さまざまな測定方法を使用してフルーツドリンクの血糖指数を確立する
さまざまな測定方法を使用して、フルーツジュースとスムージーの摂取に対する血糖反応を調べるための研究。
Glycaemic responses to carbohydrates ingested as fruit sugars may vary depending on factors inherent to the fruit and the type of sugar. The aim of this project is to investigate the glycaemic responses to a range of commercially available fruit drinks and to establish the glycaemic index for each product relative to a glucose reference. Differences in recorded responses could also be influenced by the sample type (capillary blood vs interstitial fluid) and participant characteristics. Participants will ingest 8 test drinks including 5 different fruit drinks (OJ, AJ, S&B, ENERGISE, BLUE), each matched for carbohydrate to the glucose reference (CONTROL) which will be sampled two times, an additional sample of one of the smoothies (S&B) will also be replicated. Fingerstick capillary blood sampling alongside dual sited continuous glucose monitors (CGM) will measure glucose and lactate concentrations, subjective appetite sensations will also be recorded. The tests will follow best practice guidelines for glycaemic index testing. These data will provide insight into how differing formulations can alter the glycaemic responses to fruit drinks, and whether sampling technique can affect the interpretations of measurement.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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-
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Bath、イギリス、BA2 7AY
- Department for Health, University of Bath
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Age: 18-65 years
- Body mass index 18-30 kg/m2
Exclusion Criteria:
- diagnosis of any form of diabetes
- intolerances or allergies to any of the study procedures (e.g. fructose/inulin intolerance)
- Fructose malabsorption
- Inborn errors of fructose metabolism (e.g. fructokinase deficiency, aldolase B deficiency, fructose-1,6-bisphosphatase deficiency)
- pregnant or lactating
- any condition that could introduce bias to the study (e.g. diagnoses of lipid disorders, including cardiovascular disease, or therapies that alter lipid or glucose metabolism, such as statins or niacin).
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
|
アクティブコンパレータ：CONTROL
50 g glucose (55 g dextrose powder accounting for hydration) plus 641 mL water |
Commercially available fruit drinks or smoothies |
|
アクティブコンパレータ：REPLICATE CONTROL
50 g glucose (55 g dextrose powder accounting for hydration) plus 641 mL water |
Commercially available fruit drinks or smoothies |
|
実験的：S&B
417 mL of commercially available "Strawberries & Bananas" fruit smoothie providing 50 g carbohydrate [strawberries (31%), apples, bananas (22%), white grapes, oranges, blackcurrants]. Plus 224 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
|
実験的：REPLICATE S&B
417 mL of commercially available "Strawberries & Bananas" fruit smoothie providing 50 g carbohydrate [strawberries (31%), apples, bananas (22%), white grapes, oranges, blackcurrants]. Plus 224 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
|
実験的：OJ
641 mL of commercially available "Smooth Orange Juice" providing 50 g of carbohydrate [100% oranges] |
Commercially available fruit drinks or smoothies |
|
実験的：AJ
455 mL commercially available "Apple Juice" providing 50 g of carbohydrate [apples, ascorbic acid]. Plus 186 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
|
実験的：ENERGISE
417 mL of commercially available "Energise Super Smoothie" providing 50 g carbohydrate [apples (50%), red grapes, bananas, strawberries (10%), blackcurrants, sour cherries (3.3%), pressed beetroot, flax seeds (0.56%), guarana infusion (0.01%), vitamins B1, B2, B3, B6, C & E]. Plus 224 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
|
実験的：BLUE
521 mL of commercially available "Bolt from the Blue" juice drink providing 50 g carbohydrate [apple (66%), coconut water (18%), white grapes, white guava (5.2%), passion fruit, lime (0.87%), spirulina extract (0.81%) vitamins B1, B2, B3, B6, C & E]. Plus 120 mL water to standardise volume |
Commercially available fruit drinks or smoothies |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Glycaemic indices for 5 test drinks measured using capillary blood samples
時間枠：120 minutes
|
Glycaemic indices [2-hour incremental area under the glucose curve (mmol/L-1x120 minutes) for each of the 5 test drinks relative to mean value of control conditions (CONTROL, REPLICATE CONTROL), expressed as a percentage] in capillary blood samples |
120 minutes
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Glycaemic index of all conditions with capillary blood samples vs CGM
時間枠：120 minutes
|
The difference in glycaemic index [2-hour incremental area under the glucose curve (mmol/L-1x120 minutes) for 5 test drinks relative to mean control (CONTROL, REPLICATE CONTROL), expressed as a percentage] in capillary blood samples versus continuous glucose monitors. |
120 minutes
|
その他の成果指標
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Comparisons between conditions in glucose concentration in capillary samples
時間枠：120 minutes
|
Comparison of blood glucose concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration in capillary samples
時間枠：120 minutes
|
Comparison of postprandial peak concentration mmol/L of blood glucose between test conditions (Cmax) |
120 minutes
|
|
Comparisons between conditions in glucose concentration in capillary samples
時間枠：120 minutes
|
Comparison of time to peak blood glucose concentration in minutes (Tmax) between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration in capillary samples
時間枠：120 minutes
|
Comparison of blood glucose concentration mmol/L at 2 hours between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
時間枠：120 minutes
|
Comparison of glucose concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
時間枠：120 minutes
|
Comparison of postprandial peak concentration mmol/L of glucose between test conditions (Cmax) |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
時間枠：120 minutes
|
Comparison of time to peak glucose concentration in minutes (Tmax) between test conditions |
120 minutes
|
|
Comparisons between conditions in glucose concentration with CGM
時間枠：120 minutes
|
Comparison of glucose concentration mmol/L at 2 hours between test conditions |
120 minutes
|
|
Comparisons between conditions in lactate concentration in capillary samples
時間枠：120 minutes
|
Comparison of blood lactate concentration 2-hour incremental area under the curve (iAUC) min.mmol/L between test conditions |
120 minutes
|
|
Comparisons between conditions in lactate concentration in capillary samples
時間枠：120 minutes
|
Comparison of postprandial peak concentration mmol/L of blood lactate between test conditions (Cmax) |
120 minutes
|
|
Comparisons between conditions in lactate concentration in capillary samples
時間枠：120 minutes
|
Comparison of time to peak blood lactate concentration in minutes (Tmax) between test conditions |
120 minutes
|
|
Comparisons between conditions in lactate concentration in capillary samples
時間枠：120 minutes
|
Comparison of blood lactate concentration mmol/L at 2 hours between test conditions |
120 minutes
|
|
Comparisons between conditions of appetite ratings
時間枠：120 minutes
|
Comparison of subjective appetite sensations assessed with visual analogue scales (2-hour area under the curve min.mmVAS) |
120 minutes
|
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Comparisons between individuals
時間枠：120 minutes
|
Comparison of Postprandial lactate concentration min.mmol/L between individuals 2-hour incremental area under curve (iAUC) |
120 minutes
|
|
Comparisons between individuals
時間枠：120 minutes
|
Comparison of Postprandial glucose concentration min.mmol/L between individuals 2-hour incremental area under curve (iAUC) |
120 minutes
|
|
Comparisons between individuals
時間枠：120 minutes
|
Comparison of Appetite rating responses min.mmVAS between individuals 2-hour area under curve (AUC) |
120 minutes
|
|
Comparisons within individuals
時間枠：120 minutes
|
Comparison within individuals of interstitial glucose concentrations measurements from continuous glucose monitors on left and right arms. |
120 minutes
|
協力者と研究者
スポンサー
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
個々の参加者データ (IPD) の計画
個々の参加者データ (IPD) を共有する予定はありますか?
IPD プランの説明
De-identified data will be made available open access on the University of Bath Research Data Archive (RDA) at the point of publication in a peer-reviewed journal.
IPD 共有時間枠
These will become available at the point of publication permanently
IPD 共有サポート情報タイプ
- STUDY_PROTOCOL
- SAP
- ICF
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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