Cohorte de diabète gestationnel de Wenzhou (WGDC)
The Wenzhou Gestational Diabetes Cohort (WGDC) is a prospective cohort study among women with gestational diabetes mellitus (GDM) during pregnancy and their offspring living in Wenzhou, China. The primary aim of this cohort is to characterize the continuous blood glucose response to dietary intake and physical activity among pregnant women with GDM over 2 weeks, and to facilitate the development of personalized nutritional/lifestyle recommendation among these patients. Another aim of the WGDC is to investigate the association of dietary and physical activity together with continuous glucose change during pregnancy on the adverse birth outcomes including preterm birth, macrosomia and large-for-gestational-age birth. The secondary aim is to investigate the prospective associations of diet, physical activity and continuous glucose change over 2 weeks among the patients with long-term metabolic health of the women and their offspring.
Aperçu de l'étude
Statut
Les conditions
Intervention / Traitement
Description détaillée
In China, an alarming increase in the prevalence of GDM has been observed in the past decade. GDM is of concern because it is associated with several maternal and fetal medical disorders. Lifestyle changes such as diet and physical activity modifications are key for the prevention and treatment of GDM. However, the associations between dietary intake and physical activity and health outcomes for GDM women and their children remain unclear due to subjective measurements of diet and physical activity. Recently, the development of objective measurements such as food image identification and wearable activity trackers give an opportunity to gain more precise insight into these associations. In addition, for the same food and physical activity exposure, GDM women may have different blood glucose responses, but the nature of variation is currently poorly characterized. Therefore, the present WGDC design incorporates three unique components, 1) objective measurement of physical activity during pregnancy using accelerometer; 2) measurement of dietary intake using both Food Frequency Questionnaire and daily dietary records; 3) measurement of blood glucose levels over 2 weeks using continuous glucose monitors, with three standardized test meals during the 2 weeks. We will then follow up these women participants during and after this pregnancy, and also follow up their offspring.
Type d'étude
Inscription (Estimé)
Phase
- N'est pas applicable
Contacts et emplacements
Lieux d'étude
-
-
Zhejiang
-
Wenzhou, Zhejiang, Chine, 325000
- Wenzhou People's Hospital
-
-
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
La description
Inclusion Criteria:
- Women aged 18 years or older
- Women with GDM mainly at 24-28 weeks of gestation
- Women intended to deliver at Wenzhou People's Hospital
- Women intended to remain in Wenzhou with their child for ≥4 years
Exclusion Criteria:
- Women with cancer and other serious medical disorders
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: La prévention
- Répartition: Randomisé
- Modèle interventionnel: Affectation à un seul groupe
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
|---|---|
|
Autre: Standardized breakfast
Egg (50g), whole-wheat bread (35g), celery (30g), and dried bean curd (10g) |
Participants will be provided with a standardized breakfast on a morning of the days they wear a continuous glucose monitoring (CGM) device. |
|
Autre: Standardized snack
Tomato (50g) and skim milk (200g) |
Participants will be provided with a standardized snack 2 hour after they have the standardized breakfast. |
|
Autre: Standardized lunch
Rice (40g), oats (40g), shrimp (70g), lettuce (80g), lean pork (30g), carrot (10g), soaked auricularia auricula (20g), broccoli (80g), cucumber (10g), tomato egg drop soup (200g), salt (3g), and oil (8g) |
Participants will be provided with a standardized lunch 2 h after they have the standardized snack. |
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Adverse birth outcomes
Délai: 9-12 weeks after enrollment
|
Number of participants with adverse birth outcomes, such as, preterm birth, macrosomia and neonatal hypoglycemia. |
9-12 weeks after enrollment
|
|
Continuous blood glucose change over 2 weeks
Délai: two weeks after enrollment
|
Glucose levels are assessed by continuous glucose monitoring over 2 weeks. |
two weeks after enrollment
|
Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
Number of participants developing type 2 diabetes
Délai: 6 years and 10 years after delivery
|
Risk of developing type 2 diabetes after the delivery of the women with gestational diabetes. |
6 years and 10 years after delivery
|
|
Weight changes during early childhood
Délai: at delivery, age of 6 months, 1 year, 3 years and 6 years
|
Weight in kilograms |
at delivery, age of 6 months, 1 year, 3 years and 6 years
|
Collaborateurs et enquêteurs
Parrainer
Collaborateurs
Les enquêteurs
- Chercheur principal: Ju-Sheng Zheng, PhD, Westlake University
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Réel)
Achèvement primaire (Réel)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- 20221213ZJS001
Plan pour les données individuelles des participants (IPD)
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Informations sur les médicaments et les dispositifs, documents d'étude
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