Respiratory Muscle Strength and Function in Healthy Kids
Respiratory Muscle Strength and Function in Healthy Children
研究概览
地位
条件
详细说明
The goals of this study are to collect and evaluate respiratory muscle strength training (RMST) induced changes in ventilatory function in healthy children. Children will undergo one session of pulmonary function and strength testing to quantify rate of inspiratory and expiratory pressure development and to determine whether inspiratory and expiratory pressure correlate to maximal respiratory pressures and forced pulmonary function tests. Currently normal pressure-flow-timing responses are not well-characterized in healthy children. The purpose of this study is to help develop more efficient RMST exercise prescriptions for ill children on ventilators and with neuromuscular weakness.
Participants in the study will refrain from caffeine products and exercise on the day of respiratory testing. In conjunction with respiratory testing, baseline and exertional blood pressure, heart and respiratory rate, and pulse oximetry will be monitored. Participants will complete tidal flow-volume assessments and forced expiratory maneuvers according to the AMerican Thoracic Society guidelines. Participants will undergo 5 sets of 10 maximal-effort breaths against standardized resistances (one set each at 0, 5, 10, 15, and 20 cm H20). Following each set, subjects will rate the load magnitude and their feelings of breathing discomfort using a 0-10 visual analog scale. Participants will also perform maximal inspiratory and expiratory pressure maneuvers. All tests will be separated by at least 2-3 minutes of rest.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Florida
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Gainesville、Florida、美国、32610
- University of Florida
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Male or female subjects 4-16 years of age.
- Healthy subjects
Exclusion Criteria:
- Have primary pulmonary disease
- Have primary neuromuscular disease
- Have a connective tissue or autoimmune disease
- Have had a respiratory infection with in 15 days prior to study date
- Have acute aminoglycosides antibiotic therapy with in 15 days prior to study date
- Have acute corticosteroids with in 15 days prior to study date
- Have a need to use an inhaler routinely
- Have hepatic failure
- Have hematologic failure
- Have participated in other studies related to medications or exercise
- Have used tobacco products
- Have other precautions
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Respiratory Function
Children will undergo one session of pulmonary function and strength testing
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Pulmonary Function Testing
大体时间:Day 1
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Subjects will complete tidal flow-volume assessments and forced expiratory maneuvers.
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Day 1
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合作者和调查者
调查人员
- 首席研究员:Barbara K Smith, PT, PhD、University of Florida
出版物和有用的链接
一般刊物
- Romer LM, McConnell AK. Specificity and reversibility of inspiratory muscle training. Med Sci Sports Exerc. 2003 Feb;35(2):237-44. doi: 10.1249/01.MSS.0000048642.58419.1E.
- American Thoracic Society/European Respiratory Society. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002 Aug 15;166(4):518-624. doi: 10.1164/rccm.166.4.518. No abstract available.
- Parthasarathy S, Jubran A, Laghi F, Tobin MJ. Sternomastoid, rib cage, and expiratory muscle activity during weaning failure. J Appl Physiol (1985). 2007 Jul;103(1):140-7. doi: 10.1152/japplphysiol.00904.2006. Epub 2007 Mar 29.
- Ramonatxo M, Amsalem FA, Mercier JG, Jean R, Prefaut CG. Ventilatory control during exercise in children with mild or moderate asthma. Med Sci Sports Exerc. 1989 Feb;21(1):11-7. doi: 10.1249/00005768-198902000-00003.
- Villafranca C, Borzone G, Leiva A, Lisboa C. Effect of inspiratory muscle training with an intermediate load on inspiratory power output in COPD. Eur Respir J. 1998 Jan;11(1):28-33. doi: 10.1183/09031936.98.11010028.
- Tzelepis GE, Vega DL, Cohen ME, Fulambarker AM, Patel KK, McCool FD. Pressure-flow specificity of inspiratory muscle training. J Appl Physiol (1985). 1994 Aug;77(2):795-801. doi: 10.1152/jappl.1994.77.2.795.
- Tzelepis GE, Kasas V, McCool FD. Inspiratory muscle adaptations following pressure or flow training in humans. Eur J Appl Physiol Occup Physiol. 1999 May;79(6):467-71. doi: 10.1007/s004210050538.
- Coast JR, Jensen RA, Cassidy SS, Ramanathan M, Johnson RL Jr. Cardiac output and O2 consumption during inspiratory threshold loaded breathing. J Appl Physiol (1985). 1988 Apr;64(4):1624-8. doi: 10.1152/jappl.1988.64.4.1624.
- Otis AB. Pressure-flow relationships and power output of breathing. Respir Physiol. 1977 Jun;30(1-2):7-14. doi: 10.1016/0034-5687(77)90017-2.
- Mognoni P, Saibene F, Sant'Ambrogio G, Agostoni E. Dynamics of the maximal contraction of the respiratory muscles. Respir Physiol. 1968 Mar;4(2):193-202. doi: 10.1016/0034-5687(68)90051-0. No abstract available.
- Read DJ, Freedman S, Kafer ER. Pressures developed by loaded inspiratory muscles in conscious and anesthetized man. J Appl Physiol. 1974 Aug;37(2):207-18. doi: 10.1152/jappl.1974.37.2.207. No abstract available.
- Pengelly LD, Alderson AM, Milic-Emili J. Mechanics of the diaphragm. J Appl Physiol. 1971 Jun;30(6):797-805. doi: 10.1152/jappl.1971.30.6.797. No abstract available.
- Ameredes BT, Zhan WZ, Prakash YS, Vandenboom R, Sieck GC. Power fatigue of the rat diaphragm muscle. J Appl Physiol (1985). 2000 Dec;89(6):2215-9. doi: 10.1152/jappl.2000.89.6.2215.
- Goldman MD, Grassino A, Mead J, Sears TA. Mechanics of the human diaphragm during voluntary contraction: dynamics. J Appl Physiol Respir Environ Exerc Physiol. 1978 Jun;44(6):840-8. doi: 10.1152/jappl.1978.44.6.840.
- Fitting JW, Easton PA, Grassino AE. Velocity of shortening of inspiratory muscles and inspiratory flow. J Appl Physiol (1985). 1986 Feb;60(2):670-7. doi: 10.1152/jappl.1986.60.2.670.
- Komarow HD, Myles IA, Uzzaman A, Metcalfe DD. Impulse oscillometry in the evaluation of diseases of the airways in children. Ann Allergy Asthma Immunol. 2011 Mar;106(3):191-9. doi: 10.1016/j.anai.2010.11.011. Epub 2011 Jan 6.
- Younes M, Riddle W. A model for the relation between respiratory neural and mechanical outputs. I. Theory. J Appl Physiol Respir Environ Exerc Physiol. 1981 Oct;51(4):963-78. doi: 10.1152/jappl.1981.51.4.963.
- Butler JE. Drive to the human respiratory muscles. Respir Physiol Neurobiol. 2007 Nov 15;159(2):115-26. doi: 10.1016/j.resp.2007.06.006. Epub 2007 Jun 17.
- Rowley KL, Mantilla CB, Sieck GC. Respiratory muscle plasticity. Respir Physiol Neurobiol. 2005 Jul 28;147(2-3):235-51. doi: 10.1016/j.resp.2005.03.003.
- Osborne S, Road JD. Diaphragm and phrenic nerve activities during inspiratory loading in anesthetized rabbits. Respir Physiol. 1995 Mar;99(3):321-30. doi: 10.1016/0034-5687(94)00109-d.
- American Thoracic Society; European Respiratory Society. ATS/ERS statement: raised volume forced expirations in infants: guidelines for current practice. Am J Respir Crit Care Med. 2005 Dec 1;172(11):1463-71. doi: 10.1164/rccm.200408-1141ST. No abstract available.
- Polkey MI, Hamnegard CH, Hughes PD, Rafferty GF, Green M, Moxham J. Influence of acute lung volume change on contractile properties of human diaphragm. J Appl Physiol (1985). 1998 Oct;85(4):1322-8. doi: 10.1152/jappl.1998.85.4.1322.
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- HK 176-2011
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