RD; Generic Database; Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcome trajectories in extremely preterm infants. Pediatrics. 2012 Jul;130(1):e115-25. doi: 10.1542/peds.2011-3693. Epub 2012 Jun 11.
- Puopolo KM, Mukhopadhyay S, Hansen NI, Flannery DD, Greenberg RG, Sanchez PJ, Bell EF, DeMauro SB, Wyckoff MH, Eichenwald EC, Stoll BJ. Group B Streptococcus Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years. Clin Infect Dis. 2022 Oct 12;75(8):1405-1415. doi: 10.1093/cid/ciac222.
- Kumbhat N, Eggleston B, Davis AS, DeMauro SB, Van Meurs KP, Foglia EE, Lakshminrusimha S, Walsh MC, Watterberg KL, Wyckoff MH, Das A, Handley SC; Generic Database Subcommittee of the National Institute of Child Health and Human Development Neonatal Research Network. Umbilical Cord Milking vs Delayed Cord Clamping and Associations with In-Hospital Outcomes among Extremely Premature Infants. J Pediatr. 2021 May;232:87-94.e4. doi: 10.1016/j.jpeds.2020.12.072. Epub 2021 Jan 5.
- Chandrasekharan P, Lakshminrusimha S, Chowdhury D, Van Meurs K, Keszler M, Kirpalani H, Das A, Walsh MC, McGowan EC, Higgins RD; NRN STEERING COMMITTEE. Early Hypoxic Respiratory Failure in Extreme Prematurity: Mortality and Neurodevelopmental Outcomes. Pediatrics. 2020 Oct;146(4):e20193318. doi: 10.1542/peds.2019-3318. Epub 2020 Sep 17.
- Shankaran S, Bajaj M, Natarajan G, Saha S, Pappas A, Davis AS, Hintz SR, Adams-Chapman I, Das A, Bell EF, Stoll BJ, Walsh MC, Laptook AR, Carlo WA, Van Meurs KP, Sanchez PJ, Ball MB, Hale EC, Seabrook R, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcomes Following Post-Hemorrhagic Ventricular Dilatation among Infants of Extremely Low Gestational Age. J Pediatr. 2020 Nov;226:36-44.e3. doi: 10.1016/j.jpeds.2020.07.080. Epub 2020 Jul 30.
- Kumbhat N, Eggleston B, Davis AS, Van Meurs KP, DeMauro SB, Foglia EE, Lakshminrusimha S, Walsh MC, Watterberg KL, Wyckoff MH, Das A, Handley SC; Generic Database Subcommittee of the NICHD Neonatal Research Network; undefined. Placental transfusion and short-term outcomes among extremely preterm infants. Arch Dis Child Fetal Neonatal Ed. 2021 Jan;106(1):62-68. doi: 10.1136/archdischild-2019-318710. Epub 2020 Jul 30.
- Gentle SJ, Carlo WA, Tan S, Gargano M, Ambalavanan N, Chawla S, Bell EF, Bann CM, Hintz SR, Heyne RJ, Tita A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children. Obstet Gynecol. 2020 Jun;135(6):1377-1386. doi: 10.1097/AOG.0000000000003882.
- Warren MG, Do B, Das A, Smith PB, Adams-Chapman I, Jadcherla S, Jensen EA, Goldstein RF, Goldberg RN, Cotten CM, Bell EF, Malcolm WF; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Gastrostomy Tube Feeding in Extremely Low Birthweight Infants: Frequency, Associated Comorbidities, and Long-term Outcomes. J Pediatr. 2019 Nov;214:41-46.e5. doi: 10.1016/j.jpeds.2019.06.066. Epub 2019 Aug 16.
- DeMauro SB, Jensen EA, Bann CM, Bell EF, Hibbs AM, Hintz SR, Lorch SA. Home Oxygen and 2-Year Outcomes of Preterm Infants With Bronchopulmonary Dysplasia. Pediatrics. 2019 May;143(5):e20182956. doi: 10.1542/peds.2018-2956. Epub 2019 Apr 11.
- Rysavy MA, Bell EF, Iams JD, Carlo WA, Li L, Mercer BM, Hintz SR, Stoll BJ, Vohr BR, Shankaran S, Walsh MC, Brumbaugh JE, Colaizy TT, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Discordance in Antenatal Corticosteroid Use and Resuscitation Following Extremely Preterm Birth. J Pediatr. 2019 May;208:156-162.e5. doi: 10.1016/j.jpeds.2018.12.063. Epub 2019 Feb 6.
- Duncan AF, Bann CM, Dempsey AG, Adams-Chapman I, Heyne R, Hintz SR; Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children. J Perinatol. 2019 Mar;39(3):488-496. doi: 10.1038/s41372-019-0314-0. Epub 2019 Jan 28.
- Lowe JR, Fuller JF, Do BT, Vohr BR, Das A, Hintz SR, Watterberg KL, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health; Human Development Neonatal Research Network. Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm. Early Hum Dev. 2019 Jan;128:48-54. doi: 10.1016/j.earlhumdev.2018.11.007. Epub 2018 Dec 4.
- Duncan AF, Bann CM, Dempsey A, Peralta-Carcelen M, Hintz S; Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm. J Pediatr. 2019 Jan;204:148-156.e4. doi: 10.1016/j.jpeds.2018.08.059. Epub 2018 Oct 3.
- Vohr BR, Heyne R, Bann CM, Das A, Higgins RD, Hintz SR; Eunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network. Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort. J Pediatr. 2018 Sep;200:132-139.e3. doi: 10.1016/j.jpeds.2018.04.073. Epub 2018 May 21.
- Adams-Chapman I, Heyne RJ, DeMauro SB, Duncan AF, Hintz SR, Pappas A, Vohr BR, McDonald SA, Das A, Newman JE, Higgins RD; Follow-Up Study of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental Impairment Among Extremely Preterm Infants in the Neonatal Research Network. Pediatrics. 2018 May;141(5):e20173091. doi: 10.1542/peds.2017-3091. Epub 2018 Apr 17.
- Boghossian NS, Do BT, Bell EF, Dagle JM, Brumbaugh JE, Stoll BJ, Vohr BR, Das A, Shankaran S, Sanchez PJ, Wyckoff MH, Bethany Ball M; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Efficacy of pharmacologic closure of patent ductus arteriosus in small-for-gestational-age extremely preterm infants. Early Hum Dev. 2017 Oct;113:10-17. doi: 10.1016/j.earlhumdev.2017.07.011. Epub 2017 Jul 8.
- Jensen EA, Dysart KC, Gantz MG, Carper B, Higgins RD, Keszler M, Laughon MM, Poindexter BB, Stoll BJ, Walsh MC, Schmidt B; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Association between Use of Prophylactic Indomethacin and the Risk for Bronchopulmonary Dysplasia in Extremely Preterm Infants. J Pediatr. 2017 Jul;186:34-40.e2. doi: 10.1016/j.jpeds.2017.02.003. Epub 2017 Feb 28.
- Younge N, Goldstein RF, Bann CM, Hintz SR, Patel RM, Smith PB, Bell EF, Rysavy MA, Duncan AF, Vohr BR, Das A, Goldberg RN, Higgins RD, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med. 2017 Feb 16;376(7):617-628. doi: 10.1056/NEJMoa1605566.
- Boghossian NS, Hansen NI, Bell EF, Brumbaugh JE, Stoll BJ, Laptook AR, Shankaran S, Wyckoff MH, Colaizy TT, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcomes of Extremely Preterm Infants Born to Insulin-Dependent Diabetic Mothers. Pediatrics. 2016 Jun;137(6):e20153424. doi: 10.1542/peds.2015-3424. Epub 2016 May 13.
- Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, Laptook AR, Sanchez PJ, Van Meurs KP, Wyckoff M, Das A, Hale EC, Ball MB, Newman NS, Schibler K, Poindexter BB, Kennedy KA, Cotten CM, Watterberg KL, D'Angio CT, DeMauro SB, Truog WE, Devaskar U, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA. 2015 Sep 8;314(10):1039-51. doi: 10.1001/jama.2015.10244.
- LeVan JM, Brion LP, Wrage LA, Gantz MG, Wyckoff MH, Sanchez PJ, Heyne R, Jaleel M, Finer NN, Carlo WA, Das A, Stoll BJ, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network. Change in practice after the Surfactant, Positive Pressure and Oxygenation Randomised Trial. Arch Dis Child Fetal Neonatal Ed. 2014 Sep;99(5):F386-90. doi: 10.1136/archdischild-2014-306057. Epub 2014 May 29.
- Hack M, Wright LL, Shankaran S, Tyson JE, Horbar JD, Bauer CR, Younes N. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Network, November 1989 to October 1990. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):457-64. doi: 10.1016/0002-9378(95)90557-x.
- Dorner RA, Li L, Lemmon ME, Zangeneh SZ, Das A, Discenza DA, Mancini T, Vaucher Y, Wyckoff MH, Hintz S, DeMauro SB, Carlo WA, Gustafson KE, Katheria A; Eunice Kennedy Schriver National Institute of Child Health and Human Development Neonatal Research Network. Inpatient morbidities and medical technology use at 2 years among extremely preterm infants. Pediatr Res. 2025 Dec 16:10.1038/s41390-025-04671-0. doi: 10.1038/s41390-025-04671-0. Online ahead of print.
- Messick EA, Saha S, Slaughter JL, Kielt MJ, Benninger KL, Bell EF, Stoll BJ, Puopolo KM, Mukhopadhyay S, Flannery DD, Wyckoff MH, Cotten CM, Patel RM, Laptook AR, Grisby C, Das A, Walsh MC, Sanchez PJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm. J Pediatr. 2026 Jan;288:114840. doi: 10.1016/j.jpeds.2025.114840. Epub 2025 Sep 26.
- Kaluarachchi DC, Chock VY, Do BT, Rysavy MA, Sankar MN, Laughon MM, Backes CH, Colaizy TT, Bell EF, McNamara PJ, Hintz SR, Natarajan G. Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation. J Perinatol. 2025 Sep 23:10.1038/s41372-025-02417-8. doi: 10.1038/s41372-025-02417-8. Online ahead of print.
- Brumbaugh JE, Bann CM, Bell EF, Travers CP, Vohr BR, McGowan EC, Harmon HM, Carlo WA, Hintz SR, Duncan AF; Eunice Kennedy Shriver NICHD Neonatal Research Network. The Relationship Between Hispanic Ethnicity and Outcomes for Infants Born Extremely Preterm. J Pediatr. 2025 Apr;279:114474. doi: 10.1016/j.jpeds.2025.114474. Epub 2025 Jan 23.
- Kaluarachchi DC, Rysavy MA, Do BT, Chock VY, Laughon MM, Backes CH, Colaizy TT, Bell EF, McNamara PJ. Changes in Patent Ductus Arteriosus Management and Outcomes in Infants Born at 26-28 Weeks' Gestation. J Pediatr. 2025 Apr;279:114456. doi: 10.1016/j.jpeds.2024.114456. Epub 2024 Dec 26.
- Dorner RA, Li L, DeMauro SB, Schmidt B, Zangeneh SZ, Vaucher Y, Wyckoff MH, Hintz S, Carlo WA, Gustafson KE, Das A, Katheria A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Association of a Count of Inpatient Morbidities with 2-Year Outcomes among Infants Born Extremely Preterm. J Pediatr. 2025 Mar;278:114428. doi: 10.1016/j.jpeds.2024.114428. Epub 2024 Dec 4.
- Honan BM, McDonald SA, Travers CP, Shukla VV, Ambalavanan N, Cotten CM, Jain VG, Arnold HE, Parikh NA, Tyson JE, Hintz SR, Walker SA, Gantz MG, Das A, Carlo WA. Cerebral injury and retinopathy as risk factors for blindness in extremely preterm infants. Arch Dis Child Fetal Neonatal Ed. 2025 Apr 17;110(3):253-260. doi: 10.1136/archdischild-2024-327707.
- Salas AA, Carlo WA, Bann CM, Bell EF, Colaizy TT, Younge N, Peralta M, Ambalavanan N, Poindexter BB; Eunice Kennedy Shriver NICHD Neonatal Research Network. Risk Assessment of Cognitive Impairment at 2 Years of Age in Infants Born Extremely Preterm Using the INTERGROWTH-21st Growth Standards. J Pediatr. 2024 Dec;275:114239. doi: 10.1016/j.jpeds.2024.114239. Epub 2024 Aug 19.
- Aleem S, Do BT, Gantz MG, Hibbs AM, Jensen EA, Cotten CM, Malcolm WF, Jobe AH, Greenberg RG; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. The association of the room air challenge with long-term outcomes in extremely preterm infants. J Perinatol. 2024 Sep;44(9):1300-1306. doi: 10.1038/s41372-024-02074-3. Epub 2024 Aug 3.
- Shukla VV, Carper BA, Ambalavanan N, Rysavy MA, Bell EF, Das A, Patel RM, D'Angio CT, Watterberg KL, Cotten CM, Merhar SL, Wyckoff MH, Sanchez PJ, Kumbhat N, Carlo WA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Social distancing and extremely preterm births in the initial COVID-19 pandemic period. J Perinatol. 2024 Jul;44(7):1050-1057. doi: 10.1038/s41372-024-01898-3. Epub 2024 Feb 22.
- Green CE, Tyson JE, Heyne RJ, Hintz SR, Vohr BR, Bann CM, Das A, Bell EF, Debsareea SB, Stephens E, Gantz MG, Petrie Huitema CM, Johnson KJ, Watterberg KL, Mosquera R, Peralta-Carcelen M, Wilson-Costello DE, Colaizy TT, Maitre NL, Merhar SL, Adams-Chapman I, Fuller J, Hartley-McAndrew ME, Malcolm WF, Winter S, Duncan AF, Myer GJ, Kicklighter SD, Wyckoff MH, DeMauro SB, Hibbs AM, Stoll BJ, Carlo WA, Van Meurs KP, Rysavy MA, Patel RM, Sanchez PJ, Laptook AR, Cotten CM, D'Angio CT, Walsh MC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study. J Perinatol. 2023 Nov;43(11):1398-1405. doi: 10.1038/s41372-023-01729-x. Epub 2023 Aug 4.
- Kole-White MB, Saha S, Werner EF, Chawla S, Keszler M, McGowan EC, Wyckoff MH, Laptook AR; Generic Database Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Maternal hypertensive disorders and survival without major morbidities among extremely low gestation newborns. J Perinatol. 2023 Apr;43(4):430-436. doi: 10.1038/s41372-023-01631-6. Epub 2023 Feb 22.
- Jensen EA, Laughon MM, DeMauro SB, Cotten CM, Do B, Carlo WA, Watterberg KL. Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia. Semin Perinatol. 2022 Nov;46(7):151638. doi: 10.1016/j.semperi.2022.151638. Epub 2022 Jun 10.
- Kilbride HW, Vohr BR, McGowan EM, Peralta-Carcelen M, Stringer K, Das A, Archer SW, Hintz SR. Early neurodevelopmental follow-up in the NICHD neonatal research network: Advancing neonatal care and outcomes, opportunities for the future. Semin Perinatol. 2022 Nov;46(7):151642. doi: 10.1016/j.semperi.2022.151642. Epub 2022 Jun 10.
- Bell EF, Stoll BJ, Hansen NI, Wyckoff MH, Walsh MC, Sanchez PJ, Rysavy MA, Gabrio JH, Archer SW, Das A, Higgins RD. Contributions of the NICHD neonatal research network's generic database to documenting and advancing the outcomes of extremely preterm infants. Semin Perinatol. 2022 Nov;46(7):151635. doi: 10.1016/j.semperi.2022.151635. Epub 2022 Jun 10.
- Greenberg RG, McDonald SA, Laughon MM, Tanaka D, Jensen E, Van Meurs K, Eichenwald E, Brumbaugh JE, Duncan AF, Walsh M, Das A, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Online clinical tool to estimate risk of bronchopulmonary dysplasia in extremely preterm infants. Arch Dis Child Fetal Neonatal Ed. 2022 Jun 21:fetalneonatal-2021-323573. doi: 10.1136/archdischild-2021-323573. Online ahead of print.
- Gentle SJ, Carper B, Laughon MM, Jensen EA, Williams A, Travers CP, Ambalavanan N, Lal CV, Carlo WA. Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. J Perinatol. 2022 Apr;42(4):454-460. doi: 10.1038/s41372-021-01269-2. Epub 2022 Jan 15.
- James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov;190:118-123.e4. doi: 10.1016/j.jpeds.2017.05.056. Epub 2017 Jun 21.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. april 1987
Primær færdiggørelse (Anslået)
31. marts 2030
Studieafslutning (Anslået)
31. marts 2030
Datoer for studieregistrering
Først indsendt
19. juni 2003
Først indsendt, der opfyldte QC-kriterier
19. juni 2003
Først opslået (Anslået)
20. juni 2003
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
16. marts 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
12. marts 2026
Sidst verificeret
1. marts 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- NICHD-NRN-0001
- UG1HD034216 (U.S. NIH-bevilling/kontrakt)
- UG1HD027904 (U.S. NIH-bevilling/kontrakt)
- UG1HD021364 (U.S. NIH-bevilling/kontrakt)
- UG1HD027853 (U.S. NIH-bevilling/kontrakt)
- UG1HD040689 (U.S. NIH-bevilling/kontrakt)
- UG1HD040492 (U.S. NIH-bevilling/kontrakt)
- UG1HD027851 (U.S. NIH-bevilling/kontrakt)
- UG1HD053109 (U.S. NIH-bevilling/kontrakt)
- UG1HD068278 (U.S. NIH-bevilling/kontrakt)
- UG1HD068244 (U.S. NIH-bevilling/kontrakt)
- UG1HD068263 (U.S. NIH-bevilling/kontrakt)
- UG1HD027880 (U.S. NIH-bevilling/kontrakt)
- UG1HD053089 (U.S. NIH-bevilling/kontrakt)
- UG1HD087226 (U.S. NIH-bevilling/kontrakt)
- UG1HD112079 (U.S. NIH-bevilling/kontrakt)
- UG1HD112097 (U.S. NIH-bevilling/kontrakt)
- UG1HD112100 (U.S. NIH-bevilling/kontrakt)
- U24HD095254 (U.S. NIH-bevilling/kontrakt)
- UG1HD112093 (U.S. NIH-bevilling/kontrakt)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ingen
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .