Database generico di neonati con peso alla nascita molto basso (GDB)
12 marzo 2026 aggiornato da: NICHD Neonatal Research Network
Database generico: un'indagine sulla morbilità e la mortalità nei neonati con peso alla nascita molto basso
Il Generic Database (GDB) è un registro di neonati con peso alla nascita molto basso nati vivi nei centri NICHD Neonatal Research Network (NRN).
Il GDB raccoglie i dati osservazionali di base sia sulle madri che sui neonati, nonché le terapie utilizzate e gli esiti dei neonati.
Le informazioni raccolte non sono specifiche per una malattia o un trattamento (vale a dire, sono "generiche").
I dati vengono analizzati per trovare associazioni e tendenze tra le informazioni di base, i trattamenti e l'esito infantile e per sviluppare futuri studi NRN.
Panoramica dello studio
Stato
Reclutamento
Condizioni
Intervento / Trattamento
Descrizione dettagliata
Il Generic Database (GDB) è un registro di neonati con peso alla nascita molto basso nati vivi nei centri NICHD Neonatal Research Network (NRN). Lo scopo è quello di raccogliere i dati di riferimento e di esito in modo uniforme su un'ampia coorte di VLBW e altri neonati malati ricoverati nelle unità di terapia intensiva neonatale.
Il GDB raccoglie i dati osservazionali di base sia sulle madri che sui neonati, nonché le terapie utilizzate e gli esiti dei neonati. Le informazioni raccolte non sono specifiche per una malattia o un trattamento (vale a dire, sono "generiche"). I dati di riferimento vengono raccolti subito dopo il ricovero in terapia intensiva neonatale; i dati sugli esiti vengono raccolti al momento della morte o della dimissione dall'ospedale. I dati raccolti includono informazioni su:
- Dati demografici della madre e del bambino
- Salute della madre (ad esempio, storia della gravidanza e complicanze)
- Travaglio e parto (p. es., rottura delle membrane, somministrazione di steroidi e antibiotici, modalità del parto)
- Salute del neonato (età gestazionale, punteggio di Apgar, peso, lunghezza, rianimazione in sala parto, supporto respiratorio, ecc.)
- Esito medico del neonato (cuore, polmone, sistema nervoso, sistema gastrointestinale, udito e vista, infezioni note e malformazioni/sindromi maggiori e mortalità o numero di giorni di ricovero).
Questi dati vengono utilizzati: per esaminare le associazioni tra caratteristiche di base, trattamenti e risultati; monitorare le tendenze nell'incidenza delle malattie e l'efficacia delle terapie; e per identificare le domande che richiedono ulteriori ricerche approfondite.
Consenso informato: Come richiesto dagli IRB locali.
Gli studi secondari includono:
A. Lo studio All Birth Cohort (ABC). Un registro osservazionale a tempo limitato per determinare l'incidenza della natimortalità intrapartum a 20 0/7 - 28 6/7 settimane di gestazione e i suoi fattori associati nei siti della rete.
Tipo di studio
Osservativo
Iscrizione (Stimato)
80000
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Contatto studio
- Nome: Abhik Das, PhD
- Numero di telefono: 301-230-4640
- Email: adas@rti.org
Backup dei contatti dello studio
- Nome: Ravi M Patal, MD
- Numero di telefono: 404-727-5905
- Email: rmpatel@emory.edu
Luoghi di studio
-
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Alabama
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Birmingham, Alabama, Stati Uniti, 35233
- Reclutamento
- University of Alabama at Birmingham
-
Contatto:
- Waldemar A. Carlo, MD
-
Investigatore principale:
- Waldemar A. Carlo, MD
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California
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Los Angeles, California, Stati Uniti, 90025
- Completato
- University of California - Los Angeles
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Palo Alto, California, Stati Uniti, 94304
- Reclutamento
- Stanford University
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Contatto:
- Krisa P. Van Meurs, MD
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Investigatore principale:
- Krisa P. Van Meurs, MD
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San Diego, California, Stati Uniti, 92103-8774
- Completato
- University of California at San Diego
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San Diego, California, Stati Uniti, 92123
- Reclutamento
- Sharp Mary Birch Hospital for Women & Newborns
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Contatto:
- Anup Katheria, MD
-
Investigatore principale:
- Anup Katheria, MD
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Connecticut
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New Haven, Connecticut, Stati Uniti, 06504
- Completato
- Yale University
-
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District of Columbia
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Washington D.C., District of Columbia, Stati Uniti, 20052
- Completato
- George Washington University
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Florida
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Miami, Florida, Stati Uniti, 33136
- Completato
- University of Miami
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-
Georgia
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Atlanta, Georgia, Stati Uniti, 30303
- Reclutamento
- Emory University
-
Contatto:
- David P Carlton, MD
-
Investigatore principale:
- David P Carlton, MD
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Illinois
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Chicago, Illinois, Stati Uniti, 60611
- Non ancora reclutamento
- Northwestern Lurie Children's Hospital of Chicago
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Contatto:
- Aaron Hamvas, MD
-
Investigatore principale:
- Aaron Hamvas, MD
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Indiana
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Indianapolis, Indiana, Stati Uniti, 46202
- Completato
- Indiana University
-
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Iowa
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Iowa City, Iowa, Stati Uniti, 52242
- Reclutamento
- University of Iowa
-
Contatto:
- Edward F. Bell, MD
-
Investigatore principale:
- Edward F. Bell, MD
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Massachusetts
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Boston, Massachusetts, Stati Uniti, 02111
- Completato
- Tufts Medical Center
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Cambridge, Massachusetts, Stati Uniti, 02138
- Completato
- Harvard University
-
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Michigan
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Detroit, Michigan, Stati Uniti, 48201
- Completato
- Wayne State University
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Mississippi
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Jackson, Mississippi, Stati Uniti, 39216
- Non ancora reclutamento
- University of Mississippi Medical Center - Children's of Mississippi
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Investigatore principale:
- Abhay Bhatt, MD
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Contatto:
- Abhay Bhatt, MD
-
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Missouri
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Kansas City, Missouri, Stati Uniti, 64108
- Completato
- Children's Mercy Hospital
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New Mexico
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Albuquerque, New Mexico, Stati Uniti, 87131
- Reclutamento
- University of New Mexico
-
Contatto:
- Kristi L. Watterberg, MD
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Investigatore principale:
- Kristi L. Watterberg, MD
-
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New York
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Rochester, New York, Stati Uniti, 14642
- Attivo, non reclutante
- University of Rochester
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North Carolina
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Durham, North Carolina, Stati Uniti, 27710
- Reclutamento
- Duke University
-
Contatto:
- C. Michael Cotten, MD, MHS
-
Investigatore principale:
- C. Michael Cotten, MD, MHS
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Durham, North Carolina, Stati Uniti, 27705
- Attivo, non reclutante
- RTI International
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Ohio
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Cincinnati, Ohio, Stati Uniti, 45267
- Reclutamento
- Cincinnati Children's Medical Center
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Contatto:
- Brenda Poindexter, MD MS
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Investigatore principale:
- Brenda Poindexter, MD MS
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Cleveland, Ohio, Stati Uniti, 44106
- Reclutamento
- Case Western Reserve University, Rainbow Babies and Children's Hospital
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Contatto:
- Michele C. Walsh, MD MS
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Investigatore principale:
- Michele C. Walsh, MD MS
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Columbus, Ohio, Stati Uniti, 43205
- Attivo, non reclutante
- Research Institute at Nationwide Children's Hospital
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Pennsylvania
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Philadelphia, Pennsylvania, Stati Uniti, 19104
- Reclutamento
- Univeristy of Pennsylvania
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Contatto:
- Eric Eichenwald, MD
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Investigatore principale:
- Eric Eichenwald, MD
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Rhode Island
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Providence, Rhode Island, Stati Uniti, 02905
- Attivo, non reclutante
- Brown University, Women & Infants Hospital of Rhode Island
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Tennessee
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Memphis, Tennessee, Stati Uniti, 38163
- Completato
- University of Tennessee
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Texas
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Dallas, Texas, Stati Uniti, 75235
- Reclutamento
- University of Texas Southwestern Medical Center at Dallas
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Contatto:
- Myra H Wyckoff, MD
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Investigatore principale:
- Myra H Wyckoff, MD
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Houston, Texas, Stati Uniti, 77030
- Reclutamento
- University of Texas Health Science Center at Houston
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Contatto:
- Jon E. Tyson, MD MPH
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Investigatore principale:
- Jon E. Tyson, MD MPH
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Utah
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Salt Lake City, Utah, Stati Uniti, 84108
- Reclutamento
- University of Utah
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Contatto:
- Bradley Yoder, MD
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Investigatore principale:
- Bradley Yoder, MD
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Vermont
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Burlington, Vermont, Stati Uniti, 05405
- Completato
- University of Vermont
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
Non più vecchio di 2 settimane (Bambino)
Accetta volontari sani
No
Metodo di campionamento
Campione non probabilistico
Popolazione di studio
Neonati nati nei centri NICHD NRN con peso alla nascita compreso tra 401 e 1000 grammi e/o età gestazionale <29 settimane, OPPURE neonati arruolati in uno o più studi aggiuntivi NICHD NRN.
Descrizione
Criterio di inclusione:
- Neonati nati nei centri NICHD NRN che sono:
- 401-1000 grammi di peso alla nascita e/o
- Età gestazionale da 20 0/7 a 28 6/7 settimane (<29 settimane).
- Neonati arruolati in uno o più ulteriori studi interventistici NICHD NRN o studi osservazionali a tempo limitato. Per i neonati che non soddisfano i criteri di inclusione di cui sopra, i criteri di inclusione ed esclusione per il database generico sono determinati dai criteri per le prove aggiuntive. In questi casi, i bambini di peso superiore a 1.000 grammi e/o di età superiore a 29 settimane possono essere inclusi nel GDB.
Criteri di esclusione:
- Neonati > 1.000 grammi di peso alla nascita e/o > 29 settimane di età gestazionale
Nota: questi criteri di inclusione sono stati modificati a partire dal 1/1/2008. Prima di questa data, tutti i neonati con peso alla nascita compreso tra 401 e 1500 grammi che sono stati ammessi alle UTIN entro 14 giorni dalla nascita della RRN sono stati inclusi nel database.
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Modelli osservazionali: Coorte
- Prospettive temporali: Prospettiva
Coorti e interventi
Gruppo / Coorte |
Intervento / Trattamento |
|---|---|
|
Coorte di registro
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Per mantenere un registro di dati di base e di esito per i bambini VLBW con dati raccolti in modo uniforme
Lasso di tempo: Database longitudinale attualmente finanziato attraverso il 31/03/2030
|
Per mantenere un registro dei dati di base e dei risultati per i bambini VLBW con i dati raccolti
|
Database longitudinale attualmente finanziato attraverso il 31/03/2030
|
Misure di risultato secondarie
Misura del risultato |
Lasso di tempo |
|---|---|
|
Esaminare la relazione tra le caratteristiche di base e il risultato
Lasso di tempo: Database longitudinale attualmente finanziato fino al 31/03/2021
|
Database longitudinale attualmente finanziato fino al 31/03/2021
|
|
Per monitorare le tendenze nell'incidenza di varie entità di malattia
Lasso di tempo: Database longitudinale attualmente finanziato fino al 31/03/2021
|
Database longitudinale attualmente finanziato fino al 31/03/2021
|
|
Per monitorare i cambiamenti nel VLBW e la sopravvivenza in età gestazionale precoce
Lasso di tempo: Database longitudinale attualmente finanziato fino al 31/03/2021
|
Database longitudinale attualmente finanziato fino al 31/03/2021
|
|
Fornire dati per la formulazione di ipotesi e il calcolo della dimensione del campione per gli studi multicentrici di rete
Lasso di tempo: Database longitudinale attualmente finanziato fino al 31/03/2021
|
Database longitudinale attualmente finanziato fino al 31/03/2021
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Collaboratori
Investigatori
- Investigatore principale: Jon E Tyson, MD MPH, The University of Texas Health Science Center, Houston
- Investigatore principale: Carl D'Angio, MD, University of Rochester
- Investigatore principale: Robin Ohls, MD, University of Utah
- Investigatore principale: Waldemar A Carlo, MD, University of Alabama at Birmingham
- Investigatore principale: Abhik Das, PhD, RTI International
- Investigatore principale: Abbot R Laptook, MD, Brown University, Women & Infants Hospital of Rhode Island
- Investigatore principale: Anna Maria Hibbs, MD, MSCE, FAAP, Case Western Reserve University, Rainbow Babies and Children's Hospital
- Investigatore principale: C. Michael Cotten, MD, Duke University
- Cattedra di studio: Ravi M Patel, MD, MSc, Emory University
- Investigatore principale: Krisa P Van Meurs, MD, Stanford University
- Investigatore principale: Stephanie Merhar, MD MS, Children's Hospital Medical Center, Cincinnati
- Investigatore principale: Tarah Colaizy, MD, MPH, University of Iowa
- Investigatore principale: Kristi L Watterberg, MD, University of New Mexico
- Investigatore principale: Myra Wyckoff, MD, University of Texas, Southwestern Medical Center at Dallas
- Investigatore principale: Sara DeMauro, MD, MSCE, University of Pennsylvania
- Investigatore principale: Pablo Sanchez, MD, Research Institute at Nationwide Children's Hospital
Pubblicazioni e link utili
La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.
Pubblicazioni generali
- Malcolm WF, Gantz M, Martin RJ, Goldstein RF, Goldberg RN, Cotten CM; National Institute of Child Health and Human Development Neonatal Research Network. Use of medications for gastroesophageal reflux at discharge among extremely low birth weight infants. Pediatrics. 2008 Jan;121(1):22-7. doi: 10.1542/peds.2007-0381.
- Strand M, Jobe AH. The multiple negative randomized controlled trials in perinatology--why? Semin Perinatol. 2003 Aug;27(4):343-50. doi: 10.1016/s0146-0005(03)00042-9.
- Tyson JE, Stoll BJ. Evidence-based ethics and the care and outcome of extremely premature infants. Clin Perinatol. 2003 Jun;30(2):363-87. doi: 10.1016/s0095-5108(03)00028-9.
- Wright LL. How to develop and manage a successful research network. Semin Pediatr Surg. 2002 Aug;11(3):175-80; discussion 180. doi: 10.1053/spsu.2002.33740. No abstract available.
- Wright LL, McNellis D. National Institute of Child Health and Human Development (NICHD)-sponsored Perinatal Research Networks. Semin Perinatol. 1995 Apr;19(2):112-23. doi: 10.1016/s0146-0005(05)80031-x. No abstract available.
- Adams-Chapman I, Hansen NI, Stoll BJ, Higgins R; NICHD Research Network. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008 May;121(5):e1167-77. doi: 10.1542/peds.2007-0423. Epub 2008 Apr 7.
- Ambalavanan N, Carlo WA, Bobashev G, Mathias E, Liu B, Poole K, Fanaroff AA, Stoll BJ, Ehrenkranz R, Wright LL; National Institute of Child Health and Human Development Neonatal Research Network. Prediction of death for extremely low birth weight neonates. Pediatrics. 2005 Dec;116(6):1367-73. doi: 10.1542/peds.2004-2099.
- Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R; National Institute of Child Health and Human Development Neonatal Research Network. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006 Jan;117(1):84-92. doi: 10.1542/peds.2004-2292.
- Broitman E, Ambalavanan N, Higgins RD, Vohr BR, Das A, Bhaskar B, Murray K, Hintz SR, Carlo WA; National Institute of Child Health and Human Development Neonatal Research Network. Clinical data predict neurodevelopmental outcome better than head ultrasound in extremely low birth weight infants. J Pediatr. 2007 Nov;151(5):500-5, 505.e1-2. doi: 10.1016/j.jpeds.2007.04.013. Epub 2007 Jul 12.
- Castro L, Yolton K, Haberman B, Roberto N, Hansen NI, Ambalavanan N, Vohr BR, Donovan EF. Bias in reported neurodevelopmental outcomes among extremely low birth weight survivors. Pediatrics. 2004 Aug;114(2):404-10. doi: 10.1542/peds.114.2.404.
- Cole CR, Hansen NI, Higgins RD, Ziegler TR, Stoll BJ; Eunice Kennedy Shriver NICHD Neonatal Research Network. Very low birth weight preterm infants with surgical short bowel syndrome: incidence, morbidity and mortality, and growth outcomes at 18 to 22 months. Pediatrics. 2008 Sep;122(3):e573-82. doi: 10.1542/peds.2007-3449.
- Cotten CM, Oh W, McDonald S, Carlo W, Fanaroff AA, Duara S, Stoll B, Laptook A, Poole K, Wright LL, Goldberg RN; NICHD Neonatal Research Network. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol. 2005 Oct;25(10):650-5. doi: 10.1038/sj.jp.7211369.
- Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, Ambalavanan N, Benjamin DK Jr; NICHD Neonatal Research Network. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009 Jan;123(1):58-66. doi: 10.1542/peds.2007-3423.
- Da Costa D, Bann CM, Hansen NI, Shankaran S, Delaney-Black V; National Institute of Child Health and Human Development Neonatal Research Network. Validation of the Functional Status II questionnaire in the assessment of extremely-low-birthweight infants. Dev Med Child Neurol. 2009 Jul;51(7):536-44. doi: 10.1111/j.1469-8749.2009.03318.x.
- Demarini S, Dollberg S, Hoath SB, Ho M, Donovan EF. Effects of antenatal corticosteroids on blood pressure in very low birth weight infants during the first 24 hours of life. J Perinatol. 1999 Sep;19(6 Pt 1):419-25. doi: 10.1038/sj.jp.7200245.
- Dollberg S, Demarini S, Donovan EF, Hoath SB. Maturation of thermal capabilities in preterm infants. Am J Perinatol. 2000;17(1):47-51. doi: 10.1055/s-2000-7293.
- Donovan EF, Ehrenkranz RA, Shankaran S, Stevenson DK, Wright LL, Younes N, Fanaroff AA, Korones SB, Stoll BJ, Tyson JE, Bauer CR, Lemons JA, Oh W, Papile LA. Outcomes of very low birth weight twins cared for in the National Institute of Child Health and Human Development Neonatal Research Network's intensive care units. Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):742-9. doi: 10.1016/s0002-9378(98)70075-4.
- Doyle NM, Gardner MO, Wells L, Qualls C, Papile LA. Outcome of very low birth weight infants exposed to antenatal indomethacin for tocolysis. J Perinatol. 2005 May;25(5):336-40. doi: 10.1038/sj.jp.7211256.
- Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K; National Institutes of Child Health and Human Development Neonatal Research Network. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005 Dec;116(6):1353-60. doi: 10.1542/peds.2005-0249.
- Ehrenkranz RA, Wright LL. NICHD neonatal research network: contributions and future challenges. Semin Perinatol. 2003 Aug;27(4):264-80. doi: 10.1016/s0146-0005(03)00041-7.
- Fanaroff AA, Hack M, Walsh MC. The NICHD neonatal research network: changes in practice and outcomes during the first 15 years. Semin Perinatol. 2003 Aug;27(4):281-7. doi: 10.1016/s0146-0005(03)00055-7.
- Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR, Bauer CR, Donovan EF, Korones SB, Laptook AR, Lemons JA, Oh W, Papile LA, Shankaran S, Stevenson DK, Tyson JE, Poole WK; NICHD Neonatal Research Network. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol. 2007 Feb;196(2):147.e1-8. doi: 10.1016/j.ajog.2006.09.014.
- Fanaroff AA, Wright LL, Stevenson DK, Shankaran S, Donovan EF, Ehrenkranz RA, Younes N, Korones SB, Stoll BJ, Tyson JE, et al. Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992. Am J Obstet Gynecol. 1995 Nov;173(5):1423-31. doi: 10.1016/0002-9378(95)90628-2.
- Gardner MO, Papile LA, Wright LL. Antenatal corticosteroids in pregnancies complicated by preterm premature rupture of membranes. Obstet Gynecol. 1997 Nov;90(5):851-3. doi: 10.1016/S0029-7844(97)00404-3.
- Gargus RA, Vohr BR, Tyson JE, High P, Higgins RD, Wrage LA, Poole K. Unimpaired outcomes for extremely low birth weight infants at 18 to 22 months. Pediatrics. 2009 Jul;124(1):112-21. doi: 10.1542/peds.2008-2742.
- Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL; National Institute of Child Health and Human Development Neonatal Research Network. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006 Feb;117(2):e137-42. doi: 10.1542/peds.2005-1543. Epub 2006 Jan 3.
- Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Network. Pediatrics. 1991 May;87(5):587-97.
- Heller CD, O'Shea M, Yao Q, Langer J, Ehrenkranz RA, Phelps DL, Poole WK, Stoll B, Duara S, Oh W, Lemons J, Poindexter B; NICHD Neonatal Research Network. Human milk intake and retinopathy of prematurity in extremely low birth weight infants. Pediatrics. 2007 Jul;120(1):1-9. doi: 10.1542/peds.2006-1465.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. Community supports after surviving extremely low-birth-weight, extremely preterm birth: special outpatient services in early childhood. Arch Pediatr Adolesc Med. 2008 Aug;162(8):748-55. doi: 10.1001/archpedi.162.8.748.
- Hintz SR, Bann CM, Ambalavanan N, Cotten CM, Das A, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predicting time to hospital discharge for extremely preterm infants. Pediatrics. 2010 Jan;125(1):e146-54. doi: 10.1542/peds.2009-0810. Epub 2009 Dec 14.
- Hintz SR, Kendrick DE, Stoll BJ, Vohr BR, Fanaroff AA, Donovan EF, Poole WK, Blakely ML, Wright L, Higgins R; NICHD Neonatal Research Network. Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis. Pediatrics. 2005 Mar;115(3):696-703. doi: 10.1542/peds.2004-0569.
- Hintz SR, Kendrick DE, Vohr BR, Poole WK, Higgins RD; National Institute of Child Health and Human Development Neonatal Research Network. Changes in neurodevelopmental outcomes at 18 to 22 months' corrected age among infants of less than 25 weeks' gestational age born in 1993-1999. Pediatrics. 2005 Jun;115(6):1645-51. doi: 10.1542/peds.2004-2215.
- Hintz SR, Kendrick DE, Vohr BR, Kenneth Poole W, Higgins RD; Nichd Neonatal Research Network. Gender differences in neurodevelopmental outcomes among extremely preterm, extremely-low-birthweight infants. Acta Paediatr. 2006 Oct;95(10):1239-48. doi: 10.1080/08035250600599727.
- Hintz SR, Poole WK, Wright LL, Fanaroff AA, Kendrick DE, Laptook AR, Goldberg R, Duara S, Stoll BJ, Oh W; NICHD Neonatal Research Network. Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfactant era. Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90(2):F128-33. doi: 10.1136/adc.2003.046268.
- Horbar JD, Onstad L, Wright E. Predicting mortality risk for infants weighing 501 to 1500 grams at birth: a National Institutes of Health Neonatal Research Network report. Crit Care Med. 1993 Jan;21(1):12-8. doi: 10.1097/00003246-199301000-00008.
- Horbar JD, Wright EC, Onstad L. Decreasing mortality associated with the introduction of surfactant therapy: an observational study of neonates weighing 601 to 1300 grams at birth. The Members of the National Institute of Child Health and Human Development Neonatal Research Network. Pediatrics. 1993 Aug;92(2):191-6.
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- Salas AA, Carlo WA, Bann CM, Bell EF, Colaizy TT, Younge N, Peralta M, Ambalavanan N, Poindexter BB; Eunice Kennedy Shriver NICHD Neonatal Research Network. Risk Assessment of Cognitive Impairment at 2 Years of Age in Infants Born Extremely Preterm Using the INTERGROWTH-21st Growth Standards. J Pediatr. 2024 Dec;275:114239. doi: 10.1016/j.jpeds.2024.114239. Epub 2024 Aug 19.
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Collegamenti utili
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
1 aprile 1987
Completamento primario (Stimato)
31 marzo 2030
Completamento dello studio (Stimato)
31 marzo 2030
Date di iscrizione allo studio
Primo inviato
19 giugno 2003
Primo inviato che soddisfa i criteri di controllo qualità
19 giugno 2003
Primo Inserito (Stimato)
20 giugno 2003
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
16 marzo 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
12 marzo 2026
Ultimo verificato
1 marzo 2026
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- NICHD-NRN-0001
- UG1HD034216 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD027904 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD021364 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD027853 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD040689 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD040492 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD027851 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD053109 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD068278 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD068244 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD068263 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD027880 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD053089 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD087226 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD112079 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD112097 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD112100 (Sovvenzione/contratto NIH degli Stati Uniti)
- U24HD095254 (Sovvenzione/contratto NIH degli Stati Uniti)
- UG1HD112093 (Sovvenzione/contratto NIH degli Stati Uniti)
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .