High-intensity Group Vocal Exercise to Improve Laryngeal Function in Patients With Parkinson Disease
The overall goal of this T2 translational research project is to pilot an interdisciplinary high-intensity group singing program to improve speech and swallowing in patients with Parkinson's Disease (PD) and to explore the impact of this program on quality of life (QOL). This research has three specific aims: 1) Determine the effects of a high-intensity group vocal training program on vocal function and laryngeal structure; 2) Determine the transference of vocal training to laryngeal aspects of swallowing; 3) Determine the effect of patient-reported changes in Quality of Life (QOL) as the result of participation in a group vocal training program.
Twenty patients with Parkinson Disease will be recruited from the Fresco Institute for Parkinson's & Movement Disorders to participate in a 12-week vocal training program. The program will train participants using maximum vocal function exercises targeting vocal deficits specific to PD. Choral singing therapy sessions will be conducted once weekly with daily home practice exercises based on principles that have been successful in other intensive PD vocal exercise programs.
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
Deterioration of speech and swallowing is a hallmark of Parkinson Disease (PD). There is emerging evidence that choral singing benefits people with PD across a range of modalities. Despite the increasing popularity of "Parkinson's choirs", rigorous study of these benefits is lacking. There is a large body of evidence that intense vocal training improves speech and communication for people with PD. However, the intense training places high demands on clinical and patient resources and, due to its individualized approach, lacks the potential psycho-social benefits of a group intervention.
It is hypothesized singing training program will increase vocal loudness, range of articulation, and prosodic variation during speech. Additionally, given existing evidence for neuroplastic transference of voice-related interventions to swallowing function, laryngeal components of swallowing function will also improve post-intervention. Finally, investigators expect to see improvements in patient-reported QOL measures corresponding with improved speech and laryngeal function and/or as the result of group interaction.
All participants will complete a standardized battery of assessment pre- and post- treatment including acoustic and aerodynamic assessment of voice, dynamic magnetic resonance imaging of speech and swallowing, and videofluoroscopic evaluation of swallowing. The outcome of this work will be a rigorous understanding of how choral singing therapy can positively impact the voice, swallowing function, and quality of life for patients with PD.
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
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New York
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New York, New York, Estados Unidos, 10016
- New York University School of Medicine
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Confirmed diagnosis of Stage One, Two or Three on the Hoehn and Yahr Staging of Parkinson's Disease
- Current swallowing severity of normal, mild, or moderate without aspiration
- Stable regimen of anti-PD medication for >30 days
Exclusion Criteria:
- Prior voice and/or swallowing therapy related to PD
- History of head and neck cancer
- History of oropharyngeal or laryngeal surgery
- Current or former smoker (quit < 5 years)
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Tratamiento
- Asignación: N / A
- Modelo Intervencionista: Asignación de un solo grupo
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
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Experimental: Behavioral vocal training
12-week vocal training program will use maximum vocal function exercises targeting vocal deficits specific to Parkinson Disease.
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Choral (group) singing therapy sessions will be conducted once weekly and daily home practice exercises will be assigned.
All vocal exercises are based on principles that have been successful in other intensive Parkinson Disease vocal exercise programs.
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Average speaking intensity (dB SPL)
Periodo de tiempo: 19 Weeks
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Tasks: Sustained phonation of /a/ at a comfortable pitch and loudness for 4 seconds; pitch glide throughout physiologic vocal range on /a/; standardized reading passage (CAPE-V sentences); 1-minute monologue in response to an emotionally neutral question; singing a standard song.
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19 Weeks
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Colaboradores e Investigadores
Patrocinador
Investigadores
- Investigador principal: Aaron Johnson, MD, NYU Langone Health
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- 17-00323
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
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Ensayos clínicos sobre Enfermedad de Parkinson
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Duke UniversityMedical University of South Carolina; Massachusetts General Hospital; Mayo Clinic; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) y otros colaboradoresAún no reclutandoMicrobiota intestinal | Microbioma intestinal | Enfermedad de Parkinson (EP) | ENFERMEDAD DE PARKINSON (Trastorno) | Enfermedad de Parkinson ProdrómicaEstados Unidos
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ProgenaBiomeRetiradoEnfermedad de Parkinson | Enfermedad de Parkinson con demencia | Síndrome de Parkinson-Demencia | Enfermedad de Parkinson 2 | Enfermedad de Parkinson 3 | Enfermedad de Parkinson 4Estados Unidos
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Bezmialem Vakif UniversityReclutamientoEnfermedad de Parkinson | Párkinson | Enfermedad de Parkinson (EP) | ENFERMEDAD DE PARKINSON (Trastorno) | Enfermedad de ParkinsonTurquía (Türkiye)
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University of MinnesotaParkinson's FoundationReclutamientoEnfermedad de Parkinson (EP) | ENFERMEDAD DE PARKINSON (Trastorno)Estados Unidos
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EicOsis Human Health Inc.University of California, Davis; Michael J. Fox Foundation for Parkinson's ResearchReclutamientoEnfermedad de Parkinson (EP)Estados Unidos
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Serina TherapeuticsReclutamientoEnfermedad de Parkinson avanzada | ENFERMEDAD DE PARKINSON (Trastorno)Australia, Estados Unidos
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University of Kansas Medical CenterAún no reclutandoEnfermedad de Parkinson (EP)Estados Unidos
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AbbVieReclutamiento
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Michael J. Fox Foundation for Parkinson's ResearchReclutamientoEnfermedad de Parkinson ProdrómicaEstados Unidos, Israel, Canadá, Reino Unido, Alemania, Países Bajos
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Krzysztof BankiewiczAún no reclutandoEnfermedad de Parkinson (EP) | Enfermedad de Parkinson de inicio tempranoEstados Unidos
Ensayos clínicos sobre Choral (group) singing therapy sessions
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Boston Children's HospitalTerminadoEstrés Psicológico | Problema de aculturaciónEstados Unidos