- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT00005366
Biobehavioral Mechanisms of Blood Pressure Regulation
연구 개요
상세 설명
BACKGROUND:
Hypertension is more prevalent in Black than white men, and is more prevalent in men than women. Furthermore, even controlling for blood pressure, concentric left ventricular hypertrophy, an early structural adaptation of hypertension, is more prevalent in Black than white men, and more prevalent in men than women. Concentric left ventricular hypertrophy is the strongest predictor, other than age, of the cardiovascular morbidity associated with high blood pressure.
DESIGN NARRATIVE:
In a biracial sample, concentric left ventricular hypertrophy and concentric remodelling were assessed by echocardiographic measures of left ventricular mass and relative wall thickness. Laboratory procedures were used to: (i) assess hemodynamic and neurohumoral responses during exposure to a diverse battery of physical and psychological stressors, and; (ii) evaluate alpha and beta adrenergic receptor responsiveness, baroreceptor reflex gain and minimal forearm vascular resistance. Since blood pressure during a typical workday was an established predictor of left ventricular hypertrophy, it was also assessed. A new biobehavioral model was tested that implicated the hemodynamic pattern of behaviorally-evoked pressor responses in the pathogenesis of concentric left ventricular hypertrophy. One prediction of this model was that a predisposition to exhibit increased vascular resistance during stress (characteristic of black men) would favor the development of concentric hypertrophy. Thus, systemic vascular resistance responses, evaluated in the laboratory, were hypothesized to independently predict left ventricular mass and relative wall thickness, even after controlling for established risk factors, including workday blood pressure. Sympathetic nervous system function was examined to test hypothesized mechanisms responsible for race and gender differences in the hemodynamic patterns of blood pressure regulation. The results of these studies emphasized the importance of race and gender in prescribing pharmacological and/or behavioral treatment for hypertensive heart disease.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
연구 유형
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
공부 계획
연구는 어떻게 설계됩니까?
공동 작업자 및 조사자
간행물 및 유용한 링크
일반 간행물
- Sherwood A, Hinderliter AL, Light KC. Physiological determinants of hyperreactivity to stress in borderline hypertension. Hypertension. 1995 Mar;25(3):384-90. doi: 10.1161/01.hyp.25.3.384.
- Watkins LL, Grossman P, Sherwood A. Noninvasive assessment of baroreflex control in borderline hypertension. Comparison with the phenylephrine method. Hypertension. 1996 Aug;28(2):238-43. doi: 10.1161/01.hyp.28.2.238.
- Sherwood A, May CW, Siegel WC, Blumenthal JA. Ethnic differences in hemodynamic responses to stress in hypertensive men and women. Am J Hypertens. 1995 Jun;8(6):552-7. doi: 10.1016/0895-7061(95)00036-O.
- Blumenthal JA, Thyrum ET, Gullette ED, Sherwood A, Waugh R. Do exercise and weight loss reduce blood pressure in patients with mild hypertension? N C Med J. 1995 Feb;56(2):92-5.
- Carels RA, Blumenthal JA, Sherwood A. Emotional responsivity during daily life: relationship to psychosocial functioning and ambulatory blood pressure. Int J Psychophysiol. 2000 Apr;36(1):25-33. doi: 10.1016/s0167-8760(99)00101-4.
- Sherwood A, Johnson K, Blumenthal JA, Hinderliter AL. Endothelial function and hemodynamic responses during mental stress. Psychosom Med. 1999 May-Jun;61(3):365-70. doi: 10.1097/00006842-199905000-00017.
- Carels RA, Szczepanski R, Blumenthal JA, Sherwood A. Blood pressure reactivity and marital distress in employed women. Psychosom Med. 1998 Sep-Oct;60(5):639-43. doi: 10.1097/00006842-199809000-00022.
- Watkins LL, Grossman P, Krishnan R, Sherwood A. Anxiety and vagal control of heart rate. Psychosom Med. 1998 Jul-Aug;60(4):498-502. doi: 10.1097/00006842-199807000-00018.
- Carels RA, Sherwood A, Blumenthal JA. Psychosocial influences on blood pressure during daily life. Int J Psychophysiol. 1998 Mar;28(2):117-29. doi: 10.1016/s0167-8760(97)00090-1.
- Carels RA, Sherwood A, Szczepanski R, Blumenthal JA. Ambulatory blood pressure and marital distress in employed women. Behav Med. 2000 Summer;26(2):80-5. doi: 10.1080/08964280009595755.
연구 기록 날짜
연구 주요 날짜
연구 시작
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
심장 질환에 대한 임상 시험
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