Banco de dados genérico de bebês com muito baixo peso ao nascer (GDB)
12 de março de 2026 atualizado por: NICHD Neonatal Research Network
Banco de dados genérico: uma pesquisa de morbidade e mortalidade em bebês com muito baixo peso ao nascer
O Banco de Dados Genérico (GDB) é um registro de recém-nascidos com muito baixo peso nascidos vivos nos centros da Rede de Pesquisa Neonatal (NRN) do NICHD.
O GDB coleta dados de linha de base observacionais sobre mães e bebês, e as terapias usadas e os resultados dos bebês.
As informações coletadas não são específicas para uma doença ou tratamento (ou seja, são "genéricas").
Os dados são analisados para encontrar associações e tendências entre informações de linha de base, tratamentos e resultados infantis e para desenvolver futuros ensaios NRN.
Visão geral do estudo
Status
Recrutamento
Condições
Intervenção / Tratamento
Descrição detalhada
O Banco de Dados Genérico (GDB) é um registro de recém-nascidos com muito baixo peso nascidos vivos nos centros da Rede de Pesquisa Neonatal (NRN) do NICHD. O objetivo é coletar dados de linha de base e resultados de maneira uniforme em uma grande coorte de RNMBP e outros bebês doentes internados em unidades de terapia intensiva neonatal.
O GDB coleta dados de linha de base observacionais sobre mães e bebês, e as terapias usadas e os resultados dos bebês. As informações coletadas não são específicas para uma doença ou tratamento (ou seja, são "genéricas"). Os dados da linha de base são coletados logo após a admissão na UTIN; os dados do resultado são coletados no momento da morte ou alta do hospital. Os dados recolhidos incluem informação sobre:
- Dados demográficos da mãe e do bebê
- Saúde da mãe (por exemplo, histórico de gravidez e complicações)
- Trabalho de parto e parto (por exemplo, ruptura das membranas, administração de esteróides e antibióticos, tipo de parto)
- Saúde do bebê (idade gestacional, escores de Apgar, peso, comprimento, reanimação na sala de parto, suporte respiratório, etc.)
- Resultado médico do bebê (coração, pulmão, sistema nervoso, sistema gastrointestinal, audição e visão, infecções conhecidas e malformações/síndromes graves e mortalidade ou número de dias hospitalizados).
Esses dados são usados: para examinar associações entre características basais, tratamentos e resultados; para acompanhar as tendências de incidência de doenças e eficácia das terapias; e para identificar questões que requerem pesquisa adicional aprofundada.
Consentimento Informado: Conforme exigido pelos IRBs locais.
Estudos Secundários incluem:
A. Estudo de Coorte de Todos os Nascimentos (ABC). Um registro observacional limitado no tempo para determinar a incidência de natimorto intraparto em 20 0/7 - 28 6/7 semanas de gestação e seus fatores associados nos sites da rede.
Tipo de estudo
Observacional
Inscrição (Estimado)
80000
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Contato de estudo
- Nome: Abhik Das, PhD
- Número de telefone: 301-230-4640
- E-mail: adas@rti.org
Estude backup de contato
- Nome: Ravi M Patal, MD
- Número de telefone: 404-727-5905
- E-mail: rmpatel@emory.edu
Locais de estudo
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Alabama
-
Birmingham, Alabama, Estados Unidos, 35233
- Recrutamento
- University of Alabama at Birmingham
-
Contato:
- Waldemar A. Carlo, MD
-
Investigador principal:
- Waldemar A. Carlo, MD
-
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California
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Los Angeles, California, Estados Unidos, 90025
- Concluído
- University of California - Los Angeles
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Palo Alto, California, Estados Unidos, 94304
- Recrutamento
- Stanford University
-
Contato:
- Krisa P. Van Meurs, MD
-
Investigador principal:
- Krisa P. Van Meurs, MD
-
San Diego, California, Estados Unidos, 92103-8774
- Concluído
- University of California at San Diego
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San Diego, California, Estados Unidos, 92123
- Recrutamento
- Sharp Mary Birch Hospital for Women & Newborns
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Contato:
- Anup Katheria, MD
-
Investigador principal:
- Anup Katheria, MD
-
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Connecticut
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New Haven, Connecticut, Estados Unidos, 06504
- Concluído
- Yale University
-
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District of Columbia
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Washington D.C., District of Columbia, Estados Unidos, 20052
- Concluído
- George Washington University
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Florida
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Miami, Florida, Estados Unidos, 33136
- Concluído
- University of Miami
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Georgia
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Atlanta, Georgia, Estados Unidos, 30303
- Recrutamento
- Emory University
-
Contato:
- David P Carlton, MD
-
Investigador principal:
- David P Carlton, MD
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Illinois
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Chicago, Illinois, Estados Unidos, 60611
- Ainda não está recrutando
- Northwestern Lurie Children's Hospital of Chicago
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Contato:
- Aaron Hamvas, MD
-
Investigador principal:
- Aaron Hamvas, MD
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Indiana
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Indianapolis, Indiana, Estados Unidos, 46202
- Concluído
- Indiana University
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Iowa
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Iowa City, Iowa, Estados Unidos, 52242
- Recrutamento
- University of Iowa
-
Contato:
- Edward F. Bell, MD
-
Investigador principal:
- Edward F. Bell, MD
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Massachusetts
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Boston, Massachusetts, Estados Unidos, 02111
- Concluído
- Tufts Medical Center
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Cambridge, Massachusetts, Estados Unidos, 02138
- Concluído
- Harvard University
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Michigan
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Detroit, Michigan, Estados Unidos, 48201
- Concluído
- Wayne State University
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Mississippi
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Jackson, Mississippi, Estados Unidos, 39216
- Ainda não está recrutando
- University of Mississippi Medical Center - Children's of Mississippi
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Investigador principal:
- Abhay Bhatt, MD
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Contato:
- Abhay Bhatt, MD
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Missouri
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Kansas City, Missouri, Estados Unidos, 64108
- Concluído
- Children's Mercy Hospital
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New Mexico
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Albuquerque, New Mexico, Estados Unidos, 87131
- Recrutamento
- University of New Mexico
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Contato:
- Kristi L. Watterberg, MD
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Investigador principal:
- Kristi L. Watterberg, MD
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New York
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Rochester, New York, Estados Unidos, 14642
- Ativo, não recrutando
- University of Rochester
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North Carolina
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Durham, North Carolina, Estados Unidos, 27710
- Recrutamento
- Duke University
-
Contato:
- C. Michael Cotten, MD, MHS
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Investigador principal:
- C. Michael Cotten, MD, MHS
-
Durham, North Carolina, Estados Unidos, 27705
- Ativo, não recrutando
- RTI International
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Ohio
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Cincinnati, Ohio, Estados Unidos, 45267
- Recrutamento
- Cincinnati Children's Medical Center
-
Contato:
- Brenda Poindexter, MD MS
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Investigador principal:
- Brenda Poindexter, MD MS
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Cleveland, Ohio, Estados Unidos, 44106
- Recrutamento
- Case Western Reserve University, Rainbow Babies and Children's Hospital
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Contato:
- Michele C. Walsh, MD MS
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Investigador principal:
- Michele C. Walsh, MD MS
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Columbus, Ohio, Estados Unidos, 43205
- Ativo, não recrutando
- Research Institute at Nationwide Children's Hospital
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Pennsylvania
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Philadelphia, Pennsylvania, Estados Unidos, 19104
- Recrutamento
- Univeristy of Pennsylvania
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Contato:
- Eric Eichenwald, MD
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Investigador principal:
- Eric Eichenwald, MD
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Rhode Island
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Providence, Rhode Island, Estados Unidos, 02905
- Ativo, não recrutando
- Brown University, Women & Infants Hospital of Rhode Island
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Tennessee
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Memphis, Tennessee, Estados Unidos, 38163
- Concluído
- University of Tennessee
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Texas
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Dallas, Texas, Estados Unidos, 75235
- Recrutamento
- University of Texas Southwestern Medical Center at Dallas
-
Contato:
- Myra H Wyckoff, MD
-
Investigador principal:
- Myra H Wyckoff, MD
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Houston, Texas, Estados Unidos, 77030
- Recrutamento
- University of Texas Health Science Center at Houston
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Contato:
- Jon E. Tyson, MD MPH
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Investigador principal:
- Jon E. Tyson, MD MPH
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Utah
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Salt Lake City, Utah, Estados Unidos, 84108
- Recrutamento
- University of Utah
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Contato:
- Bradley Yoder, MD
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Investigador principal:
- Bradley Yoder, MD
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Vermont
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Burlington, Vermont, Estados Unidos, 05405
- Concluído
- University of Vermont
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Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
Não mais velho que 2 semanas (Filho)
Aceita Voluntários Saudáveis
Não
Método de amostragem
Amostra Não Probabilística
População do estudo
Bebês nascidos em centros NICHD NRN com 401-1.000 gramas de peso ao nascer e/ou <29 semanas de idade gestacional, OU bebês inscritos em um ou mais estudos adicionais do NICHD NRN.
Descrição
Critério de inclusão:
- Bebês nascidos nos centros NICHD NRN que são:
- 401-1000 gramas de peso ao nascer e/ou
- 20 0/7 a 28 6/7 semanas (<29 semanas) de idade gestacional
- Bebês inscritos em um ou mais ensaios intervencionais NICHD NRN adicionais ou estudos observacionais limitados no tempo. Para bebês que não atendem aos critérios de inclusão acima, os critérios de inclusão e exclusão do banco de dados genérico são determinados pelos critérios do(s) estudo(s) adicional(is). Nesses casos, lactentes com mais de 1.000 gramas e/ou com mais de 29 semanas podem ser incluídos no GDB.
Critério de exclusão:
- Lactentes > 1.000 gramas de peso ao nascer e/ou > 29 semanas de idade gestacional
Nota: Esses critérios de inclusão foram alterados a partir de 01/01/2008. Antes desta data, todas as crianças com peso de nascimento entre 401 e 1500 gramas que foram admitidas em NRN NICUs dentro de 14 dias após o nascimento foram incluídas no banco de dados.
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Modelos de observação: Coorte
- Perspectivas de Tempo: Prospectivo
Coortes e Intervenções
Grupo / Coorte |
Intervenção / Tratamento |
|---|---|
|
Coorte de registro
|
O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Para manter um registro de dados de linha de base e resultados para bebês VLBW com dados coletados de maneira uniforme
Prazo: Banco de dados longitudinal atualmente financiado até 31/3/2030
|
Para manter um registro de dados de linha de base e resultados para bebês VLBW com dados coletados
|
Banco de dados longitudinal atualmente financiado até 31/3/2030
|
Medidas de resultados secundários
Medida de resultado |
Prazo |
|---|---|
|
Examinar a relação entre as características basais e o resultado
Prazo: Banco de dados longitudinal atualmente financiado até 31/03/2021
|
Banco de dados longitudinal atualmente financiado até 31/03/2021
|
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Para monitorar as tendências na incidência de várias entidades de doença
Prazo: Banco de dados longitudinal atualmente financiado até 31/03/2021
|
Banco de dados longitudinal atualmente financiado até 31/03/2021
|
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Para monitorar mudanças no VLBW e sobrevida em idade gestacional precoce
Prazo: Banco de dados longitudinal atualmente financiado até 31/03/2021
|
Banco de dados longitudinal atualmente financiado até 31/03/2021
|
|
Fornecer dados para formulação de hipóteses e cálculo do tamanho da amostra para estudos multicêntricos da Rede
Prazo: Banco de dados longitudinal atualmente financiado até 31/03/2021
|
Banco de dados longitudinal atualmente financiado até 31/03/2021
|
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Jon E Tyson, MD MPH, The University of Texas Health Science Center, Houston
- Investigador principal: Carl D'Angio, MD, University of Rochester
- Investigador principal: Robin Ohls, MD, University of Utah
- Investigador principal: Waldemar A Carlo, MD, University of Alabama at Birmingham
- Investigador principal: Abhik Das, PhD, RTI International
- Investigador principal: Abbot R Laptook, MD, Brown University, Women & Infants Hospital of Rhode Island
- Investigador principal: Anna Maria Hibbs, MD, MSCE, FAAP, Case Western Reserve University, Rainbow Babies and Children's Hospital
- Investigador principal: C. Michael Cotten, MD, Duke University
- Cadeira de estudo: Ravi M Patel, MD, MSc, Emory University
- Investigador principal: Krisa P Van Meurs, MD, Stanford University
- Investigador principal: Stephanie Merhar, MD MS, Children's Hospital Medical Center, Cincinnati
- Investigador principal: Tarah Colaizy, MD, MPH, University of Iowa
- Investigador principal: Kristi L Watterberg, MD, University of New Mexico
- Investigador principal: Myra Wyckoff, MD, University of Texas, Southwestern Medical Center at Dallas
- Investigador principal: Sara DeMauro, MD, MSCE, University of Pennsylvania
- Investigador principal: Pablo Sanchez, MD, Research Institute at Nationwide Children's Hospital
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
- Malcolm WF, Gantz M, Martin RJ, Goldstein RF, Goldberg RN, Cotten CM; National Institute of Child Health and Human Development Neonatal Research Network. Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. Pediatrics. 2008 Jan;121(1):22-7. doi: 10.1542/peds.2007-0381.
- Strand M, Jobe AH. The multiple negative randomized controlled trials in perinatology--why? Semin Perinatol. 2003 Aug;27(4):343-50. doi: 10.1016/s0146-0005(03)00042-9.
- Tyson JE, Stoll BJ. Evidence-based ethics and the care and outcome of extremely premature infants. Clin Perinatol. 2003 Jun;30(2):363-87. doi: 10.1016/s0095-5108(03)00028-9.
- Wright LL. How to develop and manage a successful research network. Semin Pediatr Surg. 2002 Aug;11(3):175-80; discussion 180. doi: 10.1053/spsu.2002.33740. No abstract available.
- Wright LL, McNellis D. National Institute of Child Health and Human Development (NICHD)-sponsored Perinatal Research Networks. Semin Perinatol. 1995 Apr;19(2):112-23. doi: 10.1016/s0146-0005(05)80031-x. No abstract available.
- Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD Research Network. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008 May;121(5):e1167-77. doi: 10.1542/peds.2007-0423. Epub 2008 Apr 7.
- Ambalavanan N, Carlo WA, Bobashev G, Mathias E, Liu B, Poole K, Fanaroff AA, Stoll BJ, Ehrenkranz R, Wright LL; National Institute of Child Health and Human Development Neonatal Research Network. Prediction of death for extremely low birth weight neonates. Pediatrics. 2005 Dec;116(6):1367-73. doi: 10.1542/peds.2004-2099.
- Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R; National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. doi: 10.1542/peds.2004-2292.
- Broitman E, Ambalavanan N, Higgins RD, Vohr BR, Das A, Bhaskar B, Murray K, Hintz SR, Carlo WA; National Institute of Child Health and Human Development Neonatal Research Network. Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants. J Pediatr. 2007 Nov;151(5):500-5, 505.e1-2. doi: 10.1016/j.jpeds.2007.04.013. Epub 2007 Jul 12.
- Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10. doi: 10.1542/peds.114.2.404.
- Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ; Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics. 2008 Sep;122(3):e573-82. doi: 10.1542/peds.2007-3449.
- Cotten CM, Oh W, McDonald S, Carlo W, Fanaroff AA, Duara S, Stoll B, Laptook A, Poole K, Wright LL, Goldberg RN; NICHD Neonatal Research Network. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol. 2005 Oct;25(10):650-5. doi: 10.1038/sj.jp.7211369.
- Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, Ambalavanan N, Benjamin DK Jr; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66. doi: 10.1542/peds.2007-3423.
- Da Costa D, Bann CM, Hansen NI, Shankaran S, Delaney-Black V; National Institute of Child Health and Human Development Neonatal Research Network. Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants. Dev Med Child Neurol. 2009 Jul;51(7):536-44. doi: 10.1111/j.1469-8749.2009.03318.x.
- Demarini S, Dollberg S, Hoath SB, Ho M, Donovan EF. Effects of antenatal corticosteroids on blood pressure in very low birth weight infants during the first 24 hours of life. J Perinatol. 1999 Sep;19(6 Pt 1):419-25. doi: 10.1038/sj.jp.7200245.
- Dollberg S, Demarini S, Donovan EF, Hoath SB. Maturation of thermal capabilities in preterm infants. Am J Perinatol. 2000;17(1):47-51. doi: 10.1055/s-2000-7293.
- Donovan EF, Ehrenkranz RA, Shankaran S, Stevenson DK, Wright LL, Younes N, Fanaroff AA, Korones SB, Stoll BJ, Tyson JE, Bauer CR, Lemons JA, Oh W, Papile LA. Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units. Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):742-9. doi: 10.1016/s0002-9378(98)70075-4.
- Doyle NM, Gardner MO, Wells L, Qualls C, Papile LA. Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis. J Perinatol. 2005 May;25(5):336-40. doi: 10.1038/sj.jp.7211256.
- Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K; National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005 Dec;116(6):1353-60. doi: 10.1542/peds.2005-0249.
- Ehrenkranz RA, Wright LL. NICHD neonatal research network: contributions and future challenges. Semin Perinatol. 2003 Aug;27(4):264-80. doi: 10.1016/s0146-0005(03)00041-7.
- Fanaroff AA, Hack M, Walsh MC. The NICHD neonatal research network: changes in practice and outcomes during the first 15 years. Semin Perinatol. 2003 Aug;27(4):281-7. doi: 10.1016/s0146-0005(03)00055-7.
- Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK; NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007 Feb;196(2):147.e1-8. doi: 10.1016/j.ajog.2006.09.014.
- Fanaroff AA, Wright LL, Stevenson DK, Shankaran S, Donovan EF, Ehrenkranz RA, Younes N, Korones SB, Stoll BJ, Tyson JE, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol. 1995 Nov;173(5):1423-31. doi: 10.1016/0002-9378(95)90628-2.
- Gardner MO, Papile LA, Wright LL. Antenatal corticosteroids in pregnancies complicated by preterm premature rupture of membranes. Obstet Gynecol. 1997 Nov;90(5):851-3. doi: 10.1016/S0029-7844(97)00404-3.
- Gargus RA, Vohr BR, Tyson JE, High P, Higgins RD, Wrage LA, Poole K. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics. 2009 Jul;124(1):112-21. doi: 10.1542/peds.2008-2742.
- Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL; National Institute of Child Health and Human Development Neonatal Research Network. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb;117(2):e137-42. doi: 10.1542/peds.2005-1543. Epub 2006 Jan 3.
- Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Network. Pediatrics. 1991 May;87(5):587-97.
- Heller CD, O'Shea M, Yao Q, Langer J, Ehrenkranz RA, Phelps DL, Poole WK, Stoll B, Duara S, Oh W, Lemons J, Poindexter B; NICHD Neonatal Research Network. Human milk intake and retinopathy of prematurity in extremely low birth weight infants. Pediatrics. 2007 Jul;120(1):1-9. doi: 10.1542/peds.2006-1465.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood. Arch Pediatr Adolesc Med. 2008 Aug;162(8):748-55. doi: 10.1001/archpedi.162.8.748.
- Hintz SR, Bann CM, Ambalavanan N, Cotten CM, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predicting time to hospital discharge for extremely preterm infants. Pediatrics. 2010 Jan;125(1):e146-54. doi: 10.1542/peds.2009-0810. Epub 2009 Dec 14.
- Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, Poole WK, Blakely ML, Wright L, Higgins R; NICHD Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005 Mar;115(3):696-703. doi: 10.1542/peds.2004-0569.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics. 2005 Jun;115(6):1645-51. doi: 10.1542/peds.2004-2215.
- Hintz SR, Kendrick DE, Vohr BR, Kenneth Poole W, Higgins RD; Nichd Neonatal Research Network. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants. Acta Paediatr. 2006 Oct;95(10):1239-48. doi: 10.1080/08035250600599727.
- Hintz SR, Poole WK, Wright LL, Fanaroff AA, Kendrick DE, Laptook AR, Goldberg R, Duara S, Stoll BJ, Oh W; NICHD Neonatal Research Network. Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F128-33. doi: 10.1136/adc.2003.046268.
- Horbar JD, Onstad L, Wright E. Predicting mortality risk for infants weighing 501 to 1500 grams at birth: a National Institutes of Health Neonatal Research Network report. Crit Care Med. 1993 Jan;21(1):12-8. doi: 10.1097/00003246-199301000-00008.
- Horbar JD, Wright EC, Onstad L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. The Members of the National Institute of Child Health and Human Development Neonatal Research Network. Pediatrics. 1993 Aug;92(2):191-6.
- Lainwala S, Perritt R, Poole K, Vohr B; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants who are transferred from neonatal intensive care units to level I or II nurseries. Pediatrics. 2007 May;119(5):e1079-87. doi: 10.1542/peds.2006-0899. Epub 2007 Apr 2.
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Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (Real)
1 de abril de 1987
Conclusão Primária (Estimado)
31 de março de 2030
Conclusão do estudo (Estimado)
31 de março de 2030
Datas de inscrição no estudo
Enviado pela primeira vez
19 de junho de 2003
Enviado pela primeira vez que atendeu aos critérios de CQ
19 de junho de 2003
Primeira postagem (Estimado)
20 de junho de 2003
Atualizações de registro de estudo
Última Atualização Postada (Real)
16 de março de 2026
Última atualização enviada que atendeu aos critérios de controle de qualidade
12 de março de 2026
Última verificação
1 de março de 2026
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- NICHD-NRN-0001
- UG1HD034216 (Concessão/Contrato do NIH dos EUA)
- UG1HD027904 (Concessão/Contrato do NIH dos EUA)
- UG1HD021364 (Concessão/Contrato do NIH dos EUA)
- UG1HD027853 (Concessão/Contrato do NIH dos EUA)
- UG1HD040689 (Concessão/Contrato do NIH dos EUA)
- UG1HD040492 (Concessão/Contrato do NIH dos EUA)
- UG1HD027851 (Concessão/Contrato do NIH dos EUA)
- UG1HD053109 (Concessão/Contrato do NIH dos EUA)
- UG1HD068278 (Concessão/Contrato do NIH dos EUA)
- UG1HD068244 (Concessão/Contrato do NIH dos EUA)
- UG1HD068263 (Concessão/Contrato do NIH dos EUA)
- UG1HD027880 (Concessão/Contrato do NIH dos EUA)
- UG1HD053089 (Concessão/Contrato do NIH dos EUA)
- UG1HD087226 (Concessão/Contrato do NIH dos EUA)
- UG1HD112079 (Concessão/Contrato do NIH dos EUA)
- UG1HD112097 (Concessão/Contrato do NIH dos EUA)
- UG1HD112100 (Concessão/Contrato do NIH dos EUA)
- U24HD095254 (Concessão/Contrato do NIH dos EUA)
- UG1HD112093 (Concessão/Contrato do NIH dos EUA)
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Não
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Não
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .