Airway Deadspace in Children: Air-Q Versus Endotracheal Tube
A Prospective Comparison of the Airway Deadspace Associated With the Air-Q® and Endotracheal Tube Using Volumetric Capnography in Young Children
調査の概要
状態
詳細な説明
There is an increasing interest in the use of supraglottic airway devices in progressively younger and younger patients. One issue that has not been well evaluated is the contribution of these devices to airway dead space in young children and infants. Volumetric capnography is the only non-invasive technology available at the current time to evaluate airway deadspace. Volumetric capnography essentially monitors the flow of CO2 over time and from the expired waveform one can determine different respiratory parameters including dead space. This is clinically important in young children as the clinician begins to evaluate whether or not to use an endotracheal tube or supraglottic airway in these patients. To perform this investigation the study team will use volumetric capnography to examine the airway dead space associated with these devices during and elective general surgery and urologic procedures in healthy children between the ages of 0 and 6 years of age (roughly 5-20 kg).
Participants in the study will be given ETT or Air-Q as an intervention, but the investigator does not assign specific interventions to the study participants.
研究の種類
入学 (実際)
連絡先と場所
研究場所
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North Carolina
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Winston-Salem、North Carolina、アメリカ、27517
- Wake Forest Baptist Medical Center
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Patients between the ages of 3 months and 6 years of age weighing between 5 and 20 kg
- Patient presenting outpatient urologic or general surgery
Exclusion Criteria:
- History of difficult airway/intubation
- Patients suspected to have a difficult airway.
- Morbid obesity BMI >39
- Emergency status of surgery
- Patients exposed to second hand smoke
- Patients with Asthma
- Patients with a URI symptom such as nasal drainage, cough, or fever within 7 days of the date of surgery
- History of Prematurity
研究計画
研究はどのように設計されていますか?
デザインの詳細
コホートと介入
グループ/コホート |
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Air-Q 5-9kg
Participants weighing 5-9kg may be chosen to wear the Air-Q device.
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Air-Q 10-14kg
Participants weighing 10-14kg may be chosen to wear the Air-Q device.
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Air-Q 15-20kg
Participants weighing 15-20kg may be chosen to wear the Air-Q device.
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ETT 5-9kg
Participants weighing 5-9kg may be chosen to wear the ETT device.
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ETT 10-14kg
Participants weighing 10-14kg may be chosen to wear the ETT device.
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ETT 15-20kg
Participants weighing 15-20kg may be chosen to wear the ETT device.
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Mean Value of Airway Dead Space
時間枠:10 minutes
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A mean value observed over the first 10 minutes following placement of the ETT or the AirQ at the beginning of the case will be recorded.
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10 minutes
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Lung Compliance measured by Respironics NM3 respiratory monitors
時間枠:10 minutes
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The values of lung compliance will be collected and reported.
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10 minutes
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Airway Resistance measured by Respironics NM3 respiratory monitors
時間枠:10 minutes
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The value of resistance to flow in the airways will be collected and reported
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10 minutes
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Volume of Carbon Dioxide Associated with the Devices
時間枠:10 minutes
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The volume of carbon dioxide associated with the devices will be recorded and reported.
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10 minutes
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協力者と研究者
出版物と役立つリンク
一般刊行物
- Garcia-Fernandez J, Tusman G, Suarez-Sipmann F, Llorens J, Soro M, Belda JF. Programming pressure support ventilation in pediatric patients in ambulatory surgery with a laryngeal mask airway. Anesth Analg. 2007 Dec;105(6):1585-91, table of contents. doi: 10.1213/01.ane.0000287674.64086.f1.
- Micaglio M, Bonato R, De Nardin M, Parotto M, Trevisanuto D, Zanardo V, Doglioni N, Ori C. Prospective, randomized comparison of ProSeal and Classic laryngeal mask airways in anaesthetized neonates and infants. Br J Anaesth. 2009 Aug;103(2):263-7. doi: 10.1093/bja/aep106. Epub 2009 May 19.
- Templeton TW, Hoke LK, Templeton LB, Ririe DG, Rose DM, Bryan YF. A comparison of 3 ventilation strategies in children younger than 1 year using a Proseal laryngeal mask airway: a randomized controlled trial. J Clin Anesth. 2016 Dec;35:502-508. doi: 10.1016/j.jclinane.2016.07.042. Epub 2016 Oct 19.
- Drake-Brockman TF, Ramgolam A, Zhang G, Hall GL, von Ungern-Sternberg BS. The effect of endotracheal tubes versus laryngeal mask airways on perioperative respiratory adverse events in infants: a randomised controlled trial. Lancet. 2017 Feb 18;389(10070):701-708. doi: 10.1016/S0140-6736(16)31719-6. Epub 2017 Jan 18.
- Casati A, Fanelli G, Torri G. Physiological dead space/tidal volume ratio during face mask, laryngeal mask, and cuffed oropharyngeal airway spontaneous ventilation. J Clin Anesth. 1998 Dec;10(8):652-5. doi: 10.1016/s0952-8180(98)00108-1.
- Templeton TW, Goenaga-Diaz EJ, Templeton LB, Ririe DG. An in vitro analysis of the dead space in 5 supraglottic airway devices intended for use in small children and infants. Paediatr Anaesth. 2018 Jun;28(6):570-572. doi: 10.1111/pan.13382. No abstract available.
- Templeton TW, Hoke LK, Yaung J, Aschenbrenner CA, Rose DM, Templeton LB, Bryan YF. Comparing 3 ventilation modalities by measuring several respiratory parameters using the ProSeal laryngeal mask airway in children. J Clin Anesth. 2016 Nov;34:272-8. doi: 10.1016/j.jclinane.2016.04.031. Epub 2016 May 15.
- Al-Subu A, Jooste E, Hornik CP, Fleming GA, Cheifetz IM, Ofori-Amanfo G. Correlation between minute carbon dioxide elimination and pulmonary blood flow in single-ventricle patients after stage 1 palliation and 2-ventricle patients with intracardiac shunts: A pilot study. Paediatr Anaesth. 2018 Jul;28(7):618-624. doi: 10.1111/pan.13423.
- Ream RS, Schreiner MS, Neff JD, McRae KM, Jawad AF, Scherer PW, Neufeld GR. Volumetric capnography in children. Influence of growth on the alveolar plateau slope. Anesthesiology. 1995 Jan;82(1):64-73. doi: 10.1097/00000542-199501000-00010.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
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学習記録の更新
投稿された最後の更新 (実際)
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最終確認日
詳しくは
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