Central Nervous Processing of Visual Food Stimuli in Severely Obese Subjects
Central Nervous Processing of Visual Food Stimuli in Severely Obese Subjects and After Roux-en Y Gastric Bypass Surgery - a fMRI Study
調査の概要
状態
条件
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Rorschach、スイス、9400
- Interdisciplinary Obesity Center, Cantonal Hospital St. Gallen
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
Severely obese (body mass index; BMI > 35 kg/m2) women and previously severely obese women who had undergone a Roux-en Y gastric bypass operation were recruited from the Interdisciplinary Obesity Center, cantonal hospital St. Gallen (Switzerland), and the adiposity platform of the University of Tübingen.
lean control women were recruited in St. Gallen and in Tübingen
説明
Inclusion Criteria:
- women with BMI > 35kg/m2
- women, who had undergone gastric bypass surgery at least one year ago
- lean women
Exclusion Criteria:
- known psychiatric or neurological diseases
- current medication with drug acting on the central nervous system
- drugs that are known to affect eating behavior
- contraindication for the fMRI scanning, e.g. metal implants or metal containing tattoos
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
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severely obese women
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Women after Roux-en Y gastric bypass surgery
Women recruited for this group had undergone Roux-en Y gastric bypass surgery at least one year before.
In this women measurement of brain activity and gastrointestinal and metabolic response took place between 13 and 106 month after surgery.
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lean women
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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brain activity
時間枠：brain activity was measured at a single time point in all three groups; of note: women after Roux-en Y gastric bypass surgery were measured between 13 and 106 month after surgery.
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In all women brain activity was assessed by functional magnetic resonance imaging (fMRI, BOLD Method, 1.5 Tesla fMRI Scanner, Siemens, Erlangen, Germany) during the presentation of food and non-food related pictures as well as during state conditions. In all three groups, brain activity was measured at a single time point. Of note, women, who had undergone Roux-en Y gastric bypass surgery were measured between 13 and 106 month after surgery. Brain activity was not measured before surgery in this group. |
brain activity was measured at a single time point in all three groups; of note: women after Roux-en Y gastric bypass surgery were measured between 13 and 106 month after surgery.
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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gastrointestinal and metabolic responses to standardized meal
時間枠：measured at a single time point in all three groups; of note: women after Roux-en Y gastric bypass surgery were measured between 13 and 106 month after surgery at a single time point
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The gastrointestinal and metabolic responses to standardized meal were measured in the morning between 7:30 and 10:30 a.m. gastrointestinal and metabolic response were measured in all women at a single time point. Of note, women, who had undergone Roux-en Y gastric bypass surgery were measured between 13 and 106 month after surgery. Gastrointestinal and metabolic responses were not measured before surgery in this group. |
measured at a single time point in all three groups; of note: women after Roux-en Y gastric bypass surgery were measured between 13 and 106 month after surgery at a single time point
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協力者と研究者
捜査官
- 主任研究者：Bernd Schultes, Prof. Dr. med.、Interdisciplinary Obesity Center, Kantonal Hospital St. Gallen, Rorschach, Switzerland
- 主任研究者：Niels Birbaumer, Prof. Dr.、Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, Tübingen, Germany
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
その他の研究ID番号
- EKSG09/033/2B
- 09/033/2B (その他の識別子：ID by EKSG)
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