The Impact of Omega-3 Fatty Acid Supplementation on the Composition of Erythrocyte Membranes in Athletes (OMEGA-PERFORM)
Effects of Omega-3 Fatty Acid Supplementation on Omega-3 Index, Cognitive Function, Hormonal Profile, Speed, and Endurance in Competitive Athletes Aged 16-35 Years: A Randomized Placebo-Controlled Trial
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
Skeletal muscle function, including the ability to generate force, sustain repeated high-intensity efforts, and resist fatigue, is essential for soccer performance. In addition to neuromuscular adaptations, increasing evidence suggests that nutritional interventions, particularly omega-3 fatty acid supplementation, may influence muscle function, recovery, inflammation, and cognitive performance. However, despite growing interest in omega-3 fatty acids, evidence regarding their effects on physical and cognitive performance in competitive soccer players remains limited.
The present randomized, placebo-controlled trial aims to evaluate the effects of four weeks of high-dose omega-3 fatty acid supplementation in competitive male soccer players aged 16 to 35 years. Participants will continue their regular soccer training and maintain their habitual mixed diet throughout the study.
The primary objective is to determine the effects of supplementation on the Omega-3 Index and the erythrocyte fatty acid profile, including omega-3, omega-6, trans fatty acids, and arachidonic acid (AA). In addition, the study will evaluate changes in cognitive function, hormonal profile, speed and endurance performance, hematological parameters, lipid profile, inflammatory markers, oxidative-antioxidant status, and erythrocyte membrane composition.
The fatty acid profile will be assessed using a validated laboratory method that enables quantitative determination of individual fatty acids in erythrocyte membranes, providing an objective biomarker of long-term omega-3 status and membrane lipid composition. This approach allows comprehensive evaluation of the biological response to omega-3 supplementation in competitive athletes.
The findings of this study are expected to improve understanding of the physiological effects of high-dose omega-3 fatty acid supplementation in soccer players and may contribute to evidence-based nutritional strategies aimed at optimizing health, recovery, cognitive function, and athletic performance.
연구 유형
연구 유형
등록 (추정된)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 연락처
연구 연락처
- 이름: Małgorzata Magdalena Michalczyk, Professor
- 전화번호: +48535016532
- 이메일: m.michalczyk@awf.katowice.pl
연구 연락처 백업
- 이름: Grzegorz Henryk Zydek, assistante profesor
- 전화번호: 504332664
- 이메일: g.zydek@awf.katowice.pl
연구 장소
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Mikolowska 72a
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Katowice, Mikolowska 72a, 폴란드, 40-065
- 모병
- Jerzy Kukuczka Academy of Physical Education in Katowice
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연락하다:
- Małgorzata Michalczyk, Proffesor
- 전화번호: 535016532
- 이메일: m.michalczyk@awf.katowice.pl
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연락하다:
- Grzegorz H Zydek, assistance profesor
- 전화번호: 504332664
- 이메일: g.zydek@awf.katowice.pl
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참여기준
자격 기준
자격 기준
공부할 수 있는 나이
- 어린이
- 성인
건강한 자원 봉사자를 받아들입니다
설명
**Inclusion Criteria:**
- Male competitive soccer players aged 16-35 years.
- Regular participation in organized soccer training and competition.
- A minimum of 6 years of systematic soccer training experience.
- Participation in regular team training during the study period.
- Habitual mixed diet.
- Ability and willingness to maintain usual dietary habits and training load throughout the 4-week intervention.
- Written informed consent provided by the participant.
- For participants under 18 years of age, written informed consent provided by a parent or legal guardian and assent provided by the participant.
**Exclusion Criteria:**
- Current use of omega-3 fatty acid supplements or fish-oil products.
- Use of omega-3 supplements within the 3 months preceding enrollment.
- Known allergy or hypersensitivity to fish, seafood, fish oil, or any ingredient of the study supplements.
- Diagnosed cardiovascular, metabolic, endocrine, gastrointestinal, neurological, inflammatory, autoimmune, or hematological disease.
- Acute infection, injury, or illness that could affect participation in training or study assessments.
- Use of medications or dietary supplements that could influence lipid metabolism, inflammatory status, hormonal profile, blood coagulation, cognitive function, or physical performance.
- Regular use of anticoagulant or antiplatelet medication.
- Significant change in diet, training volume, or supplementation during the study period.
- Failure to comply with the supplementation protocol or attendance requirements.
- Participation in another clinical or nutritional intervention study during the study period.
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 특수 증상
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 더블
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
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실험적: Omega-3 fatty acid supplementation group
Participants will received 3.5g EPA+ DHA for 4 weeks
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Participants will randomly assigned to the supplemented group.
The supplement will be administered in a dose of 4 capsules twice a day for 4 weeks.
Daily dose will contain 3500mg EPA + DHA
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위약 비교기: Placebo group
Participants will received 3.5g placebo for 4 weeks
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Participants will randomly assigned to the Placebo group.
The placebo will be administered in a dose of 4 capsules twice a day for 4 weeks.
Daily dose will contain 3500mg MCT.
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연구는 무엇을 측정합니까?
주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Change in Omega Index
기간: From enrollment to the end of 4-week supplementation
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The Omega-3 Index will be assessed in erythrocytes as the combined percentage of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) relative to total fatty acids in erythrocyte membranes.
Blood samples will be collected at baseline and after the 4-week supplementation period.
In addition to the Omega-3 Index, the erythrocyte fatty acid profile, including individual omega-3 and omega-6 fatty acids, arachidonic acid (AA), and trans fatty acids, will be assessed.
Changes from baseline to the end of the 4-week intervention will be evaluated.
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From enrollment to the end of 4-week supplementation
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2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Neuromuscular function
기간: From enrollment to the end of supplementation period of 4 weeks
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Neuromuscular function was assessed using tensiomyography (TMG), a non-invasive method for evaluating the contractile properties of skeletal muscles.
Parameters including contraction time (Tc), delay time (Td), sustain time (Ts), relaxation time (Tr), and maximal radial displacement (Dm) were measured at baseline and after the 4-week intervention.
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From enrollment to the end of supplementation period of 4 weeks
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Hematological parameters and hormones
기간: From enrollment to the end of supplementation period of 4 weeks
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Hematological parameters were assessed using fasting venous blood samples.
Outcome measures included complete blood count variables, including red blood cell count, white blood cell count, hemoglobin, hematocrit, platelet count, and red blood cell indices.
Also testosteron and cortisol concentration was measured.
Changes from baseline to the end of the 4-week intervention were evaluated.
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From enrollment to the end of supplementation period of 4 weeks
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Lipoprteine profile
기간: From enrollment to the end of supplementation period of 4 weeks
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The lipoprotein profile was assessed using fasting blood samples.
Outcome measures included total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides.
Changes from baseline to the end of the 4-week intervention were evaluated.
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From enrollment to the end of supplementation period of 4 weeks
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Cognitive function
기간: From enrollment to the end of supplementation period of 4 weeks
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Cognitive function was assessed using the Corsi Block-Tapping Test, which evaluates visuospatial working memory, short-term memory capacity, and executive cognitive performance.
Changes in test performance were compared between baseline and the end of the 4-week intervention.
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From enrollment to the end of supplementation period of 4 weeks
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Speed on 5 and 30m
기간: From enrollment to the end of supplementation period of 4 weeks
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Running times will be recorded using two pairs of dual-beam Witty Gate photocells (Microgate, Bolzano, Italy), a valid and reliable system for sprint performance assessment.
Following a standardized warm-up, participants will perform two maximal 30-m sprint trials on an indoor artificial grass surface, with 15 minutes of passive recovery between trials.
To prevent premature activation of the timing system, participants will start with the leading foot positioned 0.5 m behind the first timing gate.
Split times at 5 m and 30 m will be recorded automatically, and the best performance from the two trials will be used for statistical analysis.
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From enrollment to the end of supplementation period of 4 weeks
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Anaerobic performance
기간: From enrollment to the end of supplementation period of 4 weeks
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Anaerobic performance will be assessed using the Running-Based Anaerobic Sprint Test (RAST).
Following a standardized warm-up, participants will perform six maximal 35-m sprints separated by 10 seconds of passive recovery.
Sprint times will be recorded using an electronic timing system.
Peak power, mean power, minimum power, fatigue index, and total sprint time will be calculated according to the standard RAST protocol.
All tests will be performed under standardized environmental conditions, and participants will receive standardized verbal encouragement throughout the test.
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From enrollment to the end of supplementation period of 4 weeks
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CMJ performance
기간: From enrollment to the end of 4-week supplementation
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Countermovement jump performance will be assessed using dual force plates (ForceDecks, VALD Performance, Australia), a validated system for quantifying vertical jump kinetics and kinematics. Before testing, participants will stand quietly on the force plates for 3 seconds to determine body mass and baseline force. The testing protocol will include bilateral countermovement jumps with arm swing (CMJa) and unilateral countermovement jumps performed separately on the dominant and non-dominant limbs. Participants will perform a rapid countermovement followed immediately by a maximal vertical jump. Three maximal trials will be completed for each test, with 1 minute of passive recovery between bilateral trials and 30 seconds between unilateral trials. The best trial for each test will be retained for analysis. Vertical ground reaction force data will be sampled at 1000 Hz and analyzed using the manufacturer's software. Outcome measures will incl |
From enrollment to the end of 4-week supplementation
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Change in Reactive Strength and Leg Stiffness
기간: From enrollment to the end of 4-week supplementation
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Reactive strength and lower-limb stiffness will be assessed using the Myotest Pro system during three consecutive maximal plyometric jumps.
Outcome measures will include reactive strength index (RSI) and leg stiffness.
Changes from baseline to the end of the 4-week intervention will be evaluated.
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From enrollment to the end of 4-week supplementation
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공동 작업자 및 조사자
스폰서
스폰서
수사관
수사관
- 연구 책임자: Małgorzata M Michalczyk, Proffesor, Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
연구 시작
기본 완료 (실제)
기본 완료
연구 완료 (추정된)
연구 완료
연구 등록 날짜
최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
처음 게시됨
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
마지막 업데이트 게시됨
QC 기준을 충족하는 마지막 업데이트 제출
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
기타 연구 ID 번호
- 4-I/2024 (기타 보조금/기금 번호: The Jerzy Kukuczka Academy of Physical Education in Katowice)
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
IPD 계획 설명
IPD 공유 지원 정보 유형
- 연구_프로토콜
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