Multiple Sclerosis and Progressive Resistance Training
Multiple Sclerosis - Inflammatory, Neurological and Muscular Adaptations to Progressive Resistance Training
研究概览
详细说明
Exercise in general, and progressive resistance training (PRT) in particular, is regarded as an important tool in the rehabilitation of people with multiple sclerosis (MS).
Previous studies have reported positive effects of PRT on muscle strength, functional capacity, fatigue and quality of life. Also, a possible disease modifying effect has been proposed. However, the underlying physiological mechanisms that might explain these beneficial effects and the possible effects on disease progression are unresolved. Additionally, none of the previous studies has been concerned with the possible impact of MS progression type, gender and/or medication.
The purpose of this randomized, controlled, gender stratified trial is to investigate underlying mechanisms possibly explaining the beneficial effects of progressive resistance training for people with multiple sclerosis.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Aarhus C、丹麦、8000
- MS Clinic, Department of Neurology, Aarhus University Hospital
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Aarhus C、丹麦、8000
- Sport Science, Aarhus University
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Diagnosed relapsing-remitting MS according to the McDonald criteria
- Expanded Disability Status Scale (EDSS) between 2.0 and 5.5
- Be able to train twice a week at the University
- Use interferon based medication
Exclusion Criteria:
- Alcohol abuse, Alzheimer's and pacemaker (or other metallic implant)
- Comorbidities like cardiovascular-, respiratory-, orthopaedic or metabolic diseases
- Having had an attack in a period of 8 weeks prior to the start of the intervention period
- Having an attack during the intervention period
- Pregnancy
- Systematic resistance training in a period of 3 months prior to the start of the intervention period.
- Training adherence of less than 85%.
学习计划
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
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无干预：控制
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实验性的：训练
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Bi-weekly progressive resistance training
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Blood-borne biomarkers
大体时间：Change from baseline to 24 weeks
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Resting levels of bloodbourne biomarkers;
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Change from baseline to 24 weeks
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Neuro-muscular function of knee extensors
大体时间：Change from baseline to 24 weeks
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By use of an isokinetic dynamometer, EMG and stimulation equipment the following will be assessed for the knee extensors;
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Change from baseline to 24 weeks
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Walking performance
大体时间：Change from baseline to 24 weeks
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Walking performance will be assessed by the;
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Change from baseline to 24 weeks
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Self-reported measures
大体时间：Change from baseline to 24 weeks
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The self-reported measures contains questionnaires regarding;
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Change from baseline to 24 weeks
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Brain volume
大体时间：Change from baseline to 24 weeks
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MRI-scans of the head will provide the following measurements;
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Change from baseline to 24 weeks
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Body Composition
大体时间：Change from baseline to 24 weeks
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Weight and Bodyfat-% will be assessed with a Bodycomposition weight (Tanita SC220)
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Change from baseline to 24 weeks
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Thigh muscle cross-sectional area
大体时间：Change from baseline to 24 weeks
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MRI-scans of the thigh will provide cross-sectional area of
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Change from baseline to 24 weeks
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合作者和调查者
调查人员
- 首席研究员：Tue Kjølhede, M.Sc.、Sport Science, Department of Public Health, Aarhus University
- 学习椅：Ulrik Dalgas, Ph.D.、Sport Science, Department of Public Health, Aarhus University
- 学习椅：Kristian Vissing, Ph.D.、Sport Science, Department of Public Health, Aarhus University
- 学习椅：Thor Petersen, Dr.med、MS Clinic, Department of Neurology, Aarhus University Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Training的临床试验
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Karolinska InstitutetMinistry of Health and Social Affairs, Sweden完全的
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