Cerebrovascular Reactivity in Obstructive Sleep Apnea (OSA) Subjects
Spatial and Temporal Response of Cerebrovascular Response in OSA
Obstructive sleep apnea (OSA) is a prevalent sleep breathing disorder in the general population in which recurrent collapse of the upper airway occurs during sleep. OSA is more prevalent in subjects with stroke and is associated with a 3 fold increased risk of stroke. This makes it a serious public health problem. Approximately 50% of subjects with OSA are asymptomatic and are often only detected following investigation for the cause of heart disease or a stroke. In subjects who are treated for OSA many are intolerant or poorly compliant with treatment. Therefore, the identification of those subjects with OSA most at risk of adverse consequences such as stroke is important, so that treatment compliance can be improved.
Therfore, the investigators want to determine if compared to subjects without OSA, subjects with OSA have evidence of increased stroke risk by assessment of changes in cerebral blood flow (cerebrovascular reactivity) as measured on Doppler ultrasound of the middle cerebral artery (TCD) and blood oxygen level-dependent magnetic resonance imaging of patterns of cerebral blood flow (BOLD MRI) to two stimuli. These stimuli include increased carbon dioxide concentrations (causes increased cerebral blood flow) and reduced oxygen concentrations (causing decreased cerebral blood flow). In order to deliver these stimuli the investigators will use a special machine (RespiractTM) which allows for the precise control of carbon dioxide and oxygen concentrations in the lungs and blood. The precise control of carbon dioxide and oxygen in conjunction with BOLD MRI has enabled the production of detailed maps of the brain that identify areas of healthy and abnormal blood supply.
調査の概要
状態
条件
詳細な説明
研究の種類
入学 (予想される)
連絡先と場所
研究場所
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Ontario
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Toronto、Ontario、カナダ、M5G 2N2
- 募集
- Toronto Gneral Hospital
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主任研究者:
- Clodagh Ryan, MD
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副調査官:
- J Fisher, MD
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副調査官:
- J Duffin, PhD
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副調査官:
- D Mikulis, MD
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副調査官:
- a Battisti, BSc
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副調査官:
- O Pucci, BSc
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Subjects referred for sleep studies
Exclusion Criteria:
- Known cardiac, neurological or major liver or kidney disease -
- Cardioverter/defibrillator metal heart valve or pacemaker
- Vascular stent implanted within 6 weeks
- Severe claustrophobia
- Pregnancy
- Shrapnel or history of ophthalmic foreign body
- Resting oxygen saturation on room air < 95%
- Insulin-dependent diabetes
- Obstructive or restrictive lung disease such that subject is unable to walk up 2 flights of stairs
- Major depression.
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 観測モデル:コホート
- 時間の展望:見込みのある
コホートと介入
グループ/コホート |
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Control without Sleep Apnea
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Subjects with Sleep Apnea
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
時間枠 |
---|---|
Document the diurnal differences in global CVR as measured by TCD, between those with and without OSA
時間枠:Between 8pm and 7am approximately
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Between 8pm and 7am approximately
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二次結果の測定
結果測定 |
時間枠 |
---|---|
Use BOLD MRI to quantify global and regional CVR in various regions and vascular territories of the brain in subjects with OSA.
時間枠:one week
|
one week
|
協力者と研究者
捜査官
- 主任研究者:Clodagh M Ryan、Toronto General Hospital
研究記録日
主要日程の研究
研究開始
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
睡眠時無呼吸の臨床試験
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University Hospital, Bonnわからない合併症 | 睡眠時無呼吸 (Apnea Hypopnea Index > 5/h として定義) | 頭蓋内動脈瘤のサイズ | 血圧の薬 | 合併症(くも膜下出血)ドイツ