- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00904774
Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants (GENBPD)
Polymorphisms of Genes Controlling Alveolar Development and Risk of Bronchopulmonary Dysplasia
Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this disease must be found. BPD appears to result from arrested lung development, but its etiology has not yet been fully established. Besides the role of the exposure of the immature lung to injurious factors in the development of BPD, a genetic susceptibility for BPD in preterm infants was recently evidenced. Taking advantage of new genomic technologies, the objective of the investigators' project is to identify predisposing human genetic variants through:
- a genome-wide association (GWA) study in VLBW neonates,
- a candidate-gene association study, including selection of single nucleotide polymorphisms (SNPs) found in (a) and
- functional studies of any SNP found to be convincingly associated with BPD in (a) and (b).
Study Overview
Status
Conditions
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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Creteil, France, 94000
- Centre Hospitalier Intercommunal
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Gestational age < 28 weeks
- Inborn birth
- Prophylactic administration of surfactant in the delivery room
- Written informed consent obtained from parents
Exclusion Criteria:
- Gestational age of 28 weeks or more
- Outborn birth
- No prophylactic administration of surfactant in the delivery room
- Congenital malformation
- Absence of written informed consent obtained from parents
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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premature neonates
gestational age less than 28 weeks
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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bronchopulmonary dysplasia
Time Frame: 36 weeks of postconceptional age
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36 weeks of postconceptional age
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Collaborators and Investigators
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AOR 07 018
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