- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT05820659
Racediskrimination og stressreaktion
Racediskrimination og dysreguleret stressreaktion: Risiko/beskyttelsesfaktorer
Målet med denne undersøgelse er at lære om, hvorvidt unge med etniske minoriteters racediskriminationsoplevelse er relateret til dysregulerede biologiske reaktioner på subtil racisme, og hvordan forholdet kan svækkes eller forværres af et sæt sociale og kognitive faktorer. De vigtigste spørgsmål, den sigter mod at besvare er:
- at afsløre forholdet mellem racediskriminationsoplevelser og etniske minoritetsunges stressreaktion på subtil racisme
- at teste forældrenes etnisk-racesocialisering, børns tilskrivning til subtil racisme og deres raceidentitet som potentielle risiko- og beskyttende faktorer.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Erfaringer med racediskrimination udgør betydelige risici for etniske minoritetsunges fysiske og psykiske helbredsproblemer. En forklaring antyder, at kronisk stress kan føre til ændrede, dysregulerede stressreaktioner, som kan gøre individer modtagelige for helbredsproblemer. I øjeblikket er der ingen eksperimentel undersøgelse, der udtømmende måler etniske minoritetsunges stressreaktion på subtil racisme eller undersøger de bidragende roller af racediskriminationsoplevelse og mulige risiko- og beskyttende faktorer.
En fællesskabsprøve af 11-14-årige etniske minoritetsunge (40 latinamerikanske, 40 sorte/afrikanske amerikanske) og deres forældre vil blive rekrutteret. Undersøgelsen anvender en tilpasset peer-afvisningsopgave, som er blevet meget brugt med unge, og omhyggeligt designet til at fremkalde oplevelsen af subtil racediskrimination fra hvide jævnaldrende. Teenageres kardiovaskulære aktivitet og spytprøver vil blive taget på flere tidspunkter før, under og efter peer-afvisningsopgaven, idet der trykkes på respons, der involverer hypothalamus-hypofyse-binyre (HPA) aksen, autonomt nervesystem (ANS) og inflammatorisk mediator ( JEG ER). Unge vil rapportere deres racediskriminationsoplevelse, komme med tilskrivninger om oplevelsen af peer-afvisning og vurdere deres raceidentitet. Forældre vil udfylde et spørgeskema for at rapportere deres etnisk-raciale socialiseringspraksis.
Målene med dette forslag er: 1) Afsløre forholdet mellem racediskriminationsoplevelser og unge med etniske minoriteters stressreaktion på subtil racisme; og 2) Test forældrenes etnisk-racesocialisering, børns tilskrivning til subtil racisme og deres raceidentitet som potentielle risiko- og beskyttende faktorer.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
-
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Kentucky
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Bowling Green, Kentucky, Forenede Stater, 42101
- Western Kentucky University
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
- Barn
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Beskrivelse
Inklusionskriterier:
- 6.-8. klasser
- identificeret som latinamerikansk eller sort/afroamerikaner
- Bor i Warren County of Kentucky
- Forældre til berettigede unge
Ekskluderingskriterier:
Unge deltager ikke i afvisningsopgaven, når de rapporterer at have:
- hyppige oplevelser af jævnaldrende offer
- hyppige oplevelser med racediskrimination
- svær depression
- svær social angst
- svær generaliseret angstlidelse
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: stress inducing task
Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, then discuss the peer rejection task with parents, as well as an impossible puzzle task to elicit cognitive stress.
|
Peer rejection task: Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with PsychoPy software. Conversation about peer rejection: parents and adolescents will discuss the peer rejection task guided with suggested question prompts. Impossible puzzle task: Adolescents will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided. |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Mean Arterial Pressure for Peer Rejection
Tidsramme: baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
|
adolescents' diastolic and systolic blood pressure will be continuously monitored.
|
baseline (5 minute before to right before the task), during (start to the end of the task), and post-task (right after to 45 minutes after the peer rejection task)
|
|
Change in Stress Hormones for Peer Rejection
Tidsramme: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
adolescents' salivary samples will be collected, frozen, and assayed for cortisol.
|
five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
|
Change in Inflammatory Biomarker of Interleukin 6 for Peer Rejection
Tidsramme: five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
|
five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
|
Change in Inflammatory Biomarker of C-reactive Protein for Peer Rejection
Tidsramme: adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
adolescents' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
|
adolescents' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
|
|
Attribution About the Peer Rejection for Peer Rejection
Tidsramme: immediately after the 5-minute peer rejection task ends
|
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale.
The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
|
immediately after the 5-minute peer rejection task ends
|
|
Emotional Experience for Peer Rejection
Tidsramme: immediately after the 5-minute peer rejection task ends
|
adolescents will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale.
The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
|
immediately after the 5-minute peer rejection task ends
|
|
Change in Skin Conductance Activity for Peer Rejection
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
|
adolescents' skin conductance will be continuously monitored for the peer rejection task.
|
baseline (5 minutes before to right before the task), during (start to end of the task), first post-task (right after to 15 minutes after) and second post-task (15 to 45 minutes after) the peer rejection task
|
|
Change in Respiratory Sinus Arrhythmia for Peer Rejection
Tidsramme: baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
|
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.
|
baseline (5 minutes before to right before the task), during (start to the end of the task), first post-task (right after to 15 minutes after the task) and second post-task (15 to 45 minutes after the task)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Change in Mean Arterial Pressure for Impossible Puzzle
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
adolescents' systolic and diastolic blood pressure will be continuously monitored for the impossible puzzle task
|
baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
|
Emotional Experience for Impossible Puzzle
Tidsramme: immediately after the 5-minute impossible puzzle task ends
|
adolescents will complete the questionnaire, Emotions In The Impossible Puzzle (EITIP) to rate the emotional experiences in the impossible puzzle task using a 7-point scale.
The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the impossible puzzle task
|
immediately after the 5-minute impossible puzzle task ends
|
|
Attribution for Impossible Puzzle
Tidsramme: immediately after the 5-minute impossible puzzle task ends
|
adolescents will complete the questionnaire, Attribution About The Impossible Puzzle (AATIP) to rate the likelihood of various reasons for the experience of not being able to complete the puzzle using a 7-point scale.
The higher total score for the 3 intrinsic reasons (possible range: 3-21) indicates the higher tendency of making intrinsic attribution about performance in the impossible puzzle task.
|
immediately after the 5-minute impossible puzzle task ends
|
|
Change in Skin Conductance for Impossible Puzzle
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
|
adolescents' skin conductance will be continuously monitored for the impossible puzzle task
|
baseline (5 minutes before to right before the task), during (start to end of the task), and post (right after to 15 minutes after the task)
|
|
Change in Respiratory Sinus Arrhythmia for Impossible Puzzle
Tidsramme: baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the impossible puzzle task
|
baseline (5 minutes before to right before the task), during (start to end of the task), and post-task (right after to 15 minutes after the task)
|
|
Change in Mean Arterial Pressure for Conversation About Peer Rejection
Tidsramme: baseline (2.5 minute of discussion about last night's dinner before the conversation about peer rejection), during (5 minutes about the peer rejection task)
|
adolescents' diastolic and systolic blood pressure will be continuously monitored.
|
baseline (2.5 minute of discussion about last night's dinner before the conversation about peer rejection), during (5 minutes about the peer rejection task)
|
|
Change in Skin Conductance Activity in Conversation About Peer Rejection
Tidsramme: baseline (2.5 minutes about last night's dinner before the conversation about peer rejection), during (5 minutes discussion about peer rejection)
|
adolescents' skin conductance level will be continuously monitored before and during the conversation about peer rejection.
|
baseline (2.5 minutes about last night's dinner before the conversation about peer rejection), during (5 minutes discussion about peer rejection)
|
|
Change in Respiratory Sinus Arrhythmia for Conversation About Peer Rejection
Tidsramme: Baseline (2.5 minutes of discussion on last night's dinner before the conversation about peer rejection), during the task (5 minutes of discussion on peer rejection task)
|
adolescents' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the conversation about peer rejection
|
Baseline (2.5 minutes of discussion on last night's dinner before the conversation about peer rejection), during the task (5 minutes of discussion on peer rejection task)
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Qingfang Song, Ph.D, Western Kentucky University
Publikationer og nyttige links
Generelle publikationer
- Lucas T, Wegner R, Pierce J, Lumley MA, Laurent HK, Granger DA. Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women. Psychosom Med. 2017 Apr;79(3):293-305. doi: 10.1097/PSY.0000000000000406.
- Silk JS, Stroud LR, Siegle GJ, Dahl RE, Lee KH, Nelson EE. Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task. Soc Cogn Affect Neurosci. 2012 Jan;7(1):93-105. doi: 10.1093/scan/nsr044. Epub 2011 Jul 20.
- Sladek MR, Castro SA, Doane LD. Ethnic-Racial discrimination experiences predict Latinx adolescents' physiological stress processes across college transition. Psychoneuroendocrinology. 2021 Jun;128:105212. doi: 10.1016/j.psyneuen.2021.105212. Epub 2021 Apr 1.
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- U5GMACGETKJ1
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
IPD-planbeskrivelse
IPD-delingstidsramme
IPD-delingsadgangskriterier
IPD-deling Understøttende informationstype
- STUDY_PROTOCOL
- SAP
- ICF
- ANALYTIC_CODE
- CSR
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