Hepatitis C Virus in Neutrophil Granulocyte Progenitor Cells
研究概览
地位
条件
详细说明
Neutrophil granulocytes are important components of the innate immune system and pioneers in the fight against both fungal and bacterial infections. If pathogens enter the body, they are marked as foreign by antibodies and the complement system. Afterwards receptors on the neutrophils recognize and bind on these foreign substances to make them harmless. This process is called phagocytosis. Hepatitis C virus (HCV) and neutrophils are rarely associated. The HCV belongs to the Flaviviridae. It is a single-stranded, enveloped RNA virus with a positive polarity, which cause chronic hepatitis C (CHC) in approximately 170 million people worldwide. Subsequently, such an infection leads to liver cirrhosis and carcinoma in a significant proportion of patients. The virus infects mainly hepatocytes, but extrahepatic replication has also been shown. HCV usually enters the cell through receptor-mediated endocytosis (claudin-1, cluster of differentiation (CD)81, occludin and scavenger receptor 1), before it abuses the cell's own infrastructure for the viral protein synthesis.
The aim of this study is to determine neutrophil function in chronic hepatitis C infected patients. Furthermore the investigators want to examine if neutrophils or their precursor cells are infected with HCV and if this leads to their dysfunction.
研究类型
联系人和位置
学习地点
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Graz、奥地利、8010
- Department of Internal Medicine, Medical University of Graz
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- chronic hepatitis C
- Genotype 1-4
Exclusion Criteria:
- acute hepatitis C
学习计划
研究是如何设计的?
设计细节
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
viral RNA
大体时间:day 1
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hepatitis C virus RNA
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day 1
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
neutrophil phagocytic capacity
大体时间:day 1
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function of neutrophil granulocytes in hepatitis C patients
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day 1
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hepatitis C virus proteins
大体时间:day 1
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presence of hepatitis C virus proteins in neutrophils
|
day 1
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合作者和调查者
调查人员
- 首席研究员:Vanessa Stadlbauer、Medical University of Graz
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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