Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants (GENBPD)
Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia
Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:
- a genome-wide association (GWA) study in VLBW neonates,
- a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and
- functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).
研究概览
地位
条件
研究类型
注册 (预期的)
联系人和位置
学习地点
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Creteil、法国、94000
- Centre Hospitalier Intercommunal
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Gestational age < 28 weeks
- Inborn birth
- Prophylactic administration of surfactant in the delivery room
- Written informed consent obtained from parents
Exclusion Criteria:
- Gestational age of 28 weeks or more
- Outborn birth
- No prophylactic administration of surfactant in the delivery room
- Congenital malformation
- Absence of written informed consent obtained from parents
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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premature neonates
gestational age less than 28 weeks
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研究衡量的是什么?
主要结果指标
结果测量 |
大体时间 |
---|---|
bronchopulmonary dysplasia
大体时间:36 weeks of postconceptional age
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36 weeks of postconceptional age
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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