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Prevalence of Sarcopenia and Its Associated Factors in Patients With Knee Osteoarthritis in a Tertiary Care Hospital in Upper Egypt

27. april 2026 opdateret af: Esraa Mostafa Hosny Ibrahim, Assiut University
Osteoarthritis (OA) and sarcopenia are two highly prevalent, interconnected geriatric syndromes that often coexist, leading to a condition termed "osteosarcopenia". Globally, the pooled prevalence of sarcopenia in patients with knee OA is estimated at approximately 25.07%, significantly higher than in the general population.

Studieoversigt

Status

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Betingelser

Detaljeret beskrivelse

Chronic inflammation, joint pain, and reduced physical activity in OA patients create a vicious cycle that accelerates muscle mass loss and functional decline. While international data is robust, Egyptian epidemiological data remains limited. Recent studies in Egypt have identified a high risk of sarcopenia among older adults with fragility fractures and a prevalence of 17.7% in nursing home residents. However, targeted data on the OA population in Egypt is still lacking. Current management in Egyptian primary care centers primarily focuses on symptomatic relief of OA through analgesics and physical therapy. Sarcopenia often remains underdiagnosed because routine screening tools, such as the SARC-F questionnaire or Bioelectrical Impedance Analysis (BIA), are not yet integrated into standard family medicine protocols. This oversight leads to increased frailty and poorer surgical outcomes for patients requiring joint replacement. In the family medicine practice, identifying sarcopenia early is vital for holistic care. Understanding the local prevalence and risk factors-such as Vitamin D deficiency, sedentary behavior, and low protein intake-is essential to tailor interventions. This research aims to provide the evidentiary basis for incorporating sarcopenia screening into primary care OA management, ultimately improving patient mobility and quality of life

Undersøgelsestype

Observationel

Tilmelding (Anslået)

224

Kontakter og lokationer

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Studiesteder

Deltagelseskriterier

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Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Adult patients aged 40 years and older, diagnosed with knee osteoarthritis, who are attending the Assiut University Trauma Hospital.

Beskrivelse

Inclusion Criteria:

  • Adults aged 40 years and older diagnosed with knee OA based on the American College of Rheumatology (ACR) criteria.
  • Patients who are willing to participate and provide informed written consent.Exclusion Criteria:
  • Inflammatory arthritis: patients with rheumatoid arthritis, gouty arthritis, or systemic lupus erythematosus (SLE) to avoid confusion with inflammatory muscle wasting.
  • Physical Limitations: amputees or those with severe physical deformities preventing gait speed tests or handgrip measurement.
  • Patients with cardiac pacemakers or implanted electronic devices (as these interfere with Bioelectrical Impedance Analysis (BIA)).
  • Severe Comorbidities: end-stage renal or hepatic disease, advanced malignancy or cachexia.
  • Severe neurological disorders (e.g., Parkinson's disease, Stroke with paralysis) that directly affect muscle mass and mobility.
  • Prolonged use of systemic corticosteroids (which cause secondary sarcopenia)

Studieplan

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Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Knee Osteoarthritis Patients
Adults aged 40 years and older diagnosed with knee osteoarthritis based on the American College of Rheumatology (ACR) criteria attending the Assiut University Trauma Hospital.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Prevalence of sarcopenia in knee osteoarthritis patients
Tidsramme: at baseline
Prevalence of OA patients who meet the diagnostic criteria for sarcopenia (low muscle mass, strength, and physical performance) according to the European Working Group on Sarcopenia in Older People (EWGSOP2) revised consensus.
at baseline

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Nutritional Risk Assessment via Malnutrition Universal Screening Tool (MUST)
Tidsramme: Baseline
Evaluation of nutritional status as a factor associated with sarcopenia. The MUST score is a five-step screening tool with a total score ranging from 0 (low risk) to 2 or more (high risk).
Baseline
The Quality of Life Factor (EQ-5D Index)
Tidsramme: Baseline
Assessment of the impact of sarcopenia and OA on quality of life. The 5 dimensions (Mobility, Self-care, Usual activities, Pain/discomfort, Anxiety/depression)
Baseline

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Sponsor

Assiut University

Datoer for undersøgelser

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Studer store datoer

Studiestart (Anslået)

1. maj 2026

Primær færdiggørelse (Anslået)

1. april 2027

Studieafslutning (Anslået)

1. juli 2027

Datoer for studieregistrering

Først indsendt

15. april 2026

Først indsendt, der opfyldte QC-kriterier

27. april 2026

Først opslået (Faktiske)

5. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

5. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

27. april 2026

Sidst verificeret

1. april 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • Sarcopenia_OA_Assiut

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