Stråleterapi med RapidPlan Kunnskapsbasert planlegging vs menneskedrevet planlegging for behandling av prostatakreft
Randomisert fase III-studie av rask plan kunnskapsbasert planlegging vs menneskedrevet planlegging for prostatakreft strålebehandling
This phase III trial compares the effects of radiation therapy using RapidPlan, trademark, knowledge-based planning to human-driven planning in treating patients with prostate cancer. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Successful delivery of radiation requires planning to develop a treatment plan for how and where the radiation is to be delivered. RapidPlan is a knowledge-based treatment planning tool that automatically creates an optimal treatment plan based on identified targets and organs at risk for radiation exposure. Human-driven treatment planning by a dosimetrist, the current standard of care, requires significant resources and time and may vary within and among radiation centers. Giving radiation therapy with RapidPlan knowledge-based planning may have similar or less side effects compared to human-driven planning in treating patients with prostate cancer.
Studieoversikt
Status
Forhold
Intervensjon / Behandling
- Fremgangsmåte: Biospecimen Collection
- Fremgangsmåte: Magnetic Resonance Imaging
- Annen: Questionnaire Administration
- Fremgangsmåte: Positron Emission Tomography
- Stråling: Photon Beam Radiation Therapy
- Stråling: Radiation Therapy Treatment Planning and Simulation
- Stråling: Radiation Therapy Treatment Planning and Simulation
Detaljert beskrivelse
PRIMARY OBJECTIVE:
I. To determine if RapidPlan knowledge-based planning is non-inferior to human-driven planning regarding treatment-related rates of grade 3 or higher genitourinary (GU) and gastrointestinal (GI) adverse events at 3 months post-radiotherapy for prostate cancer.
EXPLORATORY OBJECTIVES:
I. After completion of radiation therapy, determine the incidence of:
Ia. Grade 2 or greater GU and GI toxicity at 3 months (Common Terminology Criteria for Adverse Events [CTCAE] version 5); Ib. Quality of life 3 months post-radiotherapy; Ic. Rate of achieving dose-volume constraints. II. Determine if there are any statistical differences in dose-volumes results with RapidPlan knowledge-based planning.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM A (HUMAN-DRIVEN): Patients receive human-driven treatment planning and undergo radiation therapy over 15-30 minutes on 5-44 fractions per standard of care. Additionally, patients undergo magnetic resonance imaging (MRI) pre-treatment and blood sample collection and positron emission tomography (PET) throughout study.
ARM B (KNOWLEDGE-BASED): Patients receive RapidPlan treatment planning and undergo radiation therapy over 15-30 minutes on 5-44 fractions per standard of care. Additionally, patients undergo MRI pre-treatment and blood sample collection and PET throughout study.
After completion of study treatment, patients are followed up at 3 and 12 months then yearly for up to year 5.
Studietype
Registrering (Antatt)
Fase
- Fase 3
Kontakter og plasseringer
Studiekontakt
- Navn: Clinical Trials Referral Office
- Telefonnummer: 855-776-0015
- E-post: mayocliniccancerstudies@mayo.edu
Studer Kontakt Backup
- Navn: Cancer Clinical Trials Referral Office
- Telefonnummer: 507-293-6386
Studiesteder
-
-
Arizona
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Scottsdale, Arizona, Forente stater, 85259
- Rekruttering
- Mayo Clinic in Arizona
-
Ta kontakt med:
- Clinical Trials Referral Office
- Telefonnummer: 855-776-0015
- E-post: mayocliniccancerstudies@mayo.edu
-
Hovedetterforsker:
- Nathan Y. Yu, MD
-
Ta kontakt med:
- Cancer Clinical Trials Referral Office
- Telefonnummer: 507-293-6386
-
-
Florida
-
Jacksonville, Florida, Forente stater, 32224-9980
- Har ikke rekruttert ennå
- Mayo Clinic in Florida
-
Ta kontakt med:
- Clinical Trials Referral Office
- Telefonnummer: 855-776-0015
- E-post: mayocliniccancerstudies@mayo.edu
-
Ta kontakt med:
- Cancer Clinical Trials Referral Office
- Telefonnummer: 507-293-6386
-
Hovedetterforsker:
- Homan Mohammadi, MD
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Patients must be at least 18 years old
- Histologically confirmed prostate cancer
- Clinical or pathologic stages T1c-T3b, Nx or N0-1, M0-1 (American Joint Committee on Cancer [AJCC] criteria 8th edition [Ed])
- Planned definitive dose radiotherapy to the prostate or prostate bed
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2 assessed within 90 days of enrollment
- Patients must sign Institutional Review Board (IRB) approved study specific informed consent
- Patients must complete all required pre-entry tests within the specified time frames
- Patients must be able to start treatment (radiation) within 180 days of study registration
- In case of confusion about the eligibility or ineligibility of an individual patient, the principal investigator (PI) can be used as the arbiter and a note to file will be added to the subject's regulatory binder to document outcome
Exclusion Criteria:
- Previous pelvic radiation > 5 Gy
- Planned delivery of radiotherapy to pelvic lymph nodes
- Planned delivery of brachytherapy of the prostate
- Active rectal diverticulitis, Crohn's disease affecting the rectum, or ulcerative colitis (non-active diverticulitis and Crohn's disease not affecting the rectum are allowed)
- Prior hip replacement or penile implant
- Major medical, addictive, or psychiatric illness which in the investigator's opinion, will prevent the consent process, completion of the treatment and/or interfere with follow-up. (consent by legal authorized representative is not permitted for this study)
- Indwelling or intermittent urinary catheter use
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Aktiv komparator: Arm A (human-driven treatment planning, radiation therapy)
Patients receive human-driven treatment planning and undergo radiation therapy over 15-30 minutes on 5-44 fractions per standard of care. Additionally, patients undergo MRI pre-treatment and blood sample collection and PET throughout study. |
Undergo blood sample collection
Andre navn:
Undergo MRI
Andre navn:
Ancillary studies Undergo PET
Andre navn:
Undergo radiation therapy
Andre navn:
Receive human-driven treatment planning
Andre navn:
Receive RapidPlan treatment planning
Andre navn:
|
|
Eksperimentell: Arm B (RapidPlan treatment planning, radiation therapy)
Patients receive RapidPlan treatment planning and undergo radiation therapy over 15-30 minutes on 5-44 fractions per standard of care. Additionally, patients undergo MRI pre-treatment and blood sample collection and PET throughout study. |
Undergo blood sample collection
Andre navn:
Undergo MRI
Andre navn:
Ancillary studies Undergo PET
Andre navn:
Undergo radiation therapy
Andre navn:
Receive human-driven treatment planning
Andre navn:
Receive RapidPlan treatment planning
Andre navn:
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Incidence of grade 3 or higher genitourinary (GU) and gastrointestinal (GI) adverse events (AEs)
Tidsramme: Up to 3 months post-radiotherapy
|
AEs will be defined using Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Comparisons between treatment arms will be made using a non-inferiority test for the difference between two proportions with an alpha level of 5%. The proportion of patients experiencing grade 3 or higher GU or GI AEs over the number of patients eligible for toxicity will be estimated. |
Up to 3 months post-radiotherapy
|
Samarbeidspartnere og etterforskere
Sponsor
Etterforskere
- Hovedetterforsker: Nathan Y. Yu, MD, Mayo Clinic
Publikasjoner og nyttige lenker
Hjelpsomme linker
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Antatt)
Studiet fullført (Antatt)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Urogenitale sykdommer
- Kjønnssykdommer
- Genitale neoplasmer, hanner
- Urogenitale neoplasmer
- Neoplasmer etter nettsted
- Neoplasmer
- Kjønnssykdommer, mannlige
- Prostata sykdommer
- Mannlige urogenitale sykdommer
- Prostatiske neoplasmer
- Undersøkelsesteknikker
- Kliniske laboratorieteknikker
- Diagnostiske teknikker og prosedyrer
- Diagnose
- Fysiske fenomener
- Kjemisteknikker, analytisk
- Spektrumanalyse
- Elektromagnetiske fenomener
- Magnetiske fenomener
- Elektromagnetisk stråling
- Elementære partikler
- Lys
- Optiske fenomener
- Stråling, ikke -ionisering
- Stråling
- Prøvehåndtering
- Magnetisk resonansspektroskopi
- Fotoner
Andre studie-ID-numre
- GMROA2451
- GMROA2451 (Annen identifikator: Mayo Clinic Radiation Oncology)
- NCI-2024-07870 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
- 24-006449 (Annen identifikator: Mayo Clinic Institutional Review Board)
Legemiddel- og utstyrsinformasjon, studiedokumenter
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