Rytuksymab i chemioterapia skojarzona z lenalidomidem lub bez w leczeniu pacjentów z nowo rozpoznanym chłoniakiem rozlanym z dużych komórek B w stadium II-IV
Randomizowane badanie otwarte fazy II lenalidomidu R-CHOP (R2CHOP) w porównaniu z RCHOP (rytuksymab, cyklofosfamid, doksorubicyna, winkrystyna i prednizon) u pacjentów z nowo zdiagnozowanym chłoniakiem rozlanym z dużych komórek B
This randomized phase II trial studies how well rituximab and combination chemotherapy with or without lenalidomide work in treating patients with newly diagnosed stage II-IV diffuse large B cell lymphoma. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Lenalidomide may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether rituximab and combination chemotherapy are more effective when given with or without lenalidomide in treating patients with diffuse large B cell lymphoma.
Przegląd badań
Status
Status
Warunki
Warunki
Interwencja / Leczenie
Interwencja / Leczenie
Szczegółowy opis
PRIMARY OBJECTIVES:
I. Progression-free survival (PFS).
SECONDARY OBJECTIVES:
I. Response rate (RR). II. Complete remission (CR) rate as defined by positron emission tomography (PET)-computed tomography (CT) criteria.
III. Overall survival (OS).
TERTIARY OBJECTIVES:
I. Impact of diffuse large B cell lymphoma (DLBCL) molecular subtype on outcome.
II. Interim PET scan results in relation to treatment outcome.
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM A: Patients receive rituximab intravenously (IV), cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone orally (PO) on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 2 years, every 6 months for 1 year, and then annually for up to 7 years.
Typ studiów
Typ studiów
Zapisy (Rzeczywisty)
Zapisy
Faza
Faza
- Faza 2
Kontakty i lokalizacje
Lokalizacje studiów
-
-
Alaska
-
Anchorage, Alaska, Stany Zjednoczone, 99508
- Alaska Breast Care and Surgery LLC
-
Anchorage, Alaska, Stany Zjednoczone, 99508
- Alaska Women's Cancer Care
-
Anchorage, Alaska, Stany Zjednoczone, 99508
- Anchorage Oncology Centre
-
Anchorage, Alaska, Stany Zjednoczone, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, Stany Zjednoczone, 99508
- Providence Alaska Medical Center
-
-
Arizona
-
Scottsdale, Arizona, Stany Zjednoczone, 85259
- Mayo Clinic in Arizona
-
Tucson, Arizona, Stany Zjednoczone, 85719
- Banner University Medical Center - Tucson
-
Tucson, Arizona, Stany Zjednoczone, 85719
- University of Arizona Cancer Center-North Campus
-
-
Arkansas
-
Little Rock, Arkansas, Stany Zjednoczone, 72205
- John L McClellan Memorial Veterans Hospital
-
-
California
-
Antioch, California, Stany Zjednoczone, 94531
- Kaiser Permanente-Deer Valley Medical Center
-
Auburn, California, Stany Zjednoczone, 95602
- Sutter Auburn Faith Hospital
-
Baldwin Park, California, Stany Zjednoczone, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, Stany Zjednoczone, 90706
- Kaiser Permanente-Bellflower
-
Burbank, California, Stany Zjednoczone, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
-
Harbor City, California, Stany Zjednoczone, 90710
- Kaiser Permanente South Bay
-
Irvine, California, Stany Zjednoczone, 92618
- Kaiser Permanente-Irvine
-
Loma Linda, California, Stany Zjednoczone, 92354
- Loma Linda University Medical Center
-
Modesto, California, Stany Zjednoczone, 95355
- Memorial Medical Center
-
Mountain View, California, Stany Zjednoczone, 94040
- Palo Alto Medical Foundation-Camino Division
-
Mountain View, California, Stany Zjednoczone, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
-
Oakland, California, Stany Zjednoczone, 94611
- Kaiser Permanente-Oakland
-
Orange, California, Stany Zjednoczone, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
-
Palo Alto, California, Stany Zjednoczone, 94304
- Stanford Cancer Institute Palo Alto
-
Palo Alto, California, Stany Zjednoczone, 94301
- Palo Alto Medical Foundation Health Care
-
Panorama City, California, Stany Zjednoczone, 91402
- Kaiser Permanente - Panorama City
-
Richmond, California, Stany Zjednoczone, 94801
- Kaiser Permanente-Richmond
-
Sacramento, California, Stany Zjednoczone, 95816
- Sutter Medical Center Sacramento
-
Sacramento, California, Stany Zjednoczone, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, Stany Zjednoczone, 95825
- Kaiser Permanente Sacramento Medical Center
-
San Diego, California, Stany Zjednoczone, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, Stany Zjednoczone, 92108
- Kaiser Permanente-Rio San Diego
-
San Francisco, California, Stany Zjednoczone, 94115
- Kaiser Permanente-San Francisco
-
San Francisco, California, Stany Zjednoczone, 94115
- California Pacific Medical Center-Pacific Campus
-
San Jose, California, Stany Zjednoczone, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Jose, California, Stany Zjednoczone, 95124
- Stanford Cancer Center South Bay
-
San Marcos, California, Stany Zjednoczone, 92078
- Kaiser Permanente-San Marcos
-
San Rafael, California, Stany Zjednoczone, 94903
- Kaiser Permanente-San Rafael
-
Santa Clara, California, Stany Zjednoczone, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Cruz, California, Stany Zjednoczone, 95065
- Palo Alto Medical Foundation-Santa Cruz
-
Santa Rosa, California, Stany Zjednoczone, 95403
- Kaiser Permanente-Santa Rosa
-
Santa Rosa, California, Stany Zjednoczone, 95403
- Sutter Pacific Medical Foundation
-
South San Francisco, California, Stany Zjednoczone, 94080
- Kaiser Permanente-South San Francisco
-
Sunnyvale, California, Stany Zjednoczone, 94086
- Palo Alto Medical Foundation-Sunnyvale
-
Walnut Creek, California, Stany Zjednoczone, 94596
- Kaiser Permanente-Walnut Creek
-
Woodland Hills, California, Stany Zjednoczone, 91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora, Colorado, Stany Zjednoczone, 80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora, Colorado, Stany Zjednoczone, 80012
- The Medical Center of Aurora
-
Boulder, Colorado, Stany Zjednoczone, 80303
- Boulder Community Foothills Hospital
-
Colorado Springs, Colorado, Stany Zjednoczone, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Stany Zjednoczone, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver, Colorado, Stany Zjednoczone, 80205
- Kaiser Permanente-Franklin
-
Denver, Colorado, Stany Zjednoczone, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Stany Zjednoczone, 80220
- Rose Medical Center
-
Denver, Colorado, Stany Zjednoczone, 80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver, Colorado, Stany Zjednoczone, 80220
- Rocky Mountain Cancer Centers-Rose
-
Denver, Colorado, Stany Zjednoczone, 80218
- Colorado Blood Cancer Institute
-
Denver, Colorado, Stany Zjednoczone, 80222
- Western States Cancer Research NCORP
-
Denver, Colorado, Stany Zjednoczone, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver, Colorado, Stany Zjednoczone, 80210
- AdventHealth Porter
-
Durango, Colorado, Stany Zjednoczone, 81301
- Mercy Medical Center
-
Englewood, Colorado, Stany Zjednoczone, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood, Colorado, Stany Zjednoczone, 80113
- Swedish Medical Center
-
Golden, Colorado, Stany Zjednoczone, 80401
- Mountain Blue Cancer Care Center
-
Greeley, Colorado, Stany Zjednoczone, 80631
- Banner North Colorado Medical Center
-
Greenwood Village, Colorado, Stany Zjednoczone, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
-
Lafayette, Colorado, Stany Zjednoczone, 80026
- Kaiser Permanente-Rock Creek
-
Lakewood, Colorado, Stany Zjednoczone, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Lakewood, Colorado, Stany Zjednoczone, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
-
Littleton, Colorado, Stany Zjednoczone, 80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton, Colorado, Stany Zjednoczone, 80122
- AdventHealth Littleton
-
Lone Tree, Colorado, Stany Zjednoczone, 80124
- Sky Ridge Medical Center
-
Lone Tree, Colorado, Stany Zjednoczone, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Longmont, Colorado, Stany Zjednoczone, 80501
- Longmont United Hospital
-
Longmont, Colorado, Stany Zjednoczone, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland, Colorado, Stany Zjednoczone, 80539
- Banner North Colorado Medical Center - Loveland Campus
-
Parker, Colorado, Stany Zjednoczone, 80138
- Rocky Mountain Cancer Centers-Parker
-
Parker, Colorado, Stany Zjednoczone, 80138
- AdventHealth Parker
-
Pueblo, Colorado, Stany Zjednoczone, 81004
- Saint Mary Corwin Medical Center
-
Thornton, Colorado, Stany Zjednoczone, 80260
- Rocky Mountain Cancer Centers-Thornton
-
Wheat Ridge, Colorado, Stany Zjednoczone, 80401
- Intermountain Health Lutheran Hospital
-
-
Connecticut
-
Hartford, Connecticut, Stany Zjednoczone, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
-
New Britain, Connecticut, Stany Zjednoczone, 06050
- The Hospital of Central Connecticut
-
New Haven, Connecticut, Stany Zjednoczone, 06520
- Yale University
-
-
Delaware
-
Dover, Delaware, Stany Zjednoczone, 19901
- Bayhealth Hospital Kent Campus
-
Lewes, Delaware, Stany Zjednoczone, 19958
- Beebe Medical Center
-
Newark, Delaware, Stany Zjednoczone, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Stany Zjednoczone, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Stany Zjednoczone, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Stany Zjednoczone, 19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach, Delaware, Stany Zjednoczone, 19971
- Beebe Health Campus
-
Seaford, Delaware, Stany Zjednoczone, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
-
District of Columbia
-
Washington D.C., District of Columbia, Stany Zjednoczone, 20016
- Sibley Memorial Hospital
-
-
Florida
-
Lakeland, Florida, Stany Zjednoczone, 33805
- The Watson Clinic
-
Orlando, Florida, Stany Zjednoczone, 32806
- Orlando Health Cancer Institute
-
-
Georgia
-
Atlanta, Georgia, Stany Zjednoczone, 30322
- Emory University Hospital/Winship Cancer Institute
-
Atlanta, Georgia, Stany Zjednoczone, 30342
- Northside Hospital
-
Decatur, Georgia, Stany Zjednoczone, 30033
- Atlanta VA Medical Center
-
Lawrenceville, Georgia, Stany Zjednoczone, 30046
- Northside Hospital - Gwinnett
-
Macon, Georgia, Stany Zjednoczone, 31201
- Atrium Health Navicent
-
Savannah, Georgia, Stany Zjednoczone, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
-
Hawaii
-
Honolulu, Hawaii, Stany Zjednoczone, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Stany Zjednoczone, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Stany Zjednoczone, 96819
- Kaiser Permanente Moanalua Medical Center
-
-
Idaho
-
Boise, Idaho, Stany Zjednoczone, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Stany Zjednoczone, 83712
- Saint Luke's Cancer Institute - Boise
-
Fruitland, Idaho, Stany Zjednoczone, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Stany Zjednoczone, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Stany Zjednoczone, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Stany Zjednoczone, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Twin Falls, Idaho, Stany Zjednoczone, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Bloomington, Illinois, Stany Zjednoczone, 61704
- Illinois CancerCare-Bloomington
-
Canton, Illinois, Stany Zjednoczone, 61520
- Illinois CancerCare-Canton
-
Carthage, Illinois, Stany Zjednoczone, 62321
- Illinois CancerCare-Carthage
-
Chicago, Illinois, Stany Zjednoczone, 60611
- Northwestern University
-
Chicago, Illinois, Stany Zjednoczone, 60657
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
-
Chicago, Illinois, Stany Zjednoczone, 60640
- Weiss Memorial Hospital
-
Danville, Illinois, Stany Zjednoczone, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Stany Zjednoczone, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Stany Zjednoczone, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Decatur, Illinois, Stany Zjednoczone, 62526
- Heartland Cancer Research NCORP
-
Effingham, Illinois, Stany Zjednoczone, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Stany Zjednoczone, 62401
- Carle Physician Group-Effingham
-
Elk Grove Village, Illinois, Stany Zjednoczone, 60007
- Ascension Alexian Brothers - Elk Grove Village
-
Eureka, Illinois, Stany Zjednoczone, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, Stany Zjednoczone, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Stany Zjednoczone, 60134
- Northwestern Medicine Cancer Center Delnor
-
Harvey, Illinois, Stany Zjednoczone, 60426
- Ingalls Memorial Hospital
-
Hinsdale, Illinois, Stany Zjednoczone, 60521
- Hinsdale Hematology Oncology Associates Incorporated
-
Joliet, Illinois, Stany Zjednoczone, 60435
- Duly Health and Care Joliet
-
Kewanee, Illinois, Stany Zjednoczone, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, Stany Zjednoczone, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Stany Zjednoczone, 61938
- Carle Physician Group-Mattoon/Charleston
-
Moline, Illinois, Stany Zjednoczone, 61265
- Trinity Medical Center
-
Monmouth, Illinois, Stany Zjednoczone, 61462
- Illinois CancerCare-Monmouth
-
Niles, Illinois, Stany Zjednoczone, 60714
- Illinois Cancer Specialists-Niles
-
O'Fallon, Illinois, Stany Zjednoczone, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, Stany Zjednoczone, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Stany Zjednoczone, 61554
- Illinois CancerCare-Pekin
-
Peoria, Illinois, Stany Zjednoczone, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, Stany Zjednoczone, 61354
- Illinois CancerCare-Peru
-
Princeton, Illinois, Stany Zjednoczone, 61356
- Illinois CancerCare-Princeton
-
River Forest, Illinois, Stany Zjednoczone, 60305
- West Suburban Medical Center
-
Rockford, Illinois, Stany Zjednoczone, 61104
- Swedish American Hospital
-
Rockford, Illinois, Stany Zjednoczone, 61114
- UW Health Carbone Cancer Center Rockford
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Springfield Clinic
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Stany Zjednoczone, 62781
- Springfield Memorial Hospital
-
Urbana, Illinois, Stany Zjednoczone, 61801
- Carle Cancer Center
-
Urbana, Illinois, Stany Zjednoczone, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Stany Zjednoczone, 60555
- Northwestern Medicine Cancer Center Warrenville
-
-
Indiana
-
Elkhart, Indiana, Stany Zjednoczone, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Stany Zjednoczone, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Stany Zjednoczone, 46514-2098
- Elkhart Clinic
-
Indianapolis, Indiana, Stany Zjednoczone, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Stany Zjednoczone, 46219
- IU Health Central Indiana Cancer Centers-East
-
Kokomo, Indiana, Stany Zjednoczone, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Stany Zjednoczone, 46350
- IU Health La Porte Hospital
-
Lafayette, Indiana, Stany Zjednoczone, 47904
- IU Health Arnett Cancer Care
-
Merrillville, Indiana, Stany Zjednoczone, 46410
- Premier Oncology Hematology Associates
-
Mishawaka, Indiana, Stany Zjednoczone, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Stany Zjednoczone, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Muncie, Indiana, Stany Zjednoczone, 47303
- IU Health Ball Memorial Hospital
-
Plymouth, Indiana, Stany Zjednoczone, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Stany Zjednoczone, 47374
- Reid Health
-
South Bend, Indiana, Stany Zjednoczone, 46628
- Northern Indiana Cancer Research Consortium
-
Westville, Indiana, Stany Zjednoczone, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, Stany Zjednoczone, 50010
- McFarland Clinic - Ames
-
Cedar Rapids, Iowa, Stany Zjednoczone, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Stany Zjednoczone, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Stany Zjednoczone, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Des Moines, Iowa, Stany Zjednoczone, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Stany Zjednoczone, 50309
- Iowa-Wide Oncology Research Coalition NCORP
-
Des Moines, Iowa, Stany Zjednoczone, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Stany Zjednoczone, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Mason City, Iowa, Stany Zjednoczone, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, Stany Zjednoczone, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, Stany Zjednoczone, 51101
- Siouxland Regional Cancer Center
-
Waterloo, Iowa, Stany Zjednoczone, 50702
- MercyOne Waterloo Cancer Center
-
West Des Moines, Iowa, Stany Zjednoczone, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Lawrence, Kansas, Stany Zjednoczone, 66044
- Lawrence Memorial Hospital
-
Prairie Village, Kansas, Stany Zjednoczone, 66208
- Kansas City NCI Community Oncology Research Program
-
Wichita, Kansas, Stany Zjednoczone, 67214
- Wesley Medical Center
-
-
Kentucky
-
Bardstown, Kentucky, Stany Zjednoczone, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Louisville, Kentucky, Stany Zjednoczone, 40202
- Jewish Hospital
-
Louisville, Kentucky, Stany Zjednoczone, 40245
- UofL Health Medical Center Northeast
-
-
Louisiana
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70809
- Ochsner Health Center-Summa
-
Kenner, Louisiana, Stany Zjednoczone, 70065
- Ochsner Medical Center Kenner
-
Monroe, Louisiana, Stany Zjednoczone, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Stany Zjednoczone, 70121
- Ochsner Medical Center Jefferson
-
Shreveport, Louisiana, Stany Zjednoczone, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, Stany Zjednoczone, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Stany Zjednoczone, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Stany Zjednoczone, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Stany Zjednoczone, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Stany Zjednoczone, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, Stany Zjednoczone, 21921
- Christiana Care - Union Hospital
-
Salisbury, Maryland, Stany Zjednoczone, 21801
- TidalHealth Peninsula Regional
-
-
Massachusetts
-
Boston, Massachusetts, Stany Zjednoczone, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Stany Zjednoczone, 02118
- Boston Medical Center
-
Springfield, Massachusetts, Stany Zjednoczone, 01199
- Baystate Medical Center
-
Worcester, Massachusetts, Stany Zjednoczone, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Stany Zjednoczone, 48109
- University of Michigan Rogel Cancer Center
-
Ann Arbor, Michigan, Stany Zjednoczone, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Stany Zjednoczone, 49017
- Bronson Battle Creek
-
Dearborn, Michigan, Stany Zjednoczone, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Stany Zjednoczone, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Stany Zjednoczone, 48236
- Henry Ford Health Saint John Hospital
-
Escanaba, Michigan, Stany Zjednoczone, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, Stany Zjednoczone, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Stany Zjednoczone, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Stany Zjednoczone, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Jackson, Michigan, Stany Zjednoczone, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Stany Zjednoczone, 49007
- West Michigan Cancer Center
-
Livonia, Michigan, Stany Zjednoczone, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Muskegon, Michigan, Stany Zjednoczone, 49444
- Trinity Health Muskegon Hospital
-
Pontiac, Michigan, Stany Zjednoczone, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Stany Zjednoczone, 48060
- Lake Huron Medical Center
-
Reed City, Michigan, Stany Zjednoczone, 49677
- Corewell Health Reed City Hospital
-
Saginaw, Michigan, Stany Zjednoczone, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Stany Zjednoczone, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Stany Zjednoczone, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Traverse City, Michigan, Stany Zjednoczone, 49684
- Munson Medical Center
-
Warren, Michigan, Stany Zjednoczone, 48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Stany Zjednoczone, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, Stany Zjednoczone, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Stany Zjednoczone, 55433
- Mercy Hospital
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, Stany Zjednoczone, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Stany Zjednoczone, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Stany Zjednoczone, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Stany Zjednoczone, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Stany Zjednoczone, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Stany Zjednoczone, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Stany Zjednoczone, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Stany Zjednoczone, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Stany Zjednoczone, 55454
- Health Partners Inc
-
Robbinsdale, Minnesota, Stany Zjednoczone, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Stany Zjednoczone, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Stany Zjednoczone, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Stany Zjednoczone, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Stany Zjednoczone, 55102
- United Hospital
-
Shakopee, Minnesota, Stany Zjednoczone, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Stany Zjednoczone, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Stany Zjednoczone, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Stany Zjednoczone, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Stany Zjednoczone, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Mississippi
-
Jackson, Mississippi, Stany Zjednoczone, 39216
- University of Mississippi Medical Center
-
-
Missouri
-
Bolivar, Missouri, Stany Zjednoczone, 65613
- Central Care Cancer Center - Bolivar
-
Cape Girardeau, Missouri, Stany Zjednoczone, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Stany Zjednoczone, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Stany Zjednoczone, 63017
- Saint Luke's Hospital
-
Jefferson City, Missouri, Stany Zjednoczone, 65109
- MU Health Care Goldschmidt Cancer Center
-
Kansas City, Missouri, Stany Zjednoczone, 64111
- Saint Luke's Hospital of Kansas City
-
Rolla, Missouri, Stany Zjednoczone, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Stany Zjednoczone, 65401
- Phelps Health Delbert Day Cancer Institute
-
Springfield, Missouri, Stany Zjednoczone, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Stany Zjednoczone, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Stany Zjednoczone, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Stany Zjednoczone, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Stany Zjednoczone, 63141
- Mercy Hospital Saint Louis
-
-
Montana
-
Billings, Montana, Stany Zjednoczone, 59101
- Billings Clinic Cancer Center
-
Bozeman, Montana, Stany Zjednoczone, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Stany Zjednoczone, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Stany Zjednoczone, 59405
- Benefis Sletten Cancer Institute
-
Kalispell, Montana, Stany Zjednoczone, 59901
- Logan Health Medical Center
-
Missoula, Montana, Stany Zjednoczone, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Stany Zjednoczone, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Stany Zjednoczone, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Stany Zjednoczone, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Stany Zjednoczone, 68506
- Nebraska Hematology and Oncology
-
Lincoln, Nebraska, Stany Zjednoczone, 68510
- Nebraska Cancer Research Center
-
Lincoln, Nebraska, Stany Zjednoczone, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Stany Zjednoczone, 68198
- University of Nebraska Medical Center
-
-
Nevada
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Stany Zjednoczone, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Stany Zjednoczone, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Stany Zjednoczone, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stany Zjednoczone, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Stany Zjednoczone, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Stany Zjednoczone, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Stany Zjednoczone, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Stany Zjednoczone, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Stany Zjednoczone, 89120
- Nevada Cancer Research Foundation NCORP
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89183
- OptumCare Cancer Care at Fort Apache
-
-
New Hampshire
-
Concord, New Hampshire, Stany Zjednoczone, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, Stany Zjednoczone, 03820
- Wentworth-Douglass Hospital
-
Laconia, New Hampshire, Stany Zjednoczone, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Lebanon, New Hampshire, Stany Zjednoczone, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, Stany Zjednoczone, 03103
- Solinsky Center for Cancer Care
-
-
New Jersey
-
Camden, New Jersey, Stany Zjednoczone, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, Stany Zjednoczone, 07631
- Englewood Hospital and Medical Center
-
Livingston, New Jersey, Stany Zjednoczone, 07039
- Cooperman Barnabas Medical Center
-
Mount Holly, New Jersey, Stany Zjednoczone, 08060
- Virtua Memorial
-
Mullica Hill, New Jersey, Stany Zjednoczone, 08062
- Inspira Medical Center Mullica Hill
-
Paramus, New Jersey, Stany Zjednoczone, 07652
- The Valley Hospital - Luckow Pavilion
-
Ridgewood, New Jersey, Stany Zjednoczone, 07450
- Valley Health System Ridgewood Campus
-
Vineland, New Jersey, Stany Zjednoczone, 08360
- Inspira Medical Center Vineland
-
Westwood, New Jersey, Stany Zjednoczone, 07675
- Valley Health System-Hematology/Oncology
-
-
New Mexico
-
Albuquerque, New Mexico, Stany Zjednoczone, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Stany Zjednoczone, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Stany Zjednoczone, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, Stany Zjednoczone, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Brooklyn, New York, Stany Zjednoczone, 11203
- Kings County Hospital
-
Brooklyn, New York, Stany Zjednoczone, 11203
- State University of New York Downstate Medical Center
-
Buffalo, New York, Stany Zjednoczone, 14263
- Roswell Park Cancer Institute
-
East Syracuse, New York, Stany Zjednoczone, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
New York, New York, Stany Zjednoczone, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Stany Zjednoczone, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Plattsburgh, New York, Stany Zjednoczone, 12901
- Champlain Valley Physicians Hospital Medical Center
-
Rochester, New York, Stany Zjednoczone, 14642
- University of Rochester
-
Syracuse, New York, Stany Zjednoczone, 13210
- State University of New York Upstate Medical University
-
The Bronx, New York, Stany Zjednoczone, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Stany Zjednoczone, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Stany Zjednoczone, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheboro, North Carolina, Stany Zjednoczone, 27203
- Randolph Hospital
-
Chapel Hill, North Carolina, Stany Zjednoczone, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Stany Zjednoczone, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Stany Zjednoczone, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Stany Zjednoczone, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Stany Zjednoczone, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Stany Zjednoczone, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Stany Zjednoczone, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kinston, North Carolina, Stany Zjednoczone, 28501
- ECU Health Oncology Kinston
-
Reidsville, North Carolina, Stany Zjednoczone, 27320
- Annie Penn Memorial Hospital
-
Statesville, North Carolina, Stany Zjednoczone, 28677
- Iredell Memorial Hospital
-
Washington, North Carolina, Stany Zjednoczone, 27889
- Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
-
Winston-Salem, North Carolina, Stany Zjednoczone, 27157
- Wake Forest University Health Sciences
-
-
North Dakota
-
Bismarck, North Dakota, Stany Zjednoczone, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Stany Zjednoczone, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Stany Zjednoczone, 58122
- Sanford Broadway Medical Center
-
-
Ohio
-
Akron, Ohio, Stany Zjednoczone, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Stany Zjednoczone, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Stany Zjednoczone, 44203
- Summa Health System - Barberton Campus
-
Canton, Ohio, Stany Zjednoczone, 44708
- Cleveland Clinic Mercy Hospital
-
Chardon, Ohio, Stany Zjednoczone, 44024
- Geauga Hospital
-
Cincinnati, Ohio, Stany Zjednoczone, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Stany Zjednoczone, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Stany Zjednoczone, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Stany Zjednoczone, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Stany Zjednoczone, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Stany Zjednoczone, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Stany Zjednoczone, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Stany Zjednoczone, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Stany Zjednoczone, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Stany Zjednoczone, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Stany Zjednoczone, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Stany Zjednoczone, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Stany Zjednoczone, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Stany Zjednoczone, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Stany Zjednoczone, 45415
- Miami Valley Hospital North
-
Elyria, Ohio, Stany Zjednoczone, 44035
- Mercy Cancer Center-Elyria
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Blanchard Valley Hospital
-
Lima, Ohio, Stany Zjednoczone, 45801
- Saint Rita's Medical Center
-
Marietta, Ohio, Stany Zjednoczone, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Stany Zjednoczone, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Mayfield Heights, Ohio, Stany Zjednoczone, 44124
- UH Seidman Cancer Center at Landerbrook Health Center
-
Mentor, Ohio, Stany Zjednoczone, 44060
- UH Seidman Cancer Center at Lake Health Mentor Campus
-
Newark, Ohio, Stany Zjednoczone, 43055
- Licking Memorial Hospital
-
Sandusky, Ohio, Stany Zjednoczone, 44870
- UH Seidman Cancer Center at Firelands Regional Medical Center
-
Springfield, Ohio, Stany Zjednoczone, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Stany Zjednoczone, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Stany Zjednoczone, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Stany Zjednoczone, 43614
- University of Toledo
-
Westerville, Ohio, Stany Zjednoczone, 43081
- Saint Ann's Hospital
-
Westlake, Ohio, Stany Zjednoczone, 44145
- UH Seidman Cancer Center at Saint John Medical Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Stany Zjednoczone, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Clackamas, Oregon, Stany Zjednoczone, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Stany Zjednoczone, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Stany Zjednoczone, 97420
- Bay Area Hospital
-
Newberg, Oregon, Stany Zjednoczone, 97132
- Providence Newberg Medical Center
-
Oregon City, Oregon, Stany Zjednoczone, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Stany Zjednoczone, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Stany Zjednoczone, 97225
- Providence Saint Vincent Medical Center
-
-
Pennsylvania
-
Allentown, Pennsylvania, Stany Zjednoczone, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Stany Zjednoczone, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, Stany Zjednoczone, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Stany Zjednoczone, 17822
- Geisinger Medical Center
-
Doylestown, Pennsylvania, Stany Zjednoczone, 18901
- Doylestown Hospital
-
Drexel Hill, Pennsylvania, Stany Zjednoczone, 19026
- Delaware County Memorial Hospital
-
Ephrata, Pennsylvania, Stany Zjednoczone, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Stany Zjednoczone, 17522
- Ephrata Community Hospital
-
Gettysburg, Pennsylvania, Stany Zjednoczone, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Stany Zjednoczone, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, Stany Zjednoczone, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Stany Zjednoczone, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Stany Zjednoczone, 17837
- Geisinger Medical Oncology-Lewisburg
-
Paoli, Pennsylvania, Stany Zjednoczone, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Stany Zjednoczone, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Stany Zjednoczone, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Stany Zjednoczone, 19140
- Temple University Hospital
-
Pottstown, Pennsylvania, Stany Zjednoczone, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, Stany Zjednoczone, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Stany Zjednoczone, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Selinsgrove, Pennsylvania, Stany Zjednoczone, 17870
- Geisinger Medical Oncology-Selinsgrove
-
Sellersville, Pennsylvania, Stany Zjednoczone, 18960
- Grand View Hospital
-
State College, Pennsylvania, Stany Zjednoczone, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Stany Zjednoczone, 19380
- Chester County Hospital
-
West Reading, Pennsylvania, Stany Zjednoczone, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Stany Zjednoczone, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, Stany Zjednoczone, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Stany Zjednoczone, 17403
- WellSpan Health-York Hospital
-
-
South Carolina
-
Boiling Springs, South Carolina, Stany Zjednoczone, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Stany Zjednoczone, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, Stany Zjednoczone, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Stany Zjednoczone, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Stany Zjednoczone, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Stany Zjednoczone, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Stany Zjednoczone, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, Stany Zjednoczone, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, Stany Zjednoczone, 29672
- Prisma Health Cancer Institute - Seneca
-
-
South Dakota
-
Rapid City, South Dakota, Stany Zjednoczone, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Nashville, Tennessee, Stany Zjednoczone, 37232
- Vanderbilt University/Ingram Cancer Center
-
-
Texas
-
Austin, Texas, Stany Zjednoczone, 78701
- Dell Seton Medical Center at The University of Texas
-
Dallas, Texas, Stany Zjednoczone, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Stany Zjednoczone, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Fort Sam Houston, Texas, Stany Zjednoczone, 78234
- Brooke Army Medical Center
-
Lubbock, Texas, Stany Zjednoczone, 79410
- Covenant Medical Center-Lakeside
-
Lubbock, Texas, Stany Zjednoczone, 79430
- Texas Tech University Health Sciences Center-Lubbock
-
San Antonio, Texas, Stany Zjednoczone, 78229
- University of Texas Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, Stany Zjednoczone, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Virginia
-
Charlottesville, Virginia, Stany Zjednoczone, 22908
- University of Virginia Cancer Center
-
Fishersville, Virginia, Stany Zjednoczone, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Martinsville, Virginia, Stany Zjednoczone, 24112
- Sovah Health Martinsville
-
-
Washington
-
Edmonds, Washington, Stany Zjednoczone, 98026
- Swedish Cancer Institute-Edmonds
-
Longview, Washington, Stany Zjednoczone, 98632
- PeaceHealth Saint John Medical Center
-
Seattle, Washington, Stany Zjednoczone, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Stany Zjednoczone, 98122
- Swedish Medical Center-First Hill
-
Vancouver, Washington, Stany Zjednoczone, 98664
- PeaceHealth Southwest Medical Center
-
-
West Virginia
-
Charleston, West Virginia, Stany Zjednoczone, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Antigo, Wisconsin, Stany Zjednoczone, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Stany Zjednoczone, 54911
- ThedaCare Regional Cancer Center
-
Burlington, Wisconsin, Stany Zjednoczone, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Eau Claire, Wisconsin, Stany Zjednoczone, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Stany Zjednoczone, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Germantown, Wisconsin, Stany Zjednoczone, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Stany Zjednoczone, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Stany Zjednoczone, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Stany Zjednoczone, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Stany Zjednoczone, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Stany Zjednoczone, 54301
- Bellin Memorial Hospital
-
Green Bay, Wisconsin, Stany Zjednoczone, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Johnson Creek, Wisconsin, Stany Zjednoczone, 53038
- University of Wisconsin Carbone Cancer Center - Johnson Creek
-
Kenosha, Wisconsin, Stany Zjednoczone, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Stany Zjednoczone, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Stany Zjednoczone, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Stany Zjednoczone, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Stany Zjednoczone, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Stany Zjednoczone, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Stany Zjednoczone, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, Stany Zjednoczone, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Stany Zjednoczone, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Stany Zjednoczone, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Stany Zjednoczone, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Stany Zjednoczone, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Stany Zjednoczone, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Stany Zjednoczone, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Stany Zjednoczone, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Stany Zjednoczone, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, Stany Zjednoczone, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Stany Zjednoczone, 54868
- Marshfield Medical Center-Rice Lake
-
Rice Lake, Wisconsin, Stany Zjednoczone, 54868
- Lakeview Medical Center-Marshfield Clinic
-
Sheboygan, Wisconsin, Stany Zjednoczone, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Stany Zjednoczone, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Stany Zjednoczone, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Stany Zjednoczone, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- ProHealth Waukesha Memorial Hospital
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Stany Zjednoczone, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, Stany Zjednoczone, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, Stany Zjednoczone, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Stany Zjednoczone, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Stany Zjednoczone, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Kryteria uczestnictwa
Kryteria kwalifikacji
Kryteria kwalifikacji
Wiek uprawniający do nauki
Akceptuje zdrowych ochotników
Płeć kwalifikująca się do nauki
Opis
Inclusion Criteria:
- PRE-REGISTRATION (STEP 0)
- Histologically confirmed DLBCL expressing CD20 antigen; patients with transformed lymphoma are excluded; in this regard, patients with composite lymphoma in the diagnostic tissue (concomitant DLBCL and follicular or other low-grade lymphoma component) are excluded; however, patients with DLBCL in primary diagnostic tissue but a bone marrow that shows low grade or indeterminate lymphoma are eligible; patients with known primary mediastinal large B-cell lymphoma (PMLBCL) are excluded; similarly, patients with known c-myc translocation (by fluorescence in situ hybridization) positive DLBCL are encouraged to participate in trials specifically designed for these patients; however patients with known c-myc DLBC positive are NOT excluded from this study; c-myc testing prior to study enrollment is NOT required
- Stages II bulky disease (defined as mass size of more than 10 cm), stage III, or IV (Ann Arbor staging); patients with stage I and stage II non-bulky disease are excluded from this study
- A paraffin-embedded tumor tissue specimen from the initial diagnostic biopsy has been located and ready to ship to the Mayo Clinic Lymphoma Laboratory following pre-registration; Note: excisional tumor biopsy is preferred; core needle biopsies will be considered adequate if there is enough tissue for the mandatory central pathology review immunohistochemistry and Genomics Education Partnership (GEP); submission of a tumor block is preferred, but if unavailable submit alternative materials
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Previously untreated and not receiving any other agent that would be considered as a treatment for the lymphoma; for subjects with severe systemic symptoms, compressive disease, or rapidly progressing symptomatic adenopathy, are allowed for lymphoma associated symptom treatment with up to 1 mg/kg/day prednisone, or equivalent, for a maximum of 7 days is permitted prior to beginning the treatment, at the discretion of the investigator; a washout period does not apply
- No known central nervous system (CNS) lymphoma or cerebrospinal fluid involvement with malignant lymphoma cells; these patients are usually treated with CNS directed therapy; screening for cerebrospinal fluid (CSF)/CNS involvement is NOT required but can be performed per treating medical doctor (MD) discretion; intrathecal (IT) methotrexate or IT cytarabine prophylaxis in patients with negative CSF who are felt to be at high risk of CNS relapse is allowed per local MD discretion; this should be noted on the treatment form
- Absence of history of myocardial infarction =< 6 months, or congestive heart failure requiring use of ongoing maintenance therapy for life-threatening ventricular arrhythmias
- Absence of history of deep venous thrombosis/embolism, threatening thromboembolism or known thrombophilia; patients with a history of deep vein thrombosis(DVT)/pulmonary embolism (PE) or thrombophilia may participate if they are willing to be on full anticoagulation during the treatment if randomized to rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R2CHOP) arm A; full anticoagulation is defined as warfarin, factor X inhibitors, or low molecular weight heparin at therapeutic doses
- Patient must be able and willing to receive anticoagulation therapy with aspirin 70-325 mg daily prophylaxis, low molecular weight heparin, factor X inhibitors or warfarin; patients unable or unwilling to take any prophylaxis are NOT eligible
- Absence of history of acquired immune deficiency syndrome (AIDS)-related conditions (other than the presenting DLBCL) or post-transplant lymphoproliferative disorder (PTLD) in immunocompromised patients; patients with human immunodeficiency virus (HIV) on antiretroviral therapy other than zidovudine (AZT) and/or stavudine and without prior AIDS defining conditions and adequate CD4 count (> 400) are eligible
- No other active malignancy requiring therapy such as radiation, chemotherapy, or immunotherapy; exceptions to this are as follows: localized non-melanotic skin cancer and any cancer that in the judgment of the investigator has been treated with curative intent and will not interfere with the study treatment plan and response assessment
- No history of radiation therapy to >= 25% of the bone marrow for other diseases or history of anthracycline therapy
- Patients must not be receiving erythroid stimulating agents (EPO: Procrit, Aranesp)
- RANDOMIZATION (STEP 1)
- Patient meets the eligibility criteria outlined above
- Site has received notification from Mayo Clinic - Rochester Division of Hematopathology of the central confirmation of diagnosis and tissue adequacy for mandatory research studies
- Patients must have measurable disease (at least 1 lesion of >= 1.5 cm in one diameter) as detected by computed tomography (CT) or the CT images of the positron emission tomography (PET)/CT
- International Prognostic Index (IPI) of 2 or greater
- Ejection fraction of >= 45% by either multi-gated acquisition (MUGA) scan or echocardiogram (ECHO)
- Absence of co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Absolute neutrophil count (ANC) >= 1500
- Platelets (PLT) >= 100,000
- Total bilirubin =< 1.5 x upper limit of normal (ULN) or if total bilirubin is > 1.5 x ULN, the direct bilirubin must be normal
- Alkaline (Alk.) phosphatase =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
- Aspartate aminotransferase (AST) =< 3 x ULN unless evidence of the direct liver involvement by lymphoma - then =< 5 x ULN
- Creatinine =< 2 x ULN or creatinine clearance (CrCl) > 30 ml/min
- Women must not be pregnant or breast-feeding
- Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 25 mIU/mL within 10-14 days prior to and again within 24 hours of starting lenalidomide and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking lenalidomide; FCBP must also agree to ongoing pregnancy testing; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy; all patients must be counseled at a minimum of every 28 days about pregnancy precautions and risks of fetal exposure
Plan studiów
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Leczenie
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Brak (otwarta etykieta)
Liczba ramion
Broń i interwencje
Grupa uczestników / ArmGrupa uczestników / Arm |
Interwencja / LeczenieInterwencja / Leczenie |
|---|---|
|
Eksperymentalny: Arm A (rituximab, combination chemotherapy, lenalidomide)
Patients receive rituximab IV, cyclophosphamide IV, doxorubicin hydrochloride IV, and vincristine sulfate IV on day 1; prednisone PO on days 1-5; and lenalidomide PO on days 1-10. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. |
Correlative studies Given IV
Inne nazwy:
Given IV
Inne nazwy:
Given PO
Inne nazwy:
Given PO
Inne nazwy:
Given IV
Inne nazwy:
Given IV
Inne nazwy:
|
|
Aktywny komparator: Arm B (rituximab, combination chemotherapy)
Patients receive rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone as in Arm A. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. |
Correlative studies Given IV
Inne nazwy:
Given IV
Inne nazwy:
Given PO
Inne nazwy:
Given IV
Inne nazwy:
Given IV
Inne nazwy:
|
Co mierzy badanie?
Podstawowe miary wyniku
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
3-year Progression-free Survival Rate
Ramy czasowe: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10, 3-year PFS rate reported
|
Progression-free survival is defined as the time from randomization to disease progression, new primary of the same type or death, whichever occurs first. Progressive disease is defined as:
|
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10, 3-year PFS rate reported
|
Miary wyników drugorzędnych
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Proportion of Patients With Response
Ramy czasowe: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Response is defined as complete response (CR) or partial response (PR) CR: Complete disappearance of all detectable clinical evidence of disease and disease-related symptoms PR:
|
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
|
Proportion of Patients With Complete Response
Ramy czasowe: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Complete response is defined as complete disappearance of all detectable clinical evidence of disease, and disease-related symptoms if present prior to therapy. |
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
|
Overall Survival Rate at 3 Years
Ramy czasowe: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Overall survival is defined as time from randomization to death or date last known alive. Overall survival rate at 3 years was calculated using the method of Kaplan Meier. |
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Inne miary wyników
Inne miary wyników
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Wpływ podtypu molekularnego DLBCL na wynik.
Ramy czasowe: Oceniana na początku badania, co 3 miesiące przez 2 lata, co 6 miesięcy przez rok 3, a następnie co roku przez lata 4-10
|
Oceniana na początku badania, co 3 miesiące przez 2 lata, co 6 miesięcy przez rok 3, a następnie co roku przez lata 4-10
|
|
|
Interim PET Scan Results in Relation to Treatment Outcome
Ramy czasowe: Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
|
Assessed every 3 months for 2 years, every 6 months for year 3, and then annually for years 4-10
|
Współpracownicy i badacze
Sponsor
Sponsor
Śledczy
Śledczy
- Główny śledczy: Grzegorz S Nowakowski, ECOG-ACRIN Cancer Research Group
Publikacje i pomocne linki
Daty zapisu na studia
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
Rozpoczęcie studiów
Zakończenie podstawowe (Rzeczywisty)
Zakończenie podstawowe
Ukończenie studiów (Szacowany)
Ukończenie studiów
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy wysłany (Szacowany)
Pierwszy wysłany
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
Ostatnia wysłana aktualizacja
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia weryfikacja
Ostatnia weryfikacja
Więcej informacji
Terminy związane z tym badaniem
Dodatkowe istotne warunki MeSH
- Aminokwasy, peptydy i białka
- Białka
- Organiczne chemikalia
- Związki heterocykliczne, 1-ring
- Związki heterocykliczne
- Związki heterocykliczne, 2-ring
- Związki heterocykliczne, sterowanie stopieniem
- Węglowodory
- Węglowodory, cykliczne
- Węglowodany
- Kwasy karboksylowe
- Alkaloidy
- Policykliczne aromatyczne węglowodory
- Węglowodory, aromatyczne
- Związki policykliczne
- Glikozydy
- Piperydyny
- Indole
- Przeciwciała, monoklonalne
- Przeciwciała
- Immunoglobuliny
- Immunoproteiny
- Białka krwi
- Globuliny w surowicy
- Globuliny
- Ciąży
- Ciężarne
- Steroidy
- Związki sterownika
- Mostki fosforamidu
- Związki musztardy azotu
- Związki musztardy
- Węglowodory, uboczne
- Fosforamidy
- Związki okorosfosforowe
- Ciąży
- Vinca alkaloidy
- Sesologanina alkaloidy tryptaminy
- Alkaloidy indole
- Indolizicyny
- Indolizyny
- Antracykliny
- Naftaceny
- Aminoglikozydy
- Przeciwciała, monoklonalne, mysie
- Daunorubicyna
- Ftalimidy
- Kwasy ftaliczne
- Kwasy, karbocykliczne
- Piperidones
- Izoindoles
- Lenalidomid
- Rytuksymab
- Prednizon
- Cyklofosfamid
- Doksorubicyna
- Winkrystyna
- CT-P10
- Deltacortene
- prednielidene
Inne numery identyfikacyjne badania
Inne numery identyfikacyjne badania
- NCI-2013-00959
- U10CA180820 (Grant/umowa NIH USA)
- U24CA196172 (Grant/umowa NIH USA)
- U10CA021115 (Grant/umowa NIH USA)
- NCI-2013-00959 (Identyfikator rejestru: CTRP (Clinical Trial Reporting Program))
- ECOG-E1412
- S13-01316
- E1412 (Inny identyfikator: CTEP)
- E1412
- E1412 (Inny identyfikator: ECOG-ACRIN Cancer Research Group)
Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .