- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT05820659
Rasediskriminering og stressrespons
Rasediskriminering og dysregulert stressrespons: Risiko/beskyttelsesfaktorer
Målet med denne studien er å lære om hvorvidt etniske minoritetsungdoms opplevelse av rasediskriminering er relatert til dysregulerte biologiske responser på subtil rasisme, og hvordan forholdet kan svekkes eller forverres av et sett av sosiale og kognitive faktorer. Hovedspørsmålene den tar sikte på å besvare er:
- å avsløre forholdet mellom rasediskrimineringserfaringer og etniske minoritetsungdoms stressrespons på subtil rasisme
- å teste foreldrenes etnisk-rase sosialisering, barns tilskrivelse til subtil rasisme og deres raseidentitet som potensielle risiko- og beskyttende faktorer.
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
Erfaringer med rasediskriminering utgjør betydelig risiko for etniske minoritetsungdoms fysiske og psykiske helseproblemer. En forklaring antyder at kronisk stress kan føre til endrede, dysregulerte stressresponser, noe som kan gjøre individer utsatt for helseproblemer. Foreløpig er det ingen eksperimentell studie som uttømmende måler etniske minoritetsungdoms stressrespons på subtil rasisme, eller som undersøker de bidragende rollene til erfaring med rasediskriminering og mulige risiko- og beskyttende faktorer.
Et fellesskapsutvalg av 11-14 år gamle etniske minoriteter (40 latinamerikanske, 40 svarte/afrikanske amerikanske) og deres foreldre vil bli rekruttert. Studien bruker en tilpasset avvisningsoppgave som har blitt mye brukt med ungdom, og nøye utformet for å fremkalle opplevelsen av subtil rasediskriminering fra hvite jevnaldrende. Ungdoms kardiovaskulære aktivitet og spyttprøver vil bli tatt på flere tidspunkter før, under og etter avvisningsoppgaven med jevnaldrende, ved å trykke på respons som involverer hypothalamus-hypofyse-binyreaksen (HPA), autonomt nervesystem (ANS) og inflammatorisk mediator ( JEG ER). Ungdom vil rapportere sin erfaring med rasediskriminering, gi attribusjon om erfaringen med avvisning av jevnaldrende og vurdere sin raseidentitet. Foreldre vil fylle ut et spørreskjema for å rapportere deres etnisk-rase sosialiseringspraksis.
Målene med dette forslaget er: 1) Avsløre forholdet mellom rasediskrimineringserfaringer og ungdom med etniske minoriteters stressrespons på subtil rasisme; og 2) Test foreldrenes etnisk-rase sosialisering, barns tilskrivelse til subtil rasisme og deres raseidentitet som potensielle risiko- og beskyttende faktorer.
Studietype
Registrering (Faktiske)
Fase
- Ikke aktuelt
Kontakter og plasseringer
Studiesteder
-
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Kentucky
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Bowling Green, Kentucky, Forente stater, 42101
- Western Kentucky University
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-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Barn
- Voksen
- Eldre voksen
Tar imot friske frivillige
Beskrivelse
Inklusjonskriterier:
- 6.-8.klassinger
- identifisert som latinamerikansk eller svart/afroamerikansk
- Bor i Warren fylke i Kentucky
- Foreldre til kvalifiserte ungdommer
Ekskluderingskriterier:
Ungdom vil ikke delta i avvisningsoppgaven når de rapporterer å ha:
- hyppige opplevelser av likemannsoffer
- hyppige opplevelser av rasediskriminering
- alvorlig depresjon
- alvorlig sosial angstlidelse
- alvorlig generalisert angstlidelse
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
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Eksperimentell: stress inducing task
Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, then discuss the peer rejection task with parents, as well as an impossible puzzle task to elicit cognitive stress.
|
Peer rejection task: Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with PsychoPy software. Conversation about peer rejection: parents and adolescents will discuss the peer rejection task guided with suggested question prompts. Impossible puzzle task: Adolescents will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided. |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Mean Arterial Pressure for Peer Rejection
Tidsramme: baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
|
adolescents' diastolic and systolic blood pressure will be continuously monitored.
|
baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
|
|
Change in Stress Hormones for Peer Rejection
Tidsramme: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
adolescents' salivary samples will be collected, frozen, and assayed for cortisol.
|
five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
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Change in Inflammatory Biomarker of Interleukin 6 for Peer Rejection
Tidsramme: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
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five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
|
Change in Inflammatory Biomarker of C-reactive Protein for Peer Rejection
Tidsramme: adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
|
adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
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Attribution About the Peer Rejection for Peer Rejection
Tidsramme: immediately after the 5-minute peer rejection task ends
|
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale.
The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
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immediately after the 5-minute peer rejection task ends
|
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Emotional Experience for Peer Rejection
Tidsramme: immediately after the 5-minute peer rejection task ends
|
adolescents will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale.
The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
|
immediately after the 5-minute peer rejection task ends
|
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Change in Skin Conductance Activity for Peer Rejection
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
|
adolescents' skin conductance will be continuously monitored for the peer rejection task.
|
baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
|
|
Change in Respiratory Sinus Arrhythmia for Peer Rejection
Tidsramme: baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
|
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.
|
baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Mean Arterial Pressure for Impossible Puzzle
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
adolescents' systolic and diastolic blood pressure will be continuously monitored for the impossible puzzle task
|
baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
|
Emotional Experience for Impossible Puzzle
Tidsramme: immediately after the 5-minute impossible puzzle task ends
|
adolescents will complete the questionnaire, Emotions In The Impossible Puzzle (EITIP) to rate the emotional experiences in the impossible puzzle task using a 7-point scale.
The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the impossible puzzle task
|
immediately after the 5-minute impossible puzzle task ends
|
|
Attribution for Impossible Puzzle
Tidsramme: immediately after the 5-minute impossible puzzle task ends
|
adolescents will complete the questionnaire, Attribution About The Impossible Puzzle (AATIP) to rate the likelihood of various reasons for the experience of not being able to complete the puzzle using a 7-point scale.
The higher total score for the 3 intrinsic reasons (possible range: 3-21) indicates the higher tendency of making intrinsic attribution about performance in the impossible puzzle task.
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immediately after the 5-minute impossible puzzle task ends
|
|
Change in Skin Conductance for Impossible Puzzle
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
|
adolescents' skin conductance will be continuously monitored for the impossible puzzle task
|
baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
|
|
Change in Respiratory Sinus Arrhythmia for Impossible Puzzle
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the impossible puzzle task
|
baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
|
Change in Mean Arterial Pressure for Conversation About Peer Rejection
Tidsramme: baseline (2.5 minute of discussion about last night's dinner before the conversation about peer rejection), during (5 minutes about the peer rejection task)
|
adolescents' diastolic and systolic blood pressure will be continuously monitored.
|
baseline (2.5 minute of discussion about last night's dinner before the conversation about peer rejection), during (5 minutes about the peer rejection task)
|
|
Change in Skin Conductance Activity in Conversation About Peer Rejection
Tidsramme: baseline (2.5 minutes about last night's dinner before the conversation about peer rejection), during (5 minutes discussion about peer rejection)
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adolescents' skin conductance level will be continuously monitored before and during the conversation about peer rejection.
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baseline (2.5 minutes about last night's dinner before the conversation about peer rejection), during (5 minutes discussion about peer rejection)
|
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Change in Respiratory Sinus Arrhythmia for Conversation About Peer Rejection
Tidsramme: Baseline (2.5 minutes of discussion on last night's dinner before the conversation about peer rejection), during the task (5 minutes of discussion on peer rejection task)
|
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the conversation about peer rejection
|
Baseline (2.5 minutes of discussion on last night's dinner before the conversation about peer rejection), during the task (5 minutes of discussion on peer rejection task)
|
Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Hovedetterforsker: Qingfang Song, Ph.D, Western Kentucky University
Publikasjoner og nyttige lenker
Generelle publikasjoner
- Lucas T, Wegner R, Pierce J, Lumley MA, Laurent HK, Granger DA. Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women. Psychosom Med. 2017 Apr;79(3):293-305. doi: 10.1097/PSY.0000000000000406.
- Silk JS, Stroud LR, Siegle GJ, Dahl RE, Lee KH, Nelson EE. Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task. Soc Cogn Affect Neurosci. 2012 Jan;7(1):93-105. doi: 10.1093/scan/nsr044. Epub 2011 Jul 20.
- Sladek MR, Castro SA, Doane LD. Ethnic-Racial discrimination experiences predict Latinx adolescents' physiological stress processes across college transition. Psychoneuroendocrinology. 2021 Jun;128:105212. doi: 10.1016/j.psyneuen.2021.105212. Epub 2021 Apr 1.
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- U5GMACGETKJ1
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
IPD-planbeskrivelse
IPD-delingstidsramme
Tilgangskriterier for IPD-deling
IPD-deling Støtteinformasjonstype
- STUDY_PROTOCOL
- SEVJE
- ICF
- ANALYTIC_CODE
- CSR
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