Telerehabilitation and Biomarkers of Recovery After Stroke in Brazil (TR-BR-1)

Inclusion Criteria:

1. Age 18-80 years at the time of randomization.
2. The index stroke was radiologically verified, due to ischemia, and had time of onset 120±30 days prior to randomization.
3. The stroke caused upper extremity deficits as defined by Action Research.
4. Arm Test score 18-44 (out of 57) at Baseline Visit.
5. Box & Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit.
6. Able to successfully perform all 3 rehabilitation exercise test examples (simple commands) at Baseline Visit.
7. Informed consent and behavioral contract signed by the subject (i.e., no surrogate consent).

Exclusion Criteria:

1. A major, active, coexistent neurological, psychiatric, or medical disease that reduces the likelihood that a subject will be able to comply with all study procedures.
2. Unable or unwilling to perform study procedures/therapy, or expectation of noncompliance with study procedures/therapy, or expectation that subject cannot participate in all study visits.
3. A diagnosis (apart from the index stroke) that substantially affects paretic arm function.
4. Severe depression, defined as Geriatric Depression Scale Score >10/15 at Baseline Visit.
5. Significant cognitive impairment, defined as Montreal Cognitive Assessment [a lower score can be permitted at the discretion of the PI].
6. Deficits in communication that interfere with reasonable study participation.
7. Severe UE spasticity, defined as presence of contracture or modified Ashworth Scale score=4 in either biceps or pectoralis.
8. Modified Rankin Scale score >2 prior to the index stroke.
9. A new symptomatic stroke has occurred since the index stroke, or a separate stroke occurred within 30 days prior to the index stroke.
10. Lacking visual acuity, with or without corrective lens, of 20/50 or better in at least one eye.
11. Life expectancy < 9 months
12. Pregnancy; women of child-bearing potential must have a negative pregnancy test.
13. Botulinum toxin to the paretic arm: received in the prior 3 months or expected by the 1-Month Visit.
14. Concurrent enrollment in another therapy-based investigational study where the duration of the investigational therapy's activity is likely to occur during the subject's participation in the study.
15. Subject lacks sufficient Portuguese to comply with study procedures and TR instructions.
16. Contraindication to MRI.
17. Contraindication to TMS.
18. Box and Block Test score of ≥30 blocks with the unaffected arm within 60 seconds at Baseline Visit;
19. Spatial neglect interfering with reasonable participation in the study;
20. On isolation precautions, e.g., due to active COVID-19.
21. Expectation that participant will not have a single domicile address during the 6 weeks of therapy.
22. Distance from the participant's home to the study site greater than 120 km [this can be waived at the discretion of the PI].

22. Availability of a 2 m² space for a table and chair setup.