前瞻性城乡流行病学研究 (PURE)
2024年1月29日 更新者：Salim Yusuf's office、Population Health Research Institute
检查健康决定因素对个人的影响（例如
健康相关行为）和社会层面（例如
环境因素、健康相关政策、卫生系统质量）对健康结果的影响（例如
死亡、非传染性疾病的发展）在一系列社会经济和卫生资源环境中。
这项研究的其他组成部分将检查非传染性疾病的遗传因素。
这将通过横截面组件和前瞻性（队列组件）进行检查。
研究概览
详细说明
- 旨在检查社会影响与危险因素和慢性非传染性疾病流行之间的关系。 社会决定因素是通过 4 个感兴趣领域的措施指数来衡量的：建筑环境、食品和营养政策、社会心理/社会经济因素和烟草。
- 检查社会决定因素与慢性非传染性疾病事件（例如 心血管疾病、癌症）以及选定风险因素（例如 抽烟）
- 检查健康相关行为之间的关系（例如 饮食、身体活动、吸烟、饮酒）和健康结果（例如 死亡、非传染性疾病）
- 各种卫生资源环境中卫生系统的质量，以及这如何影响健康结果
- 非传染性疾病的遗传因素
研究类型
观察性的
注册 (估计的)
200000
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Sumathy Rangarajan, MSc
- 电话号码：40464 905-521-2100
- 邮箱：sumathy.rangarajan@phri.ca
研究联系人备份
- 姓名：Janette Panhuis, BScN, MBA
- 电话号码：40386 905-521-2100
- 邮箱：janette.panhuis@phri.ca
学习地点
-
-
-
Beijing、中国
- 招聘中
- State Key Laboratory of Cardiovascular Disease, Fuwai Hospital
-
接触：
- Wei Li, PhD
- 邮箱：liwei@mrbc-nccd.com
-
-
-
-
-
Isfahan、伊朗伊斯兰共和国
- 招聘中
- Isfahan University of Medical Sciences
-
接触：
- Roya Kelishadi, MD
- 邮箱：roya.kelishadi@gmail.com
-
-
-
-
-
Kemerovo、俄罗斯联邦
- 招聘中
- Research Institute for Complex Issues of Cardiovascular Diseases
-
接触：
- Olga Barbarash
- 邮箱：olb61@mail.ru
-
-
-
-
British Columbia
-
Vancouver、British Columbia、加拿大
- 招聘中
- Simon Fraser University
-
接触：
- Scott Lear, PhD
- 邮箱：SLear@providencehealth.bc.ca
-
-
Ontario
-
Hamilton、Ontario、加拿大、L8L2X2
- 招聘中
- Population Health Research Institute
-
接触：
- Sandy Trottier
- 电话号码：40456 905-521-2100
- 邮箱：sandy.trottier@phri.ca
-
首席研究员：
- Koon Teo, MB, PhD
-
Ottawa、Ontario、加拿大、K1H8L6
- 招聘中
- University of Ottawa
-
接触：
- Andreas Wielgosz, MD, PhD
- 邮箱：wielgosz@uottawa.ca
-
-
Quebec
-
Quebec City、Quebec、加拿大
- 招聘中
- Université Laval Institut universitaire de cardiologie et de pneumologie de Québec
-
接触：
- Gilles Dagenais, MD
- 邮箱：Gilles.Dagenais@criucpq.ulaval.ca
-
-
-
-
-
Bellville、南非
- 招聘中
- School of Public Health, University of the Western Cape
-
接触：
- Thandi Puoane, MPH, Dr PH
- 邮箱：tpuoane@uwc.ac.za
-
Potchefstroom、南非
- 招聘中
- North-West University
-
接触：
- Lanthe Kruger, PhD
- 邮箱：lanthe.kruger@nwu.ac.za
-
-
-
-
-
Chandigarh、印度
- 招聘中
- Post Graduate Institute of Medical Education and Research (PGIMER)
-
接触：
- Rajesh Kumar, MD
- 邮箱：dr.rajeshkumar@gmail.com
-
-
Karnataka
-
Bangalore、Karnataka、印度
- 招聘中
- St John's Research Institute
-
接触：
- Prem K Mony, MD, MSc
- 邮箱：premkmony@gmail.com
-
-
Kerala
-
Thiruvananthapuram、Kerala、印度
- 招聘中
- Health Action by People
-
接触：
- Raman Kutty, MD, MPH
- 邮箱：kuttyr@gmail.com
-
-
Rajasthan
-
Jaipur、Rajasthan、印度
- 招聘中
- Eternal Heart Care Centre and Research Institute
-
接触：
- Rajeev Gupta, MD, PhD
- 邮箱：rajeevgg@gmail.com
-
-
Tamil Nadu
-
Chennai、Tamil Nadu、印度
- 招聘中
- Madras Diabetes Research Foundation
-
接触：
- V Mohan, MD
- 邮箱：drmohans@diabetes.ind.in
-
-
-
-
-
Bishkek、吉尔吉斯斯坦
- 招聘中
- Kyrgyz Society of Cardiology, National Center of Cardiology and Internal Disease
-
接触：
- Erkin Mirrakhimov, MD
- 邮箱：erkmirr@gmail.com
-
-
-
-
-
Almaty、哈萨克斯坦
- 招聘中
- Research Institute of Cardiology & Internal Diseases
-
接触：
- Kairat Davletov, MD
- 邮箱：davletovkairat@gmail.com
-
-
-
-
Santander
-
Floridablanca、Santander、哥伦比亚
- 招聘中
- Fundacion Oftalmologica de Santander - FOSCAL
-
接触：
- Patricio Lopez-Jaramillo, MD, PhD
- 邮箱：jplopezj@gmail.com
-
-
-
-
-
Moshi、坦桑尼亚
- 招聘中
- Pamoja Tunaweza Women Center
-
接触：
- Karen Yeates, MD
- 邮箱：yeatesk@queensu.ca
-
-
-
-
-
Dhaka、孟加拉国
- 招聘中
- Independent University, Bangladesh
-
接触：
- Omar Rahman, MD, MPH, DSc
- 邮箱：orahman@iub.edu.bd
-
接触：
- Rita Yusuf, PhD
- 邮箱：ritayusuf@iub.edu.bd
-
-
-
-
-
Ramallah、巴勒斯坦领土，被占领
- 招聘中
- Birzeit University, Birzeit
-
接触：
- Rasha Khatib, PhD
- 邮箱：Rasha.Khatib@phri.ca
-
-
-
-
-
Karachi、巴基斯坦
- 招聘中
- Aga Khan University
-
接触：
- Romaina Iqbal, PhD
- 邮箱：romaina.iqbal@aku.edu
-
-
-
-
-
São Paulo、巴西
- 招聘中
- Dante Pazzanese Institute of Cardiology
-
接触：
- Alvaro Avezum, MD. PhD
- 邮箱：avezum@yahoo.com
-
-
-
-
-
Temuco、智利
- 招聘中
- Universidad de La Frontera
-
接触：
- Fernando Lanas, MD, MSc
- 邮箱：lanastomas@gmail.com
-
-
-
-
-
Riyadh、沙特阿拉伯
- 招聘中
- King Saud University
-
接触：
- Khalid F AlHabib, MBBS
- 邮箱：khalidalhabib13@hotmail.com
-
-
-
-
-
Wrocław、波兰
- 招聘中
- Wroclaw Medical University & Department of Internal Medicine
-
接触：
- Andrzej Szuba, MD, PhD
- 邮箱：andrzej.szuba@umed.wroc.pl
-
-
-
-
-
Harare、津巴布韦
- 招聘中
- University of Zimbabwe College of Health Sciences
-
接触：
- Jephat Chifamba, DPhil
- 邮箱：chifamb@medic.uz.ac.zw
-
-
-
-
-
İstanbul、火鸡
- 招聘中
- Istanbul Medeniyet University
-
接触：
- Aytekin Oguz, MD
- 邮箱：aytekinoguz@hotmail.com
-
-
-
-
-
Göteborg、瑞典
- 招聘中
- Sahlgrenska University Hospital/Östra Hospital
-
接触：
- Annika Rosengren, MD, PhD
- 邮箱：annika.rosengren@gu.se
-
-
-
-
-
Lima、秘鲁
- 招聘中
- Universidad Peruana Cayetano Heredia
-
接触：
- Jaime Miranda, MD, PhD
- 邮箱：jaime.miranda@upch.pe
-
-
-
-
-
Manila、菲律宾
- 招聘中
- University of Philippines, Section of Adult Medicine & Medical Research Unit
-
接触：
- Antonio L Dans, MD
- 邮箱：antoniodans@gmail.com
-
-
-
-
-
Dubai、阿拉伯联合酋长国
- 招聘中
- Dubai Medical University
-
接触：
- Afzalhussein Yusufali, MD
- 邮箱：ahYusufali@dha.gov.ae
-
-
-
-
Santa Fe
-
Rosario、Santa Fe、阿根廷
- 招聘中
- Estudios Clinicos Latinoamerica ECLA
-
接触：
- Rafael Diaz, MD
- 邮箱：rdiazmd@eclainternational.org
-
-
-
-
-
Kuala Lumpur、马来西亚
- 招聘中
- Universiti Teknologi MARA, UCSI Universiti
-
接触：
- Khalid Yusoff, MBBS
- 邮箱：kyusoff@gmail.com
-
Kuala Lumpur、马来西亚
- 招聘中
- University Kebangsaan Malaysia
-
接触：
- Noorhassim Ismail, MD
- 邮箱：ramalbaru@gmail.com
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
35年 至 70年 (成人、年长者)
接受健康志愿者
不适用
取样方法
非概率样本
研究人群
来自世界低收入、中等收入和高收入地区社区的 35 至 70 岁的成年人代表着不同的发展水平，并具有巨大的社会文化多样性。
描述
纳入标准：
- 35-70岁之间同意的成年人
排除标准：
- 没有任何
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
|---|
|
成年人
入学时年龄在 35 至 70 岁之间
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
突发性心血管疾病
大体时间：平均随访 10 年
|
心血管死亡、中风、心肌梗塞、心力衰竭
|
平均随访 10 年
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
癌症事件
大体时间：平均随访 10 年
|
总和导致特定癌症
|
平均随访 10 年
|
|
事件慢性阻塞性肺病
大体时间：平均随访 10 年
|
慢性阻塞性肺病的发展
|
平均随访 10 年
|
|
突发性哮喘
大体时间：平均随访 10 年
|
哮喘的发展
|
平均随访 10 年
|
|
肺炎
大体时间：平均随访 10 年
|
肺炎住院
|
平均随访 10 年
|
|
呼吸结果
大体时间：平均随访 10 年
|
肺功能检查改变
|
平均随访 10 年
|
|
全因住院
大体时间：平均随访 10 年
|
全因住院
|
平均随访 10 年
|
|
肾脏疾病
大体时间：平均随访 10 年
|
终末期肾病、透析、移植、肾功能改变
|
平均随访 10 年
|
|
全因死亡率和特定原因死亡率
大体时间：平均随访 10 年
|
各种原因导致的死亡，以及特定原因导致的死亡
|
平均随访 10 年
|
|
糖尿病
大体时间：平均随访 10 年
|
糖尿病的发展
|
平均随访 10 年
|
|
肥胖
大体时间：平均随访 10 年
|
肥胖的发展，BMI的变化
|
平均随访 10 年
|
|
高血压
大体时间：平均随访 10 年
|
高血压的发展和血压的变化
|
平均随访 10 年
|
|
事故伤害
大体时间：平均随访 10 年
|
评估道路交通事故和跌倒造成的致命和非致命伤害
|
平均随访 10 年
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Salim Yusuf, DPhil、Executive Director
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Yusuf S, Islam S, Chow CK, Rangarajan S, Dagenais G, Diaz R, Gupta R, Kelishadi R, Iqbal R, Avezum A, Kruger A, Kutty R, Lanas F, Lisheng L, Wei L, Lopez-Jaramillo P, Oguz A, Rahman O, Swidan H, Yusoff K, Zatonski W, Rosengren A, Teo KK; Prospective Urban Rural Epidemiology (PURE) Study Investigators. Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): a prospective epidemiological survey. Lancet. 2011 Oct 1;378(9798):1231-43. doi: 10.1016/S0140-6736(11)61215-4. Epub 2011 Aug 26.
- Dehghan M, Al Hamad N, Yusufali A, Nusrath F, Yusuf S, Merchant AT. Development of a semi-quantitative food frequency questionnaire for use in United Arab Emirates and Kuwait based on local foods. Nutr J. 2005 May 27;4:18. doi: 10.1186/1475-2891-4-18.
- Mente A, O'Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, Morrison H, Li W, Wang X, Di C, Mony P, Devanath A, Rosengren A, Oguz A, Zatonska K, Yusufali AH, Lopez-Jaramillo P, Avezum A, Ismail N, Lanas F, Puoane T, Diaz R, Kelishadi R, Iqbal R, Yusuf R, Chifamba J, Khatib R, Teo K, Yusuf S; PURE Investigators. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014 Aug 14;371(7):601-11. doi: 10.1056/NEJMoa1311989.
- O'Donnell M, Mente A, Rangarajan S, McQueen MJ, Wang X, Liu L, Yan H, Lee SF, Mony P, Devanath A, Rosengren A, Lopez-Jaramillo P, Diaz R, Avezum A, Lanas F, Yusoff K, Iqbal R, Ilow R, Mohammadifard N, Gulec S, Yusufali AH, Kruger L, Yusuf R, Chifamba J, Kabali C, Dagenais G, Lear SA, Teo K, Yusuf S; PURE Investigators. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014 Aug 14;371(7):612-23. doi: 10.1056/NEJMoa1311889. Erratum In: N Engl J Med. 2014 Sep 25;371(13):1267.
- Merchant AT, Dehghan M, Chifamba J, Terera G, Yusuf S. Nutrient estimation from an FFQ developed for a Black Zimbabwean population. Nutr J. 2005 Dec 13;4:37. doi: 10.1186/1475-2891-4-37.
- Merchant AT, Dehghan M. Food composition database development for between country comparisons. Nutr J. 2006 Jan 19;5:2. doi: 10.1186/1475-2891-5-2.
- Vaz M, Bharathi AV, Thomas T, Yusuf S, Kurpad AV. The repeatability of self reported physical activity patterns in rural South India. Asia Pac J Clin Nutr. 2009;18(1):71-5.
- Dehghan M, del Cerro S, Zhang X, Cuneo JM, Linetzky B, Diaz R, Merchant AT. Validation of a semi-quantitative Food Frequency Questionnaire for Argentinean adults. PLoS One. 2012;7(5):e37958. doi: 10.1371/journal.pone.0037958. Epub 2012 May 25.
- Dehghan M, Martinez S, Zhang X, Seron P, Lanas F, Islam S, Merchant AT. Relative validity of an FFQ to estimate daily food and nutrient intakes for Chilean adults. Public Health Nutr. 2013 Oct;16(10):1782-8. doi: 10.1017/S1368980012004107. Epub 2012 Sep 21.
- Dehghan M, Lopez Jaramillo P, Duenas R, Anaya LL, Garcia RG, Zhang X, Islam S, Merchant AT. Development and validation of a quantitative food frequency questionnaire among rural- and urban-dwelling adults in Colombia. J Nutr Educ Behav. 2012 Nov-Dec;44(6):609-13. doi: 10.1016/j.jneb.2010.10.001. Epub 2011 Jul 7.
- Khatib R, Schwalm JD, Yusuf S, Haynes RB, McKee M, Khan M, Nieuwlaat R. Patient and healthcare provider barriers to hypertension awareness, treatment and follow up: a systematic review and meta-analysis of qualitative and quantitative studies. PLoS One. 2014 Jan 15;9(1):e84238. doi: 10.1371/journal.pone.0084238. eCollection 2014.
- Teo K, Chow CK, Vaz M, Rangarajan S, Yusuf S; PURE Investigators-Writing Group. The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low-, middle-, and high-income countries. Am Heart J. 2009 Jul;158(1):1-7.e1. doi: 10.1016/j.ahj.2009.04.019.
- Chow CK, Lock K, Teo K, Subramanian SV, McKee M, Yusuf S. Environmental and societal influences acting on cardiovascular risk factors and disease at a population level: a review. Int J Epidemiol. 2009 Dec;38(6):1580-94. doi: 10.1093/ije/dyn258. Epub 2009 Mar 4.
- Bharathi AV, Kurpad AV, Thomas T, Yusuf S, Saraswathi G, Vaz M. Development of food frequency questionnaires and a nutrient database for the Prospective Urban and Rural Epidemiological (PURE) pilot study in South India: methodological issues. Asia Pac J Clin Nutr. 2008;17(1):178-85.
- Iqbal R, Ajayan K, Bharathi AV, Zhang X, Islam S, Soman CR, Merchant AT. Refinement and validation of an FFQ developed to estimate macro- and micronutrient intakes in a south Indian population. Public Health Nutr. 2009 Jan;12(1):12-8. doi: 10.1017/S1368980008001845. Epub 2008 Mar 7.
- Chow CK, Lock K, Madhavan M, Corsi DJ, Gilmore AB, Subramanian SV, Li W, Swaminathan S, Lopez-Jaramillo P, Avezum A, Lear SA, Dagenais G, Teo K, McKee M, Yusuf S. Environmental Profile of a Community's Health (EPOCH): an instrument to measure environmental determinants of cardiovascular health in five countries. PLoS One. 2010 Dec 10;5(12):e14294. doi: 10.1371/journal.pone.0014294.
- Mir H, Buchanan D, Gilmore A, McKee M, Yusuf S, Chow CK. Cigarette pack labelling in 12 countries at different levels of economic development. J Public Health Policy. 2011 May;32(2):146-64. doi: 10.1057/jphp.2011.3. Epub 2011 Mar 3.
- Gasevic D, Vukmirovich I, Yusuf S, Teo K, Chow C, Dagenais G, Lear SA. A direct assessment of "obesogenic" built environments: challenges and recommendations. J Environ Public Health. 2011;2011:161574. doi: 10.1155/2011/161574. Epub 2011 Nov 15.
- Corsi DJ, Subramanian SV, McKee M, Li W, Swaminathan S, Lopez-Jaramillo P, Avezum A, Lear SA, Dagenais G, Rangarajan S, Teo K, Yusuf S, Chow CK. Environmental Profile of a Community's Health (EPOCH): an ecometric assessment of measures of the community environment based on individual perception. PLoS One. 2012;7(9):e44410. doi: 10.1371/journal.pone.0044410. Epub 2012 Sep 4.
- Dehghan M, Ilow R, Zatonska K, Szuba A, Zhang X, Mente A, Regulska-Ilow B. Development, reproducibility and validity of the food frequency questionnaire in the Poland arm of the Prospective Urban and Rural Epidemiological (PURE) study. J Hum Nutr Diet. 2012 Jun;25(3):225-32. doi: 10.1111/j.1365-277X.2012.01240.x. Epub 2012 Mar 6.
- Teo K, Lear S, Islam S, Mony P, Dehghan M, Li W, Rosengren A, Lopez-Jaramillo P, Diaz R, Oliveira G, Miskan M, Rangarajan S, Iqbal R, Ilow R, Puone T, Bahonar A, Gulec S, Darwish EA, Lanas F, Vijaykumar K, Rahman O, Chifamba J, Hou Y, Li N, Yusuf S; PURE Investigators. Prevalence of a healthy lifestyle among individuals with cardiovascular disease in high-, middle- and low-income countries: The Prospective Urban Rural Epidemiology (PURE) study. JAMA. 2013 Apr 17;309(15):1613-21. doi: 10.1001/jama.2013.3519.
- Chow CK, Teo KK, Rangarajan S, Islam S, Gupta R, Avezum A, Bahonar A, Chifamba J, Dagenais G, Diaz R, Kazmi K, Lanas F, Wei L, Lopez-Jaramillo P, Fanghong L, Ismail NH, Puoane T, Rosengren A, Szuba A, Temizhan A, Wielgosz A, Yusuf R, Yusufali A, McKee M, Liu L, Mony P, Yusuf S; PURE (Prospective Urban Rural Epidemiology) Study investigators. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013 Sep 4;310(9):959-68. doi: 10.1001/jama.2013.184182.
- Corsi DJ, Subramanian SV, Chow CK, McKee M, Chifamba J, Dagenais G, Diaz R, Iqbal R, Kelishadi R, Kruger A, Lanas F, Lopez-Jaramilo P, Mony P, Mohan V, Avezum A, Oguz A, Rahman MO, Rosengren A, Szuba A, Li W, Yusoff K, Yusufali A, Rangarajan S, Teo K, Yusuf S. Prospective Urban Rural Epidemiology (PURE) study: Baseline characteristics of the household sample and comparative analyses with national data in 17 countries. Am Heart J. 2013 Oct;166(4):636-646.e4. doi: 10.1016/j.ahj.2013.04.019. Epub 2013 Jul 27.
- Duong M, Islam S, Rangarajan S, Teo K, O'Byrne PM, Schunemann HJ, Igumbor E, Chifamba J, Liu L, Li W, Ismail T, Shankar K, Shahid M, Vijayakumar K, Yusuf R, Zatonska K, Oguz A, Rosengren A, Heidari H, Almahmeed W, Diaz R, Oliveira G, Lopez-Jaramillo P, Seron P, Killian K, Yusuf S; PURE-BREATH Study Investigators. Global differences in lung function by region (PURE): an international, community-based prospective study. Lancet Respir Med. 2013 Oct;1(8):599-609. doi: 10.1016/S2213-2600(13)70164-4. Epub 2013 Sep 10.
- Mahajan R, Malik M, Bharathi AV, Lakshmi PV, Patro BK, Rana SK, Kumar R. Reproducibility and validity of a quantitative food frequency questionnaire in an urban and rural area of northern India. Natl Med J India. 2013 Sep-Oct;26(5):266-72.
- Mente A, O'Donnell MJ, Dagenais G, Wielgosz A, Lear SA, McQueen MJ, Jiang Y, Xingyu W, Jian B, Calik KB, Akalin AA, Mony P, Devanath A, Yusufali AH, Lopez-Jaramillo P, Avezum A Jr, Yusoff K, Rosengren A, Kruger L, Orlandini A, Rangarajan S, Teo K, Yusuf S. Validation and comparison of three formulae to estimate sodium and potassium excretion from a single morning fasting urine compared to 24-h measures in 11 countries. J Hypertens. 2014 May;32(5):1005-14; discussion 1015. doi: 10.1097/HJH.0000000000000122.
- Lear SA, Teo K, Gasevic D, Zhang X, Poirier PP, Rangarajan S, Seron P, Kelishadi R, Tamil AM, Kruger A, Iqbal R, Swidan H, Gomez-Arbelaez D, Yusuf R, Chifamba J, Kutty VR, Karsidag K, Kumar R, Li W, Szuba A, Avezum A, Diaz R, Anand SS, Rosengren A, Yusuf S; Prospective Urban Rural Epidemiology (PURE) study. The association between ownership of common household devices and obesity and diabetes in high, middle and low income countries. CMAJ. 2014 Mar 4;186(4):258-66. doi: 10.1503/cmaj.131090. Epub 2014 Feb 10. Erratum In: CMAJ. 2014 Apr 1;186(6):453.
- Yusuf S, Rangarajan S, Teo K, Islam S, Li W, Liu L, Bo J, Lou Q, Lu F, Liu T, Yu L, Zhang S, Mony P, Swaminathan S, Mohan V, Gupta R, Kumar R, Vijayakumar K, Lear S, Anand S, Wielgosz A, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Yusoff K, Ismail N, Iqbal R, Rahman O, Rosengren A, Yusufali A, Kelishadi R, Kruger A, Puoane T, Szuba A, Chifamba J, Oguz A, McQueen M, McKee M, Dagenais G; PURE Investigators. Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med. 2014 Aug 28;371(9):818-27. doi: 10.1056/NEJMoa1311890.
- Batool S, O'Donnell M, Sharma M, Islam S, Dagenais GR, Poirier P, Lear SA, Wielgosz A, Teo K, Stotts G, McCreary CR, Frayne R, DeJesus J, Rangarajan S, Yusuf S, Smith EE; PURE Study Investigators. Incidental magnetic resonance diffusion-weighted imaging-positive lesions are rare in neurologically asymptomatic community-dwelling adults. Stroke. 2014 Jul;45(7):2115-7. doi: 10.1161/STROKEAHA.114.005782. Epub 2014 Jun 12.
- Chow CK, Corsi DJ, Lock K, Madhavan M, Mackie P, Li W, Yi S, Wang Y, Swaminathan S, Lopez-Jaramillo P, Gomez-Arbelaez D, Avezum A, Lear SA, Dagenais G, Teo K, McKee M, Yusuf S. A novel method to evaluate the community built environment using photographs--Environmental Profile of a Community Health (EPOCH) photo neighbourhood evaluation tool. PLoS One. 2014 Nov 4;9(11):e110042. doi: 10.1371/journal.pone.0110042. eCollection 2014.
- Smith EE, O'Donnell M, Dagenais G, Lear SA, Wielgosz A, Sharma M, Poirier P, Stotts G, Black SE, Strother S, Noseworthy MD, Benavente O, Modi J, Goyal M, Batool S, Sanchez K, Hill V, McCreary CR, Frayne R, Islam S, DeJesus J, Rangarajan S, Teo K, Yusuf S; PURE Investigators. Early cerebral small vessel disease and brain volume, cognition, and gait. Ann Neurol. 2015 Feb;77(2):251-61. doi: 10.1002/ana.24320.
- Mayhew AJ, Lock K, Kelishadi R, Swaminathan S, Marcilio CS, Iqbal R, Dehghan M, Yusuf S, Chow CK. Nutrition labelling, marketing techniques, nutrition claims and health claims on chip and biscuit packages from sixteen countries. Public Health Nutr. 2016 Apr;19(6):998-1007. doi: 10.1017/S1368980015000658. Epub 2015 Mar 30. Erratum In: Public Health Nutr. 2016 Apr;19(6):1145.
- Rosengren A, Teo K, Rangarajan S, Kabali C, Khumalo I, Kutty VR, Gupta R, Yusuf R, Iqbal R, Ismail N, Altuntas Y, Kelishadi R, Diaz R, Avezum A, Chifamba J, Zatonska K, Wei L, Liao X, Lopez-Jaramillo P, Yusufali A, Seron P, Lear SA, Yusuf S. Psychosocial factors and obesity in 17 high-, middle- and low-income countries: the Prospective Urban Rural Epidemiologic study. Int J Obes (Lond). 2015 Aug;39(8):1217-23. doi: 10.1038/ijo.2015.48. Epub 2015 Apr 14.
- Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, Seron P, Ahmed SH, Rosengren A, Kelishadi R, Rahman O, Swaminathan S, Iqbal R, Gupta R, Lear SA, Oguz A, Yusoff K, Zatonska K, Chifamba J, Igumbor E, Mohan V, Anjana RM, Gu H, Li W, Yusuf S; Prospective Urban Rural Epidemiology (PURE) Study investigators. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015 Jul 18;386(9990):266-73. doi: 10.1016/S0140-6736(14)62000-6. Epub 2015 May 13.
- Gupta R, Islam S, Mony P, Kutty VR, Mohan V, Kumar R, Thakur JS, Shankar VK, Mohan D, Vijayakumar K, Rahman O, Yusuf R, Iqbal R, Shahid M, Mohan I, Rangarajan S, Teo KK, Yusuf S. Socioeconomic factors and use of secondary preventive therapies for cardiovascular diseases in South Asia: The PURE study. Eur J Prev Cardiol. 2015 Oct;22(10):1261-71. doi: 10.1177/2047487314540386. Epub 2014 Jun 18.
- Smyth A, Teo KK, Rangarajan S, O'Donnell M, Zhang X, Rana P, Leong DP, Dagenais G, Seron P, Rosengren A, Schutte AE, Lopez-Jaramillo P, Oguz A, Chifamba J, Diaz R, Lear S, Avezum A, Kumar R, Mohan V, Szuba A, Wei L, Yang W, Jian B, McKee M, Yusuf S; PURE Investigators. Alcohol consumption and cardiovascular disease, cancer, injury, admission to hospital, and mortality: a prospective cohort study. Lancet. 2015 Nov 14;386(10007):1945-1954. doi: 10.1016/S0140-6736(15)00235-4. Epub 2015 Sep 17.
- Savell E, Gilmore AB, Sims M, Mony PK, Koon T, Yusoff K, Lear SA, Seron P, Ismail N, Calik KB, Rosengren A, Bahonar A, Kumar R, Vijayakumar K, Kruger A, Swidan H, Gupta R, Igumbor E, Afridi A, Rahman O, Chifamba J, Zatonska K, Mohan V, Mohan D, Lopez-Jaramillo P, Avezum A, Poirier P, Orlandini A, Li W, McKee M, Rangarajan S, Yusuf S, Chow CK. The environmental profile of a community's health: a cross-sectional study on tobacco marketing in 16 countries. Bull World Health Organ. 2015 Dec 1;93(12):851-61G. doi: 10.2471/BLT.15.155846.
- Lamelas PM, Mente A, Diaz R, Orlandini A, Avezum A, Oliveira G, Lanas F, Seron P, Lopez-Jaramillo P, Camacho-Lopez P, O Donnell MJ, Rangarajan S, Teo K, Yusuf S. Association of Urinary Sodium Excretion With Blood Pressure and Cardiovascular Clinical Events in 17,033 Latin Americans. Am J Hypertens. 2016 Jul;29(7):796-805. doi: 10.1093/ajh/hpv195. Epub 2015 Dec 18.
- Khatib R, McKee M, Shannon H, Chow C, Rangarajan S, Teo K, Wei L, Mony P, Mohan V, Gupta R, Kumar R, Vijayakumar K, Lear SA, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Yusoff K, Ismail N, Kazmi K, Rahman O, Rosengren A, Monsef N, Kelishadi R, Kruger A, Puoane T, Szuba A, Chifamba J, Temizhan A, Dagenais G, Gafni A, Yusuf S; PURE study investigators. Availability and affordability of cardiovascular disease medicines and their effect on use in high-income, middle-income, and low-income countries: an analysis of the PURE study data. Lancet. 2016 Jan 2;387(10013):61-9. doi: 10.1016/S0140-6736(15)00469-9. Epub 2015 Oct 20.
- Mente A, Dagenais G, Wielgosz A, Lear SA, McQueen MJ, Zeidler J, Fu L, DeJesus J, Rangarajan S, Bourlaud AS, De Bluts AL, Corber E, de Jong V, Boomgaardt J, Shane A, Jiang Y, de Groh M, O'Donnell MJ, Yusuf S, Teo K. Assessment of Dietary Sodium and Potassium in Canadians Using 24-Hour Urinary Collection. Can J Cardiol. 2016 Mar;32(3):319-26. doi: 10.1016/j.cjca.2015.06.020. Epub 2015 Jun 25.
- Li W, Gu H, Teo KK, Bo J, Wang Y, Yang J, Wang X, Zhang H, Sun Y, Jia X, He X, Zhao X, Cheng X, Li J, Rangarajan S, Chen C, Yusuf S, Liu L; PURE China Investigators. Hypertension prevalence, awareness, treatment, and control in 115 rural and urban communities involving 47 000 people from China. J Hypertens. 2016 Jan;34(1):39-46. doi: 10.1097/HJH.0000000000000745.
- Raina P, Sohel N, Oremus M, Shannon H, Mony P, Kumar R, Li W, Wang Y, Wang X, Yusoff K, Yusuf R, Iqbal R, Szuba A, Oguz A, Rosengren A, Kruger A, Chifamba J, Mohammadifard N, Darwish EA, Dagenais G, Diaz R, Avezum A, Lopez-Jaramillo P, Seron P, Rangarajan S, Teo K, Yusuf S; PURE Investigators. Assessing global risk factors for non-fatal injuries from road traffic accidents and falls in adults aged 35-70 years in 17 countries: a cross-sectional analysis of the Prospective Urban Rural Epidemiological (PURE) study. Inj Prev. 2016 Apr;22(2):92-8. doi: 10.1136/injuryprev-2014-041476. Epub 2015 Oct 28.
- Leong DP, Teo KK, Rangarajan S, Kutty VR, Lanas F, Hui C, Quanyong X, Zhenzhen Q, Jinhua T, Noorhassim I, AlHabib KF, Moss SJ, Rosengren A, Akalin AA, Rahman O, Chifamba J, Orlandini A, Kumar R, Yeates K, Gupta R, Yusufali A, Dans A, Avezum A, Lopez-Jaramillo P, Poirier P, Heidari H, Zatonska K, Iqbal R, Khatib R, Yusuf S. Reference ranges of handgrip strength from 125,462 healthy adults in 21 countries: a prospective urban rural epidemiologic (PURE) study. J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):535-546. doi: 10.1002/jcsm.12112. Epub 2016 Apr 12.
- Dagenais GR, Gerstein HC, Zhang X, McQueen M, Lear S, Lopez-Jaramillo P, Mohan V, Mony P, Gupta R, Kutty VR, Kumar R, Rahman O, Yusoff K, Zatonska K, Oguz A, Rosengren A, Kelishadi R, Yusufali A, Diaz R, Avezum A, Lanas F, Kruger A, Peer N, Chifamba J, Iqbal R, Ismail N, Xiulin B, Jiankang L, Wenqing D, Gejie Y, Rangarajan S, Teo K, Yusuf S. Variations in Diabetes Prevalence in Low-, Middle-, and High-Income Countries: Results From the Prospective Urban and Rural Epidemiological Study. Diabetes Care. 2016 May;39(5):780-7. doi: 10.2337/dc15-2338. Epub 2016 Mar 10.
- Mente A, O'Donnell M, Rangarajan S, Dagenais G, Lear S, McQueen M, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Li W, Lu Y, Yi S, Rensheng L, Iqbal R, Mony P, Yusuf R, Yusoff K, Szuba A, Oguz A, Rosengren A, Bahonar A, Yusufali A, Schutte AE, Chifamba J, Mann JF, Anand SS, Teo K, Yusuf S; PURE, EPIDREAM and ONTARGET/TRANSCEND Investigators. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016 Jul 30;388(10043):465-75. doi: 10.1016/S0140-6736(16)30467-6. Epub 2016 May 20. Erratum In: Lancet. 2021 Apr 10;397(10282):1350.
- Miller V, Yusuf S, Chow CK, Dehghan M, Corsi DJ, Lock K, Popkin B, Rangarajan S, Khatib R, Lear SA, Mony P, Kaur M, Mohan V, Vijayakumar K, Gupta R, Kruger A, Tsolekile L, Mohammadifard N, Rahman O, Rosengren A, Avezum A, Orlandini A, Ismail N, Lopez-Jaramillo P, Yusufali A, Karsidag K, Iqbal R, Chifamba J, Oakley SM, Ariffin F, Zatonska K, Poirier P, Wei L, Jian B, Hui C, Xu L, Xiulin B, Teo K, Mente A. Availability, affordability, and consumption of fruits and vegetables in 18 countries across income levels: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet Glob Health. 2016 Oct;4(10):e695-703. doi: 10.1016/S2214-109X(16)30186-3. Epub 2016 Aug 23.
- Camacho PA, Gomez-Arbelaez D, Molina DI, Sanchez G, Arcos E, Narvaez C, Garcia H, Perez M, Hernandez EA, Duran M, Cure C, Sotomayor A, Rico A, David TM, Cohen DD, Rangarajan S, Yusuf S, Lopez-Jaramillo P. Social disparities explain differences in hypertension prevalence, detection and control in Colombia. J Hypertens. 2016 Dec;34(12):2344-2352. doi: 10.1097/HJH.0000000000001115.
- Avezum A, Oliveira GBF, Lanas F, Lopez-Jaramillo P, Diaz R, Miranda JJ, Seron P, Camacho-Lopez PA, Orlandini A, Bernabe-Ortiz A, Cordeiro Mattos A, Islam S, Rangarajan S, Teo K, Yusuf S. Secondary CV Prevention in South America in a Community Setting: The PURE Study. Glob Heart. 2017 Dec;12(4):305-313. doi: 10.1016/j.gheart.2016.06.001. Epub 2016 Oct 20.
- Palafox B, McKee M, Balabanova D, AlHabib KF, Avezum AJ, Bahonar A, Ismail N, Chifamba J, Chow CK, Corsi DJ, Dagenais GR, Diaz R, Gupta R, Iqbal R, Kaur M, Khatib R, Kruger A, Kruger IM, Lanas F, Lopez-Jaramillo P, Minfan F, Mohan V, Mony PK, Oguz A, Palileo-Villanueva LM, Perel P, Poirier P, Rangarajan S, Rensheng L, Rosengren A, Soman B, Stuckler D, Subramanian SV, Teo K, Tsolekile LP, Wielgosz A, Yaguang P, Yeates K, Yongzhen M, Yusoff K, Yusuf R, Yusufali A, Zatonska K, Yusuf S. Wealth and cardiovascular health: a cross-sectional study of wealth-related inequalities in the awareness, treatment and control of hypertension in high-, middle- and low-income countries. Int J Equity Health. 2016 Dec 8;15(1):199. doi: 10.1186/s12939-016-0478-6.
- Duong M, Rangarajan S, Zhang X, Killian K, Mony P, Swaminathan S, Bharathi AV, Nair S, Vijayakumar K, Mohan I, Gupta R, Mohan D, Rani S, Mohan V, Iqbal R, Kazmi K, Rahman O, Yusuf R, Pinnaka LV, Kumar R, O'Byrne P, Yusuf S. Effects of bidi smoking on all-cause mortality and cardiorespiratory outcomes in men from south Asia: an observational community-based substudy of the Prospective Urban Rural Epidemiology Study (PURE). Lancet Glob Health. 2017 Feb;5(2):e168-e176. doi: 10.1016/S2214-109X(17)30004-9.
- Gupta R, Kaur M, Islam S, Mohan V, Mony P, Kumar R, Kutty VR, Iqbal R, Rahman O, Deepa M, Antony J, Vijaykumar K, Kazmi K, Yusuf R, Mohan I, Panwar RB, Rangarajan S, Yusuf S. Association of Household Wealth Index, Educational Status, and Social Capital with Hypertension Awareness, Treatment, and Control in South Asia. Am J Hypertens. 2017 Apr 1;30(4):373-381. doi: 10.1093/ajh/hpw169.
- Leong DP, McKee M, Yusuf S; PURE Investigators. Population Muscle Strength Predicts Olympic Medal Tallies: Evidence from 20 Countries in the PURE Prospective Cohort Study. PLoS One. 2017 Jan 20;12(1):e0169821. doi: 10.1371/journal.pone.0169821. eCollection 2017.
- Khatib R, Giacaman R, Khammash U, Yusuf S. Challenges to conducting epidemiology research in chronic conflict areas: examples from PURE- Palestine. Confl Health. 2017 Feb 22;10:33. doi: 10.1186/s13031-016-0101-x. eCollection 2016.
- Chow CK, Corsi DJ, Gilmore AB, Kruger A, Igumbor E, Chifamba J, Yang W, Wei L, Iqbal R, Mony P, Gupta R, Vijayakumar K, Mohan V, Kumar R, Rahman O, Yusoff K, Ismail N, Zatonska K, Altuntas Y, Rosengren A, Bahonar A, Yusufali A, Dagenais G, Lear S, Diaz R, Avezum A, Lopez-Jaramillo P, Lanas F, Rangarajan S, Teo K, McKee M, Yusuf S. Tobacco control environment: cross-sectional survey of policy implementation, social unacceptability, knowledge of tobacco health harms and relationship to quit ratio in 17 low-income, middle-income and high-income countries. BMJ Open. 2017 Mar 31;7(3):e013817. doi: 10.1136/bmjopen-2016-013817.
- Yusufali AM, Khatib R, Islam S, Alhabib KF, Bahonar A, Swidan HM, Khammash U, Alshamiri MQ, Rangarajan S, Yusuf S. Prevalence, awareness, treatment and control of hypertension in four Middle East countries. J Hypertens. 2017 Jul;35(7):1457-1464. doi: 10.1097/HJH.0000000000001326.
- Walli-Attaei M, Rosengren A, Rangarajan S, Breet Y, Abdul-Razak S, Sharief WA, Alhabib KF, Avezum A, Chifamba J, Diaz R, Gupta R, Hu B, Iqbal R, Ismail R, Kelishadi R, Khatib R, Lang X, Li S, Lopez-Jaramillo P, Mohan V, Oguz A, Palileo-Villanueva LM, Poltyn-Zaradna K, R SP, Pinnaka LVM, Seron P, Teo K, Verghese ST, Wielgosz A, Yeates K, Yusuf R, Anand SS, Yusuf S; PURE investigators. Metabolic, behavioural, and psychosocial risk factors and cardiovascular disease in women compared with men in 21 high-income, middle-income, and low-income countries: an analysis of the PURE study. Lancet. 2022 Sep 10;400(10355):811-821. doi: 10.1016/S0140-6736(22)01441-6.
- Narula N, Wong ECL, Dehghan M, Mente A, Rangarajan S, Lanas F, Lopez-Jaramillo P, Rohatgi P, Lakshmi PVM, Varma RP, Orlandini A, Avezum A, Wielgosz A, Poirier P, Almadi MA, Altuntas Y, Ng KK, Chifamba J, Yeates K, Puoane T, Khatib R, Yusuf R, Bostrom KB, Zatonska K, Iqbal R, Weida L, Yibing Z, Sidong L, Dans A, Yusufali A, Mohammadifard N, Marshall JK, Moayyedi P, Reinisch W, Yusuf S. Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study. BMJ. 2021 Jul 14;374:n1554. doi: 10.1136/bmj.n1554.
- Pertiwi K, Kupers LK, Geleijnse JM, Zock PL, Wanders AJ, Kruger HS, van Zyl T, Kruger IM, Smuts CM. Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults. Lipids Health Dis. 2020 Jun 16;19(1):138. doi: 10.1186/s12944-020-01318-3.
- Dehghan M, Mente A, Rangarajan S, Mohan V, Lear S, Swaminathan S, Wielgosz A, Seron P, Avezum A, Lopez-Jaramillo P, Turbide G, Chifamba J, AlHabib KF, Mohammadifard N, Szuba A, Khatib R, Altuntas Y, Liu X, Iqbal R, Rosengren A, Yusuf R, Smuts M, Yusufali A, Li N, Diaz R, Yusoff K, Kaur M, Soman B, Ismail N, Gupta R, Dans A, Sheridan P, Teo K, Anand SS, Yusuf S. Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries. Am J Clin Nutr. 2020 Apr 1;111(4):795-803. doi: 10.1093/ajcn/nqz348.
- Wentzel-Viljoen E, Laubscher R, Vorster HH. Changes in food intake from 2005 to 2010 by a cohort of black rural and urban African men and women in the North West Province of South Africa: the PURE-NWP-SA study. Public Health Nutr. 2018 Nov;21(16):2941-2958. doi: 10.1017/S1368980018001878. Epub 2018 Aug 28.
- Wentzel-Viljoen E, Lee S, Laubscher R, Vorster HH. Accelerated nutrition transition in the North West Province of South Africa: results from the Prospective Urban and Rural Epidemiology (PURE-NWP-SA) cohort study, 2005 to 2010. Public Health Nutr. 2018 Oct;21(14):2630-2641. doi: 10.1017/S1368980018001118. Epub 2018 May 8.
有用的网址
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2002年1月1日
初级完成 (估计的)
2030年12月31日
研究完成 (估计的)
2030年12月31日
研究注册日期
首次提交
2017年7月19日
首先提交符合 QC 标准的
2017年7月19日
首次发布 (实际的)
2017年7月21日
研究记录更新
最后更新发布 (估计的)
2024年1月31日
上次提交的符合 QC 标准的更新
2024年1月29日
最后验证
2024年1月1日
更多信息
与本研究相关的术语
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
是的
IPD 计划说明
在研究期间，仅与参与/为研究做出贡献的研究人员进行。
选择摘要数据可能会出于特定目的与政策制定者共享。研究执行者将在研究完成 3 年后考虑非贡献个人对数据分析的具体请求（即
完成招募和至少 10 年的跟进），参与的调查人员有机会探索他们感兴趣的问题。
与数据管理和相关工作相关的成本将需要由任何不参与研究和请求分析的人承担
IPD 共享时间框架
完成招募和至少 10 年的跟进
IPD 共享访问标准
研究执行者将在研究完成 3 年后考虑非贡献个人对数据分析的具体请求（即
完成招募和至少 10 年的跟进），参与的调查人员有机会探索他们感兴趣的问题。
IPD 共享支持信息类型
- 研究方案
- 企业社会责任
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.