Base de datos genérica de recién nacidos de muy bajo peso al nacer (GDB)
7 de noviembre de 2023 actualizado por: NICHD Neonatal Research Network
Base de datos genérica: una encuesta de morbilidad y mortalidad en lactantes de muy bajo peso al nacer
La base de datos genérica (GDB, por sus siglas en inglés) es un registro de bebés de muy bajo peso nacidos vivos en los centros de la Red de Investigación Neonatal (NRN, por sus siglas en inglés) del NICHD.
El GDB recopila datos de referencia de observación tanto de madres como de bebés, y las terapias utilizadas y los resultados de los bebés.
La información recopilada no es específica de una enfermedad o tratamiento (es decir, es "genérica").
Los datos se analizan para encontrar asociaciones y tendencias entre la información inicial, los tratamientos y el resultado del lactante, y para desarrollar ensayos NRN futuros.
Descripción general del estudio
Estado
Reclutamiento
Descripción detallada
La base de datos genérica (GDB, por sus siglas en inglés) es un registro de bebés de muy bajo peso nacidos vivos en los centros de la Red de Investigación Neonatal (NRN, por sus siglas en inglés) del NICHD. El propósito es recopilar datos de referencia y de resultados de manera uniforme en una gran cohorte de MBPN y otros bebés enfermos ingresados en unidades de cuidados intensivos neonatales.
El GDB recopila datos de referencia de observación tanto de madres como de bebés, y las terapias utilizadas y los resultados de los bebés. La información recopilada no es específica de una enfermedad o tratamiento (es decir, es "genérica"). Los datos de referencia se recopilan poco después de la admisión a la UCIN; los datos de resultado se recopilan en el momento de la muerte o el alta del hospital. Los datos recopilados incluyen información sobre:
- Demografía de la madre y el bebé
- Salud de la madre (p. ej., historial de embarazo y complicaciones)
- Trabajo de parto y parto (p. ej., ruptura de las membranas, administración de esteroides y antibióticos, modo de parto)
- Salud del bebé (edad gestacional, puntuaciones de Apgar, peso, talla, reanimación en la sala de partos, soporte respiratorio, etc.)
- Resultado médico del bebé (corazón, pulmón, sistema nervioso, sistema gastrointestinal, audición y visión, infecciones conocidas y malformaciones/síndromes importantes y mortalidad o número de días de hospitalización).
Estos datos se utilizan: para examinar las asociaciones entre las características iniciales, los tratamientos y los resultados; para realizar un seguimiento de las tendencias en la incidencia de enfermedades y la eficacia de las terapias; y para identificar preguntas que requieren una investigación adicional en profundidad.
Consentimiento informado: según lo requieran los IRB locales.
Los estudios secundarios incluyen:
A. El Estudio de Cohorte de Todos los Nacimientos (ABC). Un registro observacional de tiempo limitado para determinar la incidencia de muerte fetal intraparto a las 20 0/7 - 28 6/7 semanas de gestación y sus factores asociados en los sitios de la Red.
Tipo de estudio
De observación
Inscripción (Estimado)
80000
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Estudio Contacto
- Nombre: Abhik Das, PhD
- Número de teléfono: 301-230-4640
- Correo electrónico: adas@rti.org
Copia de seguridad de contactos de estudio
- Nombre: Ravi M Patal, MD
- Número de teléfono: 404-727-5905
- Correo electrónico: rmpatel@emory.edu
Ubicaciones de estudio
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Alabama
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Birmingham, Alabama, Estados Unidos, 35233
- Reclutamiento
- University of Alabama at Birmingham
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Contacto:
- Waldemar A. Carlo, MD
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Investigador principal:
- Waldemar A. Carlo, MD
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California
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Los Angeles, California, Estados Unidos, 90025
- Terminado
- University of California - Los Angeles
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Palo Alto, California, Estados Unidos, 94304
- Reclutamiento
- Stanford University
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Contacto:
- Krisa P. Van Meurs, MD
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Investigador principal:
- Krisa P. Van Meurs, MD
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San Diego, California, Estados Unidos, 92103-8774
- Terminado
- University of California at San Diego
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San Diego, California, Estados Unidos, 92123
- Reclutamiento
- Sharp Mary Birch Hospital for Women & Newborns
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Contacto:
- Anup Katheria, MD
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Investigador principal:
- Anup Katheria, MD
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Connecticut
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New Haven, Connecticut, Estados Unidos, 06504
- Terminado
- Yale University
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District of Columbia
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Washington, District of Columbia, Estados Unidos, 20052
- Terminado
- George Washington University
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Florida
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Miami, Florida, Estados Unidos, 33136
- Terminado
- University of Miami
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Georgia
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Atlanta, Georgia, Estados Unidos, 30303
- Reclutamiento
- Emory University
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Contacto:
- David P Carlton, MD
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Investigador principal:
- David P Carlton, MD
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Illinois
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Chicago, Illinois, Estados Unidos, 60611
- Aún no reclutando
- Northwestern Lurie Children's Hospital of Chicago
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Contacto:
- Aaron Hamvas, MD
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Investigador principal:
- Aaron Hamvas, MD
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Indiana
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Indianapolis, Indiana, Estados Unidos, 46202
- Terminado
- Indiana University
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Iowa
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Iowa City, Iowa, Estados Unidos, 52242
- Reclutamiento
- University of Iowa
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Contacto:
- Edward F. Bell, MD
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Investigador principal:
- Edward F. Bell, MD
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Massachusetts
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Boston, Massachusetts, Estados Unidos, 02111
- Terminado
- Tufts Medical Center
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Cambridge, Massachusetts, Estados Unidos, 02138
- Terminado
- Harvard University
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Michigan
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Detroit, Michigan, Estados Unidos, 48201
- Terminado
- Wayne State University
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Mississippi
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Jackson, Mississippi, Estados Unidos, 39216
- Aún no reclutando
- University of Mississippi Medical Center - Children's of Mississippi
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Investigador principal:
- Abhay Bhatt, MD
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Contacto:
- Abhay Bhatt, MD
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Missouri
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Kansas City, Missouri, Estados Unidos, 64108
- Terminado
- Children's Mercy Hospital
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New Mexico
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Albuquerque, New Mexico, Estados Unidos, 87131
- Reclutamiento
- University of New Mexico
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Contacto:
- Kristi L. Watterberg, MD
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Investigador principal:
- Kristi L. Watterberg, MD
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New York
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Rochester, New York, Estados Unidos, 14642
- Activo, no reclutando
- University of Rochester
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North Carolina
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Durham, North Carolina, Estados Unidos, 27710
- Reclutamiento
- Duke University
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Contacto:
- C. Michael Cotten, MD, MHS
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Investigador principal:
- C. Michael Cotten, MD, MHS
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Durham, North Carolina, Estados Unidos, 27705
- Activo, no reclutando
- RTI International
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Ohio
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Cincinnati, Ohio, Estados Unidos, 45267
- Reclutamiento
- Cincinnati Children's Medical Center
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Contacto:
- Brenda Poindexter, MD MS
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Investigador principal:
- Brenda Poindexter, MD MS
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Cleveland, Ohio, Estados Unidos, 44106
- Reclutamiento
- Case Western Reserve University, Rainbow Babies and Children's Hospital
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Contacto:
- Michele C. Walsh, MD MS
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Investigador principal:
- Michele C. Walsh, MD MS
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Columbus, Ohio, Estados Unidos, 43205
- Activo, no reclutando
- Research Institute at Nationwide Children's Hospital
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Pennsylvania
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Philadelphia, Pennsylvania, Estados Unidos, 19104
- Reclutamiento
- Univeristy of Pennsylvania
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Contacto:
- Eric Eichenwald, MD
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Investigador principal:
- Eric Eichenwald, MD
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Rhode Island
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Providence, Rhode Island, Estados Unidos, 02905
- Activo, no reclutando
- Brown University, Women & Infants Hospital of Rhode Island
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Tennessee
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Memphis, Tennessee, Estados Unidos, 38163
- Terminado
- University of Tennessee
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Texas
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Dallas, Texas, Estados Unidos, 75235
- Reclutamiento
- University of Texas Southwestern Medical Center at Dallas
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Contacto:
- Myra H Wyckoff, MD
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Investigador principal:
- Myra H Wyckoff, MD
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Houston, Texas, Estados Unidos, 77030
- Reclutamiento
- University of Texas Health Science Center at Houston
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Contacto:
- Jon E. Tyson, MD MPH
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Investigador principal:
- Jon E. Tyson, MD MPH
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Utah
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Salt Lake City, Utah, Estados Unidos, 84108
- Reclutamiento
- University of Utah
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Contacto:
- Bradley Yoder, MD
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Investigador principal:
- Bradley Yoder, MD
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Vermont
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Burlington, Vermont, Estados Unidos, 05405
- Terminado
- University of Vermont
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Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
No mayor que 2 semanas (Niño)
Acepta Voluntarios Saludables
No
Método de muestreo
Muestra no probabilística
Población de estudio
Bebés nacidos en los centros de la NRN del NICHD que pesan entre 401 y 1000 gramos al nacer y/o tienen menos de 29 semanas de edad gestacional, O bebés inscritos en uno o más estudios adicionales de la NRN del NICHD.
Descripción
Criterios de inclusión:
- Bebés nacidos en centros NICHD NRN que son:
- 401-1000 gramos de peso al nacer, y/o
- 20 0/7 a 28 6/7 semanas (<29 semanas) edad gestacional
- Bebés inscritos en uno o más ensayos de intervención adicionales del NICHD NRN o estudios observacionales de tiempo limitado. Para los bebés que no cumplen con los criterios de inclusión anteriores, los criterios de inclusión y exclusión para la base de datos genérica están determinados por los criterios para los ensayos adicionales. En estos casos, los lactantes mayores de 1.000 gramos y/o mayores de 29 semanas podrán ser incluidos en la BGF.
Criterio de exclusión:
- Lactantes >1000 gramos de peso al nacer y/o >29 semanas de edad gestacional
Nota: Estos criterios de inclusión se cambiaron a partir del 1/1/2008. Antes de esta fecha, todos los bebés con pesos al nacer entre 401 y 1500 gramos que ingresaron en las UCIN de la NRN dentro de los 14 días posteriores al nacimiento se incluyeron en la base de datos.
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Modelos observacionales: Grupo
- Perspectivas temporales: Futuro
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Periodo de tiempo |
|---|---|
|
Mantener un registro de datos de referencia y de resultados para lactantes con MBPN con datos recopilados de manera uniforme
Periodo de tiempo: Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Medidas de resultado secundarias
Medida de resultado |
Periodo de tiempo |
|---|---|
|
Examinar la relación entre las características iniciales y el resultado.
Periodo de tiempo: Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
|
Para monitorear las tendencias en la incidencia de varias entidades de enfermedades.
Periodo de tiempo: Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
|
Para monitorear los cambios en MBPN y la supervivencia en edad gestacional temprana
Periodo de tiempo: Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
|
Proporcionar datos para la formulación de hipótesis y el cálculo del tamaño de la muestra para estudios multicéntricos de la Red.
Periodo de tiempo: Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Base de datos longitudinal actualmente financiada hasta el 31/03/2021
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Jon E Tyson, MD MPH, The University of Texas Health Science Center, Houston
- Investigador principal: Carl D'Angio, MD, University of Rochester
- Investigador principal: Robin Ohls, MD, University of Utah
- Investigador principal: Waldemar A Carlo, MD, University of Alabama at Birmingham
- Investigador principal: Abhik Das, PhD, RTI International
- Investigador principal: Abbot R Laptook, MD, Brown University, Women & Infants Hospital of Rhode Island
- Investigador principal: Anna Maria Hibbs, MD, MSCE, FAAP, Case Western Reserve University, Rainbow Babies and Children's Hospital
- Investigador principal: C. Michael Cotten, MD, Duke University
- Silla de estudio: Ravi M Patel, MD, MSc, Emory University
- Investigador principal: Krisa P Van Meurs, MD, Stanford University
- Investigador principal: Stephanie Merhar, MD MS, Children's Hospital Medical Center, Cincinnati
- Investigador principal: Tarah Colaizy, MD, MPH, University of Iowa
- Investigador principal: Kristi L Watterberg, MD, University of New Mexico
- Investigador principal: Myra Wyckoff, MD, University of Texas, Southwestern Medical Center at Dallas
- Investigador principal: Sara DeMauro, MD, MSCE, University of Pennsylvania
- Investigador principal: Pablo Sanchez, MD, Research Institute at Nationwide Children's Hospital
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Publicaciones Generales
- Malcolm WF, Gantz M, Martin RJ, Goldstein RF, Goldberg RN, Cotten CM; National Institute of Child Health and Human Development Neonatal Research Network. Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. Pediatrics. 2008 Jan;121(1):22-7. doi: 10.1542/peds.2007-0381.
- Strand M, Jobe AH. The multiple negative randomized controlled trials in perinatology--why? Semin Perinatol. 2003 Aug;27(4):343-50. doi: 10.1016/s0146-0005(03)00042-9.
- Tyson JE, Stoll BJ. Evidence-based ethics and the care and outcome of extremely premature infants. Clin Perinatol. 2003 Jun;30(2):363-87. doi: 10.1016/s0095-5108(03)00028-9.
- Wright LL. How to develop and manage a successful research network. Semin Pediatr Surg. 2002 Aug;11(3):175-80; discussion 180. doi: 10.1053/spsu.2002.33740. No abstract available.
- Wright LL, McNellis D. National Institute of Child Health and Human Development (NICHD)-sponsored Perinatal Research Networks. Semin Perinatol. 1995 Apr;19(2):112-23. doi: 10.1016/s0146-0005(05)80031-x. No abstract available.
- Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD Research Network. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008 May;121(5):e1167-77. doi: 10.1542/peds.2007-0423. Epub 2008 Apr 7.
- Ambalavanan N, Carlo WA, Bobashev G, Mathias E, Liu B, Poole K, Fanaroff AA, Stoll BJ, Ehrenkranz R, Wright LL; National Institute of Child Health and Human Development Neonatal Research Network. Prediction of death for extremely low birth weight neonates. Pediatrics. 2005 Dec;116(6):1367-73. doi: 10.1542/peds.2004-2099.
- Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R; National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. doi: 10.1542/peds.2004-2292.
- Broitman E, Ambalavanan N, Higgins RD, Vohr BR, Das A, Bhaskar B, Murray K, Hintz SR, Carlo WA; National Institute of Child Health and Human Development Neonatal Research Network. Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants. J Pediatr. 2007 Nov;151(5):500-5, 505.e1-2. doi: 10.1016/j.jpeds.2007.04.013. Epub 2007 Jul 12.
- Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10. doi: 10.1542/peds.114.2.404.
- Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ; Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics. 2008 Sep;122(3):e573-82. doi: 10.1542/peds.2007-3449.
- Cotten CM, Oh W, McDonald S, Carlo W, Fanaroff AA, Duara S, Stoll B, Laptook A, Poole K, Wright LL, Goldberg RN; NICHD Neonatal Research Network. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol. 2005 Oct;25(10):650-5. doi: 10.1038/sj.jp.7211369.
- Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, Ambalavanan N, Benjamin DK Jr; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66. doi: 10.1542/peds.2007-3423.
- Da Costa D, Bann CM, Hansen NI, Shankaran S, Delaney-Black V; National Institute of Child Health and Human Development Neonatal Research Network. Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants. Dev Med Child Neurol. 2009 Jul;51(7):536-44. doi: 10.1111/j.1469-8749.2009.03318.x.
- Demarini S, Dollberg S, Hoath SB, Ho M, Donovan EF. Effects of antenatal corticosteroids on blood pressure in very low birth weight infants during the first 24 hours of life. J Perinatol. 1999 Sep;19(6 Pt 1):419-25. doi: 10.1038/sj.jp.7200245.
- Dollberg S, Demarini S, Donovan EF, Hoath SB. Maturation of thermal capabilities in preterm infants. Am J Perinatol. 2000;17(1):47-51. doi: 10.1055/s-2000-7293.
- Donovan EF, Ehrenkranz RA, Shankaran S, Stevenson DK, Wright LL, Younes N, Fanaroff AA, Korones SB, Stoll BJ, Tyson JE, Bauer CR, Lemons JA, Oh W, Papile LA. Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units. Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):742-9. doi: 10.1016/s0002-9378(98)70075-4.
- Doyle NM, Gardner MO, Wells L, Qualls C, Papile LA. Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis. J Perinatol. 2005 May;25(5):336-40. doi: 10.1038/sj.jp.7211256.
- Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K; National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005 Dec;116(6):1353-60. doi: 10.1542/peds.2005-0249.
- Ehrenkranz RA, Wright LL. NICHD neonatal research network: contributions and future challenges. Semin Perinatol. 2003 Aug;27(4):264-80. doi: 10.1016/s0146-0005(03)00041-7.
- Fanaroff AA, Hack M, Walsh MC. The NICHD neonatal research network: changes in practice and outcomes during the first 15 years. Semin Perinatol. 2003 Aug;27(4):281-7. doi: 10.1016/s0146-0005(03)00055-7.
- Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK; NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007 Feb;196(2):147.e1-8. doi: 10.1016/j.ajog.2006.09.014.
- Fanaroff AA, Wright LL, Stevenson DK, Shankaran S, Donovan EF, Ehrenkranz RA, Younes N, Korones SB, Stoll BJ, Tyson JE, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol. 1995 Nov;173(5):1423-31. doi: 10.1016/0002-9378(95)90628-2.
- Gardner MO, Papile LA, Wright LL. Antenatal corticosteroids in pregnancies complicated by preterm premature rupture of membranes. Obstet Gynecol. 1997 Nov;90(5):851-3. doi: 10.1016/S0029-7844(97)00404-3.
- Gargus RA, Vohr BR, Tyson JE, High P, Higgins RD, Wrage LA, Poole K. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics. 2009 Jul;124(1):112-21. doi: 10.1542/peds.2008-2742.
- Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL; National Institute of Child Health and Human Development Neonatal Research Network. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb;117(2):e137-42. doi: 10.1542/peds.2005-1543. Epub 2006 Jan 3.
- Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Network. Pediatrics. 1991 May;87(5):587-97.
- Hack M, Wright LL, Shankaran S, Tyson JE, Horbar JD, Bauer CR, Younes N. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Network, November 1989 to October 1990. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):457-64. doi: 10.1016/0002-9378(95)90557-x. Erratum In: Am J Obstet Gynecol 1995 Sep;173(3 Pt 1):961.
- Heller CD, O'Shea M, Yao Q, Langer J, Ehrenkranz RA, Phelps DL, Poole WK, Stoll B, Duara S, Oh W, Lemons J, Poindexter B; NICHD Neonatal Research Network. Human milk intake and retinopathy of prematurity in extremely low birth weight infants. Pediatrics. 2007 Jul;120(1):1-9. doi: 10.1542/peds.2006-1465.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood. Arch Pediatr Adolesc Med. 2008 Aug;162(8):748-55. doi: 10.1001/archpedi.162.8.748.
- Hintz SR, Bann CM, Ambalavanan N, Cotten CM, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predicting time to hospital discharge for extremely preterm infants. Pediatrics. 2010 Jan;125(1):e146-54. doi: 10.1542/peds.2009-0810. Epub 2009 Dec 14.
- Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, Poole WK, Blakely ML, Wright L, Higgins R; NICHD Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005 Mar;115(3):696-703. doi: 10.1542/peds.2004-0569.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics. 2005 Jun;115(6):1645-51. doi: 10.1542/peds.2004-2215.
- Hintz SR, Kendrick DE, Vohr BR, Kenneth Poole W, Higgins RD; Nichd Neonatal Research Network. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants. Acta Paediatr. 2006 Oct;95(10):1239-48. doi: 10.1080/08035250600599727.
- Hintz SR, Poole WK, Wright LL, Fanaroff AA, Kendrick DE, Laptook AR, Goldberg R, Duara S, Stoll BJ, Oh W; NICHD Neonatal Research Network. Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F128-33. doi: 10.1136/adc.2003.046268.
- Horbar JD, Onstad L, Wright E. Predicting mortality risk for infants weighing 501 to 1500 grams at birth: a National Institutes of Health Neonatal Research Network report. Crit Care Med. 1993 Jan;21(1):12-8. doi: 10.1097/00003246-199301000-00008.
- Horbar JD, Wright EC, Onstad L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. The Members of the National Institute of Child Health and Human Development Neonatal Research Network. Pediatrics. 1993 Aug;92(2):191-6.
- Lainwala S, Perritt R, Poole K, Vohr B; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants who are transferred from neonatal intensive care units to level I or II nurseries. Pediatrics. 2007 May;119(5):e1079-87. doi: 10.1542/peds.2006-0899. Epub 2007 Apr 2.
- Laptook AR, O'Shea TM, Shankaran S, Bhaskar B; NICHD Neonatal Network. Adverse neurodevelopmental outcomes among extremely low birth weight infants with a normal head ultrasound: prevalence and antecedents. Pediatrics. 2005 Mar;115(3):673-80. doi: 10.1542/peds.2004-0667.
- Laptook AR, Salhab W, Bhaskar B; Neonatal Research Network. Admission temperature of low birth weight infants: predictors and associated morbidities. Pediatrics. 2007 Mar;119(3):e643-9. doi: 10.1542/peds.2006-0943. Epub 2007 Feb 12.
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Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio
1 de enero de 1987
Finalización primaria (Estimado)
31 de marzo de 2030
Finalización del estudio (Estimado)
31 de marzo de 2030
Fechas de registro del estudio
Enviado por primera vez
19 de junio de 2003
Primero enviado que cumplió con los criterios de control de calidad
19 de junio de 2003
Publicado por primera vez (Estimado)
20 de junio de 2003
Actualizaciones de registros de estudio
Última actualización publicada (Estimado)
8 de noviembre de 2023
Última actualización enviada que cumplió con los criterios de control de calidad
7 de noviembre de 2023
Última verificación
1 de marzo de 2023
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- NICHD-NRN-0001
- M01RR000633 (Subvención/contrato del NIH de EE. UU.)
- UG1HD034216 (Subvención/contrato del NIH de EE. UU.)
- UG1HD027904 (Subvención/contrato del NIH de EE. UU.)
- UG1HD021364 (Subvención/contrato del NIH de EE. UU.)
- UG1HD027853 (Subvención/contrato del NIH de EE. UU.)
- UG1HD040689 (Subvención/contrato del NIH de EE. UU.)
- UG1HD040492 (Subvención/contrato del NIH de EE. UU.)
- UG1HD027851 (Subvención/contrato del NIH de EE. UU.)
- UG1HD087229 (Subvención/contrato del NIH de EE. UU.)
- UG1HD053109 (Subvención/contrato del NIH de EE. UU.)
- UG1HD068278 (Subvención/contrato del NIH de EE. UU.)
- UG1HD068244 (Subvención/contrato del NIH de EE. UU.)
- UG1HD068263 (Subvención/contrato del NIH de EE. UU.)
- UG1HD027880 (Subvención/contrato del NIH de EE. UU.)
- UG1HD053089 (Subvención/contrato del NIH de EE. UU.)
- UG1HD087226 (Subvención/contrato del NIH de EE. UU.)
- U10HD036790 (Subvención/contrato del NIH de EE. UU.)
- U10HD021364 (Subvención/contrato del NIH de EE. UU.)
- U10HD021373 (Subvención/contrato del NIH de EE. UU.)
- U10HD021385 (Subvención/contrato del NIH de EE. UU.)
- U10HD027851 (Subvención/contrato del NIH de EE. UU.)
- U10HD027853 (Subvención/contrato del NIH de EE. UU.)
- U10HD027856 (Subvención/contrato del NIH de EE. UU.)
- U10HD027871 (Subvención/contrato del NIH de EE. UU.)
- U10HD027880 (Subvención/contrato del NIH de EE. UU.)
- U10HD027904 (Subvención/contrato del NIH de EE. UU.)
- U10HD034216 (Subvención/contrato del NIH de EE. UU.)
- U10HD040492 (Subvención/contrato del NIH de EE. UU.)
- U10HD040689 (Subvención/contrato del NIH de EE. UU.)
- U10HD053089 (Subvención/contrato del NIH de EE. UU.)
- U10HD053109 (Subvención/contrato del NIH de EE. UU.)
- U10HD053119 (Subvención/contrato del NIH de EE. UU.)
- U10HD053124 (Subvención/contrato del NIH de EE. UU.)
- UL1RR024139 (Subvención/contrato del NIH de EE. UU.)
- UL1RR025744 (Subvención/contrato del NIH de EE. UU.)
- M01RR000059 (Subvención/contrato del NIH de EE. UU.)
- U01HD019897 (Subvención/contrato del NIH de EE. UU.)
- U10HD021415 (Subvención/contrato del NIH de EE. UU.)
- U10HD027881 (Subvención/contrato del NIH de EE. UU.)
- M01RR008084 (Subvención/contrato del NIH de EE. UU.)
- M01RR000750 (Subvención/contrato del NIH de EE. UU.)
- M01RR000070 (Subvención/contrato del NIH de EE. UU.)
- M01RR000997 (Subvención/contrato del NIH de EE. UU.)
- U10HD021397 (Subvención/contrato del NIH de EE. UU.)
- U01HD021466 (Subvención/contrato del NIH de EE. UU.)
- U01HD021438 (Subvención/contrato del NIH de EE. UU.)
- U10HD034167 (Subvención/contrato del NIH de EE. UU.)
- U10HD040461 (Subvención/contrato del NIH de EE. UU.)
- U10HD040498 (Subvención/contrato del NIH de EE. UU.)
- U10HD040521 (Subvención/contrato del NIH de EE. UU.)
- U10HD042638 (Subvención/contrato del NIH de EE. UU.)
- M01RR000032 (Subvención/contrato del NIH de EE. UU.)
- M01RR000039 (Subvención/contrato del NIH de EE. UU.)
- M01RR000044 (Subvención/contrato del NIH de EE. UU.)
- M01RR000054 (Subvención/contrato del NIH de EE. UU.)
- M01RR000064 (Subvención/contrato del NIH de EE. UU.)
- M01RR000080 (Subvención/contrato del NIH de EE. UU.)
- M01RR001032 (Subvención/contrato del NIH de EE. UU.)
- M01RR002172 (Subvención/contrato del NIH de EE. UU.)
- M01RR002635 (Subvención/contrato del NIH de EE. UU.)
- M01RR007122 (Subvención/contrato del NIH de EE. UU.)
- M01RR016587 (Subvención/contrato del NIH de EE. UU.)
- U10HD068244 (Subvención/contrato del NIH de EE. UU.)
- U10HD068263 (Subvención/contrato del NIH de EE. UU.)
- U10HD068270 (Subvención/contrato del NIH de EE. UU.)
- U10HD068278 (Subvención/contrato del NIH de EE. UU.)
- U10HD068284 (Subvención/contrato del NIH de EE. UU.)
- UG1HD027856 (Subvención/contrato del NIH de EE. UU.)
- UG1HD068284 (Subvención/contrato del NIH de EE. UU.)
- UG1HD068270 (Subvención/contrato del NIH de EE. UU.)
- UG1HD112079 (Subvención/contrato del NIH de EE. UU.)
- UG1HD112097 (Subvención/contrato del NIH de EE. UU.)
- UG1HD112100 (Subvención/contrato del NIH de EE. UU.)
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