The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases (QFS)
27. november 2017 opdateret af: Louis Pérusse
The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours
The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.
Studieoversigt
Status
Afsluttet
Betingelser
Detaljeret beskrivelse
The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992.
During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited.
During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited.
During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
951
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
10 år og ældre (Barn, Voksen, Ældre voksen)
Tager imod sunde frivillige
N/A
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Ikke-sandsynlighedsprøve
Studiebefolkning
The QFS cohort is a mixture of random sampling and ascertainment through obese individuals.
In Phase 1 of the study, subjects were randomly selected from French-Canadian families living in the Quebec city area, In Phases 2 and 3 of the study, families with a least one obese parent and one obese offspring were recruited.
Beskrivelse
Inclusion Criteria:
- Age over 10 years
Exclusion Criteria:
- Not applicable
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Body composition
Tidsramme: Through study completion, an average of 24 years
|
Body composition as assessed by underwater weighing
|
Through study completion, an average of 24 years
|
|
Body mass index (kg/m^2)
Tidsramme: Through study completion, an average of 24 years
|
Body mass index assessed from height and weight
|
Through study completion, an average of 24 years
|
|
Abdominal fat
Tidsramme: Through study completion, an average of 24 years
|
Abdominal fat as assessed by commuted tomography
|
Through study completion, an average of 24 years
|
|
Waist and hip circumferences (cm)
Tidsramme: Through study completion, an average of 24 years
|
Waist and hip circumferences (cm)
|
Through study completion, an average of 24 years
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Caloric intake
Tidsramme: Through study completion, an average of 24 years
|
Total caloric intake and macronutrient intake using a 3-day dietary record
|
Through study completion, an average of 24 years
|
|
Eating behaviour
Tidsramme: Through study completion, an average of 24 years
|
Eating behaviour assessed using the Three-Factor Eating questionnaire
|
Through study completion, an average of 24 years
|
|
Energy expenditure
Tidsramme: Through study completion, an average of 24 years
|
Oxygen consumption at rest and during exercise
|
Through study completion, an average of 24 years
|
|
Physical activity level
Tidsramme: Through study completion, an average of 24 years
|
Physical activity level assessed by questionnaire
|
Through study completion, an average of 24 years
|
|
Blood pressure (mm Hg)
Tidsramme: Through study completion, an average of 24 years
|
Systolic and diastolic blood pressure
|
Through study completion, an average of 24 years
|
|
Plasma lipid levels (mmol/L)
Tidsramme: Through study completion, an average of 24 years
|
Fasting levels of triglycerides, LDL-cholesterol and HDL-cholesterol in mmo/L
|
Through study completion, an average of 24 years
|
|
Glucose levels (mmol/L)
Tidsramme: Through study completion, an average of 24 years
|
Plasma glucose levels in a fasting state and following an oral glucose tolerance test, inflammatory markers. Plasma glucose levels in a fasting state and during an oral glucose tolerance test |
Through study completion, an average of 24 years
|
|
Insulin levels (pmol/L)
Tidsramme: Through study completion, an average of 24 years
|
Plasma insulin levels in a fasting state and following an oral glucose tolerance test.
|
Through study completion, an average of 24 years
|
|
C-reactive protein (CRP in mg/ml)
Tidsramme: Through study completion, an average of 24 years
|
C-reactive protein (CRP in mg/ml)
|
Through study completion, an average of 24 years
|
|
Adiponectin levels (in micrograms/ml)
Tidsramme: Through study completion, an average of 24 years
|
Adiponectin levels (in micrograms/ml)
|
Through study completion, an average of 24 years
|
|
Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml
Tidsramme: Through study completion, an average of 24 years
|
Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml
|
Through study completion, an average of 24 years
|
|
Smoking habits (nb of cigarettes per day)
Tidsramme: Through study completion, an average of 24 years
|
Smoking habits (nb of cigarettes per day)
|
Through study completion, an average of 24 years
|
|
Sleeping (hours/day)
Tidsramme: Through study completion, an average of 24 years
|
Sleeping (hours/day)
|
Through study completion, an average of 24 years
|
|
Alcohol consumption
Tidsramme: Through study completion, an average of 24 years
|
Alcohol consumption (nb of drinks per week)
|
Through study completion, an average of 24 years
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Claude Bouchard, Ph.D., Pennington Biomedical Center
- Studieleder: Louis Perusse, Ph.D., Laval University
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Chaput JP, Perusse L, Despres JP, Tremblay A, Bouchard C. Findings from the Quebec Family Study on the Etiology of Obesity: Genetics and Environmental Highlights. Curr Obes Rep. 2014 Jan 4;3(1):54-66. doi: 10.1007/s13679-013-0086-3. eCollection 2014.
- Jacob R, Drapeau V, Tremblay A, Provencher V, Bouchard C, Perusse L. The role of eating behavior traits in mediating genetic susceptibility to obesity. Am J Clin Nutr. 2018 Sep 1;108(3):445-452. doi: 10.1093/ajcn/nqy130.
Hjælpsomme links
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. juni 1978
Primær færdiggørelse (Faktiske)
5. september 2002
Studieafslutning (Faktiske)
5. september 2002
Datoer for studieregistrering
Først indsendt
16. november 2017
Først indsendt, der opfyldte QC-kriterier
27. november 2017
Først opslået (Faktiske)
28. november 2017
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
28. november 2017
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
27. november 2017
Sidst verificeret
1. november 2017
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2010-075 CG
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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