Vitamin D Levels and Survival in Cancer Patients
28. august 2017 opdateret af: Icelandic Heart Association
Association of Pre-diagnostic Vitamin D Levels and Survival in Older Individuals With Cancer
Using the population-based data sources in Iceland and the well-characterized AGES-Reykjavik cohort, our overarching aims are on exploring whether pre-diagnostic serum levels of 25-hydroxyvitamin D (25(OH)D) among older individuals living in Iceland were associated with survival after cancer diagnosis.
We also wanted to assess the risk of being diagnosed with cancer in association with 25(OH)D levels.
In this population living just south of the arctic circle, vitamin D levels largely depend on dietary- and supplemental sources.
Studieoversigt
Status
Afsluttet
Betingelser
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
5764
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
66 år til 98 år (Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Sandsynlighedsprøve
Studiebefolkning
In 1967, all 30,795 men and women living in the capital area of Iceland and born between 1907 and 1935 were invited by the Icelandic Heart Association to join a prospective cohort study.
Approximately 19,000 attended the clinic at least once and became participants of the Reykjavik Study.
Subsequently, in 2002, a random sample of the cohort comprising 5,764 men and women who were still alive in Iceland and aged 66 to 96 years entered the Ages Gene/Environment Susceptibility (AGES) - Reykjavik Study (20).
Serum 25(OH)D was measured in 5,519 of all 5,764 (96%) participants at study entry in year 2002 through 2006.
Beskrivelse
Inclusion Criteria:
To be part of the AGES-Reykjavik Study, initiated between 2002 and 2006.
Exclusion Criteria:
Diagnosed with cancer at study entry
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Overall mortality among cancer patients
Tidsramme: Patients were followed from date of diagnosis since 2002 until death or censored at end of the follow-up (December 31, 2014)
|
We tested the association between pre-diagnostic 25(OH)D levels and total survival
|
Patients were followed from date of diagnosis since 2002 until death or censored at end of the follow-up (December 31, 2014)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Cancer-specific mortality among cancer patients
Tidsramme: Patients were followed from date of diagnosis since 2002 until death or censored at end of the follow-up (December 31, 2014)
|
We tested the association between pre-diagnostic 25(OH)D levels and cancer survival
|
Patients were followed from date of diagnosis since 2002 until death or censored at end of the follow-up (December 31, 2014)
|
Andre resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Pre-diagnostic 25(OH)D levels and cancer risk
Tidsramme: Participants without cancer were followed from the study entry since 2002 until cancer diagnosis, death or end of the observation period whichever occurred first (December 31, 2014)
|
We tested the association between pre-diagnostic 25(OH)D levels and risk of being diagnosed with cancer
|
Participants without cancer were followed from the study entry since 2002 until cancer diagnosis, death or end of the observation period whichever occurred first (December 31, 2014)
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. januar 2002
Primær færdiggørelse (Faktiske)
30. december 2006
Studieafslutning (Faktiske)
30. december 2006
Datoer for studieregistrering
Først indsendt
28. august 2017
Først indsendt, der opfyldte QC-kriterier
28. august 2017
Først opslået (Faktiske)
30. august 2017
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
30. august 2017
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
28. august 2017
Sidst verificeret
1. august 2017
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- HI14010102
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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