- ICH GCP
- Registro de ensayos clínicos de EE. UU.
- Ensayo clínico NCT03671980
IBD Self-management Website and Home Faecal Calprotectin Monitoring
Feasibility and Acceptability of an Inflammatory Bowel Disease Self-management Website and Home Faecal Calprotectin Monitoring After Treatment De-escalation
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
IBD can be challenging to manage as disease flares are often unpredictable and rarely coincide with scheduled outpatient appointments. Websites are a novel way of assisting patients to take more control over monitoring and managing symptoms and have been shown to improve outcomes in some chronic diseases. The My Medical Record (MyMR) webiste was developed to help patients learn about IBD, access test results, monitor symptoms, and manage their medications, with email support from the IBD team.
The use of home faecal calprotectin monitoring will also be explored. This marker of IBD activity is normally performed in hospital laboratories and becomes elevated before the onset of clinical symptoms of an IBD flare. New technologies enable patients to perform the test at home with the aid of a smartphone application.
A 6 month exploratory feasibility study will be conducted to assess if a combination of MyMR and a home faecal testing kit is a feasible and acceptable means for patients to monitor their illness. Their use will be targeted to patients who have recently stopped (or reduced) a treatment for IBD, as up to 50% of these patients may have a disease flare within a year.
Interventions
- Clinic appointments Study participants will not be required to attend any routine outpatient follow up appointments for the 6 month study period, after which they will be reviewed by a member of the IBD team.
- Questionnaires and interviews Partcipants will receive questionnaires and a sample will also undergo interviews to explore their views regarding the website and stool test.
- Website
Participants will be encouraged to use all functions of the website at least monthly:
- Secure email messaging service
- IBD educational material
- Stool, nutritional and flare journals
- Blood and test results
Faecal calprotectin monitoring - monthly testing (or sooner if symptoms of a flare-up) using QuantonCal home faecal calprotectin smartphone application. Participants will test and monitor their FC levels monthly. The results will be overseen by the IBD team who will make contact within a week in the event of abnormal results if the participant has not already done so.
- Blood tests All participants will have a routine blood test at 0 and 6 months. Those taking azathioprine, mercaptopurine and methotrexate should continue regular blood monitoring (minimum of 3 monthly FBC, U&E, LFT and CRP) as usual practice. Participants will be provided with blood test results and explanations of their significance via MyMR. The results will be overseen by the IBD team who will make contact within a week in the event of abnormal results if the patient has not already done so.
- Safety Patients can contact the IBD team the email messaging service at any time for advice and support.
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
-
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Hampshire
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Southampton, Hampshire, Reino Unido, SO16 6YD
- Univesity Hospital Southampton NHS Foundation Trust
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-
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Adults aged ≥ 18 years currently under secondary care outpatient follow up for IBD
- Diagnosed with IBD at least one year prior to study enrolment (to ensure patients are familiar with their disease and treatments)
- Stopped or reduced the dose of one or more treatments for IBD (for any reason) within the last 8 weeks
- Able to understand English and provide written consent.
- Own, or have regular (at least weekly) access to a smartphone +/- personal computer with internet
Exclusion Criteria:
- Inability to read, understand informed consent
- Inability to use a smartphone
- Likely requirement of IBD surgery within the study period
- Ileostomy
- Pregnancy or planned pregnancy within next 6 months
- Terminal illness with limited (< 1year) life expectancy
- Current participation in another IBD research study
- Any reason, in the opinion of the investigators, which is likely to make the patient unsuitable for the study
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Otro
- Asignación: N / A
- Modelo Intervencionista: Asignación de un solo grupo
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
---|---|
Experimental: Web-intervention
30 participants using a self-management website and home faecal calprotectin smartphone monitoring instead of usual outpatient follow up as a means of managing their inflammatory bowel disease for 6 months after stopping an IBD medication.
|
Website comprising patient records, blood and other test results, useful information on IBD, and messaging service to communicate with IBD team, plus home smartphone faecal calprotectin monitoring.
|
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Faecal calprotectin testing completion rates
Periodo de tiempo: 6 months
|
Number of patients completing monthly faecal calprotectin testing
|
6 months
|
MyMR website usage
Periodo de tiempo: 6 months
|
Number of patients logging in to MyMR website at least monthly
|
6 months
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Recruitment
Periodo de tiempo: 6 months
|
Number of patients recruited per month
|
6 months
|
IBD email contact
Periodo de tiempo: 6 months
|
Number of email messaging contacts per patient to IBD specialist nursing team
|
6 months
|
IBD flareline calls
Periodo de tiempo: 6 months
|
Number of IBD flareline telephone calls per patient to IBD specialist nursing team
|
6 months
|
IT support contact
Periodo de tiempo: 6 months
|
Number of IT support email contacts per patient
|
6 months
|
Questionnaire response rates
Periodo de tiempo: 6 months
|
Response rates to pre-and post-study questionnaires
|
6 months
|
Retention rate
Periodo de tiempo: 6 months
|
Study retention rate (target 80%).
Study retention will be defined as successful completion of at least 5 out of 7 home faecal calprotectin tests, with no periods without login to website of greater than 3 consecutive months.
|
6 months
|
Calprotectin levels
Periodo de tiempo: 6 months
|
Mean faecal calprotectin levels at 0, 4, 8, 12, 16, 20, and 24 weeks.
|
6 months
|
IBD-Control
Periodo de tiempo: 6 months
|
Mean IBD-Control scores at 0, 4, 8, 12, 16, 20, and 24 weeks
|
6 months
|
SIBDQ
Periodo de tiempo: 6 months
|
Mean quality of life (SIBDQ) scores at 0 and 26 weeks
|
6 months
|
IBD knowledge
Periodo de tiempo: 6 months
|
Mean IBD knowledge scores (CC-KNOW) at 0 and 26 weeks.
|
6 months
|
Colaboradores e Investigadores
Patrocinador
Colaboradores
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- RHM MED1269
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
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