Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
Intrauterine Growth Restriction Has an Impact on Amplitude-integrated EEG in Preterm Infants
Objective: The impact of intrauterine growth restriction (IUGR) on perinatal morbidity and long-term neurodevelopmental outcome has been published in numerous studies. Throughout this analysis, the influence of IUGR on the postnatal amplitude-integrated EEG (aEEG) in preterm infants below 30 weeks of gestation was assessed. The second concern was the correlation between the pattern of the aEEG in the first two weeks with neurodevelopmental outcome, comparing infants with and without IUGR.
Methods: Routinely assessed aEEG data of preterm infants with IUGR born below 30 weeks of gestation in the years 2005 until 2007 were analysed retrospectively according to the aEEG score (combining occurrence of sleep-wake-cycles, background activity and suspected seizure activity). Neurodevelopmental outcome was evaluated at 24 months using the Bayley Scales of Infant Development and standardized neurologic examination.
연구 개요
상태
개입 / 치료
연구 유형
등록 (실제)
연락처 및 위치
연구 장소
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Vienna, 오스트리아, 1090
- Medical University Vienna
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참여기준
자격 기준
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연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- preterm infants below 30 weeks of gestation
Exclusion Criteria:
- congenital anomalies
- severe asphyxia
공부 계획
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디자인 세부사항
코호트 및 개입
그룹/코호트 |
개입 / 치료 |
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Intrauterine growth restriction
birth weight <10th percentile first intervention: aEEG second intervention: assessment of neurodevelopmental follow-up
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The amplitude integrated EEG was performed using a single-channel, biparietal aEEG (CFM 6000; Natus Medical Incorporated, San Carlos, CA)
다른 이름들:
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Appropriate for gestation age
control group with birth weight >10th percentile first intervention: aEEG second intervention: assessment of neurodevelopmental follow-up
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The amplitude integrated EEG was performed using a single-channel, biparietal aEEG (CFM 6000; Natus Medical Incorporated, San Carlos, CA)
다른 이름들:
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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aEEG score (including background pattern, occurrence of sleep-wake-cycling and presence of seizure activity)
기간: first 14 days of life
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composite score background activity (BA), occurrence of sleep-wake-cycling (SWC) and presence of seizure activity (SA) meaning score 1= normal (normal BA, SWC yes, SA no) and score 2 and 3 = abnormal (2=abnormality in 1 category (BA, SWC or SA) and score 3= abnormality in 2 or 3 categories
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first 14 days of life
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Neurodevelopmental outcome
기간: 24 months
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composite score: Bayley Scales of Infant Development (>85= normal, <70 severely impaired, 71-84= mildly impaired) and standardized neurologic examination (normal or abnormal)
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24 months
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기타 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Morbidity, mortality and neurodevelopmental outcome of patients with IUGR compared to controls
기간: 24 months
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morbidities until discharge (Intraventricular hemorrhage, retinopathy, chronic lung disease, necrotizing enterocolitis, periventricular leucomalacia); mortality and neurodevelopmental outcome (via Bayley Scales of Infant Development >85= normal, <70 = severly impaired)
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24 months
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공동 작업자 및 조사자
수사관
- 수석 연구원: Katrin Klebermass-Schrehof, MD, Medical University of Vienna
연구 기록 날짜
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기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
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추가 정보
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