Randomisierte, eingebettete, multifaktorielle adaptive Plattformstudie für ambulant erworbene Pneumonie (REMAP-CAP)
30. Oktober 2026 aktualisiert von: Lennie Derde, UMC Utrecht
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.
The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of hospitalised patients admitted to intensive care with respiratory tract infections.
In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.
REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.
Studienübersicht
Status
Status
Rekrutierung
Bedingungen
Bedingungen
Intervention / Behandlung
Intervention / Behandlung
- Arzneimittel: Ceftriaxone + Macrolide
- Arzneimittel: Moxifloxacin or Levofloxacin
- Arzneimittel: Piperacillin-tazobactam + Macrolide
- Arzneimittel: Ceftaroline + Macrolide
- Arzneimittel: Amoxicillin-clavulanate + Macrolide
- Arzneimittel: Standard course macrolide
- Arzneimittel: Extended course macrolide
- Sonstiges: No systemic corticosteroid
- Arzneimittel: Fixed-duration Hydrocortisone
- Arzneimittel: Shock-dependent hydrocortisone
- Arzneimittel: Fixed-duration higher dose Hydrocortisone
- Arzneimittel: Fixed-duration dexamethasone
- Sonstiges: No antiviral agent for influenza
- Arzneimittel: Five-days oseltamivir
- Arzneimittel: Ten-days oseltamivir
- Arzneimittel: Baloxavir Marboxil
- Arzneimittel: Five-days oseltamivir + baloxavir marboxil
- Arzneimittel: Ten-days oseltamivir + baloxavir marboxil
- Sonstiges: No antiviral agent for COVID-19
- Arzneimittel: Lopinavir / Ritonavir
- Arzneimittel: Hydroxychloroquine
- Arzneimittel: Hydroxychloroquine + lopinavir/ritonavir
- Arzneimittel: Ivermectin
- Sonstiges: No immune modulation for COVID-19
- Arzneimittel: Interferon beta-1a
- Arzneimittel: Anakinra
- Arzneimittel: Tocilizumab
- Arzneimittel: Sarilumab
- Arzneimittel: Tocilizumab
- Arzneimittel: Local standard venous thromboprophylaxis
- Arzneimittel: Therapeutic dose anticoagulation
- Arzneimittel: Conventional low dose thromboprophylaxis
- Arzneimittel: Intermediate dose thromboprophylaxis
- Arzneimittel: Continuation of therapeutic dose anticoagulation
- Sonstiges: No immunoglobulin
- Biologisch: Convalescent plasma
- Biologisch: Delayed administration of convalescent plasma
- Sonstiges: No vitamin C
- Arzneimittel: Vitamin C
- Sonstiges: No simvastatin
- Arzneimittel: Simvastatin
- Sonstiges: No antiplatelet
- Arzneimittel: Aspirin
- Arzneimittel: P2Y12 inhibitor
- Verfahren: Clinician-preferred mechanical ventilation strategy
- Verfahren: Protocolised mechanical ventilation strategy
- Arzneimittel: Eritoran
- Arzneimittel: Apremilast
- Sonstiges: No renin-angiotensin system inhibitor
- Arzneimittel: Angiotensin converting enzyme inhibitor
- Arzneimittel: Angiotensin Receptor Blockers
- Arzneimittel: ARB + DMX-200
- Sonstiges: No cysteamine
- Arzneimittel: Cysteamine
- Sonstiges: No endothelial modulator
- Arzneimittel: Imatinib
- Sonstiges: No Immune Modulator for Influenza
- Arzneimittel: Baricitinib
- Arzneimittel: Nirmatrelvir/ritonavir
- Arzneimittel: Remdesivir
- Arzneimittel: Nirmatrelvir/ritonavir + remdesivir
- Arzneimittel: Amoxicillin-clavulanate + Ceftazidime + Macrolide
- Arzneimittel: Meropenem + Macrolide
Detaillierte Beschreibung
Background: Respiratory tract infections that are of sufficient severity to require admission to hospital are associated with substantial mortality. All hospitalized patients with respiratory tract infections will receive therapy that consists of a combination of multiple different treatments. For many of these treatments, different options are available currently. For example, several antibiotics exist that are active against the microorganisms that commonly cause pneumonia but it is not known if one antibiotic strategy is best, or whether all suitable antibiotic strategies have similar levels of effectiveness. Of all the treatments that clinicians use for patients with respiratory tract infections, only a small minority have been tested in randomized controlled trials to determine their comparative effectiveness. As a consequence, the standard treatments that are administered vary between and within countries. Current conventional clinical trials methods to assess the efficacy of treatments for respiratory tract infections generally compare two treatment options (either two options for the same treatment modality, where both are in common use; or a new treatment against no treatment or placebo, where the effectiveness of the new treatment is not known). Using this approach, in a series of separate and sequential trials, it will take an inordinate length of time to study all the treatment options. Additionally, with conventional trial designs it is not possible to evaluate interactions between treatment options.
Aim: The primary objective of this platform trial is, for patients hospitalized with respiratory tract infection, to identify the effect of a range of interventions to improve patient outcomes.
Methods: The study will enroll hospitalized patients with respiratory tract infection using a trial design known as a REMAP, which is a type of platform trial. Within this platform trial, eligible participants will be randomized to receive one intervention in each of one or more domains. The primary outcome is a composite of 90-day all-cause mortality and, among survivors, a daily ordinal scale analyzed as a trajectory of illness and recovery to 28-days. There will also be both Platform and domain-specific secondary outcome measures.
In a conventional trial enrollment continues until a pre-specified sample size is obtained, at which time enrollment ceases and the trial data are analyzed to obtain a result. The possible results are that a difference is detected, or no that no difference is detected. However, when the conclusion of the statistical test is "no difference", this could reflect that there truly is no meaningful difference or that the result is indeterminate (i.e., it is possible that if more patients had been enrolled a clinically relevant difference may have been detected).
In comparison to a conventional trial this Platform uses an adaptive design that:
- avoids indeterminate results by concluding an answer to a question when sufficient data have accrued (not when a pre-specified sample is reached);
- utilizes already accrued data to increase the likelihood that patients within the trial are more likely to be randomized to treatments that are more likely to be beneficial;
- is intended to be perpetual (or at least open-ended), substituting new questions in series as initial questions are answered; and
- can evaluate the interaction between interventions in different domains, added at different timepoints into the Platform.
Bayesian statistical methods will be used to define Statistical Triggers that reflect thresholds for decision making within a domain. While a limited number of initial treatments and treatment domains were specified at initiation, other interventions and domains have been evaluated over time, and it is planned that this platform trial will continue to evaluate other treatments in the future. Furthermore, in the event of a future epidemic, this Platform is able to adapt to evaluate the most relevant treatment options.
Studientyp
Studientyp
Interventionell
Einschreibung (Geschätzt)
Einschreibung
20000
Phase
Phase
- Phase 3
Kontakte und Standorte
Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.
Studienkontakt
Studienkontakt
- Name: Cameron Green, MSc
- E-Mail: info@remapcap.org
Studieren Sie die Kontaktsicherung
- Name: Svenja Peters, MSc
- E-Mail: EU.remapcap@umcutrecht.nl
Studienorte
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Australian Capital Territory
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Canberra, Australian Capital Territory, Australien, 2605
- Rekrutierung
- Canberra Hospital
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New South Wales
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Bankstown, New South Wales, Australien, 2200
- Rekrutierung
- Bankstown-Lidcombe Hospital
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Blacktown, New South Wales, Australien, 2148
- Rekrutierung
- Blacktown Hospital
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Campbelltown, New South Wales, Australien, 2560
- Rekrutierung
- Campbelltown Hospital
-
Caringbah, New South Wales, Australien, 2229
- Rekrutierung
- Sutherland Hospital
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Concord, New South Wales, Australien, 2139
- Rekrutierung
- Concord Hospital
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Dubbo, New South Wales, Australien, 2830
- Rekrutierung
- Dubbo Base Hospital
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Frenchs Forest, New South Wales, Australien, 2086
- Rekrutierung
- Northern Beaches Hospital
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Kingswood, New South Wales, Australien, 2750
- Rekrutierung
- Nepean Hospital
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Kogarah, New South Wales, Australien, 2217
- Rekrutierung
- St. George Hospital
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Liverpool, New South Wales, Australien, 2170
- Rekrutierung
- Liverpool Hospital
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Newcastle, New South Wales, Australien, 2305
- Rekrutierung
- John Hunter Hospital
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Orange, New South Wales, Australien, 2800
- Noch keine Rekrutierung
- Orange Health Service
-
Sydney, New South Wales, Australien, 2065
- Rekrutierung
- Royal North Shore Hospital
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Sydney, New South Wales, Australien, 2010
- Rekrutierung
- St Vincent's Hospital Sydney
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Sydney, New South Wales, Australien, 2031
- Rekrutierung
- Prince of Wales Hospital
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Sydney, New South Wales, Australien, 2050
- Noch keine Rekrutierung
- Royal Prince Alfred Hospital
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Sydney, New South Wales, Australien, 2500
- Rekrutierung
- Wollongong Hospital
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Wagga Wagga, New South Wales, Australien, 2650
- Noch keine Rekrutierung
- Wagga Wagga Base Hospital
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Westmead, New South Wales, Australien, 2145
- Rekrutierung
- Westmead Hospital
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Northern Territory
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Darwin, Northern Territory, Australien, 0810
- Noch keine Rekrutierung
- Royal Darwin Hospital,
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Queensland
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Birtinya, Queensland, Australien, 4575
- Noch keine Rekrutierung
- Sunshine Coast University Hospital
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Brisbane, Queensland, Australien, 4102
- Rekrutierung
- Princess Alexandra Hospital
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Brisbane, Queensland, Australien, 4032
- Rekrutierung
- The Prince Charles Hospital
-
Brisbane, Queensland, Australien, 4101
- Rekrutierung
- Mater Hospital Brisbane
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Caboolture, Queensland, Australien, 4510
- Rekrutierung
- Caboolture Hospital
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Coopers Plains, Queensland, Australien, 4110
- Rekrutierung
- Queen Elizabeth II Jubilee Hospital
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Logan City, Queensland, Australien, 4129
- Noch keine Rekrutierung
- Logan Hospital
-
Redcliffe, Queensland, Australien, 4020
- Noch keine Rekrutierung
- Redcliffe Hospital
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Rockhampton, Queensland, Australien, 4700
- Noch keine Rekrutierung
- Rockhampton Hospital
-
Southport, Queensland, Australien, 4215
- Rekrutierung
- Gold Coast University Hospital
-
Toowoomba, Queensland, Australien, 4350
- Rekrutierung
- Toowoomba Hospital
-
Townsville, Queensland, Australien, 4814
- Rekrutierung
- Townsville Hospital
-
-
South Australia
-
Adelaide, South Australia, Australien, 5000
- Rekrutierung
- Royal Adelaide Hospital
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Adelaide, South Australia, Australien, 5011
- Rekrutierung
- The Queen Elizabeth Hospital
-
Adelaide, South Australia, Australien, 5112
- Rekrutierung
- Lyell McEwin Hospital
-
Bedford Park, South Australia, Australien, 5042
- Rekrutierung
- Flinders Medical Centre
-
-
Tasmania
-
Launceston, Tasmania, Australien, 7250
- Rekrutierung
- Launceston Hospital
-
-
Victoria
-
Ballarat, Victoria, Australien, 3350
- Rekrutierung
- Ballarat Base Hospital
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Bendigo, Victoria, Australien, 3550
- Rekrutierung
- Bendigo Hospital
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Berwick, Victoria, Australien, 3806
- Rekrutierung
- Casey Hospital
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Box Hill, Victoria, Australien, 3128
- Rekrutierung
- Box Hill Hospital
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Clayton, Victoria, Australien, 3168
- Rekrutierung
- Monash Medical Centre
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Dandenong, Victoria, Australien, 3175
- Rekrutierung
- Dandenong Hospital
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Ferntree Gully, Victoria, Australien, 3156
- Noch keine Rekrutierung
- Angliss Hospital
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Footscray, Victoria, Australien, 3011
- Rekrutierung
- Footscray Hospital
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Geelong, Victoria, Australien, 3220
- Rekrutierung
- University Hosptial Geelong
-
Melbourne, Victoria, Australien, 3004
- Rekrutierung
- The Alfred Hospital
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Melbourne, Victoria, Australien, 3050
- Rekrutierung
- Royal Melbourne Hospital
-
Melbourne, Victoria, Australien, 3065
- Rekrutierung
- St Vincent's Hospital Melbourne
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Ringwood East, Victoria, Australien, 3135
- Rekrutierung
- Maroondah Hospital
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Sunshine, Victoria, Australien, 3021
- Rekrutierung
- Sunshine Hospital
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Werribee, Victoria, Australien, 3030
- Rekrutierung
- Werribee Mercy Hospital
-
-
Western Australia
-
Midland, Western Australia, Australien, 6056
- Rekrutierung
- St John of God Hospital Midland
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Murdoch, Western Australia, Australien, 6150
- Noch keine Rekrutierung
- St John of God Hospital Murdoch
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Perth, Western Australia, Australien, 6000
- Rekrutierung
- Royal Perth Hospital
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Perth, Western Australia, Australien, 6150
- Rekrutierung
- Fiona Stanley Hospital
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Perth, Western Australia, Australien, 6009
- Rekrutierung
- Sir Charles Gairdner Hospital
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Subiaco, Western Australia, Australien, 6008
- Rekrutierung
- St John of God Subiaco
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-
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Charleroi, Belgien, 6042
- Rekrutierung
- CHU de Charleroi - Hôpital Civil Marie Curie
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Kontakt:
- Patrick Biston, MD
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Ghent, Belgien, 9000
- Rekrutierung
- Universitair Ziekenhuis Gent
-
Kontakt:
- Pieter Depuydt, Prof.
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Namur, Belgien, 5530
- Rekrutierung
- CHU Namur site Godinne
-
Kontakt:
- Pierre Bulpa, MD
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Berlin, Deutschland, 10117
- Zurückgezogen
- Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie
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Berlin, Deutschland, 12351
- Abgeschlossen
- Vivantes Klinikum Neukölln
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Berlin, Deutschland, 13509
- Zurückgezogen
- Vivantes Humboldt-Klinikum
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Berlin, Deutschland, 13353
- Suspendiert
- Charite Universitätsmedizin Berlin
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Cologne, Deutschland, 50937
- Zurückgezogen
- University Hospital of Cologne
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Cottbus, Deutschland, 03058
- Abgeschlossen
- Carl-Thiem-Klinikum Cottbus
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Dortmund, Deutschland, 44137
- Abgeschlossen
- Klinikum Dortmund
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Essen, Deutschland, 45138
- Abgeschlossen
- Elisabeth Hospital Essen
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Frankfurt, Deutschland, 60590
- Zurückgezogen
- Universitätsklinikum Frankfurt
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Hamburg, Deutschland, 20251
- Suspendiert
- University Medical Center Hamburg-Eppendorf (UKE)
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Jena, Deutschland, 07747
- Suspendiert
- Universitätsklinikum Jena
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Leipzig, Deutschland, 04103
- Suspendiert
- University Hospital Leipzig
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Leipzig, Deutschland, 04103
- Suspendiert
- Universitätsklinikum Leipzig
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München, Deutschland, 81675
- Suspendiert
- Klinikum rechts der Isar der TU München
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Münster, Deutschland, 48149
- Suspendiert
- Universitätsklinikum Münster
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Tübingen, Deutschland, 72076
- Abgeschlossen
- Universitäts Klinikum Tübingen
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Würzburg, Deutschland, 97080
- Suspendiert
- Universitätsklinikum Würzburg
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-
-
-
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Tartu, Estland, 50406
- Suspendiert
- Tartu University Hospital
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-
-
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Helsinki, Finnland, 00290
- Suspendiert
- Helsinki University Hospital
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Tampere, Finnland, 33520
- Suspendiert
- Tampere University Hospital
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-
-
-
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Argenteuil, Frankreich, 95107
- Aktiv, nicht rekrutierend
- CH Argenteuil
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Aurillac, Frankreich, 15000
- Abgeschlossen
- Centre Hospitalier Henri Mondor d'Aurillac
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Beauvais, Frankreich, 60000
- Aktiv, nicht rekrutierend
- Beauvais General Hospital
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Belfort, Frankreich, 90400
- Suspendiert
- Hopital Nord Franche-Comte
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Boulogne-Billancourt, Frankreich, 92100
- Rekrutierung
- Ambroise Pare Hospital
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Kontakt:
- Antoine Vieillard Baron, MD
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Béthune, Frankreich, 62660
- Rekrutierung
- Centre hospitalier Bethune Beuvry
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Kontakt:
- Christophe Vinsonneau, MD
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Dax, Frankreich, 40100
- Rekrutierung
- CH de Dax
-
Kontakt:
- Adrien Auvet, MD
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Dieppe, Frankreich, 76202
- Rekrutierung
- Centre Hospitalier de Dieppe
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Kontakt:
- Peierre-Louis Declercq, MD
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Dijon, Frankreich, 21000
- Rekrutierung
- CHU Dijon Bourgogne
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Kontakt:
- Jean-Pierre Quenot, MD
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Eaubonne, Frankreich, 95600
- Aktiv, nicht rekrutierend
- Hopital Simone Veil Eaubonne
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Garches, Frankreich, 92380
- Rekrutierung
- Hospital Raymond Poincare
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Kontakt:
- Djillali Annane, MD
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La Roche-sur-Yon, Frankreich, 85000
- Rekrutierung
- CHD Vendee
-
Kontakt:
- Gwenael Colin, MD
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Le Mans, Frankreich, 72027
- Rekrutierung
- Centre Hospitalier Le Mans
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Kontakt:
- Christophe Guitton, MD
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Limoges, Frankreich, 87000
- Rekrutierung
- CHU Dupuytren
-
Kontakt:
- Francois Bruno, MD
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Melun, Frankreich, 77000
- Aktiv, nicht rekrutierend
- Centre Hospitalier de Melun
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Mont-de-Marsan, Frankreich, 40024
- Rekrutierung
- Centre Hospitalier Layne - Mont-de-Marsan
-
Kontakt:
- Arnaud Sement, MD
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Morlaix, Frankreich, 29600
- Rekrutierung
- Centre Hospitalier des Pays de Morlaix
-
Kontakt:
- Pierre Yves Egreteau, MD
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Orléans, Frankreich, 45100
- Aktiv, nicht rekrutierend
- CHR d'Orleans
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Paris, Frankreich, 75010
- Aktiv, nicht rekrutierend
- Lariboisiere Hospital
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Paris, Frankreich, 75020
- Aktiv, nicht rekrutierend
- Hopital Tenon
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Strasbourg, Frankreich, 67200
- Aktiv, nicht rekrutierend
- Hopital de Hautepierre Strasbourg
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Strasbourg, Frankreich, 67000
- Rekrutierung
- Nouvel Hopital Civil Strasbourg
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Kontakt:
- Ferhat Meziani, MD
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Tours, Frankreich, 37000
- Rekrutierung
- CHRU Tours Hopital Bretonneau
-
Kontakt:
- Emmanuelle Mercier, MD
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Étampes, Frankreich, 91150
- Aktiv, nicht rekrutierend
- Sud Essonne Hospital Etampes
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-
-
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Tamil Nadu
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Chennai, Tamil Nadu, Indien, 600006
- Aktiv, nicht rekrutierend
- Apollo Main Hospital
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Chennai, Tamil Nadu, Indien, 600010
- Rekrutierung
- Apollo First Med Hospital
-
Kontakt:
- Meghena Mathew, MD
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Chennai, Tamil Nadu, Indien, 600095
- Aktiv, nicht rekrutierend
- Apollo Vanagaram Hospital
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Chennai, Tamil Nadu, Indien, 600096
- Rekrutierung
- Apollo Speciality Hospital - OMR
-
Kontakt:
- Deva Jayakumar, MD
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-
-
-
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Cork, Irland, T12 DC4A
- Aktiv, nicht rekrutierend
- Cork University Hospital
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Dublin, Irland
- Rekrutierung
- Beaumont Hospital
-
Kontakt:
- Ger Curley, Prof.
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Dublin, Irland
- Rekrutierung
- St. Vincent's University Hospital
-
Kontakt:
- Alistair Nichol, Prof.
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Galway, Irland
- Rekrutierung
- University Hospital Galway
-
Kontakt:
- John Laffey, M.D.
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Waterford, Irland, X91 ER8E
- Aktiv, nicht rekrutierend
- University Hospital Waterford
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-
-
-
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Haifa, Israel, 3109601
- Zurückgezogen
- Rambam Medical Center
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Petah Tikva, Israel, 4941492
- Suspendiert
- Beilinson Hospital, Rabin Medical Center
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Poria – Neve Oved, Israel, 1528001
- Zurückgezogen
- The Baruch Padeh Medical Center
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-
-
-
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Brescia, Italien, 25123
- Rekrutierung
- AO Spedali Civili di Brescia
-
Kontakt:
- Simone Piva, MD
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Milan, Italien, 20132
- Rekrutierung
- IRCCS Ospedale San Raffaele
-
Kontakt:
- Giovanni Landoni, MD
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Milan, Italien, 20089
- Rekrutierung
- Humanitas Research Hospital
-
Kontakt:
- Maurizio Cecconi, MD
-
Milan, Italien, 20122
- Rekrutierung
- Ca' Granda Ospedale Maggiore Policlinico
-
Kontakt:
- Francesco Blasi, MD
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Palermo, Italien, 90127
- Rekrutierung
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
-
Kontakt:
- Andrea Cortegiani, MD
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Palermo, Italien, 90127
- Rekrutierung
- Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione
-
Kontakt:
- Gennaro Martucci, MD
-
Reggio Emilia, Italien, 42123
- Rekrutierung
- Arcispedale S. Maria Nuova
-
Kontakt:
- Elena Mantovani, MD
-
Rimini, Italien, 47923
- Noch keine Rekrutierung
- Ospedale Infermi di Rimini
-
Kontakt:
- Jonathan Montomoli, MD
-
-
-
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Kanagawa
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Kawasaki, Kanagawa, Japan, 216-8511
- Rekrutierung
- St Marianna University School of Medicine
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Yokohama, Kanagawa, Japan, 236-0004
- Rekrutierung
- Yokohama City University Hospital
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Yokohama, Kanagawa, Japan, 241-0811
- Rekrutierung
- St. Marianna University Yokohama City Seibu Hospital
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-
Kumamoto
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Minami, Kumamoto, Japan, 861-4193
- Rekrutierung
- Saiseikai Kumamoto Hospital
-
-
Osaka
-
Osaka, Osaka, Japan, 534-0021
- Rekrutierung
- Osaka City General Hospital
-
-
Tokyo
-
Tokyo, Tokyo, Japan, 130-8575
- Rekrutierung
- Nerima Hikarigaoka Hospital
-
Tokyo, Tokyo, Japan, 130-8575
- Rekrutierung
- Tokyo Metropolitan Bokutoh Hospital
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Tokyo, Tokyo, Japan, 174-0051
- Rekrutierung
- Itabashi Chuo Medical Center
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Tokyo, Tokyo, Japan, 279-0001
- Rekrutierung
- Tokyo bay Urayasu-Ichikawa Medical Center
-
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Wakayama
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Wakayama, Wakayama, Japan, 641-8509
- Rekrutierung
- Wakayama Medical University
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-
-
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Alberta
-
Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, nicht rekrutierend
- Foothills Medical Centre
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Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, nicht rekrutierend
- Peter Lougheed Centre
-
Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, nicht rekrutierend
- Rockyview General Hospital
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Calgary, Alberta, Kanada, T2W 1S7
- Aktiv, nicht rekrutierend
- South Health Campus
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Edmonton, Alberta, Kanada, T5H 3V9
- Rekrutierung
- Royal Alexandra Hospital, Alberta
-
Kontakt:
- Demetrios Kutsogiannis, MD
-
Edmonton, Alberta, Kanada, T6G 2C8
- Rekrutierung
- University of Alberta Hospital
-
Kontakt:
- Wendy Sligl, MD
-
-
British Columbia
-
Surrey, British Columbia, Kanada, V3V 1Z2
- Noch keine Rekrutierung
- Surrey Memorial Hospital
-
Kontakt:
- Anish Mitra, MD
-
-
Manitoba
-
Winnipeg, Manitoba, Kanada, R3A 1R9
- Rekrutierung
- Health Sciences Centre Winnipeg
-
Kontakt:
- Ryan Zarychanski, MD
-
Winnipeg, Manitoba, Kanada, R2H 2A6
- Rekrutierung
- St Boniface General Hospital
-
Kontakt:
- Ryan Zarychanski, MD
-
Winnipeg, Manitoba, Kanada, R3J 3M7
- Rekrutierung
- Grace Hospital
-
Kontakt:
- Gloria Vazquez-Grande, MD
-
-
New Brunswick
-
Fredericton, New Brunswick, Kanada, E3B 4R3
- Noch keine Rekrutierung
- Dr. Everett Chalmers Regional Hospital
-
Kontakt:
- Zeeshan Aslam, MD
-
Fredericton, New Brunswick, Kanada, E3B 4R3
- Noch keine Rekrutierung
- The Moncton Hospital
-
Kontakt:
- Daniel Smyth, MD
-
Fredericton, New Brunswick, Kanada, E3B 4R3
- Noch keine Rekrutierung
- The Saint John General Hospital
-
Kontakt:
- Stephen Robinson, MD
-
-
Ontario
-
Brampton, Ontario, Kanada, L6R 3J7
- Rekrutierung
- William Osler Health System
-
Kontakt:
- Alexandra Binnie, MD
-
Brantford, Ontario, Kanada, N3R 1G9
- Rekrutierung
- Brantford General Hospital
-
Kontakt:
- Brenda Reeve, MD
-
Hamilton, Ontario, Kanada, L8N 4A6
- Rekrutierung
- St. Joseph's Healthcare Hamilton
-
Kontakt:
- Deborah Cook, MD
-
Hamilton, Ontario, Kanada, L8L 8E7
- Rekrutierung
- Juravinski Hospital
-
Kontakt:
- Bram Rochwerg, MD
-
Hamilton, Ontario, Kanada, L8L 8E7
- Rekrutierung
- Hamilton general Hospital
-
Kontakt:
- Alison Fox-Robichaud, MD
-
Kingston, Ontario, Kanada, K7L 2V7
- Aktiv, nicht rekrutierend
- Kingston Health Sciences Centre
-
Kitchener, Ontario, Kanada, N2G 4K9
- Rekrutierung
- Grand River Hospital
-
Kontakt:
- Theresa Liu, MD
-
Kitchener, Ontario, Kanada, N2M 1B2
- Rekrutierung
- St Mary's General Hospital
-
Kontakt:
- Rebecca Kruisselbrink, MD
-
Ottawa, Ontario, Kanada, K1H 8L6
- Rekrutierung
- The Ottawa Hospital
-
Kontakt:
- Lauralyn McIntyre, MD
-
Saint Catharines, Ontario, Kanada, L2S 0A9
- Rekrutierung
- Niagara Health
-
Kontakt:
- Jennifer Tsang, MD
-
Thunder Bay, Ontario, Kanada, P7B 6V4
- Aktiv, nicht rekrutierend
- Thunder Bay General Hospital
-
Toronto, Ontario, Kanada, M5G 2C4
- Rekrutierung
- Toronto General Hospital
-
Kontakt:
- Lorenzo del Sorbo, MD
-
Toronto, Ontario, Kanada, M4N 3M5
- Rekrutierung
- Sunnybrook Health Sciences Centre
-
Kontakt:
- Rob Fowler, MD
-
Toronto, Ontario, Kanada, M5T 2S8
- Rekrutierung
- Toronto Western Hospital
-
Kontakt:
- Elizabeth Wilcox, MD
-
Toronto, Ontario, Kanada, M5G 1X5
- Rekrutierung
- Mount Sinai Hospital
-
Kontakt:
- Sangeeta Mehta, MD
-
Toronto, Ontario, Kanada, M5B 1W8
- Rekrutierung
- St. Michael's Hospital Unity Health Toronto
-
Kontakt:
- John Marshall, MD
-
Toronto, Ontario, Kanada, M6R 1B5
- Aktiv, nicht rekrutierend
- St Joseph's Health Centre
-
-
Quebec
-
Lévis, Quebec, Kanada, G6V 3Z1
- Noch keine Rekrutierung
- CIUSS Chaudieres-Appalaches (Levis)
-
Kontakt:
- Patrick Archambault, MD
-
Montreal, Quebec, Kanada, H3H 2R9
- Rekrutierung
- McGill University Health Centre
-
Kontakt:
- Kosar Khwaja, MD
-
Montreal, Quebec, Kanada, H2X 0A9
- Rekrutierung
- Centre Hospitalier de l'Universite de Montreal
-
Kontakt:
- Michael Chasse, MD
-
Montreal, Quebec, Kanada, H1T 2M4
- Aktiv, nicht rekrutierend
- Hospital Maisonneuve-Rosemont
-
Montreal, Quebec, Kanada, H2B 1K3
- Noch keine Rekrutierung
- Hôpital Fleury
-
Kontakt:
- Thomas Hemmerling, MD
-
Montreal, Quebec, Kanada, H4J 1C5
- Rekrutierung
- Hopital du Sacre-Coeur de Montreal
-
Kontakt:
- Martin Albert, MD
-
Québec, Quebec, Kanada, G1V 4G5
- Rekrutierung
- IUCPQ-UL
-
Kontakt:
- Francois Lellouche, MD
-
Québec, Quebec, Kanada, G1R 2J6
- Rekrutierung
- CHU de Québec - Université Laval
-
Kontakt:
- Alexis Turgeon, MD
-
Sherbrooke, Quebec, Kanada, J1J 3H5
- Rekrutierung
- Centre Hospitalier de l'Université de Sherbrooke
-
Kontakt:
- Francois Lamontagne, MD
-
-
Saskatchewan
-
Saskatoon, Saskatchewan, Kanada, S7K 0M7
- Rekrutierung
- Regina General Hospital
-
Kontakt:
- Eric Sy, MD
-
-
-
-
Cundinamarca
-
Chía, Cundinamarca, Kolumbien
- Rekrutierung
- Universidad de La Sabana
-
-
-
-
-
Požega, Kroatien, 34000
- Rekrutierung
- General County Hospital Požega
-
Kontakt:
- Zdravko Andrić, MD
-
Zagreb, Kroatien, 10000
- Rekrutierung
- University Hospital Centre Zagreb
-
Kontakt:
- Ana Vujaklija Brajković, MD
-
Zagreb, Kroatien, 10000
- Zurückgezogen
- University Hospital for Infectious Diseases
-
-
-
-
-
Bharatpur, Nepal, 44200
- Rekrutierung
- Chitwan Medical College
-
Kontakt:
- Basanta Gauli, MD
-
Kathmandu, Nepal, 44600
- Rekrutierung
- Grande International Hospital
-
Kontakt:
- Sushil Khanal, MD
-
Kathmandu, Nepal, 44600
- Rekrutierung
- Hospital for Advanced Medicine and Surgery (HAMS)
-
Kontakt:
- Hem Paneru, MD
-
Kathmandu, Nepal, 44600
- Rekrutierung
- Nepal Mediciti
-
Kontakt:
- Diptesh Aryal, MD
-
-
-
-
-
Auckland, Neuseeland, 0620
- Rekrutierung
- North Shore Hospital
-
Kontakt:
- Robert Everitt, MD
-
Auckland, Neuseeland, 1023
- Rekrutierung
- CVICU, Auckland City Hospital
-
Kontakt:
- Shay McGuinness, MD
-
Auckland, Neuseeland, 1023
- Rekrutierung
- DCCM, Auckland City Hospital
-
Kontakt:
- Colin McArthur, MD
-
Auckland, Neuseeland, 2104
- Rekrutierung
- Middlemore Hospital
-
Kontakt:
- Tony Williams, MD
-
Christchurch, Neuseeland, 8011
- Rekrutierung
- Christchurch Hospital
-
Kontakt:
- Jay Ritzema-Carter, MD
-
Hamilton, Neuseeland, 3204
- Rekrutierung
- Waikato Hospital
-
Kontakt:
- Robert Martynoga, MD
-
New Plymouth, Neuseeland, 4310
- Rekrutierung
- Taranaki Base Hospital
-
Kontakt:
- Jonathan Albrett, MD
-
Rotorua, Neuseeland, 3010
- Rekrutierung
- Rotorua Hospital
-
Kontakt:
- Ulrike Buehner, MD
-
Tauranga, Neuseeland, 3112
- Rekrutierung
- Tauranga Hospital
-
Kontakt:
- Troy Browne, MD
-
Wellington, Neuseeland, 6021
- Rekrutierung
- Wellington Regional Hospital
-
Kontakt:
- Paul Young, MD
-
Whangarei, Neuseeland, 0148
- Rekrutierung
- Whangarei Hospital
-
Kontakt:
- Ralph Fuchs, MD
-
-
-
-
-
's-Hertogenbosch, Niederlande
- Rekrutierung
- Jeroen Bosch Ziekenhuis
-
Kontakt:
- Koen Simons, M.D.
-
Almelo, Niederlande, 7609PP
- Rekrutierung
- ZGT Almelo
-
Kontakt:
- Bastiaan Wittekamp, MD
-
Amersfoort, Niederlande
- Rekrutierung
- Meander Medisch Centrum
-
Kontakt:
- Laura van Gulik, M.D.
-
Amsterdam, Niederlande, 1091AC
- Aktiv, nicht rekrutierend
- OLVG
-
Arnhem, Niederlande, 6815AD
- Rekrutierung
- Rijnstate Hospital
-
Kontakt:
- Robert-Jan Hassing, MD
-
Deventer, Niederlande, 7416SE
- Aktiv, nicht rekrutierend
- Deventer Hospital
-
Ede, Niederlande, 6716RP
- Aktiv, nicht rekrutierend
- Ziekenhuis Gelderse Vallei
-
Eindhoven, Niederlande, 5631BM
- Aktiv, nicht rekrutierend
- Maxima Medisch Centrum Eindhoven
-
Groningen, Niederlande
- Zurückgezogen
- Martini Hospital Groningen
-
Groningen, Niederlande
- Aktiv, nicht rekrutierend
- University Medical Center Groningen
-
Leeuwarden, Niederlande, 8934AD
- Aktiv, nicht rekrutierend
- Medisch Centrum Leeuwarden
-
Leiden, Niederlande
- Rekrutierung
- Leiden University Medical Center
-
Kontakt:
- Evert De Jonge, Prof.
-
Nijmegen, Niederlande
- Rekrutierung
- Radboud University Medical Center
-
Kontakt:
- Frank van de Veerdonk, Prof.
-
Nijmegen, Niederlande
- Rekrutierung
- Canisius Wilhelmina Ziekenhuis
-
Kontakt:
- Oscar Hoiting, M.D.
-
Roermond, Niederlande, 6043CV
- Aktiv, nicht rekrutierend
- Laurentius Hospital
-
Rotterdam, Niederlande, 3079DZ
- Rekrutierung
- Maasstad Ziekenhuis
-
Kontakt:
- Corstiaan den Uil, MD
-
The Hague, Niederlande, 2545AA
- Rekrutierung
- Hagaziekenhuis
-
Kontakt:
- Thomas Ottens, MD
-
Uden, Niederlande, 5406PT
- Aktiv, nicht rekrutierend
- Bernhoven Hospital
-
-
Utrecht
-
Utrecht, Utrecht, Niederlande, 3584 CX
- Rekrutierung
- University Medical Center Utrecht
-
Kontakt:
- Marc Bonten, Prof.
-
Kontakt:
- Lennie Derde, MD
-
-
-
-
Sindh
-
Karachi, Sindh, Pakistan, 75000
- Rekrutierung
- Ziauddin University Hospital Clifton Campus
-
Kontakt:
- Madiha Hashmi, MD
-
Karachi, Sindh, Pakistan, 75300
- Rekrutierung
- Abbasi Shaheed Hospital
-
Kontakt:
- Aneela Kidwai, MD
-
Karachi, Sindh, Pakistan, 75510
- Rekrutierung
- National Institute of Cardiovascular Diseases, Karachi
-
Kontakt:
- Nawal Salahuddin, MD
-
Karachi, Sindh, Pakistan, 75600
- Rekrutierung
- South City Hospital, Karachi
-
Kontakt:
- Nasir Khoso, MD
-
Karachi, Sindh, Pakistan
- Rekrutierung
- Ziauddin University North Nazimabad Campus
-
Kontakt:
- Quratul Ain, MD
-
-
-
-
-
Abrantes, Portugal
- Rekrutierung
- Centro Hospitalar do Medio Tejo
-
Kontakt:
- Nuno Catorze, M.D.
-
Lisbon, Portugal, 1169-050
- Suspendiert
- Hospital Ocidental
-
Lisbon, Portugal
- Suspendiert
- Hospital Lusíadas Lisbon
-
-
-
-
-
Bucharest, Rumänien, 030303
- Suspendiert
- Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes"
-
-
-
-
-
Riyadh, Saudi-Arabien, 14611
- Rekrutierung
- King Abdulaziz Medical City
-
Kontakt:
- Yaseen Arabi, MD
-
-
-
-
-
Zurich, Schweiz, 8091
- Suspendiert
- University Hospital Zürich
-
-
-
-
-
Belgrade, Serbien, 11000
- Suspendiert
- University Hospital Center Dr Dragiša Mišović
-
Belgrade, Serbien, 11000
- Suspendiert
- University Clinical Centre of Serbia
-
Niš, Serbien, 18000
- Rekrutierung
- Clinical Centre of Niš
-
Kontakt:
- Tanja Pejčić, MD
-
-
-
-
-
Golnik, Slowenien, 4204
- Suspendiert
- University Clinic of Respiratory and Allergic Diseases Golnik
-
Maribor, Slowenien, 2000
- Rekrutierung
- University Medical Centre Maribor
-
Kontakt:
- Andre Markota, MD
-
-
-
-
-
Barcelona, Spanien
- Rekrutierung
- Hospital del Mar
-
Kontakt:
- Rosana Munoz-Bermúdez, M.D.
-
Cadiz, Spanien, 11407
- Rekrutierung
- Hospital Universitario de Jerez
-
Kontakt:
- Ángel Estella, MD
-
Córdoba, Spanien, 14004
- Rekrutierung
- Reina Sofia University Hospital
-
Kontakt:
- Eduardo Aguilar Alonso, M.D.
-
Madrid, Spanien, 28034
- Rekrutierung
- Ramon y Cajal University Hospital
-
Kontakt:
- Cruz Soriano, MD
-
Málaga, Spanien, 29010
- Rekrutierung
- Hospital Regional de Málaga
-
Kontakt:
- Manuel Herrera Gutiérrez, MD
-
Ourense, Spanien, 32005
- Rekrutierung
- Hospital Universitario de Ourense
-
Kontakt:
- Pablo Vidal, MD
-
Santander, Spanien, 39008
- Rekrutierung
- Hospital Marqués de Valdecilla
-
Kontakt:
- Borja Suberviola, MD
-
Tortosa, Spanien, 43500
- Rekrutierung
- Hospital Verge de la Cinta
-
Kontakt:
- Ferran Roche Campo, MD
-
Valencia, Spanien, 46026
- Rekrutierung
- Hospital La Fe
-
Kontakt:
- Paula Ramírez, MD
-
Valencia, Spanien, 46017
- Rekrutierung
- Doctor Peset University Hospital
-
Kontakt:
- Rafael Zaragoza, MD
-
-
-
-
-
Prague, Tschechien, 10000
- Rekrutierung
- Fakultní nemocnice Královské Vinohrady
-
Kontakt:
- František Duška, MD
-
Teplice, Tschechien, 41501
- Suspendiert
- Teplice Hospital
-
-
-
-
-
Nyíregyháza, Ungarn, 4400
- Abgeschlossen
- Jósa András County Hospital
-
Ózd, Ungarn, 3600
- Abgeschlossen
- Almási Balogh Pál Kórház
-
-
-
-
Florida
-
Jacksonville, Florida, Vereinigte Staaten, 32209
- Rekrutierung
- University of Florida
-
Kontakt:
- Hadi Hatoum, MD
-
-
Georgia
-
Augusta, Georgia, Vereinigte Staaten, 30912
- Noch keine Rekrutierung
- Augusta University
-
Kontakt:
- Jose Vazquez, MD
-
-
Illinois
-
Chicago, Illinois, Vereinigte Staaten, 60612
- Rekrutierung
- University of Illinois Health
-
Kontakt:
- Jeffrey Jacobson, MD
-
-
Louisiana
-
New Orleans, Louisiana, Vereinigte Staaten, 70112
- Noch keine Rekrutierung
- Tulane Medical Center
-
Kontakt:
- Joshua Denson, MD
-
-
Michigan
-
Ann Arbor, Michigan, Vereinigte Staaten, 48109
- Rekrutierung
- University of Michigan
-
Kontakt:
- Robert Hyzy, MD
-
-
New York
-
New York, New York, Vereinigte Staaten, 10065
- Rekrutierung
- Memorial Sloan Kettering Cancer Center
-
Kontakt:
- Stephen Pastores, MD
-
-
North Carolina
-
Winston-Salem, North Carolina, Vereinigte Staaten, 27157-1009
- Noch keine Rekrutierung
- Wake Forest Baptist Health
-
Kontakt:
- Ashish Khanna, MD
-
-
Ohio
-
Columbus, Ohio, Vereinigte Staaten, 43210
- Rekrutierung
- The Ohio State University Wexner Medical Center
-
Kontakt:
- Matthew Exline, MD
-
-
Oregon
-
Portland, Oregon, Vereinigte Staaten, 97239-3098
- Rekrutierung
- Oregon Health and Science University
-
Kontakt:
- Akram Khankhana, MD
-
-
Pennsylvania
-
Pittsburgh, Pennsylvania, Vereinigte Staaten
- Rekrutierung
- University of Pittsburgh Medical Centre
-
Kontakt:
- Stephanie Mongomery
-
-
Rhode Island
-
Providence, Rhode Island, Vereinigte Staaten, 02903
- Noch keine Rekrutierung
- Brown University - Rhode Island Hospital
-
Kontakt:
- Mitchell Levy, MD
-
-
-
-
-
Belfast, Vereinigtes Königreich, BT16 1RH
- Rekrutierung
- Ulster Hospital
-
Kontakt:
- Christopher Murray, MD
-
Bristol, Vereinigtes Königreich, BS2 8BJ
- Rekrutierung
- Bristol Royal Childrens Hospital
-
Kontakt:
- Jolanta Bernatoniene, MD
-
Bury, Vereinigtes Königreich, BL9 7TD
- Rekrutierung
- Fairfield General Hospital
-
Kontakt:
- Andrew Claxton, MD
-
Crewe, Vereinigtes Königreich, CW1 4QJ
- Rekrutierung
- Leighton Hospital
-
Kontakt:
- Richard Lowsby, MD
-
Dorchester, Vereinigtes Königreich, DT1 2JY
- Abgeschlossen
- Dorset County Hospital
-
Gloucester, Vereinigtes Königreich, GL1 3NN
- Abgeschlossen
- Gloucester Royal Hospital
-
Haywards Heath, Vereinigtes Königreich, RH16 4EX
- Aktiv, nicht rekrutierend
- The Princess Royal Hospital Haywards Heath
-
Leeds, Vereinigtes Königreich, LS9 7TF
- Rekrutierung
- St. James University Hospital
-
Kontakt:
- E Paramasivam, MD
-
London, Vereinigtes Königreich, NW1 2BU
- Rekrutierung
- University College London Hospital
-
Kontakt:
- Michael Marks, MD
-
London, Vereinigtes Königreich, SW10 9NH
- Rekrutierung
- Chelsea and Westminster Hospital
-
Kontakt:
- Roger Davies, MD
-
London, Vereinigtes Königreich, E9 6SR
- Suspendiert
- Homerton Hospital
-
Margate, Vereinigtes Königreich, CT9 4AN
- Suspendiert
- Queen Elizabeth and Queen Mother Hospital
-
Newcastle upon Tyne, Vereinigtes Königreich, NE1 4LP
- Rekrutierung
- Newcastle Royal Victoria Infirmary (Paediatrics)
-
Kontakt:
- Marieke Emonts, MD
-
North Shields, Vereinigtes Königreich, Ne29 8NH
- Suspendiert
- North Tyneside General Hospital
-
Warwick, Vereinigtes Königreich, CV34 5BW
- Aktiv, nicht rekrutierend
- Warwick Hospital
-
West Bromwich, Vereinigtes Königreich, B71 4HJ
- Rekrutierung
- Sandwell General Hospital
-
Kontakt:
- Jonathan Hulme, MD
-
-
England
-
Basildon, England, Vereinigtes Königreich, SS16 5NL
- Aktiv, nicht rekrutierend
- Basildon Hospital
-
Basingstoke, England, Vereinigtes Königreich, RG24 9NA
- Rekrutierung
- Basingstoke and North Hampshire Hospital
-
Kontakt:
- Irena Grecu, MD
-
Bath, England, Vereinigtes Königreich, BA1 3NG
- Aktiv, nicht rekrutierend
- Royal United Hospital, Bath
-
Birmingham, England, Vereinigtes Königreich, B15 2TH
- Rekrutierung
- Queen Elizabeth Hospital Birmingham
-
Kontakt:
- Dhruv Parekh
-
Birmingham, England, Vereinigtes Königreich, B18 7QH
- Rekrutierung
- Birmingham City Hospital
-
Kontakt:
- Jonathan Hulme
-
Blackburn, England, Vereinigtes Königreich, BB2 3HH
- Rekrutierung
- Royal Blackburn Teaching Hospital
-
Kontakt:
- Srikanth Chukkambotla, MD
-
Boston, England, Vereinigtes Königreich, PE21 9QS
- Suspendiert
- Pilgrim Hospital ULHT
-
Bournemouth, England, Vereinigtes Königreich, BH7 7DW
- Aktiv, nicht rekrutierend
- Royal Bournemouth Hospital
-
Brighton, England, Vereinigtes Königreich, BN2 5BE
- Suspendiert
- Royal Sussex County Hospital
-
Bristol, England, Vereinigtes Königreich, BS10 5NB
- Suspendiert
- Southmead Hospital
-
Bristol, England, Vereinigtes Königreich, BS2 8EX
- Aktiv, nicht rekrutierend
- Bristol Royal Infirmary
-
Burton-on-Trent, England, Vereinigtes Königreich, DE13 0RB
- Aktiv, nicht rekrutierend
- Queen's Hospital, Burton
-
Cambridge, England, Vereinigtes Königreich, CB2 0AY
- Aktiv, nicht rekrutierend
- Royal Papworth Hospital
-
Cambridge, England, Vereinigtes Königreich, CB2 0QQ
- Aktiv, nicht rekrutierend
- Addenbrookes Hospital
-
Carlisle, England, Vereinigtes Königreich, CA2 7HY
- Suspendiert
- North Cumberland Infirmary
-
Chertsey, England, Vereinigtes Königreich, KT16 0P
- Aktiv, nicht rekrutierend
- St Peter's Hospital
-
Chester, England, Vereinigtes Königreich, CH2 1UL
- Aktiv, nicht rekrutierend
- Countess of Chester Hospital
-
Chesterfield, England, Vereinigtes Königreich, S44 5BL
- Rekrutierung
- Chesterfield Royal Hospital
-
Kontakt:
- Euan Mackay
-
Colchester, England, Vereinigtes Königreich, CO4 5JL
- Rekrutierung
- Colchester Hospital
-
Kontakt:
- Mohamed Ramali
-
Coventry, England, Vereinigtes Königreich, CV2 2DX
- Aktiv, nicht rekrutierend
- University Hospital Coventry
-
Darlington, England, Vereinigtes Königreich, DL3 6HX
- Suspendiert
- Darlington Memorial Hospital
-
Dartford, England, Vereinigtes Königreich, DA2 8DA
- Zurückgezogen
- Darent Valley Hospital
-
Dudley, England, Vereinigtes Königreich, DY1 2HQ
- Aktiv, nicht rekrutierend
- Russells Hall Hospital
-
Exeter, England, Vereinigtes Königreich, Ex2 5DW
- Suspendiert
- Royal Devon and Exeter Hospital
-
Frimley, England, Vereinigtes Königreich, GU16 7 UJ
- Suspendiert
- Frimley Park Hospital
-
Gateshead, England, Vereinigtes Königreich, NE9 6SX
- Aktiv, nicht rekrutierend
- Queen Elizabeth Hospital Gateshead
-
Gillingham, England, Vereinigtes Königreich, ME7 5NY
- Abgeschlossen
- Medway Maritime Hospital
-
Great Yarmouth, England, Vereinigtes Königreich, NR31 6LA
- Abgeschlossen
- James Paget University Hospital
-
Guildford, England, Vereinigtes Königreich, GU2 7XX
- Rekrutierung
- Royal Surrey County Hospital
-
Kontakt:
- Ben Creagh-Brown
-
Harrow, England, Vereinigtes Königreich, HA1 3UJ
- Aktiv, nicht rekrutierend
- Northwick Park Hospital
-
Hereford, England, Vereinigtes Königreich, HR1 2ER
- Rekrutierung
- Hereford County Hospital
-
Kontakt:
- Charlotte Small
-
High Barnet, England, Vereinigtes Königreich, EN5 3DJ
- Aktiv, nicht rekrutierend
- Barnet Hospital
-
Huddersfield, England, Vereinigtes Königreich, HD3 3EA
- Aktiv, nicht rekrutierend
- Huddersfield Royal Infirmary
-
Ilford, England, Vereinigtes Königreich, IG3 8YB
- Aktiv, nicht rekrutierend
- King George Hospital
-
Ipswich, England, Vereinigtes Königreich, IP4 5PD
- Zurückgezogen
- Ipswich Hospital
-
Kettering, England, Vereinigtes Königreich, NN16 8UZ
- Rekrutierung
- Kettering Hospital
-
Kontakt:
- Dhinesh Sundaran
-
Leeds, England, Vereinigtes Königreich, LS9 7TF
- Aktiv, nicht rekrutierend
- Leeds General Infirmary
-
Leicester, England, Vereinigtes Königreich, LE1 5WW
- Suspendiert
- Leicester Royal Infirmary
-
Leicester, England, Vereinigtes Königreich, LE3 9QP
- Suspendiert
- Glenfield Hospital
-
Lincoln, England, Vereinigtes Königreich, LN2 5QY
- Suspendiert
- Lincoln County Hospital
-
Liverpool, England, Vereinigtes Königreich, L7 8XP
- Aktiv, nicht rekrutierend
- Royal Liverpool University Hospital
-
Liverpool, England, Vereinigtes Königreich, L14 3PE
- Abgeschlossen
- Liverpool Heart and Chest Hospital
-
Liverpool, England, Vereinigtes Königreich, L14 5AB
- Abgeschlossen
- Alder Hey Hospital
-
Liverpool, England, Vereinigtes Königreich, L9 7AL
- Suspendiert
- University Hospital Aintree
-
London, England, Vereinigtes Königreich, SE5 9RS
- Rekrutierung
- King's College Hospital
-
Kontakt:
- Phillip Hopkins
-
London, England, Vereinigtes Königreich, W12 0HS
- Rekrutierung
- Hammersmith Hospital
-
Kontakt:
- Stephen Brett
-
London, England, Vereinigtes Königreich, W2 1NY
- Rekrutierung
- St Mary's Hospital
-
Kontakt:
- Anthony Gordon
-
London, England, Vereinigtes Königreich, W6 8RF
- Rekrutierung
- Charing Cross Hospital
-
Kontakt:
- David Antcliffe
-
London, England, Vereinigtes Königreich, CR7 7YE
- Aktiv, nicht rekrutierend
- Croydon University Hospital
-
London, England, Vereinigtes Königreich, E1 1FR
- Aktiv, nicht rekrutierend
- Royal London Hospital
-
London, England, Vereinigtes Königreich, E11 1NR
- Aktiv, nicht rekrutierend
- Whipps Cross Hospital
-
London, England, Vereinigtes Königreich, E13 8SL
- Aktiv, nicht rekrutierend
- Newham University Hospital
-
London, England, Vereinigtes Königreich, EC1A 7BE
- Aktiv, nicht rekrutierend
- St Bartholomew's Hospital
-
London, England, Vereinigtes Königreich, N18 1QX
- Aktiv, nicht rekrutierend
- North Middlesex University Hospital
-
London, England, Vereinigtes Königreich, NW3 2QG
- Aktiv, nicht rekrutierend
- Royal Free Hospital
-
London, England, Vereinigtes Königreich, SE1 7EH
- Rekrutierung
- St Thomas Hospital
-
Kontakt:
- Marlies Ostermann
-
London, England, Vereinigtes Königreich, SE1 9RT
- Aktiv, nicht rekrutierend
- Guy's Hospital
-
London, England, Vereinigtes Königreich, SE18 4QH
- Aktiv, nicht rekrutierend
- Queen Elizabeth Hospital, Woolwich
-
London, England, Vereinigtes Königreich, SW3 6JJ
- Aktiv, nicht rekrutierend
- Royal Marsden Hospital
-
London, England, Vereinigtes Königreich, SW3 6NP
- Aktiv, nicht rekrutierend
- Royal Brompton Hospital
-
London, England, Vereinigtes Königreich, SW17 0QT
- Rekrutierung
- St George's University Hospital
-
Kontakt:
- Susannah Leaver
-
Luton, England, Vereinigtes Königreich, LU4 0DZ
- Suspendiert
- Luton and Dunstable University Hospital
-
Maidstone, England, Vereinigtes Königreich, ME16 9QQ
- Rekrutierung
- Maidstone Hospital
-
Kontakt:
- David Golden, MD
-
Manchester, England, Vereinigtes Königreich, M13 9WL
- Suspendiert
- Manchester Royal Infirmary
-
Manchester, England, Vereinigtes Königreich, M20 4BX
- Abgeschlossen
- The Christie Hospital
-
Manchester, England, Vereinigtes Königreich, M23 9LT
- Suspendiert
- Wythenshawe Hospital
-
Manchester, England, Vereinigtes Königreich, M8 5RB
- Aktiv, nicht rekrutierend
- North Manchester General Hospital
-
Metropolitan Borough of Wirral, England, Vereinigtes Königreich, CH49 5PE
- Rekrutierung
- Arrowe Park Hospital
-
Kontakt:
- Craig Denmade, MD
-
Middlesbrough, England, Vereinigtes Königreich, TS4 3BW
- Rekrutierung
- The James Cook University Hospital
-
Kontakt:
- Jeremy Henning, MD
-
Milton Keynes, England, Vereinigtes Königreich, MK6 5LD
- Rekrutierung
- Milton Keynes University Hospital
-
Kontakt:
- Richard Stewart, MD
-
Newcastle, England, Vereinigtes Königreich, NE1 4LP
- Suspendiert
- Royal Victoria Infirmary, Newcastle
-
Newcastle, England, Vereinigtes Königreich, NE7 7DN
- Suspendiert
- Newcastle Freeman Hospital
-
Northampton, England, Vereinigtes Königreich, NN1 5BD
- Suspendiert
- Northampton General Hospital
-
Norwich, England, Vereinigtes Königreich, NR4 7UY
- Abgeschlossen
- Norfolk and Norwich University Hospital
-
Nottingham, England, Vereinigtes Königreich, NG5 1PB
- Rekrutierung
- City Hospital Nottingham
-
Kontakt:
- Daniel Harvey, MD
-
Nottingham, England, Vereinigtes Königreich, NG7 2UH
- Rekrutierung
- Queen's Medical Centre - Nottingham University Hospitals NHS Trust
-
Kontakt:
- Daniel Harvey, MD
-
Nuneaton, England, Vereinigtes Königreich, CV10 7DJ
- Aktiv, nicht rekrutierend
- George Eliot Hospital
-
Oldham, England, Vereinigtes Königreich, Ol1 2JH
- Rekrutierung
- Royal Oldham Hospital
-
Kontakt:
- Redmond Tully, MD
-
Orpington, England, Vereinigtes Königreich, BR6 8ND
- Suspendiert
- Princess Royal University Hospital
-
Oxford, England, Vereinigtes Königreich, OX3 9DU
- Aktiv, nicht rekrutierend
- John Radcliffe Hospital
-
Plymouth, England, Vereinigtes Königreich, PL6 8DH
- Rekrutierung
- Derriford Hospital
-
Kontakt:
- Nikitas Nikitas, MD
-
Poole, England, Vereinigtes Königreich, BH15 2JB
- Rekrutierung
- Poole Hospital NHS Foundation Trust
-
Kontakt:
- Henrik Reschreiter, MD
-
Portsmouth, England, Vereinigtes Königreich, PO6 3LY
- Rekrutierung
- Queen Alexandra Hospital
-
Kontakt:
- David Pogson, MD
-
Prescot, England, Vereinigtes Königreich, L35 5DR
- Beendet
- Whiston Hospital
-
Preston, England, Vereinigtes Königreich, PR2 9HT
- Suspendiert
- Royal Preston Hospital
-
Reading, England, Vereinigtes Königreich, RG1 5AN
- Rekrutierung
- Royal Berkshire Hospital
-
Kontakt:
- Andrew Walden, MD
-
Redditch, England, Vereinigtes Königreich, B98 7UB
- Aktiv, nicht rekrutierend
- Alexandra Hospital, Redditch
-
Romford, England, Vereinigtes Königreich, RM7 0AG
- Aktiv, nicht rekrutierend
- Queen's Hospital Romford
-
Rotherham, England, Vereinigtes Königreich, S60 2UD
- Rekrutierung
- Rotherham Hospital
-
Kontakt:
- Anil Hormis, MD
-
Royal Tunbridge Wells, England, Vereinigtes Königreich, TN2 4QJ
- Rekrutierung
- Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust
-
Kontakt:
- David Golden, MD
-
Salford, England, Vereinigtes Königreich, M6 8HD
- Rekrutierung
- Salford Royal Hospital
-
Kontakt:
- Paul Dark, MD
-
Salisbury, England, Vereinigtes Königreich, SP2 8BJ
- Rekrutierung
- Salisbury District Hospital
-
Kontakt:
- Phil Donnison, MD
-
Sheffield, England, Vereinigtes Königreich, S10 2JF
- Rekrutierung
- Royal Hallamshire Hospital
-
Kontakt:
- Gary Mills, MD
-
Sheffield, England, Vereinigtes Königreich, S5 7AU
- Rekrutierung
- Northern General Hospital
-
Kontakt:
- Gary Mills, MD
-
Slough, England, Vereinigtes Königreich, SL2 4HL
- Aktiv, nicht rekrutierend
- Wexham Park Hospital
-
South Shields, England, Vereinigtes Königreich, NE34 0PL
- Rekrutierung
- South Tyneside District Hospital
-
Kontakt:
- Alistair Roy, MD
-
Southampton, England, Vereinigtes Königreich, SO16 6YD
- Rekrutierung
- Southampton General Hospital
-
Kontakt:
- Ahilanandan Dushianthan, MD
-
Stockport, England, Vereinigtes Königreich, SK2 7JE
- Rekrutierung
- Stepping Hill Hospital
-
Kontakt:
- Hywel Garrard, MD
-
Stockton-on-Tees, England, Vereinigtes Königreich, TS19 8PE
- Rekrutierung
- University Hospital of North Tees
-
Kontakt:
- Farooq Brohi, MD
-
Stoke-on-Trent, England, Vereinigtes Königreich, ST4 6QG
- Rekrutierung
- Royal Stoke University Hospital
-
Kontakt:
- Ramprasad Matsa, MD
-
Sunderland, England, Vereinigtes Königreich, SR4 7TP
- Rekrutierung
- Sunderland Royal Hospital
-
Kontakt:
- Alistair Roy, MD
-
Sutton in Ashfield, England, Vereinigtes Königreich, NG17 4JL
- Rekrutierung
- King's Mill Hospital
-
Kontakt:
- Sandaruwan Herath, MD
-
Swindon, England, Vereinigtes Königreich, SN3 6BB
- Rekrutierung
- Western General Hospital
-
Kontakt:
- Jonathan Rhodes, MD
-
Swindon, England, Vereinigtes Königreich, SN3 6BB
- Aktiv, nicht rekrutierend
- Great Western Hospital
-
Taunton, England, Vereinigtes Königreich, TA1 5DA
- Rekrutierung
- Musgrove Park Hospital
-
Kontakt:
- Richard Innes, MD
-
Torquay, England, Vereinigtes Königreich, TQ2 7AA
- Rekrutierung
- Torbay Hospital
-
Kontakt:
- Adam Revill, MD
-
Truro, England, Vereinigtes Königreich, TR1 3LJ
- Rekrutierung
- Royal Cornwall Hospital
-
Kontakt:
- Michael Spivey, MD
-
Uxbridge, England, Vereinigtes Königreich, UB9 6JH
- Abgeschlossen
- Harefield Hospital
-
Watford, England, Vereinigtes Königreich, WD18 0HB
- Rekrutierung
- Watford General Hospital
-
Kontakt:
- Valarie Page, MD
-
Westcliff-on-Sea, England, Vereinigtes Königreich, ISS0 0RY
- Aktiv, nicht rekrutierend
- Southend Hospital
-
Whitehaven, England, Vereinigtes Königreich, CA28 8JG
- Zurückgezogen
- West Cumberland Hospital
-
Wigan, England, Vereinigtes Königreich, WN1 2NN
- Aktiv, nicht rekrutierend
- Royal Albert Edward Infirmary
-
Winchester, England, Vereinigtes Königreich, SO22 5DG
- Rekrutierung
- Royal Hampshire County Hospital
-
Kontakt:
- Irina Grecu, MD
-
Wolverhampton, England, Vereinigtes Königreich, WV10 0QP
- Aktiv, nicht rekrutierend
- New Cross Hospital Wolverhampton
-
Worcester, England, Vereinigtes Königreich, WR5 1DD
- Aktiv, nicht rekrutierend
- Worcestershire Royal Hospital
-
York, England, Vereinigtes Königreich, Y031 8HE
- Rekrutierung
- York Teaching Hospital
-
Kontakt:
- Joseph Carter, MD
-
-
Northern Ireland
-
Antrim, Northern Ireland, Vereinigtes Königreich, BT41 2RL
- Rekrutierung
- Antrim Area Hospital
-
Kontakt:
- Paul Johnston, MD
-
Belfast, Northern Ireland, Vereinigtes Königreich, BT14 6AB
- Rekrutierung
- Mater Hospital
-
Kontakt:
- Michael McGinlay, MD
-
Belfast, Northern Ireland, Vereinigtes Königreich, BT9 7AB
- Rekrutierung
- Belfast City Hospital
-
Kontakt:
- Michael McGinlay, MD
-
Belfast, Northern Ireland, Vereinigtes Königreich, BT12 6BA
- Rekrutierung
- Royal Victoria Hospital Belfast
-
Kontakt:
- Michael McGinlay, MD
-
Londonderry, Northern Ireland, Vereinigtes Königreich, BT47 6SB
- Rekrutierung
- Altnagelvin Hospital
-
Kontakt:
- Adrian Donnelly, MD
-
-
Scotland
-
Aberdeen, Scotland, Vereinigtes Königreich, AB25 2ZN
- Abgeschlossen
- Aberdeen Royal Infirmary
-
Dundee, Scotland, Vereinigtes Königreich, DD1 9SY
- Rekrutierung
- Ninewells Hospital
-
Kontakt:
- James Chambers, MD
-
Edinburgh, Scotland, Vereinigtes Königreich, EH16 4SA
- Rekrutierung
- Royal Infirmary of Edinburgh
-
Kontakt:
- Thomas Craven, MD
-
Glasgow, Scotland, Vereinigtes Königreich, G4 0SF
- Rekrutierung
- Glasgow Royal Infirmary
-
Kontakt:
- Kathryn Puxty, MD
-
Glasgow, Scotland, Vereinigtes Königreich, G51 4TF
- Rekrutierung
- Queen Elizabeth University Hospital, Glasgow
-
Kontakt:
- Malcolm Sim, MD
-
Paisley, Scotland, Vereinigtes Königreich, PA2 9PN
- Rekrutierung
- Royal Alexandra Hospital
-
Kontakt:
- Kevin Rooney, MD
-
-
Wales
-
Abergavenny, Wales, Vereinigtes Königreich, NP7 7EG
- Aktiv, nicht rekrutierend
- Neville Hall Hospital
-
Bodelwyddan, Wales, Vereinigtes Königreich, LL18 5UJ
- Aktiv, nicht rekrutierend
- Glan Clwyd Hospital
-
Bridgend, Wales, Vereinigtes Königreich, CF31 1RQ
- Aktiv, nicht rekrutierend
- Princess of Wales Hospital
-
Cardiff, Wales, Vereinigtes Königreich, CF14 4XW
- Aktiv, nicht rekrutierend
- Cardiff and Vale University Hospital Wales
-
Carmarthen, Wales, Vereinigtes Königreich, SA31 2AF
- Suspendiert
- Glangwilli Hospital
-
Cwmbran, Wales, Vereinigtes Königreich, NP44 8YN
- Aktiv, nicht rekrutierend
- Grange University Hospital
-
Newport, Wales, Vereinigtes Königreich, NP20 2UB
- Suspendiert
- Royal Gwent Hospital
-
Pont-y-clun, Wales, Vereinigtes Königreich, CF72 8XR
- Aktiv, nicht rekrutierend
- Royal Glamorgan Hospital
-
Swansea, Wales, Vereinigtes Königreich, SA6 6NL
- Aktiv, nicht rekrutierend
- Morriston Hospital
-
Wrexham, Wales, Vereinigtes Königreich, LL13 7TD
- Rekrutierung
- Wrexham Maelor Hospital
-
Kontakt:
- David Southern, MD
-
-
Teilnahmekriterien
Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.
Zulassungskriterien
Zulassungskriterien
Studienberechtigtes Alter
4 Wochen und älter (Kind, Erwachsene, Älterer Erwachsener)
Akzeptiert gesunde Freiwillige
Nein
Studienberechtigte Geschlechter
Alle
Beschreibung
The eligibility criteria for the Platform are applied at multiple levels. One level is that there are inclusion and exclusion criteria that determine eligibility for randomization within the Platform. Another level is that, once eligible for inclusion within the Platform, additional criteria (typically exclusion criteria) are applied that are specific to each domain. Finally, intervention-level eligibility criteria may be applied for interventions within a domain. A patient is eligible for inclusion within a domain when:
- All Platform inclusion criteria are met
- None of the Platform exclusion criteria are met
- Domain-specific eligibility criteria are met
- The patient is eligible for at least two interventions within a domain
As such, the key "inclusion criteria" for being eligible for a domain are that the patient is eligible for the Platform.
--
PLATFORM INCLUSION CRITERIA:
- Hospitalised patient
- Acute respiratory tract infection
- Aged 28 days or older
PLATFORM EXCLUSION CRITERIA:
- Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
- Patient is expected to be discharged from hospital within the next 24 hours
- Previous participation in this REMAP within the last 90 days
DOMAIN-SPECIFIC ELIGIBILITY CRITERIA:
Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).
Studienplan
Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.
Wie ist die Studie aufgebaut?
Designdetails
- Hauptzweck: Behandlung
- Zuteilung: Zufällig
- Interventionsmodell: Fakultätszuweisung
- Maskierung: Keine (Offenes Etikett)
Anzahl der Arme
19
Waffen und Interventionen
Teilnehmergruppe / ArmTeilnehmergruppe / Arm |
Intervention / BehandlungIntervention / Behandlung |
|---|---|
|
Sonstiges: Antibiotic Domain
Patients with community-acquired pneumonia and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment. |
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. Note: this intervention is now closed. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. |
|
Sonstiges: Macrolide Duration Domain
Patients with community-acquired pneumonia who have been allocated to receive a beta-lactam + macrolide intervention in the Antibiotic Domain will be randomised to either a standard course or extended course of macrolide therapy |
Standard course of macrolide therapy, discontinued between study day 3 and the end of study day 5. The dosing of and route of administration is not protocolised, the following guidance is provided:
Extended course of macrolide therapy discontinued at the end of study day 14 or hospital discharge (whichever occurs first). The dosing of and route of administration is not protocolised, the following guidance is provided:
|
|
Sonstiges: Corticosteroid Domain
Patients with severe lower-respiratory tract infection will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19. Note: the fixed-course hydrocortisone has been closed to recruitment |
Patients are not to receive any systemic corticosteroids, including hydrocortisone, to study day 28 or hospital discharge (whichever occurs first). 50mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days. Note: this intervention is now closed. 50mg IV hydrocortisone every 6 hours while the patient is in septic shock 100mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days. Note: this intervention was only available to patients with suspected or proven COVID-19 and is now closed. 6 mg of IV or enteral dexamethasone will be administered daily for up to 10 days while in hospital. |
|
Sonstiges: Influenza Antiviral Domain
Patients with microbiological testing confirmed influenza infection will be randomised to one of six interventions. |
No antiviral agent intended to be active against influenza infection is to be administered Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first) Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first) Baloxavir marboxil administered on days 1 and 4 post-randomisation. Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation. Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation. |
|
Sonstiges: COVID-19 Antiviral Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed. |
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU. Note: this intervention is now closed. Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first). Note: this intervention is now closed. Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU. Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first). Note: this intervention is now closed. Ivermectin administered enterally at a dose of 0.2 mg/kg once daily with a maximum daily dose of 24mg/day. Note: this intervention is now closed. |
|
Sonstiges: COVID-19 Immune Modulation Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed. |
No immune modulating agent intended to be active against COVID-19 is to be administered. Note: this intervention is now closed. IFN-β1a 10 μg will be administered as an intravenous bolus injection via a central or peripheral line. IFN-β1a will be administered once daily for 6 days or until ICU discharge, whichever occurs first. Note: this intervention is now closed.
Andere Namen:
A loading dose of 300mg anakinra will be administered as a bolus via central or peripheral line. This is followed by maintenance doses of 100mg of anakinra administered every 6 hours. In patients with renal impairment, anakinra will be administered on alternate days. Note: this intervention is now closed. Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. Note: this intervention is now closed. Sarilumab will be administered as a single dose of 400mg, via IV infusion through peripheral or central line over a one-hour period. Note: this intervention is now closed. Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. In children weighing less than 30kg, tocilizumab dose will be 12mg/kg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. |
|
Sonstiges: Anticoagulation Domain
Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation. This domain is now closed. |
Standard venous thromboprophylaxis that complies with local guidelines or usual practice will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Note: this intervention is now closed. Patients will be administered either low molecular weight heparin (LMWH) or unfractionated heparin (UFH) to achieve systemic anticoagulation. Either agent may be used and the same patient may be switched between UFH and LMWH at the discretion of the treating clinician. Note: this intervention is now closed. Low dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain. Intermediate dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain. Patients already receiving therapeutic dose anticoagulation at the time of randomisation to this intervention will be administered either unfractionated heparin by IV infusion or low-molecular weight heparin to achieve systemic anticoagulation according to local practice for acute VTE treatment for 14 days following randomisation or until hospital discharge, whichever occurs first. Note: this intervention is now closed. |
|
Sonstiges: Immunoglobulin Domain
Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma. Note: an earlier version of this domain was not restricted to immunosuppressed patients. |
No immunoglobulin intended to be active against SARS-CoV-2 infection is to be administered. Patients will receive at least one and no more than two units of ABO compatible convalescent plasma within 48 hours of randomisation. Note: this intervention is now closed. |
|
Sonstiges: Vitamin C Domain
Patients admitted to participating hospitals with community-acquired pneumonia will be randomised to receive no vitamin C, or vitamin C. Note: this domain is now closed. |
No high dose intravenous vitamin C is to be administered Note: this intervention is now closed. Intravenous Vitamin C 50mg/kg administered every 6 hours for 16 doses Note: this intervention is now closed. |
|
Sonstiges: Simvastatin Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no simvastatin, or simvastatin. Note: this domain is now closed. |
No simvastatin intended to be active against COVID-19 is to be administered Note: this intervention is now closed. Simvastatin 80mg administered once daily via enteral route, while the patient remains in hospital up to 28 days after randomisation Note: this intervention is now closed. |
|
Sonstiges: Antiplatelet Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor. Note: this domain is now closed. |
No antiplatelet agent or NSAID to be administered. Note: this intervention is now closed. Aspirin administered at either 75mg or 100mg once per day for 14 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed.
Andere Namen:
Site-selected P2Y12 inhibitor:
Note: this intervention is now closed.
Andere Namen:
|
|
Sonstiges: Mechanical Ventilation Domain
Patients with community-acquired pneumonia admitted to participating intensive care units who are intubated and receiving invasive mechanical ventilation will be randomised to protocolised mechanical ventilation strategy, or clinician-preferred mechanical ventilation strategy |
Clinician-preferred ventilation strategy, including mode of ventilation and all ventilatory parameters Invasive mechanical ventilation strategy delivered as outlined in relevant protocol documents for this domain. |
|
Sonstiges: COVID-19 Immune Modulation (2) Domain
Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions. Note: this domain is now closed. |
No immune modulating agent intended to be active against COVID-19 is to be administered. Note: this intervention is now closed. Eritoran initiated with a 26.24 mg loading dose (6.56 mg/h IV for 4 hours), followed by a second 13.12 mg loading dose (6.56 mg/h IV for 2 hours) at 12 hours after initiation. Patients will then receive twenty-six 6.56 mg maintenance doses (3.28 mg/h IV for 2 hours) every 12 hours thereafter (total of 14 days). Dosing will be stopped if the patient is discharged from hospital Note: this intervention is now closed. Apremilast administered 30mg twice daily for 14 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed. |
|
Sonstiges: ACE2 RAS Domain
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed. |
No RAS inhibitor (i.e. no ACEi or ARB) is to be administered up to the end of study day 10. Note: this intervention is now closed. Site-preferred ACEi agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed.
Andere Namen:
Site-preferred ARB agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first. Note: this intervention is now closed.
Andere Namen:
Site-preferred ARB agent administered in combination with DMX-200 for 10 days or until hospital discharge, whichever occurs first. ARB administered as directed by the treating clinician. DMX-200 administered enterally at a dose of 120mg twice daily. Note: this intervention is now closed. |
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Sonstiges: Cysteamine Domain
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no cysteamine, or cysteamine. Note: this domain is now closed. |
No cysteamine to be administered until the end of study day 10 or hospital discharge, whichever occurs first. Note: this intervention is now closed. Cysteamine administered every 8 hours at a dose of 5 mg/kg estimated or measured body weight (maximum dose of 500mg), for ten days or until ICU discharge, whichever occurs first. Note: this intervention is now closed. |
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Sonstiges: Endothelial Domain
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no endothelial modulator or enteral imatinib. |
No endothelial modulator (imatinib or another tyrosine kinase inhibitor targeting the same pathway as imatinib) is to be administered. Enteral imatinib will be administered as a single 800mg loading dose (study day 1) followed by 400mg daily until study day 14 or discharge. |
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Sonstiges: Influenza Immune Modulation
Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of three interventions. |
Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. Note: this intervention is now closed. Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg. In children weighing less than 30kg, tocilizumab dose will be 12mg/kg. Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period. No immune modulating agent intended to be active against influenza is to be administered. Baricitinib will be administered at a dose that is determined by age and renal function, for up to 10 days or hospital discharge (whichever occurs first). |
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Sonstiges: COVID-19 Antiviral (II) Domain
Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to one of up to four interventions. |
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered Nirmatrelvir-ritonavir will be administered at a dose that is dependent on renal function, for five days.
Andere Namen:
Remdesivir is administered at 200 mg on day one followed by 100 mg daily for a further four doses (i.e., for five doses in total) or until hospital discharge, whichever occurs first. Nirmatrelvir-ritonavir will be administered at a dose that is dependent on renal function, for five days. Remdesivir is administered at 200 mg on day one followed by 100 mg daily for a further four doses (i.e., for five doses in total) or until hospital discharge, whichever occurs first. |
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Sonstiges: Tropical Antibiotic Domain
Patients with community-acquired pneumonia in regions at locations where or when empiric cover for melioidosis is appropriate, and requiring empiric antibiotic therapy including cover for melioidosis, will be randomised one of two antibiotic interventions |
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice. |
Was misst die Studie?
Primäre Ergebnismessungen
Primäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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Survival and Recovery Trajectory up to day 90
Zeitfenster: Day 90
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The primary endpoint, named Survival and Recovery Trajectory, is a composite of: 90-day all-cause mortality and, among survivors, the number of days on which the patient was not receiving organ failure support during the index hospitalisation, up to the end of study day 28; and, among survivors who never receive organ failure support, hospital free days for the index hospitalisation up to the end of study day 28. For the purposes of this endpoint, organ failure support is defined as:
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Day 90
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Sekundäre Ergebnismessungen
Sekundäre Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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All-cause mortality
Zeitfenster: Day 90
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All-cause mortality to day 90 post-randomisation |
Day 90
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Days alive and free from organ-failure support
Zeitfenster: Day 28
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Days alive and free from organ failure support during the index hospitalisation to day 28 |
Day 28
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Days alive and out of hospital
Zeitfenster: Day 28
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Days alive and out of hospital for the index hospitalisation, to day 28 |
Day 28
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Health-related Quality of life assessment
Zeitfenster: 6 months
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EQ5D-5L and WHODAS 2.0 (not completed in all regions) |
6 months
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Andere Ergebnismessungen
Andere Ergebnismessungen
Ergebnis Maßnahme |
Maßnahmenbeschreibung |
Zeitfenster |
|---|---|---|
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Domain-Specific Secondary Outcome
Zeitfenster: During the index hospitalisation to Day 90 post-randomisation, unless otherwise specified
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Each domain may specify domain-specific secondary outcomes. Please see relevant Domain-Specific Protocol Documents for details. |
During the index hospitalisation to Day 90 post-randomisation, unless otherwise specified
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Mitarbeiter und Ermittler
Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.
Sponsor
Sponsor
Mitarbeiter
Mitarbeiter
Ermittler
Ermittler
- Studienstuhl: Steve Webb, Prof, Monash University, Study Chair REMAP-CAP Australia
- Studienstuhl: Colin McArthur, Dr, Medical Research Institute of New Zealand, Study Chair REMAP-CAP New Zealand
- Studienstuhl: Marc Bonten, Prof, UMC Utrecht, Study Chair REMAP-CAP Europe
- Studienstuhl: Lennie Derde, MD, UMC Utrecht, Coordinating Investigator REMAP-CAP Europe
- Studienstuhl: John Marshall, Prof, Unity Health Toronto, Study Chair REMAP-CAP Canada
- Studienstuhl: Derek Angus, Prof, University of Pittsburgh Medical Center, Study Chair REMAP-CAP USA
- Studienstuhl: Luis Felipe Reyes, MD, MSc, PhD, Clínica Universidad de la Sabana, Study Chair REMAP-CAP Colombia
Publikationen und hilfreiche Links
Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.
Allgemeine Veröffentlichungen
- Kreuzberger N, Hirsch C, Chai KL, Tomlinson E, Khosravi Z, Popp M, Neidhardt M, Piechotta V, Salomon S, Valk SJ, Monsef I, Schmaderer C, Wood EM, So-Osman C, Roberts DJ, McQuilten Z, Estcourt LJ, Skoetz N. SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19. Cochrane Database Syst Rev. 2021 Sep 2;9(9):CD013825. doi: 10.1002/14651858.CD013825.pub2.
- Tume LN, Menzies JC, Ray S, Scholefield BR; UK Paediatric Intensive Care Society Study Group. Research Priorities for U.K. Pediatric Critical Care in 2019: Healthcare Professionals' and Parents' Perspectives. Pediatr Crit Care Med. 2021 May 1;22(5):e294-e301. doi: 10.1097/PCC.0000000000002647.
- Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design. Ann Am Thorac Soc. 2020 Jul;17(7):879-891. doi: 10.1513/AnnalsATS.202003-192SD.
- REMAP-CAP Investigators; Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Cheng AC, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Lamontagne F, Lawler PR, Leavis HL, Linstrum KM, Litton E, Lorenzi E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Montgomery SK, Morpeth SC, Murthy S, Orr K, Parke RL, Parker JC, Patanwala AE, Pettila V, Rademaker E, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Webb SA, Derde LPG. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Apr 22;384(16):1491-1502. doi: 10.1056/NEJMoa2100433. Epub 2021 Feb 25.
- Fischer AL, Messer S, Riera R, Martimbianco ALC, Stegemann M, Estcourt LJ, Weibel S, Monsef I, Andreas M, Pacheco RL, Skoetz N. Antiplatelet agents for the treatment of adults with COVID-19. Cochrane Database Syst Rev. 2023 Jul 25;7(7):CD015078. doi: 10.1002/14651858.CD015078.
- REMAP-CAP Investigators; Angus DC. Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial. Intensive Care Med. 2025 Apr;51(4):665-680. doi: 10.1007/s00134-025-07861-w. Epub 2025 Apr 22.
- Derde L, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, Arabi YM, Annane D, Beane A, Beasley R, Bonten MJM, Bradbury CA, Brunkhorst FM, Buzgau A, Buxton M, Cheng AC, Cooper N, Cove M, Cremer OL, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Galea J, Goossens H, Haniffa R, Hills TE, Huang DT, Ichihara N, King A, Lamontagne F, Lawler PR, Leavis HL, Lewis RJ, Litton E, Marshall JC, Mayr FB, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Morpeth SC, Murthy S, Netea MG, Ogungbenro K, Orr K, Parke RL, Parker JC, Patanwala AE, Pettila V, Reyes LF, Saito H, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Sligl WI, Turgeon AF, Turner AM, Tong SYC, Vaara S, Youngstein T, Zarychanski R, Green C, Higgins AM, McArthur CJ, Berry LR, Lorenzi E, Berry S, Webb SA, Angus DC, van de Veerdonk FL. Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial. Thorax. 2025 Jul 15;80(8):530-539. doi: 10.1136/thorax-2024-222488.
- LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators; Adhikari NKJ, Hashmi M, Tirupakuzhi Vijayaraghavan BK, Haniffa R, Beane A, Webb SA, Angus DC, Gordon AC, Cook DJ, Guyatt GH, Berry LR, Lorenzi E, Mouncey PR, Au C, Pinto R, Menard J, Sprague S, Masse MH, Huang DT, Heyland DK, Nichol AD, McArthur CJ, de Man A, Al-Beidh F, Annane D, Anstey M, Arabi YM, Battista MC, Berry S, Bhimani Z, Bonten MJM, Bradbury CA, Brant EB, Brunkhorst FM, Burrell A, Buxton M, Cecconi M, Cheng AC, Cohen D, Cove ME, Day AG, Derde LPG, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Goossens H, Green C, Higgins AM, Hills TE, Horvat C, Ichihara N, Jayakumar D, Kanji S, Khoso MN, Lawler PR, Lewis RJ, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McQuilten ZK, McVerry BJ, Murthy S, Parke RL, Parker JC, Reyes LF, Rowan KM, Saito H, Salahuddin N, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tolppa T, Trapani T, Turgeon AF, Turner AM, Udy AA, van de Veerdonk FL, Zarychanski R, Lamontagne F. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023 Nov 14;330(18):1745-1759. doi: 10.1001/jama.2023.21407.
- REMAP-CAP Investigators; Hills TE, Lorenzi E, Berry LR, Shyamsundar M, Al-Beidh F, Annane D, Arabi Y, Aryal D, Au C, Beane A, Bhimani Z, Bonten M, Bradbury CA, Brunkhorst FM, Burrell A, Buxton M, Calfee CS, Cecconi M, Cheng AC, Cove ME, Detry MA, Estcourt LJ, Fitzgerald M, Goligher EC, Goossens H, Green C, Haniffa R, Harrison DA, Hashmi M, Higgins AM, Horvat C, Huang DT, Ichihara N, Jayakumar D, Kruger PS, Lamontagne F, Lampro L, Lawler PR, Marshall JC, Mason AJ, McGlothlin A, McGuinness S, McQuilten ZK, McVerry BJ, Mouncey PR, Murthy S, Neal MD, Nichol AD, O'Kane CM, Parke RL, Parker JC, Rabindrarajan E, Reyes LF, Rowan KM, Saito H, Santos M, Saunders CT, Seymour CW, Shankar-Hari M, Sinha P, Thompson BT, Turgeon AF, Turner AM, van de Veerdonk F, Weis S, Young IS, Zarychanski R, Lewis RJ, McArthur CJ, Angus DC, Berry SM, Derde LPG, Webb SA, Gordon AC, McAuley DF. Simvastatin in Critically Ill Patients with Covid-19. N Engl J Med. 2023 Dec 21;389(25):2341-2354. doi: 10.1056/NEJMoa2309995. Epub 2023 Oct 25.
- Bradbury CA, Lawler PR, McVerry BJ, Zarychanski R; REMAP-C. A. P. Investigators. Continuation of therapeutic dose heparin for critically ill patients with COVID-19. Intensive Care Med. 2023 Jul;49(7):873-875. doi: 10.1007/s00134-023-07095-8. Epub 2023 May 31. No abstract available.
- Writing Committee for the REMAP-CAP Investigators; Lawler PR, Derde LPG, van de Veerdonk FL, McVerry BJ, Huang DT, Berry LR, Lorenzi E, van Kimmenade R, Gommans F, Vaduganathan M, Leaf DE, Baron RM, Kim EY, Frankfurter C, Epelman S, Kwan Y, Grieve R, O'Neill S, Sadique Z, Puskarich M, Marshall JC, Higgins AM, Mouncey PR, Rowan KM, Al-Beidh F, Annane D, Arabi YM, Au C, Beane A, van Bentum-Puijk W, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Cecconi M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Ezekowitz J, Fitzgerald M, Gattas D, Godoy LC, Goossens H, Haniffa R, Harrison DA, Hills T, Horvat CM, Ichihara N, Lamontagne F, Linstrum KM, McAuley DF, McGlothlin A, McGuinness SP, McQuilten Z, Murthy S, Nichol AD, Owen DRJ, Parke RL, Parker JC, Pollock KM, Reyes LF, Saito H, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Singh V, Turgeon AF, Turner AM, Zarychanski R, Green C, Lewis RJ, Angus DC, Berry S, Gordon AC, McArthur CJ, Webb SA. Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial. JAMA. 2023 Apr 11;329(14):1183-1196. doi: 10.1001/jama.2023.4480.
- Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D, Arabi YM, Beane A, van Bentum-Puijk W, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Charles WN, Cove M, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Horvat CM, Huang DT, Ichihara N, Lamontagne F, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Neal MD, Nichol AD, Parke RL, Parker JC, Parry-Billings K, Peters SEC, Reyes LF, Rowan KM, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Stronach LM, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Gordon AC, Webb SA, Lawler PR. Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial. JAMA. 2023 Jan 3;329(1):39-51. doi: 10.1001/jama.2022.23257.
- REMAP-CAP Writing Committee for the REMAP-CAP Investigators; Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan KM, Berry LR, Lorenzi E, Zarychanski R, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Bhimani Z, Bihari S, Bonten MJM, Brunkhorst FM, Buzgau A, Buxton M, Carrier M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Huang DT, Horvat CM, Hunt BJ, Ichihara N, Lamontagne F, Leavis HL, Linstrum KM, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Morpeth SC, Murthy S, Neal MD, Nichol AD, Parke RL, Parker JC, Reyes LF, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Singh V, Tolppa T, Turgeon AF, Turner AM, van de Veerdonk FL, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Webb SA, Gordon AC. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910.
- Writing Committee for the REMAP-CAP Investigators; Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Begin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chasse M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021 Nov 2;326(17):1690-1702. doi: 10.1001/jama.2021.18178.
- REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Dzavik V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):777-789. doi: 10.1056/NEJMoa2103417. Epub 2021 Aug 4.
- ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR, Goligher EC, Berger JS, Neal MD, McVerry BJ, Nicolau JC, Gong MN, Carrier M, Rosenson RS, Reynolds HR, Turgeon AF, Escobedo J, Huang DT, Bradbury CA, Houston BL, Kornblith LZ, Kumar A, Kahn SR, Cushman M, McQuilten Z, Slutsky AS, Kim KS, Gordon AC, Kirwan BA, Brooks MM, Higgins AM, Lewis RJ, Lorenzi E, Berry SM, Berry LR, Aday AW, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Costantini TW, de Brouwer S, Derde LPG, Detry MA, Duggal A, Dzavik V, Effron MB, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Galanaud JP, Galen BT, Gandotra S, Garcia-Madrona S, Girard TD, Godoy LC, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Hamburg NM, Haniffa R, Hanna G, Hanna N, Hegde SM, Hendrickson CM, Hite RD, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Hudock K, Hunt BJ, Husain M, Hyzy RC, Iyer VN, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski AL, King AJ, Knudson MM, Kornblith AE, Krishnan V, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Lima FG, Linstrum K, Litton E, Lopez-Sendon J, Lopez-Sendon Moreno JL, Lother SA, Malhotra S, Marcos M, Saud Marinez A, Marshall JC, Marten N, Matthay MA, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Moore SC, Morillo Guerrero R, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nunez-Garcia B, Pandey A, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Perez Gonzalez YS, Pompilio M, Prekker ME, Quigley JG, Rost NS, Rowan K, Santos FO, Santos M, Olombrada Santos M, Satterwhite L, Saunders CT, Schutgens REG, Seymour CW, Siegal DM, Silva DG Jr, Shankar-Hari M, Sheehan JP, Singhal AB, Solvason D, Stanworth SJ, Tritschler T, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Wells BJ, Widmer RJ, Wilson JG, Yuriditsky E, Zampieri FG, Angus DC, McArthur CJ, Webb SA, Farkouh ME, Hochman JS, Zarychanski R. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4.
- Arabi YM, Gordon AC, Derde LPG, Nichol AD, Murthy S, Beidh FA, Annane D, Swaidan LA, Beane A, Beasley R, Berry LR, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Buzgau A, Cheng A, De Jong M, Detry MA, Duffy EJ, Estcourt LJ, Fitzgerald M, Fowler R, Girard TD, Goligher EC, Goossens H, Haniffa R, Higgins AM, Hills TE, Horvat CM, Huang DT, King AJ, Lamontagne F, Lawler PR, Lewis R, Linstrum K, Litton E, Lorenzi E, Malakouti S, McAuley DF, McGlothlin A, Mcguinness S, McVerry BJ, Montgomery SK, Morpeth SC, Mouncey PR, Orr K, Parke R, Parker JC, Patanwala AE, Rowan KM, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tong SYC, Turgeon AF, Turner AM, Van de Veerdonk FL, Zarychanski R, Green C, Berry S, Marshall JC, McArthur C, Angus DC, Webb SA; REMAP-CAP Investigators. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021 Aug;47(8):867-886. doi: 10.1007/s00134-021-06448-5. Epub 2021 Jul 12.
- Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Buzgau A, Cheng AC, de Jong M, Detry M, Estcourt L, Fitzgerald M, Goossens H, Green C, Haniffa R, Higgins AM, Horvat C, Hullegie SJ, Kruger P, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, Marshall J, McAuley D, McGlothin A, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Parker J, Rowan K, Sanil A, Santos M, Saunders C, Seymour C, Turner A, van de Veerdonk F, Venkatesh B, Zarychanski R, Berry S, Lewis RJ, McArthur C, Webb SA, Gordon AC; Writing Committee for the REMAP-CAP Investigators; Al-Beidh F, Angus D, Annane D, Arabi Y, van Bentum-Puijk W, Berry S, Beane A, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Cheng A, De Jong M, Derde L, Estcourt L, Goossens H, Gordon A, Green C, Haniffa R, Lamontagne F, Lawler P, Litton E, Marshall J, McArthur C, McAuley D, McGuinness S, McVerry B, 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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. JAMA. 2020 Oct 6;324(13):1317-1329. doi: 10.1001/jama.2020.17022.
- Boyle AJ, Ryan EG, Berry LR, Berry S, Derde L, Lawler PR, Lorenzi E, O'Kane CM, Shankar-Hari M, Veerdonk FV, Gordon AC, McAuley DF; REMAP-CAP Immune Modulation Domain Investigators. Evaluating plasma ferritin and suPAR as treatable traits for critically ill patients with COVID-19 treated with anakinra: an exploratory analysis of the immune modulation domain of the REMAP-CAP randomised clinical trial. Crit Care. 2026 Oct 1;30(1):506. doi: 10.1186/s13054-026-06311-3.
- Nurmi V, Knight C, Estcourt L, Hepojoki J, Lamikanra AA, Tsang HP, Roberts DJ, Polack FP, Simmonds P, Hedman K, Alvarez-Paggi D, Harvala H. The Relationship Between SARS-CoV-2 Neutralizing Antibody Titers and Avidity in Plasma Collected From Convalescent Nonvaccinated and Vaccinated Blood Donors. J Infect Dis. 2023 Aug 11;228(3):245-250. doi: 10.1093/infdis/jiad070.
- Goligher EC, Lawler PR, Jensen TP, Talisa V, Berry LR, Lorenzi E, McVerry BJ, Chang CH, Leifer E, Bradbury C, Berger J, Hunt BJ, Castellucci LA, Kornblith LZ, Gordon AC, McArthur C, Webb S, Hochman J, Neal MD, Zarychanski R, Berry S, Angus DC; REMAP-CAP, ATTACC, and ACTIV-4a Investigators. Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19. JAMA. 2023 Apr 4;329(13):1066-1077. doi: 10.1001/jama.2023.3651.
- UPMC REMAP-COVID Group, on behalf of the REMAP-CAP Investigators. Implementation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial in a US health system-lessons learned and recommendations. Trials. 2021 Jan 28;22(1):100. doi: 10.1186/s13063-020-04997-6.
Studienaufzeichnungsdaten
Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.
Haupttermine studieren
Studienbeginn (Tatsächlich)
Studienbeginn
11. April 2016
Primärer Abschluss (Geschätzt)
Primärer Abschluss
1. Juni 2028
Studienabschluss (Geschätzt)
Studienabschluss
1. Februar 2029
Studienanmeldedaten
Zuerst eingereicht
Zuerst eingereicht
11. Dezember 2015
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
Zuerst eingereicht, das die QC-Kriterien erfüllt hat
6. April 2016
Zuerst gepostet (Geschätzt)
Zuerst gepostet
13. April 2016
Studienaufzeichnungsaktualisierungen
Letztes Update gepostet (Tatsächlich)
Letztes Update gepostet
4. November 2026
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
Letztes eingereichtes Update, das die QC-Kriterien erfüllt
30. Oktober 2026
Zuletzt verifiziert
Zuletzt verifiziert
1. Oktober 2026
Mehr Informationen
Begriffe im Zusammenhang mit dieser Studie
Schlüsselwörter
- SARS-CoV-2
- Erkrankungen der Atemwege
- Antiinfektiva
- Lungenentzündung
- Ceftarolin
- Grippe
- COVID-19
- Antibiotika
- Tocilizumab
- Intensivpflege
- Apremilast
- Lungenkrankheit
- Levofloxacin
- Vitamin C
- Statine
- Infektionen der Atemwege
- Imatinib
- Invasive mechanische Beatmung
- Hydrocortison
- Moxifloxacin
- Intensivstation
- Ceftriaxon
- Ivermectin
- Rekonvaleszentenplasma
- Baricitinib
- Kortikosteroide
- Oseltamivir
- Baloxavir
- Antibakterielle Mittel
- Piperacillin-Tazobactam
- Amoxicillin-Clavulanat
- Therapeutische Antikoagulation
- Eritoran
- DMX-200
Zusätzliche relevante MeSH-Bedingungen
- Infektionen
- Orthomyxoviridae-Infektionen
- RNA-Virusinfektionen
- Viruserkrankungen
- Pneumonie, viral
- Coronavirus-Infektionen
- Coronaviridae-Infektionen
- Nidovirales-Infektionen
- Ambulant erworbene Infektionen
- COVID-19
- Grippe, Mensch
- Lungenkrankheit
- Lungenentzündung
- Infektionen der Atemwege
- Erkrankungen der Atemwege
- Ambulant erworbene Pneumonie
- Molekulare Mechanismen der pharmakologischen Wirkung
- Hormone
- Hormone, Hormonersatzstoffe und Hormonantagonisten
- Proteaseinhibitoren
- Enzyminhibitoren
- Peptide
- Aminosäuren, Peptide und Proteine
- Oligopeptide
- Proteine
- Schwefelverbindungen
- Organische Chemikalien
- Pyridinen
- Heterocyclische Verbindungen, 1-Ring
- Heterocyclische Verbindungen
- Benzimidazoles
- Heterocyclische Verbindungen, 2-Ring
- Heterocyclische Verbindungen, Fusionsring
- Pharmazeutische Präparate
- Thiazoles
- Azolen
- Nukleinsäuren, Nukleotide und Nukleoside
- Pharmakologische Maßnahmen
- Chemische Handlungen und Verwendung
- Kohlenwasserstoffe
- Cyclohexene
- Cyclohexane
- Cycloparaffine
- Kohlenwasserstoffe, alicyclisch
- Kohlenwasserstoffe, zyklisch
- Biologische Faktoren
- Kohlenhydrate
- Zuckersäuren
- Säuren, acyclisch
- Carboxylsäuren
- Hydroxysäuren
- Naphthenes
- Polycyclische aromatische Kohlenwasserstoffe
- Kohlenwasserstoffe, aromatisch
- Polycyclische Verbindungen
- Imidazoles
- Amides
- Amine
- Indolen
- Purines
- Aminosäuren
- Pyrimidine
- Schwangerschaft
- Steroide
- Fusions-Ring-Verbindungen
- Phenole
- Benzolderivate
- Organisationen
- Gesundheitsökonomie und Organisationen
- Laktone
- Nukleoside
- Ribonukleoside
- Pyrimidinone
- Interzelluläre Signalpeptide und Proteine
- Ethylamine
- Schwangerschaften
- Schwanger
- Makrocyclische Verbindungen
- Aminosäuren, essentiell
- Biologische Produkte
- Komplexe Gemische
- Aminosäuren, zyklisch
- 11-Hydroxycorticosteroide
- Hydroxykortikosteroide
- Nebennierenrindehormone
- 17-Hydroxycorticosteroide
- Drogenkombinationen
- Säuren, carbocyclisch
- Penicillin g
- Beta-Lactams
- Lactams
- Clavulansäure
- Clavulansäuren
- Cephalosporine
- Thiazinen
- Fluorchinolone
- 4-Quinolone
- Chinolone
- Chinoline
- Ofloxacin
- Acetamides
- Sulfone
- Cephaloridin
- Carbapenems
- Thienamycins
- Tazobactam
- Penicillansäure
- Piperacillin
- Thiophenes
- Aminoquinoline
- Benzoates
- Salicylate
- Hydroxybenzoates
- Zytokine
- Interferon Typ i
- Interferonen
- Polyketide
- Impfungen
- Benzamide
- Adenosin
- Purin -Nukleoside
- Tetrazolen
- Ampicillin
- Penicillins
- Piperazines
- Sulfhydrylverbindungen
- Virale Impfstoffe
- Ticlopidin
- Thienopyridiner
- Chloroquin
- Biphenylverbindungen
- Cefotaxim
- Cephacetril
- Lovastatin
- Dipeptide
- Interferon-Beta
- Spiro -Verbindungen
- Valine
- Aminosäuren, verzweigt
- Amoxicillin
- Mercaptoethylamine
- Prolin
- Iminosäuren
- Ticagrelor
- Clopidogrel
- Interferon beta-1a
- Moxifloxacin
- Valsartan
- Imatinibmesylat
- Prasugrelhydrochlorid
- Meropenem
- Telmisartan
- Irbesartan
- Piperacillin, Tazobactam-Medikamentenkombination
- Ceftarolin
- Aspirin
- Hydroxychloroquin
- Ceftriaxon
- Hydrocortison
- Ritonavir
- Ivermectin
- Ascorbinsäure
- Interleukin-1-Rezeptor-Antagonist-Protein
- Cysteamin
- Amoxicillin-Kaliumclavulanat-Kombination
- Ramipril
- Levofloxacin
- Losartan
- Oseltamivir
- Simvastatin
- Angiotensin-Converting-Enzym-Inhibitoren
- Angiotensin-Rezeptor-Antagonisten
- Enalapril
- Lopinavir
- Ceftazidim
- Lisinopril
- Captopril
- Perindopril
- Kongresse als Thema
- Tocilizumab
- Baricitinib
- remdesivir
- Sarilumab
- Influenza -Impfstoffe
- Apremilast
- Nirmalatrelvir- und Ritonavir -Arzneimittelkombination
- Nirmatrelvir
- Baloxavir
- Olmesartan
- Makrolide
- Candesartan
- Trandolapril
- eritoran
Andere Studien-ID-Nummern
Andere Studien-ID-Nummern
- U1111-1189-1653
- 2015-002340-14 (EudraCT-Nummer)
- 602525 (Andere Zuschuss-/Finanzierungsnummer: European Union, FP7-HEALTH-2013-INNOVATION-1, PREPARE)
- 16/631 (Andere Zuschuss-/Finanzierungsnummer: Health Research Council of New Zealand)
- APP1101719 (Andere Zuschuss-/Finanzierungsnummer: National Health and Medical Research Council, Australia)
- 158584 (Andere Zuschuss-/Finanzierungsnummer: Canadian Institute of Health Research)
- 2023-507889-89-00 (Ctis)
- 2023 (US NIH Stipendium/Vertrag)
- 2015 (US NIH Stipendium/Vertrag)
- 965313 (Andere Zuschuss-/Finanzierungsnummer: European Union, Horizon 2020 research and innovation programme, ECRAID-Base)
Plan für individuelle Teilnehmerdaten (IPD)
Planen Sie, individuelle Teilnehmerdaten (IPD) zu teilen?
JA
Arzneimittel- und Geräteinformationen, Studienunterlagen
Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt
Ja
Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt
Nein
Produkt, das in den USA hergestellt und aus den USA exportiert wird
Nein
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