3T MRI to Predict TACE Response of HCC
Combination of Dynamic Contrast-enhanced and Diffusion-weighted Imaging and Magnetic Resonance Spectroscopy in 3T MRI to Early Predict Treatment Efficacy in Patients Receiving Transarterial Chemoembolization for Hepatocellular Carcinoma
研究概览
地位
条件
详细说明
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive quantitative technique for assessing micro-vascular structure by tracking the pharmacokinetics of injected low-molecular weight contrast agents as they pass through the tumor vasculature. This modality is being increasingly used in many oncological studies to characterize tumor angiogenesis and invasiveness, and monitor the treatment response.
Diffusion-weighted imaging (DWI) enables qualitative and quantitative assessment of tissue diffusivity (apparent diffusion coefficient, ADC) without the use of gadolinium chelates. DWI has been suggested to be useful in monitoring the response of HCC after TACE because of earlier assessment of tumor necrosis with increasing ADC values.
MR spectroscopy facilitates the study of cellular metabolism and in vivo detection of abnormalities. A few studies of in vivo MR spectroscopy reported an increase in choline levels within tumors such as HCC and a reduction in the lipid-to-choline ratio after conventional TACE was performed for HCC.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Taipei、台湾、100
- 招聘中
- National Taiwan Uinversity Hospital
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接触：
- Bang-Bin Chen, MD
- 邮箱：bangbin@gmail.com
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首席研究员：
- Bang-Bin Chen, MD
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Prior Informed Consent Form
- Patients who had undergone surgery for the treatment of HCC are allowed.
- At least one measurable tumor, according to RECIST version 1.1.
- Age more than 20 years.
- ECOG performance status 0 or 1.
- Life expectancy more than 3 months.
- Child-Pugh class A.
- Unresectable, multinodular tumors
- Confirmed Diagnosis of HCC
- At least one uni-dimensional lesion measurable according to the Modified RECIST criteria by MRI
- Adequate bone marrow, liver and renal function
Exclusion Criteria:
- History of TACE
- Diffuse infiltrative HCC or presence of main portal vein invasion or extrahepatic metastasis
- Any contraindications for hepatic embolization procedures:, including hepatofugal blood flow, large intrahepatic or porto-systemic shunt, impaired clotting test, renal failure requiring hemo-or peritoneal dialysis
- Any contraindication for MRI, including known contrast allergy, electronically operated implants or devices, and claustrophobia.
- Other acute or chronic medical, psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation and is inappropriate for this study by the judgment of the investigator
- Known history of HIV infection
- Concurrent primary extrahepatic cancer
- Pregnant or breast-feeding subjects
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
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TACE patients, for HCC
unresectable HCC patients
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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tumor response
大体时间：change of tumor size from baseline to at 6 months
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change of tumor size from baseline to at 6 months
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change of tumor size from baseline to at 6 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
change of baseline MRI parameters
大体时间：change of MRI parameters from baseline to at 6 months
|
comparsion of MRI parameters from baseline to 6 months
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change of MRI parameters from baseline to at 6 months
|
合作者和调查者
调查人员
- 首席研究员：Bang-Bin Chen, MD、National Taiwan Uinversity Hospital
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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