Montelukast and Nasal Epithelial Cell Inflammatory Responses in Asthma and Rhinitis
The Effect of Montelukast on Inflammatory Responses of Nasal Epithelial Cells Cultured From Patients With Asthma, With and Without Concomitant Allergic Rhinitis
研究概览
详细说明
Hypothesis
The inflammatory secretory profile of nasal airway epithelial cells (NEC) cultured from asthmatics with concomitant allergic rhinitis (AR) will differ from that of NEC from patients with asthma alone. Treatment (in vitro and in vivo) with montelukast may have differential modulating effects in these two patient groups.
For the primary objective of this proposal we will use nasal AEC from asthmatics with or without concomitant AR as to ascertain differences in pro-inflammatory cytokine and chemokine production between these two groups and determine whether in vitro treatment with montelukast has a differential modulating effect on NEC secretion. In the secondary pilot study any modulating effects by montelukast on AEC secretion in vitro will be correlated with any in vivo response to montelukast withdrawal. This sub study will provide pilot data indicating whether in vivo response to montelukast can be predicted from in vitro effects on NEC.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Aberdeen、英国、AB25 2ZD
- University of Aberdeen
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- stable physician confirmed mild/moderate asthma (Steps 1-4 of BTS/SIGN guidelines <10 pack-year smoking histories Currently taking montelukast with a documented clinical history of benefit
Exclusion Criteria:
- Nasal corticosteroid therapy
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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asthmatic patients taking montelukast
asthma with or without rhinitis
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Effect of montelukast on nasal epithelial cell secretion in vitro.
大体时间:12 months
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12 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Effect of 1-week montelukast withdrawal on clinical scores and pro-inflammatory cytokine output by nasal epithelial cells
大体时间:12 months
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12 months
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合作者和调查者
调查人员
- 首席研究员:Garry M Walsh, PhD、University of Aberdeen
出版物和有用的链接
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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