妊娠期肿瘤治疗对母婴的影响
妊娠期肿瘤治疗:化疗的药代动力学和后代的长期随访
研究概览
详细说明
研究包含几个研究部分(协议版本 4.2):
**********第一部分。怀孕、分娩和孕产妇健康************ I.I.A.部分注册研究“怀孕期间的癌症”母亲和新生儿无第 I.I.B 部分。 产前暴露于癌症治疗对胎儿生长的影响。 胎盘病理生理机制(组织病理学和免疫组织化学)、循环母体因素和胎儿生长之间的关联。
从参与的妇女中,将在出生期间或出生后不久收集母体血液样本。 此外,还将抽取脐带血样本以及胎盘和脐带活组织检查。
第 I.II 部分 怀孕期间面对癌症诊断时母亲和父亲的焦虑和情感需求的测量 参与者将被要求完成问卷调查。 第 I.III 部分 生物库“癌症和妊娠” 从参与的女性中,将在诊断时收集新辅助治疗前的肿瘤活检标本。 此外,将在治疗之前和/或之后收集母体血液样本。
第 I.IV 部分 孕妇化疗药物的药代动力学研究 大约 10-12 次额外的外周静脉血抽取。
**********第二部分。 儿童************ 宫内接受化疗和/或放疗的儿童和青少年的长期随访 定期检查儿童,年龄为 18 个月、3 岁、6 岁、9 岁、12 岁、 15 岁和 18 岁以及 18 岁以后:每 5 年一次的心脏病学评估和问卷调查(23 岁、28 岁、33 岁、38 岁和 43 岁)。 9 岁、12 岁、15 岁和 18 岁可选:核磁共振检查。
总结第一部分:
前瞻性地登记和调查怀孕期间诊断和/或治疗癌症的母亲的结果。
总结第二部分:
在一项前瞻性试验中,我们邀请在子宫内接触过细胞毒性药物或放疗的儿童进行标准化的神经和心脏病学检查。 检查将由合格的心理学家、神经学和心脏病学儿科医生进行。
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名:Kristel Van Calsteren, MD PhD
- 电话号码:+32-16-346192
- 邮箱:kristel.vancalsteren@uzleuven.be
研究联系人备份
- 姓名:Ayaka Wakatsuki
- 电话号码:+32 16 34 41 69
- 邮箱:ayaka.wakatsuki@uzleuven.be
学习地点
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Copenhagen、丹麦
- 招聘中
- Copenhagen University Hospital (2015-ongoing)
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接触:
- Lone Storgaard, MD
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副研究员:
- Berit Woetmann Pedersen, MD
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副研究员:
- Mona Aarenstrup, MD
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副研究员:
- Cristel Maria Soerensen-Hjortshoej, MD
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Kharkov、乌克兰
- 终止
- Grigoriev Institute for medical Radiology (retrospective until 2018)
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Moscow、俄罗斯联邦
- 招聘中
- N.N.Blokchin National Medical Research Center of Oncology (2013-2018 retrospective; 2018-ongoing prospective)
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接触:
- Anastasia Parokonnaya, MD
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Moscow、俄罗斯联邦
- 招聘中
- Research Center for Obstetrics, Gynecology and Perinatology (2014-ongoing)
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接触:
- Roman Shmakov, MD
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Saint Petersburg、俄罗斯联邦
- 招聘中
- Almazov National Medical Research Center (2018-ongoing)
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接触:
- Vladim Bezrukikh
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Ixtapaluca、墨西哥、56530
- 招聘中
- Regional Hospital of High Specialty of Ixtapaluca (2018-ongoing)
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接触:
- Álvaro Cabrera Garciá, MD
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Graz、奥地利
- 终止
- Universitätsklinik für Frauenheilkunde und Geburtshilfe (retrospective 2016-2018)
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Athens、希腊
- 招聘中
- Euroclinic Hospital (2016-ongoing)
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接触:
- Georeg-Marios Makris, MD
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Athens、希腊
- 终止
- Hellenic Anticancer-Oncological Hospital of Athens (retrospective 2015-2018)
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Ioánnina、希腊
- 终止
- Ioannina University Hospital (retrosepctive 2015-2018)
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Thessaloníki、希腊
- 终止
- Hippokration Hospital (retrospective 2015-2018)
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Freiburg、德国
- 终止
- Universitätsklinik Freiburg (retrospective until 2018)
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Milan、意大利
- 招聘中
- European Institute of Oncology (2010-ongoing)
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接触:
- Fedro Peccatori, MD
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Milan、意大利
- 招聘中
- Fondazione IRCCS Ca'Granda Ospedale Maggiore (2012-ongoing)
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接触:
- Monica Fumagalli, MD
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Milan、意大利
- 招聘中
- Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Milano (2017-ongoing)
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接触:
- Giovanna Scarfone, MD
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Milan、意大利
- 招聘中
- San Raffaele Hospital (2017-ongoing)
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接触:
- Giorgia Mangili, MD
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Torino、意大利
- 招聘中
- CIttà della Salute e della Scienza di Torino (2015-ongoing)
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接触:
- Bianca Masturzo, MD
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Bergen、挪威
- 招聘中
- Haukeland University Hospital (2017-ongoing)
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接触:
- Line Bjorge
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Ostrava、捷克语
- 招聘中
- University Hospital Ostrava (2018-ongoing)
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接触:
- Jaroslav Klát, MD
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Prague、捷克语
- 招聘中
- 3rd medical faculty of Charles University (2010-ongoing)
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接触:
- Michael Halaska, MD
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Brussels、比利时
- 招聘中
- UCL Brussels (2013-ongoing)
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接触:
- Mina Mhallem
- 邮箱:katrien.vantornout@uzleuven.be
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Leuven、比利时、3000
- 招聘中
- UZ Gasthuisberg, Katholieke Universiteit Leuven (2004-ongoing)
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首席研究员:
- Frédéric Amant, MD, PhD
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接触:
- Frederic Amant, MD, PhD
- 电话号码:+32-16-344252
- 邮箱:frederic.amant@uzleuven.be
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接触:
- Kristel Van Calsteren, MD, PhD
- 电话号码:+32-16-346192
- 邮箱:kristel.vancalsteren@uzleuven.be
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副研究员:
- Lieven Lagae, MD, PhD
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副研究员:
- Luc Mertens, MD, PhD
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副研究员:
- Kristel Van Calsteren, MD
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副研究员:
- Michael Halaska, MD
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副研究员:
- Monica Fumagalli, MD PhD
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副研究员:
- Maarten Lambrecht, MD PhD
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Paris、法国
- 终止
- Hopital Bichat-Claude-Bernard (retrospective until 2018)
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Kraków、波兰
- 终止
- Medyczne Macierzynstwo (retrospective 2010-2018)
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Kraków、波兰
- 招聘中
- University Hospital Krakow (2018-ongoing)
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接触:
- Kolawa Wojciech
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副研究员:
- Marta Balajewicz-Nowak, MD
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副研究员:
- Kazimierz Pitynski, MD
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Poznań、波兰
- 招聘中
- Pozanan University of Medical Sciences (2017-ongoing)
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接触:
- Stefan Sajdak, MD
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Edirne、火鸡
- 终止
- Trakya University Faculty of Medicine (retrospective 2015-2018)
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Stockholm、瑞典
- 招聘中
- Karolinska University Hospital (2017-ongoing)
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接触:
- Kenny Rodriguez-Wallberg, MD
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Sousse、突尼斯
- 终止
- F.Hached University Teaching Hospital (retrospective 2016-2018)
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New Jersey
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Camden、New Jersey、美国、08103
- 招聘中
- Cooper University Hospital (2015-ongoing)
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接触:
- Elyce Cardonick, MD
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Rotterdam、荷兰
- 招聘中
- Erasmus Medical Center (2014-ongoing)
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接触:
- Ingrid Boere, MD PHD
- 邮箱:cip@nki.nl
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首席研究员:
- Frédéric Amant, MD PHD
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副研究员:
- C.A.R. Lok, MD PHD
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副研究员:
- M.M. Van den Heuvel-Eibrink, MD PHD
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副研究员:
- C.J.M. De Groot, MD PHD
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副研究员:
- R.C. Painter, MD PHD
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副研究员:
- P.B. Ottevanger, MD PHD
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副研究员:
- P.O. Witteveen, MD PHD
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副研究员:
- C.P. Schröder, MD PHD
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副研究员:
- S.J. Gordijn, MD PHD
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副研究员:
- J. Kroep, MD PHD
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副研究员:
- R.L.M. Bekkers, MD PHD
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副研究员:
- A.M.J. Thijs, MD PHD
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Vila Franca De Xira、葡萄牙
- 招聘中
- Hospital de Vila Franca de Xira (2017-ongoing)
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接触:
- Paula Duarte, MD
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Buenos Aires、阿根廷
- 撤销
- Instituto Alexander Fleming
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
取样方法
研究人群
描述
患者不需要同时参与两者;但是,最好同时执行两个研究部分。
*************** 第一部分:怀孕、分娩和孕产妇健康**************
患者必须符合以下纳入标准:
- 经组织学证实与妊娠相关的癌症(妊娠期间或妊娠后 5 年内被诊断为癌症)
- > 18 岁,未绝经
- 在充分理解方案的含义后签署并书面知情同意参加试验的患者
- 允许在怀孕期间接受任何细胞毒性药物或放射治疗的妇女评估母婴结局(第二部分)。
排除标准:
- 智障或显着改变的精神状态将禁止理解和给予知情同意
************** 第二部分:儿童的随访**************
纳入标准:
- 产前暴露于癌症治疗的儿童。 征得父母的知情同意。
排除标准:
- 智障或显着改变的精神状态将禁止理解和给予知情同意
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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学习小组
妊娠期癌症——所有诊断和治疗 妊娠期间被诊断患有癌症的母亲所生的孩子
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控制组
一般人口中的儿童
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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对妊娠期间确诊为癌症的母亲进行随访
大体时间:预期的
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妊娠期治疗、产科结局、产妇存活率
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预期的
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产前接受化疗或放疗的儿童的随访
大体时间:预期的
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神经和心脏病学结果
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预期的
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合作者和调查者
合作者
调查人员
- 首席研究员:Amant Frederic, MD PhD、KULeuven, Belgium
出版物和有用的链接
一般刊物
- Caluwaerts S, VAN Calsteren K, Mertens L, Lagae L, Moerman P, Hanssens M, Wuyts K, Vergote I, Amant F. Neoadjuvant chemotherapy followed by radical hysterectomy for invasive cervical cancer diagnosed during pregnancy: report of a case and review of the literature. Int J Gynecol Cancer. 2006 Mar-Apr;16(2):905-8. doi: 10.1111/j.1525-1438.2006.00223.x.
- Van Calsteren K, Berteloot P, Hanssens M, Vergote I, Amant F, Ganame J, Claus P, Mertens L, Lagae L, Delforge M, Paridaens R, Noens L, Humblet Y, Vandermeersch B, De Muylder X. In utero exposure to chemotherapy: effect on cardiac and neurologic outcome. J Clin Oncol. 2006 Apr 20;24(12):e16-7. doi: 10.1200/JCO.2006.06.1382. No abstract available.
- Lishner M, Avivi I, Apperley JF, Dierickx D, Evens AM, Fumagalli M, Nulman I, Oduncu FS, Peccatori FA, Robinson S, Van Calsteren K, Vandenbroucke T, Van den Heuvel F, Amant F. Hematologic Malignancies in Pregnancy: Management Guidelines From an International Consensus Meeting. J Clin Oncol. 2016 Feb 10;34(5):501-8. doi: 10.1200/JCO.2015.62.4445. Epub 2015 Nov 30.
- Amant F, Verheecke M, Wlodarska I, Dehaspe L, Brady P, Brison N, Van Den Bogaert K, Dierickx D, Vandecaveye V, Tousseyn T, Moerman P, Vanderstichele A, Vergote I, Neven P, Berteloot P, Putseys K, Danneels L, Vandenberghe P, Legius E, Vermeesch JR. Presymptomatic Identification of Cancers in Pregnant Women During Noninvasive Prenatal Testing. JAMA Oncol. 2015 Sep;1(6):814-9. doi: 10.1001/jamaoncol.2015.1883.
- de Haan J, Verheecke M, Amant F. Management of ovarian cysts and cancer in pregnancy. Facts Views Vis Obgyn. 2015;7(1):25-31.
- Amant F, Han SN, Gziri MM, Vandenbroucke T, Verheecke M, Van Calsteren K. Management of cancer in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2015 Jul;29(5):741-53. doi: 10.1016/j.bpobgyn.2015.02.006. Epub 2015 Mar 4.
- van Dam L, Han SN, Dierickx D, Amant F. Optimal staging of lymphoma during pregnancy is crucial. Womens Health (Lond). 2015 Mar;11(2):101-2. doi: 10.2217/whe.14.77. No abstract available.
- Han SN, Van Peer S, Peccatori F, Gziri MM, Amant F; International Network on Cancer, Infertility and Pregnancy. Contraception is as important as fertility preservation in young women with cancer. Lancet. 2015 Feb 7;385(9967):508. doi: 10.1016/S0140-6736(15)60201-X. No abstract available.
- Han SN, Verheecke M, Vandenbroucke T, Gziri MM, Van Calsteren K, Amant F. Management of gynecological cancers during pregnancy. Curr Oncol Rep. 2014 Dec;16(12):415. doi: 10.1007/s11912-014-0415-z.
- Van Calsteren K, Amant F. Cancer during pregnancy. Acta Obstet Gynecol Scand. 2014 May;93(5):443-6. doi: 10.1111/aogs.12380.
- Amant F, Halaska MJ, Fumagalli M, Dahl Steffensen K, Lok C, Van Calsteren K, Han SN, Mir O, Fruscio R, Uzan C, Maxwell C, Dekrem J, Strauven G, Mhallem Gziri M, Kesic V, Berveiller P, van den Heuvel F, Ottevanger PB, Vergote I, Lishner M, Morice P, Nulman I; ESGO task force 'Cancer in Pregnancy'. Gynecologic cancers in pregnancy: guidelines of a second international consensus meeting. Int J Gynecol Cancer. 2014 Mar;24(3):394-403. doi: 10.1097/IGC.0000000000000062. Erratum In: Int J Gynecol Cancer. 2014 May;24(4):819.
- Vandenbriele C, Dierickx D, Amant F, Delforge M. The treatment of hematologic malignancies in pregnancy. Facts Views Vis Obgyn. 2010;2(2):74-87. No abstract available.
- Deckers S, Amant F. Breast cancer in pregnancy: a literature review. Facts Views Vis Obgyn. 2009;1(2):130-41.
- Gziri MM, Goffin F, Debieve F, Amant F. [Cancer diagnosis during pregnancy: importance of a national and European registration]. Rev Med Liege. 2013 Oct;68(10):527-30. French.
- Han SN, Kesic VI, Van Calsteren K, Petkovic S, Amant F; ESGO 'Cancer in Pregnancy' Task Force. Cancer in pregnancy: a survey of current clinical practice. Eur J Obstet Gynecol Reprod Biol. 2013 Mar;167(1):18-23. doi: 10.1016/j.ejogrb.2012.10.026. Epub 2012 Nov 19.
- Han SN, Gziri MM, Van Calsteren K, Amant F. Is chemotherapy during the first trimester of pregnancy really safe? Int J Cancer. 2013 Apr 1;132(7):1728. doi: 10.1002/ijc.27815. Epub 2012 Sep 28. No abstract available.
- Han SN, Lotgerink A, Gziri MM, Van Calsteren K, Hanssens M, Amant F. Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review. BMC Med. 2012 Aug 8;10:86. doi: 10.1186/1741-7015-10-86.
- Loibl S, Han SN, Amant F. Being Pregnant and Diagnosed with Breast Cancer. Breast Care (Basel). 2012 Jun;7(3):204-209. doi: 10.1159/000339674. Epub 2012 Jun 27.
- Amant F. Safety of chemotherapy in pregnancy. Clin Adv Hematol Oncol. 2012 Apr;10(4):258-9. No abstract available.
- Verheecke M, Hermans E, Tuyaerts S, Souche E, Van Bree R, Verbist G, Everaert T, Cortes-Calabuig A, Van Houdt J, Van Calsteren K, Amant F. Acute Drug Effects on the Human Placental Tissue: The Development of a Placental Murine Xenograft Model. Reprod Sci. 2018 Dec;25(12):1637-1648. doi: 10.1177/1933719118756771. Epub 2018 Feb 13.
- Boere I, Lok C, Vandenbroucke T, Amant F. Cancer in pregnancy: safety and efficacy of systemic therapies. Curr Opin Oncol. 2017 Sep;29(5):328-334. doi: 10.1097/CCO.0000000000000386.
- Fruscio R, de Haan J, Van Calsteren K, Verheecke M, Mhallem M, Amant F. Ovarian cancer in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2017 May;41:108-117. doi: 10.1016/j.bpobgyn.2016.09.013. Epub 2016 Oct 1.
- Vercruysse DC, Deprez S, Sunaert S, Van Calsteren K, Amant F. Effects of prenatal exposure to cancer treatment on neurocognitive development, a review. Neurotoxicology. 2016 May;54:11-21. doi: 10.1016/j.neuro.2016.02.013. Epub 2016 Mar 4.
- de Haan J, Vandecaveye V, Han SN, Van de Vijver KK, Amant F. Difficulties with diagnosis of malignancies in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2016 May;33:19-32. doi: 10.1016/j.bpobgyn.2015.10.005. Epub 2015 Oct 19.
- Han SN, Mhallem Gziri M, Van Calsteren K, Amant F. Cervical cancer in pregnant women: treat, wait or interrupt? Assessment of current clinical guidelines, innovations and controversies. Ther Adv Med Oncol. 2013 Jul;5(4):211-9. doi: 10.1177/1758834013494988.
- Amant F, Han SN, Gziri MM, Dekrem J, Van Calsteren K. Chemotherapy during pregnancy. Curr Opin Oncol. 2012 Sep;24(5):580-6. doi: 10.1097/CCO.0b013e328354e754.
- Amant F, Loibl S, Neven P, Van Calsteren K. Breast cancer in pregnancy. Lancet. 2012 Feb 11;379(9815):570-9. doi: 10.1016/S0140-6736(11)61092-1.
- Han SN, Van Calsteren K, Amant F. Use of chemotherapy during pregnancy in the treatment of ovarian malignancies. Eur J Obstet Gynecol Reprod Biol. 2011 Jun;156(2):237. doi: 10.1016/j.ejogrb.2011.02.004. Epub 2011 Mar 25. No abstract available.
- Amant F, Deckers S, Van Calsteren K, Loibl S, Halaska M, Brepoels L, Beijnen J, Cardoso F, Gentilini O, Lagae L, Mir O, Neven P, Ottevanger N, Pans S, Peccatori F, Rouzier R, Senn HJ, Struikmans H, Christiaens MR, Cameron D, Du Bois A. Breast cancer in pregnancy: recommendations of an international consensus meeting. Eur J Cancer. 2010 Dec;46(18):3158-68. doi: 10.1016/j.ejca.2010.09.010.
- Amant F, Brepoels L, Halaska MJ, Gziri MM, Calsteren KV. Gynaecologic cancer complicating pregnancy: an overview. Best Pract Res Clin Obstet Gynaecol. 2010 Feb;24(1):61-79. doi: 10.1016/j.bpobgyn.2009.08.001. Epub 2009 Sep 8.
- Van Calsteren K, Hartmann D, Van Aerschot L, Verbesselt R, Van Bree R, D'Hooge R, Amant F. Vinblastine and doxorubicin administration to pregnant mice affects brain development and behaviour in the offspring. Neurotoxicology. 2009 Jul;30(4):647-57. doi: 10.1016/j.neuro.2009.04.009. Epub 2009 May 5.
- Amant F, Van Calsteren K, Halaska MJ, Beijnen J, Lagae L, Hanssens M, Heyns L, Lannoo L, Ottevanger NP, Vanden Bogaert W, Ungar L, Vergote I, du Bois A. Gynecologic cancers in pregnancy: guidelines of an international consensus meeting. Int J Gynecol Cancer. 2009 May;19 Suppl 1:S1-12. doi: 10.1111/IGC.0b013e3181a1d0ec.
- Van Calsteren K, Devlieger R, De Catte L, D'Hooghe T, Chai DC, Mwenda JM, Vergote I, Amant F. Feasibility of ultrasound-guided percutaneous samplings in the pregnant baboon: a model for studies on transplacental transport. Reprod Sci. 2009 Mar;16(3):280-5. doi: 10.1177/1933719108324890. Epub 2008 Dec 15.
- Amant F, Van Calsteren K, Vergote I, Ottevanger N. Gynecologic oncology in pregnancy. Crit Rev Oncol Hematol. 2008 Sep;67(3):187-95. doi: 10.1016/j.critrevonc.2008.01.006. Epub 2008 Mar 4.
- Van Calsteren K, Heyns L, De Smet F, Van Eycken L, Gziri MM, Van Gemert W, Halaska M, Vergote I, Ottevanger N, Amant F. Cancer during pregnancy: an analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes. J Clin Oncol. 2010 Feb 1;28(4):683-9. doi: 10.1200/JCO.2009.23.2801. Epub 2009 Oct 19.
- Amant F, Van Calsteren K, Halaska MJ, Gziri MM, Hui W, Lagae L, Willemsen MA, Kapusta L, Van Calster B, Wouters H, Heyns L, Han SN, Tomek V, Mertens L, Ottevanger PB. Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study. Lancet Oncol. 2012 Mar;13(3):256-64. doi: 10.1016/S1470-2045(11)70363-1. Epub 2012 Feb 10.
- Gziri MM, Debieve F, DE Catte L, Mertens L, Barrea C, VAN Calsteren K, Han SN, Heyns L, Amant F. Chemotherapy during pregnancy: effect of anthracyclines on fetal and maternal cardiac function. Acta Obstet Gynecol Scand. 2012 Dec;91(12):1465-8. doi: 10.1111/j.1600-0412.2012.01524.x. Epub 2012 Nov 1.
- Loibl S, Han SN, von Minckwitz G, Bontenbal M, Ring A, Giermek J, Fehm T, Van Calsteren K, Linn SC, Schlehe B, Gziri MM, Westenend PJ, Muller V, Heyns L, Rack B, Van Calster B, Harbeck N, Lenhard M, Halaska MJ, Kaufmann M, Nekljudova V, Amant F. Treatment of breast cancer during pregnancy: an observational study. Lancet Oncol. 2012 Sep;13(9):887-96. doi: 10.1016/S1470-2045(12)70261-9. Epub 2012 Aug 16.
- Gziri MM, Amant F, Debieve F, Van Calsteren K, De Catte L, Mertens L. Effects of chemotherapy during pregnancy on the maternal and fetal heart. Prenat Diagn. 2012 Jul;32(7):614-9. doi: 10.1002/pd.3847. Epub 2012 Apr 17.
- Mhallem Gziri M, Han SN, Van Calsteren K, Heyns L, Delaere P, Nuyts S, Van den Heuvel F, Cheron AC, Fossion E, Van den Weyngaert D, Lok C, Amant F. Tongue cancers during pregnancy: Case reports and review of literature. Head Neck. 2013 Apr;35(4):E102-8. doi: 10.1002/hed.21924. Epub 2011 Oct 19.
- Gziri MM, Hui W, Amant F, Van Calsteren K, Ottevanger N, Kapusta L, Mertens L. Myocardial function in children after fetal chemotherapy exposure. A tissue Doppler and myocardial deformation imaging study. Eur J Pediatr. 2013 Feb;172(2):163-70. doi: 10.1007/s00431-012-1849-7. Epub 2012 Oct 5.
- Boussios S, Han SN, Fruscio R, Halaska MJ, Ottevanger PB, Peccatori FA, Koubkova L, Pavlidis N, Amant F. Lung cancer in pregnancy: report of nine cases from an international collaborative study. Lung Cancer. 2013 Dec;82(3):499-505. doi: 10.1016/j.lungcan.2013.09.002. Epub 2013 Sep 12.
- Amant F, von Minckwitz G, Han SN, Bontenbal M, Ring AE, Giermek J, Wildiers H, Fehm T, Linn SC, Schlehe B, Neven P, Westenend PJ, Muller V, Van Calsteren K, Rack B, Nekljudova V, Harbeck N, Untch M, Witteveen PO, Schwedler K, Thomssen C, Van Calster B, Loibl S. Prognosis of women with primary breast cancer diagnosed during pregnancy: results from an international collaborative study. J Clin Oncol. 2013 Jul 10;31(20):2532-9. doi: 10.1200/JCO.2012.45.6335. Epub 2013 Apr 22.
- Verheecke M, Halaska MJ, Lok CA, Ottevanger PB, Fruscio R, Dahl-Steffensen K, Kolawa W, Gziri MM, Han SN, Van Calsteren K, Van den Heuvel F, De Vleeschouwer S, Clement PM, Menten J, Amant F; ESGO Task Force 'Cancer in Pregnancy'. Primary brain tumours, meningiomas and brain metastases in pregnancy: report on 27 cases and review of literature. Eur J Cancer. 2014 May;50(8):1462-71. doi: 10.1016/j.ejca.2014.02.018. Epub 2014 Mar 14.
- Vandenbroucke T, Van Calsteren K, Amant F. Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy. N Engl J Med. 2016 Feb 18;374(7):693. doi: 10.1056/NEJMc1515462. No abstract available.
- Amant F, Vandenbroucke T, Verheecke M, Fumagalli M, Halaska MJ, Boere I, Han S, Gziri MM, Peccatori F, Rob L, Lok C, Witteveen P, Voigt JU, Naulaers G, Vallaeys L, Van den Heuvel F, Lagae L, Mertens L, Claes L, Van Calsteren K; International Network on Cancer, Infertility, and Pregnancy (INCIP). Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy. N Engl J Med. 2015 Nov 5;373(19):1824-34. doi: 10.1056/NEJMoa1508913. Epub 2015 Sep 28.
- Loibl S, Schmidt A, Gentilini O, Kaufman B, Kuhl C, Denkert C, von Minckwitz G, Parokonnaya A, Stensheim H, Thomssen C, van Calsteren K, Poortmans P, Berveiller P, Markert UR, Amant F. Breast Cancer Diagnosed During Pregnancy: Adapting Recent Advances in Breast Cancer Care for Pregnant Patients. JAMA Oncol. 2015 Nov;1(8):1145-53. doi: 10.1001/jamaoncol.2015.2413. Erratum In: JAMA Oncol. 2015 Nov;1(8):1172.
- Vandenbroucke T, Amant F. Development of children born to mothers with cancer during pregnancy: comparing in utero chemotherapy-exposed children with nonexposed controls. Am J Obstet Gynecol. 2015 Jun;212(6):830-1. doi: 10.1016/j.ajog.2015.01.035. Epub 2015 Jan 28. No abstract available.
- Vandenbroucke T, Verheecke M, Van Calsteren K, Han S, Claes L, Amant F. Fetal outcome after prenatal exposure to chemotherapy and mechanisms of teratogenicity compared to alcohol and smoking. Expert Opin Drug Saf. 2014 Dec;13(12):1653-65. doi: 10.1517/14740338.2014.965677. Epub 2014 Nov 10.
- van Hasselt JGC, van Calsteren K, Heyns L, Han S, Mhallem Gziri M, Schellens JHM, Beijnen JH, Huitema ADR, Amant F. Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel. Ann Oncol. 2014 Oct;25(10):2059-2065. doi: 10.1093/annonc/mdu140. Epub 2014 Apr 8.
- Dekrem J, Van Calsteren K, Amant F. Effects of fetal exposure to maternal chemotherapy. Paediatr Drugs. 2013 Oct;15(5):329-34. doi: 10.1007/s40272-013-0040-6.
- Gziri MM, Pokreisz P, De Vos R, Verbeken E, Debieve F, Mertens L, Janssens SP, Amant F. Fetal rat hearts do not display acute cardiotoxicity in response to maternal Doxorubicin treatment. J Pharmacol Exp Ther. 2013 Sep;346(3):362-9. doi: 10.1124/jpet.113.205419. Epub 2013 Jun 21.
- de Haan J, Verheecke M, Van Calsteren K, Van Calster B, Shmakov RG, Mhallem Gziri M, Halaska MJ, Fruscio R, Lok CAR, Boere IA, Zola P, Ottevanger PB, de Groot CJM, Peccatori FA, Dahl Steffensen K, Cardonick EH, Polushkina E, Rob L, Ceppi L, Sukhikh GT, Han SN, Amant F; International Network on Cancer and Infertility Pregnancy (INCIP). Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet Oncol. 2018 Mar;19(3):337-346. doi: 10.1016/S1470-2045(18)30059-7. Epub 2018 Jan 26. Erratum In: Lancet Oncol. 2021 Sep;22(9):e389.
- de Haan J, van Thienen JV, Casaer M, Hannivoort RA, Van Calsteren K, van Tuyl M, van Gerwen MM, Debeer A, Amant F, Painter RC. Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma. Case Rep Oncol. 2018 Feb 15;11(1):119-124. doi: 10.1159/000487128. eCollection 2018 Jan-Apr.
- Boucek J, de Haan J, Halaska MJ, Plzak J, Van Calsteren K, de Groot CJM, Dahl Steffensen K, Fruscio R, Massolt ET, Klaritsch P, Zola P, Amant F; International Network on Cancer, Infertility, and Pregnancy. Maternal and obstetrical outcome in 35 cases of well-differentiated thyroid carcinoma during pregnancy. Laryngoscope. 2018 Jun;128(6):1493-1500. doi: 10.1002/lary.26936. Epub 2017 Oct 8.
- de Haan J, Lok CA, de Groot CJ, Crijns MB, Van Calsteren K, Dahl Steffensen K, Halaska MJ, Altintas S, Boere IA, Fruscio R, Kolawa W, Witteveen PO, Amant F; International Network on Cancer, Infertility and Pregnancy (INCIP). Melanoma during pregnancy: a report of 60 pregnancies complicated by melanoma. Melanoma Res. 2017 Jun;27(3):218-223. doi: 10.1097/CMR.0000000000000327.
- Verheecke M, Cortes Calabuig A, Finalet Ferreiro J, Brys V, Van Bree R, Verbist G, Everaert T, Leemans L, Gziri MM, Boere I, Halaska MJ, Vanhoudt J, Amant F, Van Calsteren K. Genetic and microscopic assessment of the human chemotherapy-exposed placenta reveals possible pathways contributive to fetal growth restriction. Placenta. 2018 Apr;64:61-70. doi: 10.1016/j.placenta.2018.03.002. Epub 2018 Mar 9. Erratum In: Placenta. 2018 Sep;69:117.
- Vandenbroucke T, Verheecke M, Fumagalli M, Lok C, Amant F. Effects of cancer treatment during pregnancy on fetal and child development. Lancet Child Adolesc Health. 2017 Dec;1(4):302-310. doi: 10.1016/S2352-4642(17)30091-3. Epub 2017 Sep 29.
- Gziri MM, Brunee L, Cayphas C, Prigogine T, Van Raemdonck D, Amant F, Hubinont C. Low-grade bronchial mucoepidermoid carcinoma during pregnancy successfully treated by lobectomy. J Obstet Gynaecol. 2017 Nov;37(8):1082-1084. doi: 10.1080/01443615.2017.1308325. Epub 2017 Jun 1. No abstract available.
- de Haan J, Van Calsteren K, Lok CAR, de Groot CJM, Amant F. Comment on "Maternal and perinatal outcomes in pregnancy-associated melanoma. Report of two cases and a systematic literature review". Eur J Obstet Gynecol Reprod Biol. 2017 Sep;216:261-262. doi: 10.1016/j.ejogrb.2017.07.025. Epub 2017 Jul 23. No abstract available.
- Vandenbroucke T, Han SN, Van Calsteren K, Wilderjans TF, Van den Bergh BRH, Claes L, Amant F. Psychological distress and cognitive coping in pregnant women diagnosed with cancer and their partners. Psychooncology. 2017 Aug;26(8):1215-1221. doi: 10.1002/pon.4301. Epub 2016 Nov 21. Erratum In: Psychooncology. 2018 Oct;27(10):2521.
- Gziri MM, Han SN, Amant F. Use of general anesthesia and sentinel node procedure during pregnancy. J Surg Oncol. 2012 Dec;106(8):1008. doi: 10.1002/jso.23164. Epub 2012 Jun 4. No abstract available.
- Lambrechts S, Van Calsteren K, Capoen A, Op De Beeck K, Joniau S, Timmerman D, Amant F. Polypoid endometriosis of the bladder during pregnancy mimicking urachal carcinoma. Ultrasound Obstet Gynecol. 2011 Oct;38(4):475-8. doi: 10.1002/uog.8985. Epub 2011 Sep 6.
- Van Calsteren K, Verbesselt R, Van Bree R, Heyns L, de Bruijn E, de Hoon J, Amant F. Substantial variation in transplacental transfer of chemotherapeutic agents in a mouse model. Reprod Sci. 2011 Jan;18(1):57-63. doi: 10.1177/1933719110379650. Epub 2010 Sep 8.
- Van Calsteren K, Verbesselt R, Beijnen J, Devlieger R, De Catte L, Chai DC, Van Bree R, Heyns L, de Hoon J, Amant F. Transplacental transfer of anthracyclines, vinblastine, and 4-hydroxy-cyclophosphamide in a baboon model. Gynecol Oncol. 2010 Dec;119(3):594-600. doi: 10.1016/j.ygyno.2010.08.019. Epub 2010 Sep 17.
- Calsteren KV, Verbesselt R, Devlieger R, De Catte L, Chai DC, Van Bree R, Heyns L, Beijnen J, Demarsin S, de Bruijn E, de Hoon J, Amant F. Transplacental transfer of paclitaxel, docetaxel, carboplatin, and trastuzumab in a baboon model. Int J Gynecol Cancer. 2010 Dec;20(9):1456-64. doi: 10.1111/IGC.0b013e3181fb18c8.
- Van Calsteren K, Verbesselt R, Ottevanger N, Halaska M, Heyns L, Van Bree R, de Bruijn E, Chai D, Delforge M, Noens L, Renard V, Witteveen E, Rob L, de Hoon J, Amant F. Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical study. Acta Obstet Gynecol Scand. 2010 Oct;89(10):1338-45. doi: 10.3109/00016349.2010.512070.
- Van Calsteren K, Hanssens M, Moerman P, Orye G, Bielen D, Vergote I, Amant F. Successful conservative treatment of endocervical adenocarcinoma stage Ib1 diagnosed early in pregnancy. Acta Obstet Gynecol Scand. 2008;87(2):250-3. doi: 10.1080/00016340701870794.
- Van Calsteren K, Van Mensel K, Joniau S, Oyen R, Hanssens M, Amant F, Van Poppel H. Urachal carcinoma during pregnancy. Urology. 2006 Jun;67(6):1290.e19-21. doi: 10.1016/j.urology.2005.12.041.
- Vandenbroucke T, Verheecke M, van Gerwen M, Van Calsteren K, Halaska MJ, Fumagalli M, Fruscio R, Gandhi A, Veening M, Lagae L, Ottevanger PB, Voigt JU, de Haan J, Gziri MM, Maggen C, Mertens L, Naulaers G, Claes L, Amant F; International Network on Cancer, Infertility and Pregnancy (INCIP). Child development at 6 years after maternal cancer diagnosis and treatment during pregnancy. Eur J Cancer. 2020 Oct;138:57-67. doi: 10.1016/j.ejca.2020.07.004. Epub 2020 Aug 25.
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