The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases (QFS)
2017年11月27日 更新者：Louis Pérusse
The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours
The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.
研究概览
详细说明
The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992.
During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited.
During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited.
During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.
研究类型
观察性的
注册 (实际的)
951
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
10年 及以上 (孩子、成人、年长者)
接受健康志愿者
不适用
有资格学习的性别
全部
取样方法
非概率样本
研究人群
The QFS cohort is a mixture of random sampling and ascertainment through obese individuals.
In Phase 1 of the study, subjects were randomly selected from French-Canadian families living in the Quebec city area, In Phases 2 and 3 of the study, families with a least one obese parent and one obese offspring were recruited.
描述
Inclusion Criteria:
- Age over 10 years
Exclusion Criteria:
- Not applicable
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Body composition
大体时间：Through study completion, an average of 24 years
|
Body composition as assessed by underwater weighing
|
Through study completion, an average of 24 years
|
|
Body mass index (kg/m^2)
大体时间：Through study completion, an average of 24 years
|
Body mass index assessed from height and weight
|
Through study completion, an average of 24 years
|
|
Abdominal fat
大体时间：Through study completion, an average of 24 years
|
Abdominal fat as assessed by commuted tomography
|
Through study completion, an average of 24 years
|
|
Waist and hip circumferences (cm)
大体时间：Through study completion, an average of 24 years
|
Waist and hip circumferences (cm)
|
Through study completion, an average of 24 years
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Caloric intake
大体时间：Through study completion, an average of 24 years
|
Total caloric intake and macronutrient intake using a 3-day dietary record
|
Through study completion, an average of 24 years
|
|
Eating behaviour
大体时间：Through study completion, an average of 24 years
|
Eating behaviour assessed using the Three-Factor Eating questionnaire
|
Through study completion, an average of 24 years
|
|
Energy expenditure
大体时间：Through study completion, an average of 24 years
|
Oxygen consumption at rest and during exercise
|
Through study completion, an average of 24 years
|
|
Physical activity level
大体时间：Through study completion, an average of 24 years
|
Physical activity level assessed by questionnaire
|
Through study completion, an average of 24 years
|
|
Blood pressure (mm Hg)
大体时间：Through study completion, an average of 24 years
|
Systolic and diastolic blood pressure
|
Through study completion, an average of 24 years
|
|
Plasma lipid levels (mmol/L)
大体时间：Through study completion, an average of 24 years
|
Fasting levels of triglycerides, LDL-cholesterol and HDL-cholesterol in mmo/L
|
Through study completion, an average of 24 years
|
|
Glucose levels (mmol/L)
大体时间：Through study completion, an average of 24 years
|
Plasma glucose levels in a fasting state and following an oral glucose tolerance test, inflammatory markers. Plasma glucose levels in a fasting state and during an oral glucose tolerance test |
Through study completion, an average of 24 years
|
|
Insulin levels (pmol/L)
大体时间：Through study completion, an average of 24 years
|
Plasma insulin levels in a fasting state and following an oral glucose tolerance test.
|
Through study completion, an average of 24 years
|
|
C-reactive protein (CRP in mg/ml)
大体时间：Through study completion, an average of 24 years
|
C-reactive protein (CRP in mg/ml)
|
Through study completion, an average of 24 years
|
|
Adiponectin levels (in micrograms/ml)
大体时间：Through study completion, an average of 24 years
|
Adiponectin levels (in micrograms/ml)
|
Through study completion, an average of 24 years
|
|
Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml
大体时间：Through study completion, an average of 24 years
|
Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml
|
Through study completion, an average of 24 years
|
|
Smoking habits (nb of cigarettes per day)
大体时间：Through study completion, an average of 24 years
|
Smoking habits (nb of cigarettes per day)
|
Through study completion, an average of 24 years
|
|
Sleeping (hours/day)
大体时间：Through study completion, an average of 24 years
|
Sleeping (hours/day)
|
Through study completion, an average of 24 years
|
|
Alcohol consumption
大体时间：Through study completion, an average of 24 years
|
Alcohol consumption (nb of drinks per week)
|
Through study completion, an average of 24 years
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
调查人员
- 首席研究员：Claude Bouchard, Ph.D.、Pennington Biomedical Center
- 研究主任：Louis Perusse, Ph.D.、Laval University
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
一般刊物
- Chaput JP, Perusse L, Despres JP, Tremblay A, Bouchard C. Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights. Curr Obes Rep. 2014 Jan 4;3(1):54-66. doi: 10.1007/s13679-013-0086-3. eCollection 2014.
- Jacob R, Drapeau V, Tremblay A, Provencher V, Bouchard C, Perusse L. The role of eating behavior traits in mediating genetic susceptibility to obesity. Am J Clin Nutr. 2018 Sep 1;108(3):445-452. doi: 10.1093/ajcn/nqy130.
有用的网址
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
1978年6月1日
初级完成 (实际的)
2002年9月5日
研究完成 (实际的)
2002年9月5日
研究注册日期
首次提交
2017年11月16日
首先提交符合 QC 标准的
2017年11月27日
首次发布 (实际的)
2017年11月28日
研究记录更新
最后更新发布 (实际的)
2017年11月28日
上次提交的符合 QC 标准的更新
2017年11月27日
最后验证
2017年11月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.